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Developing a profile of activities of daily living for bipolar disorder: a systematic review protocol and meta-analysis.

BMJ Open 2022 May 16;12(5):e058783. Epub 2022 May 16.

Department of Occupational Science and Occupational Therapy, University of Toronto, Toronto, Ontario, Canada

Introduction: Bipolar disorder (BD) is a severe mental health disorder that affects 2% of the adult population. Individuals with this disorder are at a higher risk for morbidity and functional difficulties. They may also experience significant challenges in their activities of daily living (ADLs). Read More

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Molecular characterization and expression analysis of septin gene family and phagocytic function of recombinant septin 2, 3 and 8 of starry flounder (Platichthys stellatus).

Fish Shellfish Immunol 2022 May 13. Epub 2022 May 13.

Department of Marine Biology & Aquaculture, College of Marine Science, Gyeongsang National University, 455, Tongyeong, 650-160, Republic of Korea. Electronic address:

Septin is an evolutionarily conserved family of GTP-binding proteins. Septins are known to be involved in a variety of cellular processes, including cell division, chromosome separation, cell polarity, motility, membrane dynamics, exocytosis, apoptosis, phagocytosis, DNA damage responses, and other immune responses. In this study, the sequences of the septin gene family of starry flounder were obtained using NGS sequencing, and the integrity of the sequences was verified through cloning and sequencing. Read More

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Systematics of Lepidothrix manakins (Aves: Passeriformes: Pipridae) using RADcap markers.

Mol Phylogenet Evol 2022 May 13:107525. Epub 2022 May 13.

Department of Biological Sciences and Museum of Natural Science, Louisiana State University, Baton Rouge, LA 70803, USA.

Although recent molecular phylogenetic analyses of Lepidothrix manakins (family Pipridae) have helped clarify their evolutionary relationships, the placement of several lineages remains in question because of low or conflicting branch support. In particular, the relationship of L. coronata to other members of the genus and relationships within the L. Read More

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Central Line Access for Hemodialysis Adversely Affects Ipsilateral Arteriovenous Graft Outcomes.

Ann Vasc Surg 2022 May 13. Epub 2022 May 13.

Central Virginia Veterans Administration Health System, Richmond, Virginia; Virginia Commonwealth University School of Medicine, Richmond, Virginia.

Objective: Central venous stenosis is a common problem that diminishes vascular access lifespan. Current national guidelines recommend that central catheters and arteriovenous grafts (AVG) be placed contralateral to an existing hemodialysis access. We set forth to delineate any clinically significant outcomes based on laterality in patients undergoing AVG placement with an existing central catheter for dialysis treatments. Read More

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Another Tradition of Chinese Medical Knowledge Dissemination: The Characteristics and Significance of the 'Zhiguai Medical Cases' of the Song Period.

Haebyoul Choi

Uisahak 2022 Apr;31(1):35-92

Department of History, Ewha Womans University.

During the explanation of the origin of 'prescription,' an interesting phenomena in the accumulation and diffusion of medical knowledge in the Song Period is that many prescriptions contain narratives with bizarre elements, such as those given by God through dreams, received from 'strange people,' or from animals appearing in these dreams. This study features an anecdote called 'zhiguai Medical Cases,' which contains bizarre elements in the dissemination process of prescription, narrative of the treatment experience, and specific content of prescription, called a 'zhiguai prescription.' In previous research, such prescriptions were often called a 'God-delivered prescription. Read More

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Can you change your mind? An ERP study of cognitive flexibility and new evidence integration.

Biol Psychol 2022 May 13:108354. Epub 2022 May 13.

Brain Mapping Unit, Instituto Pluridisciplinar. Universidad Complutense de Madrid (UCM), Madrid, Spain; CIBERSAM (Biomedical Research Networking Centre in Mental Health), Spain; Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain; Languages and Education Department, Universidad de Nebrija, Madrid, Spain.

Cognitive flexibility is an ability that allows individuals to integrate external evidence into previous expectancies. Individual differences in this ability were examined using Event-Related Potentials (ERPs), focusing on the fact that new evidence can either confirm or disprove an initial impression. Written scenarios prompted to make a prediction while either confirmatory or disconfirmatory evidence followed. Read More

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MRCON-Net: Multiscale reweighted convolutional coding neural network for low-dose CT imaging.

Comput Methods Programs Biomed 2022 May 8;221:106851. Epub 2022 May 8.

Key Laboratory of Computer Network and Information Integration (Southeast University) Ministry of Education Nanjing, China; School of Cyber Science and Engineering, Southeast University, Nanjing, China; School of Computer Science and Engineering, Southeast University, Nanjing, China.

Background And Objective: Low-dose computed tomography (LDCT) has become increasingly important for alleviating X-ray radiation damage. However, reducing the administered radiation dose may lead to degraded CT images with amplified mottle noise and nonstationary streak artifacts. Previous studies have confirmed that deep learning (DL) is promising for improving LDCT imaging. Read More

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Early severity prediction of BPD for premature infants from chest X-ray images using deep learning: A study at the 28th day of oxygen inhalation.

Comput Methods Programs Biomed 2022 May 10;221:106869. Epub 2022 May 10.

Center for Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai 200438, China; Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address:

Background And Objective: Bronchopulmonary dysplasia is a common respiratory disease in premature infants. The severity is diagnosed at the 56th day after birth or discharge by analyzing the clinical indicators, which may cause the delay of the best treatment opportunity. Thus, we proposed a deep learning-based method using chest X-ray images of the 28th day of oxygen inhalation for the early severity prediction of bronchopulmonary dysplasia in clinic. Read More

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Development and validation of apoptosis-related signature and molecular subtype to improve prognosis prediction in osteosarcoma patients.

J Clin Lab Anal 2022 May 16:e24501. Epub 2022 May 16.

Department of Hand Surgery, Department of Plastic Reconstructive Surgery, Ningbo No. 6 Hospital, Ningbo, China.

Background: Previous evidence has shown that apoptosis performs integral functions in the tumorigenesis and development of various tumors. Therefore, this study aimed to establish a molecular subtype and prognostic signature based on apoptosis-related genes (ARGs) to understand the molecular mechanisms and predict prognosis in patients with osteosarcoma.

Methods: The GEO and TARGET databases were utilized to obtain the expression levels of ARGs and clinical information of osteosarcoma patients. Read More

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Thromboelastography-Based Evaluation of Gender-Associated Hypercoagulability.

Am Surg 2022 May 16:31348221087905. Epub 2022 May 16.

Department of Surgery, 21693University of Mississippi Medical Center, Jackson, MS, USA.

Background: Age, race, and gender differences in coagulation status of healthy volunteers have been reported in previous case series; however, rigorous multivariate analysis adjusting for these factors is lacking. We aimed to investigate the effects of age, race, and gender on baseline coagulation status in healthy volunteers.

Methods: Thirty healthy volunteer controls with no history of bleeding or thrombotic events and no previous anticoagulant or antiplatelet use were recruited. Read More

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Anicteric Gallbladder Rupture with Elevated Bile Acids in Abdominal Effusion in a Dog with Cholecystitis.

J Am Anim Hosp Assoc 2022 May;58(3):146-151

From Dick White Referrals, Cambridgeshire, United Kingdom.

Anicteric gallbladder rupture has been rarely described in veterinary medicine, and, generally, it has been related to gallbladder wall necrosis secondary to gallbladder mucocele. A 5 yr old, male, neutered Labrador retriever presented for acute onset anorexia, lethargy, and vomiting. Cholecystitis was diagnosed based on the ultrasonographic findings and bactibilia, and, consequently, medical treatment was established. Read More

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Use of benznidazole to treat chronic Chagas disease: An updated systematic review with a meta-analysis.

PLoS Negl Trop Dis 2022 May 16;16(5):e0010386. Epub 2022 May 16.

National Referral Centre for Tropical Diseases, Infectious Diseases Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Background: Approximately 6 million people worldwide are affected by Chagas disease, with many in the chronic phase of the disease (CCD). It is crucial to evaluate the effectiveness of benznidazole for CCD treatment.

Methods/principal Findings: We updated a meta-analysis published in 2009 up to February 2021, including controlled trials (RCT) and prospective observational studies (OBS) that compared benznidazole vs placebo/no-treatment (P/nT). Read More

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Changing trends in hip fracture epidemiology in the Republic of Ireland: a follow-up study.

Arch Osteoporos 2022 May 16;17(1):79. Epub 2022 May 16.

The Mater Misericordiae University Hospital, Dublin, Ireland.

A national, population-based study of hip fracture epidemiology is reported following a previously published study for the same population to ascertain the accuracy of projected incidence rates. Results suggest a decline in age-specific incidence rates in females but not males, and an over-estimation of same in the previously reported projections.

Purpose: Accurate estimates of hip fracture numbers and incidence rates are necessary for health service resource planning. Read More

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Prediction of Retinal Ganglion Cell Counts Considering Various Displacement Methods From OCT-Derived Ganglion Cell-Inner Plexiform Layer Thickness.

Transl Vis Sci Technol 2022 May;11(5):13

Centre for Eye Health, University of New South Wales (UNSW), Sydney, NSW Australia.

Purpose: To compare various displacement models using midget retinal ganglion cell to cone (mRGC:C) ratios and to determine viability of estimating RGC counts from optical coherence tomography (OCT)-derived ganglion cell-inner plexiform layer (GCIPL) measurements.

Methods: Four Drasdo model variations were applied to macular visual field (VF) stimulus locations: (1) using meridian-specific Henle fiber length along the stimulus circumference; (2) using meridian-specific differences in RGC receptive field and counts along the stimulus circumference; (3) per method (2), averaged across principal meridians; and (4) per method (3), with the stimulus center displaced only. The Sjöstrand model was applied (5) along the stimulus circumference and (6) to the stimulus center only. Read More

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Exposure to air pollution and risk of ovarian cancer: a review.

Rev Environ Health 2022 May 17. Epub 2022 May 17.

Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

Objectives: Exposure to air pollution has destructive health consequences and a potential role in ovarian cancer etiology. We conducted a systematic review of the studies assessing the associations between ovarian malignancy and exposure to air pollutants.

Content: The included studies were categorized based on types of measured ambient air pollutants, including particulate matter (five studies), gases (two studies), air pollutant mixtures (eight studies), and traffic indicators for air pollution (only one study). Read More

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Prediction models as gatekeepers for diagnostic testing in angina patients with suspected chronic coronary syndrome.

Eur Heart J Qual Care Clin Outcomes 2022 May 16. Epub 2022 May 16.

Department of Cardiology, Bispebjerg Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.

Aim: Assessment of pre-test probability (PTP) is an important gatekeeper when selecting patients for diagnostic testing for coronary artery disease (CAD). The 2019 European Society of Cardiology (ESC) guidelines recommend upgrading PTP based on clinical risk factors but provide no estimates of how these affect PTP. We aimed to validate two published PTP models in a contemporary low CAD prevalence cohort and compare with ESC 2019 PTP. Read More

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Temperature and Geographic Location Impact the Distribution and Diversity of Photoautotrophic Gene Variants in Alkaline Yellowstone Hot Springs.

Microbiol Spectr 2022 May 16:e0146521. Epub 2022 May 16.

Department of Plant and Microbial Biology, University of Minnesotagrid.17635.36, St. Paul, Minnesota, USA.

Alkaline hot springs in Yellowstone National Park (YNP) provide a framework to study the relationship between photoautotrophs and temperature. Previous work has focused on studying how cyanobacteria (oxygenic phototrophs) vary with temperature, sulfide, and pH, but many questions remain regarding the ecophysiology of anoxygenic photosynthesis due to the taxonomic and metabolic diversity of these taxa. To this end, we examined the distribution of genes involved in phototrophy, carbon fixation, and nitrogen fixation in eight alkaline (pH 7. Read More

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Complex Ecotype Dynamics Evolve in Response to Fluctuating Resources.

mBio 2022 May 16:e0346721. Epub 2022 May 16.

Biodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, Arizona, USA.

Ecotypic diversification and its associated cooperative behaviors are frequently observed in natural microbial populations whose access to resources is often sporadic. However, the extent to which fluctuations in resource availability influence the emergence of cooperative ecotypes is not fully understood. To determine how exposure to repeated resource limitation affects the establishment and long-term maintenance of ecotypes in a structured environment, we followed 32 populations of Escherichia coli evolving to either 1-day or 10-day feast/famine cycles for 900 days. Read More

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Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain.

J Vis Exp 2022 Apr 28(182). Epub 2022 Apr 28.

Department of Neurology, Northwestern University Feinberg School of Medicine;

Proteinaceous fibrillar inclusions are key pathological hallmarks of multiple neurodegenerative diseases. In the early stages of Alzheimer's disease (AD), amyloid-beta peptides form protofibrils in the extracellular space, which act as seeds that gradually grow and mature into large amyloid plaques. Despite this basic understanding, current knowledge of the amyloid fibril structure, composition, and deposition patterns in the brain is limited. Read More

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GLIDER: Function Prediction from GLIDE-based Neigborhoods.

Bioinformatics 2022 May 16. Epub 2022 May 16.

Department of Computer Science, Tufts University, Medford, MA, 02155, USA.

Motivation: Protein function prediction, based on the patterns of connection in a Protein-Protein Interaction (or Association) network, is perhaps the most studied of the classical, fundamental inference problems for biological networks. A highly successful set of recent approaches use random walk-based low dimensional embeddings, that tend to place functionally similar proteins into coherent spatial regions. However, these approaches lose valuable local graph structure from the network when considering only the embedding. Read More

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3D Bioprinting of Living Materials for Structure-Dependent Production of Hyaluronic Acid.

ACS Macro Lett 2022 Apr 17;11(4):452-459. Epub 2022 Mar 17.

School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Guangming District, Shenzhen, Guangdong 518107, P. R. China.

3D bioprinting of living materials represents an interesting paradigm toward the efficacy enhancement for the biosynthesis of various functional compounds in microorganisms. Previous studies have shown the success of 3D-printed bioactive systems in the production of small molecular compounds. However, the feasibility of such a strategy in producing macromolecules and how the geometry of the 3D scaffold influences the productivity are still unknown. Read More

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In silico analysis of mutations near S1/S2 cleavage site in SARS-CoV-2 spike protein reveals increased propensity of glycosylation in Omicron strain.

J Med Virol 2022 May 16. Epub 2022 May 16.

Department of Biochemistry, Hopkins Building, University of Cambridge, Cambridge, CB2 1GA, United Kingdom.

Cleavage of the Severe Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) spike protein has been demonstrated to contribute to viral-cell fusion and syncytia formation. Studies have shown that variants of concern (VOC) and variants of interest (VOI) show differing membrane fusion capacity. Mutations near cleavage motifs, such as the S1/S2 and S2' sites, may alter interactions with host proteases and, thus, the potential for fusion. Read More

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Antimicrobial prescribing and antimicrobial resistance surveillance in equine practice.

Equine Vet J 2022 May 16. Epub 2022 May 16.

Department of Equine Clinical Science, Institute of Veterinary and Ecological Sciences, University of Liverpool, Neston, UK.

Background: Antimicrobial resistance (AMR) is an increasingly serious threat to human and animal health, therefore responsible use of antimicrobials in equine practice is vital. There is a need to have accurate, up to date data on antimicrobial prescribing in equine practice in the UK.

Objectives: To characterise current antimicrobial prescribing practices by equine veterinarians and to describe surveillance, audit processes and identification of AMR. Read More

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Investigating the ultrastructural and viscoelastic characteristics of whole blood after exposure to the heavy metals cadmium, lead and chromium, alone and in combination.

Ultrastruct Pathol 2022 May 15:1-11. Epub 2022 May 15.

Department of Anatomy, Faculty of Health Sciences, University of Pretoria, Arcadia, South Africa.

In recent years, heavy metal exposure has become a serious health concern as more humans are being exposed to heavy metals on a daily basis. Most of the environmental contamination and human exposure result from anthropogenic activities such as mining and smelting. The industrial and agricultural sectors also play a big role. Read More

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Stroke Risk Stratification in Patients With Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting.

J Am Heart Assoc 2022 May 16:e024703. Epub 2022 May 16.

Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Sweden.

Background The CHADS-VASc (congestive heart failure, hypertension, age ≥75 years, diabetes, previous stroke or TIA [transient ischemic attack], vascular disease, age 65 to 74 years, sex category female; 2 indicates 2 points, otherwise 1 point) scoring system is recommended to guide decisions on oral anticoagulation therapy for stroke prevention in patients with nonsurgery atrial fibrillation. A score ≥1 in men and ≥2 in women, corresponding to an annual stroke risk exceeding 1%, warrants long-term oral anticoagulation provided the bleeding risk is acceptable. However, in patients with new-onset postoperative atrial fibrillation, the optimal risk stratification method is unknown. Read More

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Occupational-Related Upper and Lower Extremity Musculoskeletal Pain Among Working Population of Ethiopia: Systematic Review and Meta-Analysis.

Inquiry 2022 Jan-Dec;59:469580221088620

Department of Environmental Health, College of Health and Medical Science, Haramaya University, Harar, Ethiopia.

Background: Currently, work-related musculoskeletal disorders are a significant public health concern and are a leading cause of disability-adjusted life years and reduced quality of life worldwide. In developing countries, including Ethiopia, as a result of poor occupational health and safety practices and underreporting of the problems, work-related musculoskeletal disorders have been increased, remaining less prioritized, and there is no adequate evidence on the prevalence of musculoskeletal disorders. Thus, the current study aimed to determine and provide the overall prevalence of occupational-related upper and lower extremity musculoskeletal pain among the working population of Ethiopia. Read More

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Deep-Learning-Based End-to-End Predictions of CO Capture in Metal-Organic Frameworks.

J Chem Inf Model 2022 May 16. Epub 2022 May 16.

School of Computer Science and Technology, Nanjing Tech University, Nanjing 211816, China.

Metal-organic frameworks (MOFs) have become an active topic because of their excellent carbon capture and storage (CCS) properties. However, it is quite challenging to identify MOFs with superior performance within a massive combinatorial search space. To this end, we propose a deep-learning-based end-to-end prediction model to rapidly and accurately predict the CO working capacity and CO/N selectivity of a given MOF under low-pressure conditions. Read More

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Fcγ-Receptor-Based Enzyme-Linked Immunosorbent Assays for Sensitive, Specific, and Persistent Detection of Anti-SARS-CoV-2 Nucleocapsid Protein IgG Antibodies in Human Sera.

J Clin Microbiol 2022 May 16:e0007522. Epub 2022 May 16.

Department for Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

Sensitive and specific serological tests are mandatory for epidemiological studies evaluating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prevalence as well as coronavirus disease 2019 (COVID-19) morbidity and mortality rates. The accuracy of results is challenged by antibody waning after convalescence and by cross-reactivity induced by previous infections with other pathogens. By employing a patented platform technology based on capturing antigen-antibody complexes with a solid-phase-bound Fcγ receptor (FcγR) and truncated nucleocapsid protein as the antigen, two SARS-CoV-2 IgG enzyme-linked immunosorbent assays (ELISAs), featuring different serum and antigen dilutions, were developed. Read More

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Urban-Rural Disparities in the Lung Cancer Surgical Treatment Pathway: The Paradox of a Rich, Small Region.

Front Surg 2022 28;9:884048. Epub 2022 Apr 28.

Thoracic Surgery Department, Ospedale Regionale di Bellinzona e Valli, Via Ospedale, Bellinzona, Switzerland.

Introduction: Rural populations in large countries often receive delayed or less effective diagnosis and treatment for lung cancer. Differences are related to population-based factors such as lower pro capita income or increased risk factors or to differences in access to facilities. Switzerland is a small, rich country with peculiar geographic and urban characteristics. Read More

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Spherical Convolutional Neural Networks for Survival Rate Prediction in Cancer Patients.

Front Oncol 2022 27;12:870457. Epub 2022 Apr 27.

Division of Biomedical Imaging, Department of Biomedical Engineering and Health Systems, KTH Royal Institute of Technology, Stockholm, Sweden.

Objective: Survival Rate Prediction (SRP) is a valuable tool to assist in the clinical diagnosis and treatment planning of lung cancer patients. In recent years, deep learning (DL) based methods have shown great potential in medical image processing in general and SRP in particular. This study proposes a fully-automated method for SRP from computed tomography (CT) images, which combines an automatic segmentation of the tumor and a DL-based method for extracting rotational-invariant features. Read More

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