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Comparison of transcriptome between high- and low-marbling fineness in longissimus thoracis muscle of Korean cattle.

Anim Biosci 2021 Jun 24. Epub 2021 Jun 24.

Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, College of Agriculture and Life Science, Seoul National University, Seoul 08826, Korea.

Objective: This study compared differentially expressed genes (DEGs) between groups with high and low numbers of fine marbling particles (NFMP) in the longissimus thoracis muscle (LT) of Korean cattle to understand the molecular events associated with fine marbling particle formation.

Methods: The size and distribution of marbling particles in the LT were assessed with a computer image analysis method. Based on the NFMP, 10 LT samples were selected and assigned to either high- (n = 5) or low- (n = 5) NFMP groups. Read More

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Reconsidering pathway choice: a sequential model of mammalian DNA double-strand break pathway decisions.

Tanya T Paull

Curr Opin Genet Dev 2021 Jul 19;71:55-62. Epub 2021 Jul 19.

The University of Texas at Austin, Department of Molecular Biosciences, Austin, TX, 78712, United States. Electronic address:

DNA double-strand breaks can be repaired through ligation-based pathways (non-homologous end-joining) or replication-based pathways (homologous recombination) in eukaryotic cells. The decisions that govern these outcomes are widely viewed as a competition between factors that recognize DNA ends and physically promote association of factors specific to each pathway, commonly known as 'pathway choice'. Here I review recent results in the literature and propose that this decision is better described as a sequential set of binding and end processing events, with non-homologous end joining as the first decision point. Read More

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Home-based early stimulation program targeting visual and motor functions for preterm infants with delayed tracking: Feasibility of a Randomized Clinical Trial.

Res Dev Disabil 2021 Jul 20;116:104037. Epub 2021 Jul 20.

Department of Health Science, Federal University of Santa Catarina, Araranguá, SC, Brazil. Electronic address:

Aims: To verify the feasibility of a home-based early stimulation program targeting visual and motor functions in preterm infants with delayed visual tracking.

Method: We applied a randomized controlled trial. We included thirty low-risk preterm infants, from both genders, with delayed visual tracking, gestational between 28-37 weeks, and age at entrance between 1-2 months of corrected age, and absence of visual impairments. Read More

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The Pause-then-Cancel model of human action-stopping: Theoretical considerations and empirical evidence.

Neurosci Biobehav Rev 2021 Jul 19. Epub 2021 Jul 19.

Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. Electronic address:

The ability to stop already-initiated actions is a key cognitive control ability. Recent work on human action-stopping has been dominated by two controversial debates. First, the contributions (and neural signatures) of attentional orienting and motor inhibition after stop-signals are near-impossible to disentangle. Read More

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Is flow control in a space-constrained drainage network effective? A performance assessment for combined sewer overflow reduction.

Environ Res 2021 Jul 19:111688. Epub 2021 Jul 19.

Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600, Dübendorf, Switzerland; Environmental Systems Dynamics Laboratory, University of California Berkeley, CA, 94720, USA.

Recurring combined sewer overflows (CSOs) can have a significant impact on the ecological condition of receiving water bodies. There are several structural measures, like adding retention basins and switching to low impact development solutions, that have been proposed to reduce the number of sewage overflows. Besides, several flow control strategies have been discussed in scientific literature that take advantage of the space within urban drainage networks, which is assumed to be adequate, for temporary storage. Read More

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Immunotherapy and cardiovascular diseases (CVD): novel avenues for immunotherapeutic approaches.

QJM 2021 Jul 22. Epub 2021 Jul 22.

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, Pettenkoferstraße 8a & 9, Munich, 80336, Germany.

As current therapies for cardiovascular disease (CVD), predominantly based on lipid lowering, still face an unacceptable residual risk, novel treatment strategies are being explored. Besides lipids, inflammatory processes play a major role in the pathogenesis of atherosclerosis, the underlying cause of the majority of CVD. The first clinical trials targeting the interleukin-1β-inflammasome axis have shown that targeting this pathway is successful in reducing cardiovascular events but did not decrease overall CVD mortality. Read More

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Factors associated with the use and composition of two-drug regimens in a large single-centre HIV cohort.

J Antimicrob Chemother 2021 Jul 22. Epub 2021 Jul 22.

Hospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain.

Objectives: We aimed to assess the clinical characteristics associated with the use of two-drug regimens (2DRs) and the factors associated with specific antiretrovirals in 2DRs in a large single-centre HIV cohort.

Methods: Retrospective analysis of demographics, HIV characteristics and AIDS events, antiretroviral prescription, virological failure and genotypic resistance testing, and laboratory results from all adult people with HIV (PWH) prospectively followed at the Hospital Clinic of Barcelona who were receiving a 3DR or a 2DR in January 2020. We assessed factors associated with the probability of receiving 2DRs relative to three-drug regimens (3DRs) using a logistic regression model, controlling for age, sex and year of HIV diagnosis. Read More

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Culturally based coping with COVID-19 pandemic: using constructive roles of the spiritual systems with appropriate function.

Sepideh Omidvari

Health Promot Int 2021 Jul 19. Epub 2021 Jul 19.

Cancer Research Centre, Cancer Institute of Iran, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Considering the global number of confirmed COVID-19 cases and deaths, it is not strange that COVID-19 disease is a reminiscent of concepts such as death and affliction with a serious disease. Furthermore, it might remind people of issues such as the reason(s) for occurrence of deplorable events in the universe, the meaning of life, individuals' duties toward themselves and others, the relationship between the nature and human beings, and individuals' relationship with a higher being (in case there is a belief in a higher being), i.e. Read More

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How to improve technical and tactical actions of dominant and non-dominant players in children's football?

PLoS One 2021 22;16(7):e0254900. Epub 2021 Jul 22.

Department for Elite Sport, Swiss Federal Institute of Sport Magglingen, Magglingen, Switzerland.

As young football players develop important technical and tactical skills during competitive matches, this study investigated quantity and quality of technical and tactical actions in real game conditions in a 4v4 compared to the traditional 7v7 match format. In total, three matches of each format were played by 103 young football players (10.3±0. Read More

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The influence of propofol-based total intravenous anesthesia on postoperative outcomes in end-stage renal disease patients: A retrospective observation study.

PLoS One 2021 22;16(7):e0254014. Epub 2021 Jul 22.

Department of Anesthesiology and Pain Medicine, Soonchunhyang University Hospital Seoul, Seoul, Republic of Korea.

Background: To determine whether the anesthetic method of propofol total intravenous anesthesia (TIVA) is associated with postoperative outcome in ESRD patients, we evaluated the incidence of postoperative major adverse cardiac events (MACE), comparing propofol TIVA versus anesthesia with volatile anesthesia in ESRD patients.

Methods: Retrospectively, we identified cases with ESRD patients who underwent surgery under general anesthesia. Patients were divided into those who received only volatile anesthesia (volatile group) and those who received only propofol TIVA (TIVA group). Read More

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ChIP-GSM: Inferring active transcription factor modules to predict functional regulatory elements.

PLoS Comput Biol 2021 Jul 22;17(7):e1009203. Epub 2021 Jul 22.

Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, Virginia, United States of America.

Transcription factors (TFs) often function as a module including both master factors and mediators binding at cis-regulatory regions to modulate nearby gene transcription. ChIP-seq profiling of multiple TFs makes it feasible to infer functional TF modules. However, when inferring TF modules based on co-localization of ChIP-seq peaks, often many weak binding events are missed, especially for mediators, resulting in incomplete identification of modules. Read More

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Efficacy of nintedanib plus docetaxel in patients with refractory advanced epidermal growth factor receptor mutant lung adenocarcinoma.

Clin Transl Oncol 2021 Jul 22. Epub 2021 Jul 22.

Medical Oncology Department, Hospital de La Santa Creu I Sant Pau, Sant Quintí, 89, 08041, Barcelona, Spain.

Background: Anti-angiogenic agents are reported to exert clinical activity in patients with epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC). We evaluated the outcomes of the combination of docetaxel plus nintedanib in refractory NSCLC patients harboring EGFR mutations.

Methods: We retrospectively analyzed 19 patients with advanced EGFR-mutant NSCLC who had progressed to EGFR tyrosine kinase inhibitors (TKI) and platinum-based chemotherapy receiving docetaxel and nintedanib at 14 Spanish institutions from January 2013 to December 2019. Read More

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IGF Axis Genetic Score and Sports Excellence.

J Strength Cond Res 2021 Jul 20. Epub 2021 Jul 20.

Genetics and Molecular Biology Laboratory, The Academic College at the Wingate, Wingate Institute, Netanya, Israel; Child Health and Sports Center, Pediatric Department, Meir Medical Center, Kfar Saba, Israel; and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Abstract: Ben-Zaken, S, Meckel, Y, Nemet, D, and Eliakim, A. IGF axis genetic score and sports excellence. J Strength Cond Res XX(X): 000-000, 2021-It has been suggested that IGF1 polymorphisms associated with circulating IGF1 levels may be linked to elite short-distance running performance. Read More

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Needle-based confocal laser endomicroscopy for diagnosis of pancreatic cystic lesions: a meta-analysis.

Minim Invasive Ther Allied Technol 2021 Jul 22:1-11. Epub 2021 Jul 22.

Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, China.

Background And Aim: The role of needle-based confocal laser endomicroscopy (nCLE) in the diagnosis of pancreatic cystic lesions (PCLs) remains controversial. This study aimed to systematically evaluate the diagnostic accuracy and adverse effects of nCLE in the detection of pathological subtypes in patients with PCLs.

Material And Methods: We conducted a comprehensive literature search using MEDLINE, EMBASE, and Cochrane for identifying studies that reported the use of nCLE for PCLs diagnosis (dated prior to 10 October 2020). Read More

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Schools on the front lines: School based health centers amidst COVID-19.

Sch Psychol 2021 Jul 22. Epub 2021 Jul 22.

Department of Psychiatry.

School based health centers (SBHCs) are often at the front line of medical and mental health services for students in the schools they serve. Citywide school closures in New York City in March 2020 and ongoing social distancing procedures resulted in significant changes in SBHC services as well as access to these services. Furthermore, the combination of COVID-19 related stressors and the increased likelihood of adverse childhood events experienced by urban youth creates conditions for the exacerbation of mental health concerns among youth in metropolitan areas. Read More

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Future and past autobiographical memory in persons with HIV disease.

Neuropsychology 2021 Jul 22;35(5):461-471. Epub 2021 Apr 22.

Department of Psychology, University of Houston.

While HIV disease is associated with impairment in declarative memory, the ability of people with HIV (PWH) to describe past and future autobiographical events is not known. Participants included 63 PWH and 28 seronegative individuals ages 50-78 who completed standardized neurocognitive and everyday functioning assessments. Participants described four events from the recent past and four imagined events in the near future, details from which were classified as internal or external to the main event. Read More

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In Situ Temperature-Compensated DNA Hybridization Detection Using a Dual-Channel Optical Fiber Sensor.

Anal Chem 2021 Jul 22. Epub 2021 Jul 22.

College of Information Science and Engineering, Northeastern University, Shenyang, Liaoning 110819, China.

A multifunction, high-sensitivity, and temperature-compensated optical fiber DNA hybridization sensor combining surface plasmon resonance (SPR) and Mach-Zehnder interference (MZI) has been designed and implemented. We demonstrate, for the first time to our knowledge, the dual-parameter measurement of temperature and refractive index (RI) by simultaneously using SPR and MZI in a simple single-mode fiber (SMF)-no-core fiber (NCF)-SMF structure. The experimental results show RI sensitivities of 930 and 1899 nm/RIU and temperature sensitivities of 0. Read More

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Characterizing the Chemical Space of γ-Secretase Inhibitors and Modulators.

ACS Chem Neurosci 2021 Jul 22. Epub 2021 Jul 22.

Departamento de Fisicoquímica, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.

γ-Secretase (GS) is one of the most attractive molecular targets for the treatment of Alzheimer's disease (AD). Its key role in the final step of amyloid-β peptides generation and its relationship in the cascade of events for disease development have caught the attention of many pharmaceutical groups. Over the past years, different inhibitors and modulators have been evaluated as promising therapeutics against AD. Read More

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Interventions to Support Adolescents With Cancer in Decision-Making: A Systematic Review and Meta-Analysis.

Worldviews Evid Based Nurs 2021 Jul 22. Epub 2021 Jul 22.

School of Nursing, Kaohsiung Medical University, Kaohsiung City, Taiwan.

Background: Adolescents have autonomous views and participatory rights. There is increasing support for involving adolescents with cancer in the healthcare decision-making process.

Aims: The purpose of this study was to synthesize current knowledge to identify major components and outcomes of interventions to enhance shared decision-making (SDM) by adolescents with cancer during and after treatment. Read More

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Volumetric coronary endothelial function assessment: a feasibility study exploiting stack-of-stars 3D cine MRI and image-based respiratory self-gating.

NMR Biomed 2021 Jul 21:e4589. Epub 2021 Jul 21.

Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, USA.

Abnormal coronary endothelial function (CEF), manifesting as depressed vasoreactive responses to endothelial-specific stressors, occurs early in atherosclerosis, independently predicts cardiovascular events, and responds to cardioprotective interventions. CEF is spatially heterogeneous along a coronary artery in patients with atherosclerosis, and thus recently developed and tested non-invasive 2D MRI techniques to measure CEF may not capture the extent of changes in CEF in a given coronary artery. The purpose of this study was to develop and test the first volumetric coronary 3D MRI cine method for assessing CEF along the proximal and mid-coronary arteries with isotropic spatial resolution and in free-breathing. Read More

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Phase I study of napabucasin in combination with FOLFIRI + bevacizumab in Japanese patients with metastatic colorectal cancer.

Int J Clin Oncol 2021 Jul 21. Epub 2021 Jul 21.

Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan.

Background: Napabucasin is an oral NAD(P)H:quinone oxidoreductase 1 bioactivatable agent that generates reactive oxygen species, is hypothesised to affect multiple oncogenic cellular pathways, including STAT-3, and is expected to result in cancer cell death. This phase I study investigated the safety, tolerability, and pharmacokinetics of napabucasin co-administered with fluorouracil, l-leucovorin, and irinotecan (FOLFIRI) chemotherapy plus bevacizumab in Japanese patients with metastatic colorectal cancer (CRC).

Methods: Patients with histologically confirmed unresectable stage IV CRC received oral napabucasin 240 mg twice daily (BID). Read More

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Lithosphere atmosphere ionosphere coupling associated with the 2019 M 7.1 California earthquake using GNSS and multiple satellites.

Environ Monit Assess 2021 Jul 22;193(8):501. Epub 2021 Jul 22.

Department of GNSS, Institute of Space Technology, Islamabad, Pakistan.

Global Navigation Satellite System (GNSS)-based Earthquake (EQ) anomalies in the ionosphere and troposphere provide explicit evidences to study the coupling between seismic events, atmosphere, and ionosphere in epicentral breeding regions consequent to the EQ day in the preparation period. EQs are still not predicted, but the space-based EQ anomalies aid in the development of monitoring pre- and post-seismic precursors around the seismogenic zone and associated fault lineament regions. In this paper, tropospheric and ionospheric anomalies are investigated for the July 06, 2019, M 7. Read More

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One Room Schoolhouse: A Novel Intervention for Inspired Academic Half-Day Learning in Distributed Campus Settings.

J Med Educ Curric Dev 2021 Jan-Dec;8:23821205211029462. Epub 2021 Jul 8.

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.

Introduction: Some studies on academic half days (AHDs) suggest that learning in this context is associated with a lack of educational engagement. This challenge may be amplified in distributed campus settings, where geographical disadvantages demand reliance on videoconferencing or considerable time spent travelling to in-person learning events. Concerns about the educational effectiveness of AHDs by learners within our distributed campus setting led to the development and evaluation of the One Room Schoolhouse (ORS), a unique, evidence-informed, community-based curriculum that partially replaced the AHD sessions delivered at the main campus. Read More

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Rituximab Desensitization in Liver Transplant Recipients With Preformed Donor-specific HLA Antibodies: A Japanese Nationwide Survey.

Transplant Direct 2021 Aug 16;7(8):e729. Epub 2021 Jul 16.

Department of Gastroenterological Surgery, Institute of Gastroenterology, Tokyo Women's Medical University of Medicine, Tokyo, Japan.

Background: The significance of preformed donor-specific anti-HLA antibodies (DSAs) in liver transplant recipients is controversial. Moreover, there has been no established desensitization protocol for DSA-positive recipients.

Methods: A Japanese nationwide survey was performed to investigate the clinical practice among preformed DSA-positive patients with special reference to rituximab desensitization. Read More

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Molecular Imaging and Non-molecular Imaging of Atherosclerotic Plaque Thrombosis.

Front Cardiovasc Med 2021 5;8:692915. Epub 2021 Jul 5.

Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Thrombosis in the context of atherosclerosis typically results in life-threatening consequences, including acute coronary events and ischemic stroke. As such, early detection and treatment of thrombosis in atherosclerosis patients is essential. Clinical diagnosis of thrombosis in these patients is typically based upon a combination of imaging approaches. Read More

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Adherence to a Healthy Lifestyle and the Risk of All-Cause Mortality and Cardiovascular Events in Individuals With Diabetes: The ARIC Study.

Front Nutr 2021 5;8:698608. Epub 2021 Jul 5.

Department of Emergency Medicine and National Clinical Research Center for Geriatrics, Research Laboratory of Emergency Medicine, Disaster Medicine Center, West China Hospital, Sichuan University, Chengdu, China.

The relationship between combined healthy lifestyle and cardiovascular (CV) events in diabetes is unclear. We aim to investigate the association between a healthy lifestyle score (HLS) and the risk of mortality and CV events in diabetes. We examined the associations of six lifestyle factors scores (including healthy diet, moderate alcohol and regular coffee intakes, never smoking, physical activity, and normal weight) with diabetes in the Atherosclerosis Risk in Communities (ARIC) study of 3,804 participants with diabetes from the United States at baseline. Read More

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Mild Gestational Diabetes and Adverse Pregnancy Outcome: A Systemic Review and Meta-Analysis.

Front Med (Lausanne) 2021 5;8:699412. Epub 2021 Jul 5.

Faculty of Nursing and Health Sciences, Nord University, Bodø, Norway.

Mild gestational diabetes (GDM) refers to the gestational hyperglycemia, which does not fulfill the diagnostic criteria for GDM. The results of studies on adverse pregnancy outcomes among women with mild GDM are controversial. Therefore, the aim of this systematic review and meta-analysis was to investigate the impact of mild GDM on the risk of adverse maternal and neonatal outcomes. Read More

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A systematic review of clinical trials on Ginkgo () effectiveness on sexual function and its safety.

Avicenna J Phytomed 2021 Jul-Aug;11(4):324-331

Clinical Instructor Mpilo School of Midwifery Zimbabwe. Zimbabwe Confederation of Midwives, Bulawayo, Zimbabwe.

Objective: During recent years, evidence-based practice as a way to support higher standards of care was emphasized by health care policymakers. Sexual dysfunction (SD) is a common problem that affects the quality of life in individuals. Today, the use of extract (GBE) for treating SD has been considered, so this study was performed to evaluate the current evidence for the efficacy and safety of ginkgo in treating SD. Read More

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November 2020

Phase 1b study of pegylated arginine deiminase (ADI-PEG 20) plus Pembrolizumab in advanced solid cancers.

Oncoimmunology 2021 12;10(1):1943253. Epub 2021 Jul 12.

Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: Pegylated arginine deiminase (ADI-PEG 20) is a metabolism-based strategy that depletes arginine, resulting in tumoral stress and cytotoxicity. Preclinically, ADI-PEG 20 modulates T-cell activity and enhances the therapeutic efficacy of programmed death-1 (PD-1) inhibition.

Methods: A phase 1b study, including a dose-escalation cohort and an expansion cohort, was undertaken to explore the effects of ADI-PEG 20 in combination with pembrolizumab, an anti-PD-1 antibody, for safety, pharmacodynamics, and response. Read More

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Empirical Evidence Supporting Neural Contributions to Episodic Memory Development in Early Childhood: Implications for Childhood Amnesia.

Child Dev Perspect 2020 Mar 19;14(1):41-48. Epub 2020 Jan 19.

University of Maryland, College Park.

Memories for events that happen early in life are fragile-they are forgotten more quickly than expected based on typical adult rates of forgetting. Although numerous factors contribute to this phenomenon, data show one major source of change is the protracted development of neural structures related to memory. Recent empirical studies in early childhood reveal that the development of specific subdivisions of the hippocampus (i. Read More

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