68,114 results match your criteria based inclusion

The 2016 Edition of the WHO Classification of Primary Brain Tumors: Applicable to Assess Individual Risk of Recurrence in Atypical Meningioma? A Single-Center Experience.

J Neurol Surg A Cent Eur Neurosurg 2021 Apr 12. Epub 2021 Apr 12.

Department of Neurosurgery, University Hospital of Essen, Essen, Germany.

Background And Study Aims/object:  Despite the relevance of molecular criteria for brain tumor diagnosis and prognosis, meningioma grading is still solely based on histologic features. Atypical meningiomas (AMs; WHO grade II) display a great histologic heterogeneity and individual courses of disease can differ significantly. This study aimed to identify clinically aggressive AMs that are prone to early recurrence after gross total resection (GTR) by assessing a specific histologic score. Read More

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A Systematic Review Demonstrates High Variation of Terminology, Surgical Techniques, Preoperative Diagnostic Measures, and Geographic Differences in the Treatment of Athletic Pubalgia/Sports Hernia/Core Muscle Injury/Inguinal Disruption.

Arthroscopy 2021 Apr 9. Epub 2021 Apr 9.

St. Joseph's University Medical Center, Department of Orthopaedic Surgery, Paterson NJ 07503; New Jersey Orthopaedic Institute, Wayne NJ 07470.

Purpose: To perform a systematic review of reported terminologies, surgical techniques, preoperative diagnostic measures, and geographic differences in the treatment of core muscle injury (CMI)/athletic pubalgia/inguinal disruption.

Methods: A systematic review was performed by searching PubMed, Cochrane Library, and Embase to identify clinical studies or articles that described a surgical technique to treat CMI refractory to nonoperative treatment. The search phrase used was "core muscle injury" OR "sports hernia" OR "athletic pubalgia" OR "inguinal disruption". Read More

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Factors Affecting Recruitment and Participation of Bereaved Parents in Research: A Brief Report.

J Pain Symptom Manage 2021 Apr 9. Epub 2021 Apr 9.

Division of Medicine Critical Care, Department of Pediatrics, Boston Children's Hospital, Boston, MA.

Context: Inclusion of bereaved parents in survey-based research is essential to improving end-of-life care for children and their families. However, racial and ethnic minorities are vastly underrepresented in these studies.

Objectives: Examine which child demographic characteristics are associated with parental participation in survey-based research. Read More

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Achieving cultural safety for Australia.

Aust Health Rev 2021 Apr 13. Epub 2021 Apr 13.

ObjectiveHealth practitioners' Codes of Conduct and Codes of Ethics articulate practice standards across multiple domains, including the domain of cultural safety. As key tools driving individual practice and systems reform, Codes are integral to improving health outcomes for Aboriginal and Torres Strait Islander peoples. It is, therefore, critical that their contents specify meaningful cultural safety standards as the norm for institutional and individual practice. Read More

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Can Coupling Multiple Complementary Methods Improve the Spectroscopic Based Diagnosis of Gastrointestinal Illnesses? A Proof of Principle Study Using Celiac Disease as the Model Illness.

Anal Chem 2021 Apr 12. Epub 2021 Apr 12.

Gastroenterology Research Unit, Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin 9054, New Zealand.

Spectroscopic methods are a promising approach for providing a point-of-care diagnostic method for gastrointestinal mucosa associated illnesses. Such a tool is desired to aid immediate decision making and to provide a faster pathway to appropriate treatment. In this pilot study, Raman, near-infrared, low frequency Raman, and autofluoresence spectroscopic methods were explored alone and in combination for the diagnosis of celiac disease. Read More

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[Barriers and motivating factors in the use of alcohol based products: The key to a multimodal strategy to increase compliance with hand hygiene practices. Qualitative systematic review.]

Rev Chilena Infectol 2021 Feb;38(1):22-26

Programa de Doctorado en Enfermería, Facultad de Enfermería, Universidad Andrés Bello, Santiago, Chile.

Introduction: The compliance with HH (hand hygiene) practices by health personnel is 38.7% worldwide. Using a multimodal strategy of the WHO (World Health Organization), alcohol based products was introduced. Read More

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February 2021

Factors influencing emergency department observation time following anaphylaxis: a systematic review.

CJEM 2021 Apr 12. Epub 2021 Apr 12.

Université de Sherbrooke, Sherbrooke, QC, Canada.

Objective: Anaphylaxis is a condition that warrants an observation period after symptoms resolution to detect rare but life-threatening delayed complications. There is a need for evidence to identify patients who would benefit from prolonged observation time. The purpose of this review was to identify factors that may influence the need for longer observation in the emergency department. Read More

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Exit Strategies in Natalizumab-Treated RRMS at High Risk of Progressive Multifocal Leukoencephalopathy: a Multicentre Comparison Study.

Neurotherapeutics 2021 Apr 12. Epub 2021 Apr 12.

Department "G.F. Ingrassia", MS Center, Organization University of Catania, Catania, Italy.

The main aim of the study is to evaluate the efficacy and safety profile of ocrelizumab (OCR), rituximab (RTX), and cladribine (CLA), employed as natalizumab (NTZ) exit strategies in relapsing-remitting multiple sclerosis (RRMS) patients at high-risk for progressive multifocal leukoencephalopathy (PML). This is a multicentre, retrospective, real-world study on consecutive RRMS patients from eleven tertiary Italian MS centres, who switched from NTZ to OCR, RTX, and CLA from January 1st, 2019, to December 31st, 2019. The primary study outcomes were the annualized relapse rate (ARR) and magnetic resonance imaging (MRI) outcome. Read More

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Child attachment and ADHD: a systematic review.

Eur Child Adolesc Psychiatry 2021 Apr 12. Epub 2021 Apr 12.

Department of Child and Adolescent Psychiatry, Queen Fabiola Children's University Hospital (QFCUH), Brussels, Belgium.

Attention Deficit/Hyperactivity Disorder (ADHD) is a frequent neurodevelopmental disorder in children. ADHD has a multifactorial origin, combining genetic and environmental factors. Several studies suggested an influence of early parent-child relationships on the symptomatic expression of ADHD. Read More

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RAS-NOTECHS: validity and reliability of a tool for measuring non-technical skills in robotic-assisted surgery settings.

Surg Endosc 2021 Apr 12. Epub 2021 Apr 12.

Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Ziemssenstrasse 1, 80336, Munich, Germany.

Background: Non-technical skills (NTS) are essential for safe surgical practice as they impact workflow and patient outcomes. Observational tools to measure operating room (OR) teams' NTS have been introduced. However, there are none that account for the specific teamwork challenges introduced by robotic-assisted surgery (RAS). Read More

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Radiological management of postoperative lymphorrhea.

Langenbecks Arch Surg 2021 Apr 12. Epub 2021 Apr 12.

Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Ihwa-dong, Jongno-gu, Seoul, Republic of Korea.

Purpose: Postoperative lymphorrhea can occur after different surgical procedures and may prolong the hospital stay due to the need for specific treatment. In this work, the therapeutic significance of the radiological management of postoperative lymphorrhea was assessed and illustrated.

Method: A standardized search of the literature was performed in PubMed applying the Medical Subject Headings (MeSH) term "lymphangiography. Read More

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Characterization of Adult Patients With SMA Treated in US Hospital Settings: A Natural History Study in the Premier Healthcare Database.

J Neuromuscul Dis 2021 Apr 2. Epub 2021 Apr 2.

Biogen, Cambridge, MA, USA.

Background: Spinal muscular atrophy (SMA) is a rare genetic disease characterized by progressive muscular weakness and atrophy resulting from motor neuron degeneration. Limited information is available on disease progression among older SMA patients, particularly adults.

Objective: This study sought to characterize the natural history of SMA among adult patients in US hospital settings through the assessment of symptoms, complications, costs, and healthcare resource utilization (HRU) over 3 years before the availability of disease-modifying therapies. Read More

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Wiad Lek 2021 ;74(3 cz 2):652-657


Objective: The aim: Is to scientifically substantiate the concept of personalized medicine in the prevention of arterial hypertension (AH) among the adult population at the regional level.

Patients And Methods: Materials and methods: The study, after obtaining informed consent, involved 2000 patients, residents of Zaporizhzhia Region, including 1000 patients (average age 59±0.5 years, the ratio of men to women 1:1. Read More

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January 2021


Wiad Lek 2021 ;74(3 cz 2):572-577


Objective: The aim: To empirically investigate the psychological readiness of physicians for adaptive learning during the acquisition of professional competences in the system of postgraduate medical education.

Patients And Methods: Materials and methods: We surveyed a sample of 148 physicians who began studying the discipline of Psychology of Conflict, which was specially developed by us on the principles of adaptive learning. There were three occupational groups among doctors: surgeons (n = 47), therapists (n = 53) and pediatricians (n = 48). Read More

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January 2021

The impact of asynchronous e-visits on clinical outcomes and healthcare delivery: A systematic review.

J Med Internet Res 2021 Apr 11. Epub 2021 Apr 11.

Moffitt Cancer Center, 12902 USF Magnolia Drive, MRC-CANCONT, Tampa, US.

Background: E-visits involve asynchronous communication between clinicians and patients through a secure web-based platform, such as a patient portal, to elicit symptoms and determine a diagnosis and treatment plan. E-visits are now reimbursable through Medicare due to the COVID-19 pandemic. The state of evidence regarding e-visits, such as the impact on clinical outcomes and healthcare delivery, is unclear. Read More

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Developing an online food composition database for an Indigenous population in south-western Uganda.

Public Health Nutr 2021 Apr 12:1-25. Epub 2021 Apr 12.

School of Food Science and Nutrition, University of Leeds, LS2 9JT, UK.

Objective: To develop an online food composition database of locally consumed foods among an Indigenous population in south-western Uganda.

Design: Using a community-based approach and collaboration with local nutritionists, we collected a list of foods for inclusion in the database through focus group discussions, an individual dietary survey and markets and shops assessment. The food database was then created using seven steps: identification of foods for inclusion in the database; initial data cleaning and removal of duplicate items; linkage of foods to existing generic food composition tables; mapping and calculation of the nutrient content of recipes and foods; allocating portion sizes and accompanying foods; quality checks with local and international nutritionists; translation into relevant local languages. Read More

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Surgical management of displaced femoral neck fractures in patients with dementia: a comparison in mortality between hemiarthroplasty and pins/screws.

Eur J Trauma Emerg Surg 2021 Apr 11. Epub 2021 Apr 11.

Division of Trauma and Emergency Surgery, Department of Surgery, Orebro University Hospital, Orebro, 701 85, Sweden.

Introduction: Dementia is common in patients with hip fractures and is strongly associated with increased postoperative mortality. The choice of surgical intervention for displaced femoral neck fractures (dFNF) in patients with dementia has been a matter of debate. This study aims to investigate how short- and long-term mortality differs between those who have been operated with hemiarthroplasty or pins/screws. Read More

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Hybrid Chemo-, Bio-, and Electrocatalysis for Atom-Efficient Deuteration of Cofactors in Heavy Water.

ACS Catal 2021 Mar 11;11(5):2596-2604. Epub 2021 Feb 11.

Department of Chemistry, Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QR, United Kingdom.

Deuterium-labeled nicotinamide cofactors such as [4-H]-NADH can be used as mechanistic probes in biological redox processes and offer a route to the synthesis of selectively [H] labeled chemicals biocatalytic reductive deuteration. Atom-efficient routes to the formation and recycling of [4-H]-NADH are therefore highly desirable but require careful design in order to alleviate the requirement for [H]-labeled reducing agents. In this work, we explore a suite of electrode or hydrogen gas driven catalyst systems for the generation of [4-H]-NADH and consider their use for driving reductive deuteration reactions. Read More

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A comparison of non-intubated video-assisted thoracic surgery with spontaneous ventilation and intubated video-assisted thoracic surgery: a meta-analysis based on 14 randomized controlled trials.

J Thorac Dis 2021 Mar;13(3):1624-1640

Department of Thoracic Surgery, Affiliated Hospital of Hebei University, Baoding, China.

Background: Video-assisted thoracic surgery (VATS) generally involves endotracheal intubation under general anesthesia. However, inevitably, this may cause intubation-related complications and prolong the postoperative recovery process. Gradually, non-intubated video-assisted thoracic surgery (NIVATS) is increasingly being utilized. Read More

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Body mass index trajectories among people with obesity and association with mortality: Evidence from a large Israeli database.

Obes Sci Pract 2021 Apr 23;7(2):148-158. Epub 2020 Dec 23.

Clalit Research Institute Clalit Health Services Ramat Gan Israel.

Objective: Previous studies using longitudinal weight data to characterize obesity are based on populations of limited size and mostly include individuals of all body mass index (BMI) levels, without focusing on weight changes among people with obesity. This study aimed to identify BMI trajectories over 5 years in a large population with obesity, and to determine the trajectories' association with mortality.

Methods: For inclusion, individuals aged 30-74 years at index date (1 January 2013) with continuous membership in Clalit Health Services from 2008 to 2012 were required to have ≥1 BMI measurement per year in ≥3 calendar years during this period, of which at least one was ≥30 kg/m. Read More

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Prediction model of objective response after neoadjuvant chemotherapy in patients with locally advanced gastric cancer.

Am J Transl Res 2021 15;13(3):1568-1579. Epub 2021 Mar 15.

Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200025, China.

Background: Neoadjuvant chemotherapy (NAC) plays an important role in the therapeutic strategy of locally advanced gastric cancer (LAGC). However, the response of LAGC after NAC varies among different patients. The objective response after NAC has proven to be an excellent indicator for benefiting from NAC, yet effective predictors of objective response are still lacking. Read More

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Comparative Evaluation of the Therapeutic Efficacy and Safety of Injected Histaglobulin versus Autologous Serum Therapy in Chronic Urticaria.

J Clin Aesthet Dermatol 2021 Mar 1;14(3):38-41. Epub 2021 Mar 1.

All authors are with the Department of Dermatology, Venereology, and Leprology at Guru Gobind Singh Medical College and Hospital in Faridkot, Punjab, India.

Urticaria affects 0.5 to 1 percent of the population at any given time. Treatments include nonsedative antihistamines, autologous serum therapy, and injected histaglobulin. Read More

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The Endometrial Immune Profiling May Positively Affect the Management of Recurrent Pregnancy Loss.

Front Immunol 2021 24;12:656701. Epub 2021 Mar 24.

MatriceLAB Innove SARL, Pépinière Paris Santé Cochin, Paris, France.

Introduction: The endometrial immune profiling is an innovative approach based on the analysis of the local immune reaction occurring in the endometrium at the time of the embryo implantation. By documenting the local immune activation during the period of uterine receptivity, we aim to detect and correct potential imbalances before and at the very beginning of placentation. The main objective of the study was to analyze in women with a history of repeated pregnancy loss (RPL) the association of personalized strategies based on immune dysregulations with live birth rates. Read More

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The Usefulness of Diffusion Tensor Tractography in Diagnosing Neuropathic Pain: A Narrative Review.

Front Neurosci 2021 26;15:591018. Epub 2021 Mar 26.

Department of Rehabilitation Medicine, College of Medicine, Yeungnam University, Daegu, South Korea.

Diffusion tensor tractography (DTT) is derived from diffusion tensor imaging. It has allowed visualization and estimation of neural tract injury, which may be associated with the pathogenesis of neuropathic pain (NP). The aim of the present study was to review DTT studies that demonstrated the relationship between neural injuries and NP and to describe the potential use of DTT in the evaluation of neural injuries that are involved in the pathophysiological process of NP. Read More

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Content of Health Economics Analysis Plans (HEAPs) for Trial-Based Economic Evaluations: Expert Delphi Consensus Survey.

Value Health 2021 Apr 28;24(4):539-547. Epub 2020 Nov 28.

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Objectives: Health economics analysis plans (HEAPs) currently lack consistency, with uncertainty surrounding appropriate content. We aimed to develop a list of essential items that should be included in HEAPs for economic evaluations conducted alongside randomized trials.

Methods: A list of potential items for inclusion was developed by examining existing HEAPs. Read More

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A Value Framework for the Assessment of Diagnostic Technologies: A Proposal Based on a Targeted Systematic Review and a Multistakeholder Deliberative Process in Latin America.

Value Health 2021 Apr 16;24(4):486-496. Epub 2021 Jan 16.

Health Technology Assessment and Health Economics Department, Institute for Clinical Effectiveness and Health Policy (IECS-CONICET), Buenos Aires, Argentina; University of Buenos Aires School of Medicine, Buenos Aires, Argentina; CONICET (National Scientific and Technical Research Council), Argentina.

Objectives: there are very few value frameworks (VFs) to assess health technologies that are focused on diagnostic tests; they usually do not reflect a multistakeholder process; and they are all developed in high-income countries. Our project performed a targeted systematic review, with the objective of proposing an evidence-based, up-to-date VF informed by a multinational multistakeholder group working in the health technology assessment (HTA) space.

Methods: (1) A targeted systematic review, with the aim to identify existing VFs and their dimensions; and (2) generation a VF proposal through a mixed-methods, qualitative-quantitative approach. Read More

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Web and mobile-based symptom management interventions for physical symptoms of people with advanced cancer: A systematic review and meta-analysis.

Palliat Med 2021 Apr 12:2692163211006317. Epub 2021 Apr 12.

College of Nursing, University of Iowa, Iowa City, IA, USA.

Background: Symptom management is a critical aspect of comprehensive palliative care for people with advanced cancer. Web and mobile-based applications are promising e-Health modalities that can facilitate timely access to symptom management interventions for this population.

Aim: To evaluate the efficacy of web and mobile-based symptom management interventions in alleviating physical symptom burden in people with advanced cancer. Read More

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Survival of advanced melanoma patients treated with immunotherapy and targeted therapy: a real-world study.

Pharmacoepidemiol Drug Saf 2021 Apr 11. Epub 2021 Apr 11.

School of Pharmacy, University of Queensland, Woolloongabba, Australia.

Introduction: We aimed to examine the survival outcomes plus patient and treatment characteristics of advanced melanoma patients treated with first-line immunotherapy (IT), targeted therapy (TT), and chemotherapy (CTH) and compare findings with information from pivotal trials for each therapy.

Materials And Methods: We retrospectively reviewed the use of systematic IT, TT and CTH therapies in melanoma patients in four Queensland public hospitals. We estimated median duration of overall survival (OS) and survival rates (6 months, 1, and 2 years) using Kaplan-Meier methods. Read More

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Economic evidence with respect to cost-effectiveness of the transitional care model among geriatric patients discharged from hospital to home: a systematic review.

Eur J Health Econ 2021 Apr 10. Epub 2021 Apr 10.

Medical Faculty of the Friedrich-Alexander University of Erlangen-Nuremberg, Institute for Biomedicine of Aging, Kobergerstr. 60, 90408, Nuremberg, Germany.

Background: The German hospital-to-home discharge management of geriatric patients has long been criticized. The implementation of the American Transitional Care Model (TCM) could help to reduce readmissions and costs. The objective of this review was to check the scientific evidence of the cost-effectiveness of the TCM. Read More

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Quantifying value-based determinants of drug and non-drug decision dynamics.

Psychopharmacology (Berl) 2021 Apr 10. Epub 2021 Apr 10.

Department of Psychology, University of Kentucky, Lexington, KY, USA.

Rationale: A growing body of research suggests that substance use disorder (SUD) may be characterized as disorders of decision making. However, drug choice studies assessing drug-associated decision making often lack more complex and dynamic conditions that better approximate contexts outside the laboratory and may lead to incomplete conclusions regarding the nature of drug-associated value.

Objectives: The current study assessed isomorphic (choice between identical food options) and allomorphic (choice between remifentanil [REMI] and food) choice across dynamically changing reward probabilities, magnitudes, and differentially reward-predictive stimuli in male rats to better understand determinants of drug value. Read More

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