169,024 results match your criteria basal cell

Iron(III) Complex-Functionalized Gold Nanocomposite as a Strategic Tool for Targeted Photochemotherapy in Red Light.

Inorg Chem 2021 Apr 22. Epub 2021 Apr 22.

Department of Chemistry, National Institute of Technology Manipur, Langol, Imphal West 795004, India.

Iron(III)-phenolate/carboxylate complexes exhibiting photoredox chemistry and photoactivated reactive oxygen species (ROS) generation at their ligand-to-metal charge-transfer (LMCT) bands have emerged as potential strategic tools for photoactivated chemotherapy. Herein, the synthesis, in-depth characterization, photochemical assays, and remarkable red light-induced photocytotoxicities in adenocarcinomic human immortalized human keratinocytes (HaCaT) and alveolar basal epithelial (A549) cells of iron(III)-phenolate/carboxylate complex of molecular formula, [Fe(L)(L)] (), where L is bis(3,5 di--butyl-2-hydroxybenzyl)glycine and L is 5-(1,2-dithiolan-3-yl)--(1,10-phenanthroline-5-yl)pentanamide, and the gold nanocomposite functionalized with complex (-AuNPs) are reported. There was a significant red shift in the UV-visible absorption band on functionalization of complex to the gold nanoparticles (λ: 573 nm, ; λ: 660 nm, -AuNPs), rendering the nanocomposite an ideal candidate for photochemotherapeutic applications. Read More

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Basal Cell Nevus Syndrome with Unusual Associated Findings: A Case Report with 17 Years of Follow-Up.

Am J Case Rep 2021 Apr 22;22:e928670. Epub 2021 Apr 22.

School of Dentistry, Federal University of Pará (UFPA), Belém, PA, Brazil.

BACKGROUND Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin-Goltz syndrome (GGS), is an inherited autosomal dominant disorder caused by mutations in the patched (PTCH) tumor-suppressor gene, which has high penetrance and variable phenotypic expressivity. In 1960, Gorlin and Goltz defined the condition by 3 main characteristics: multiple basal cell carcinomas, odontogenic keratocyst (OKC), and skeletal anomalies. Nowadays, many neurologic, ophthalmic, endocrine, and genital manifestations are known to be associated with this syndrome. Read More

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[Update on occupational skin cancer-basal cell carcinoma and solar UV exposure].

Hautarzt 2021 Apr 21. Epub 2021 Apr 21.

Zentrum für evidenzbasierte Gesundheitsversorgung (ZEGV), Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Deutschland.

Background: Outdoor workers are occupationally exposed to significantly higher ultraviolet (UV) doses than the rest of the population. Recent data show a doubling of basal cell carcinoma (BCC) risk in outdoor workers with high occupational UV exposure.

Objectives: To examine the stability and robustness of BCC risk estimators. Read More

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The helix-loop-helix transcriptional regulator Id4 is required for terminal differentiation of luminal epithelial cells in the prostate.

Oncoscience 2021 24;8:14-30. Epub 2021 Mar 24.

Center for Cancer Research and Therapeutics Development, Clark Atlanta University, Atlanta GA, USA.

Inhibitor of differentiation 4 (Id4), a member of the helix-loop-helix family of transcriptional regulators has emerged as a tumor suppressor in prostate cancer. In this study we investigated the effect of loss of Id4 () on mouse prostate development. Histological analysis was performed on prostates from 25 days, 3 months and 6 months old mice. Read More

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Pulmonary Alveolar Microlithiasis: A Unique Case of Familial PAM Complicated by Transplant Rejection.

Case Rep Pathol 2021 5;2021:6674173. Epub 2021 Apr 5.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Background: Pulmonary alveolar microlithiasis (PAM) is a rare lung disease characterized by the deposition of calcium phosphate microliths or calcospherites, within the alveolar airspace. Typical imaging findings demonstrate a "sandstorm" appearance due to bilateral, interstitial sand-like micronodularities with basal predominance.

Methods And Results: We describe an unusual case of a 48-year-old male with severe, familial PAM ultimately treated with a bilateral lung transplant. Read More

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The Morphogenetic Protein CotE Positions Exosporium Proteins CotY and ExsY during Sporulation of Bacillus cereus.

mSphere 2021 Apr 21;6(2). Epub 2021 Apr 21.

INRAE, Avignon Université, UMR SQPOV, Avignon, France

The exosporium is the outermost spore layer of some and species and related organisms. It mediates the interactions of spores with their environment, modulates spore adhesion and germination, and has been implicated in pathogenesis. In , the exosporium consists of a crystalline basal layer, formed mainly by the two cysteine-rich proteins CotY and ExsY, surrounded by a hairy nap composed of glycoproteins. Read More

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Primary Neural Degeneration in Noise-Exposed Human Cochleas: Correlations with Outer Hair Cell Loss and Word-Discrimination Scores.

J Neurosci 2021 Apr 20. Epub 2021 Apr 20.

Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, Massachusetts 02114.

Animal studies suggest that cochlear nerve degeneration precedes sensory cell degeneration in both noise-induced hearing loss (NIHL) and age-related hearing loss (ARHL), producing a hearing impairment that is not reflected in audiometric thresholds. Here, we investigated the histopathology of human ARHL and NIHL by comparing loss of auditory nerve fibers (ANFs), cochlear hair cells and the stria vascularis in a group of 52 cases with noise-exposure history against an age-matched control group. Although strial atrophy increased with age, there was no effect of noise history. Read More

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Mechanical compression enhances ciliary beating through cytoskeleton remodeling in human nasal epithelial cells.

Acta Biomater 2021 Apr 18. Epub 2021 Apr 18.

School of Mechanical Engineering, Yonsei University, Seoul, Korea. Electronic address:

Nasal inflammatory diseases, including nasal polyps and acute/chronic sinusitis, are characterized by impaired mucociliary clearance and eventually inflammation and infection. Contact of nasal polyps with adjacent nasal mucosa or stagnated mucus within the maxillary sinus produces compressive mechanical stresses on the apical surface of epithelium which can induce cytoskeleton remodeling in epithelial cells. In this study, we hypothesized that compressive stress modulates ciliary beating by altering the mechanical properties of the cytoskeleton of ciliated cell basal bodies. Read More

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Airway basal stem cells generate distinct subpopulations of PNECs.

Cell Rep 2021 Apr;35(3):109011

Division of Neonatology and Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

Pulmonary neuroendocrine cells (PNECs) have crucial roles in airway physiology and immunity by producing bioactive amines and neuropeptides (NPs). A variety of human diseases exhibit PNEC hyperplasia. Given accumulated evidence that PNECs represent a heterogenous population of cells, we investigate how PNECs differ, whether the heterogeneity is similarly present in mouse and human cells, and whether specific disease involves discrete PNECs. Read More

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Conveyance of cortical pacing for parkinsonian tremor-like hyperkinetic behavior by subthalamic dysrhythmia.

Cell Rep 2021 Apr;35(3):109007

Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan; Department of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan 333, Taiwan. Electronic address:

Parkinson's disease is characterized by both hypokinetic and hyperkinetic symptoms. While increased subthalamic burst discharges have a direct causal relationship with the hypokinetic manifestations (e.g. Read More

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Impaired Differentiation of COPD Bronchial Epithelial Cells Grown on Bronchial Scaffolds.

Am J Respir Cell Mol Biol 2021 Apr 21. Epub 2021 Apr 21.

AstraZeneca, Gothenburg, Sweden;

Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation, small airway remodeling and emphysema. Airway remodeling in COPD patients involves both the airway epithelium and the subepithelial extracellular matrix (ECM). However, it is currently unknown how epithelial remodeling in COPD airways depends on the relative influence from inherent defects in the epithelial cells and alterations in the ECM. Read More

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Expression Analysis of Same-Patient Metachronous and Synchronous Upper-Tract and Bladder Urothelial Carcinoma.

J Urol 2021 Apr 21:101097JU0000000000001788. Epub 2021 Apr 21.

Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Purpose: To compare upper-tract urothelial carcinoma (UTUC) and bladder urothelial carcinoma (BUC) in same-patient metachronous-(m) and synchronous-(s) UTUC and BUC using next generation sequencing.

Materials And Methods: Consecutive untreated same-patient samples of UTUC and BUC were macrodissected from unstained formalin-fixed, paraffin-embedded slides after quality control. Samples were divided into 4 groups: 1) UTUC-mBUC, 2) BUC-mUTUC, 3) sUTUC-BUC, 4) UTUC without BUC. Read More

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Promoter methylation and expression of rassf4 gene in Nile tilapia (Oreochromis niloticus).

J Fish Biol 2021 Apr 21. Epub 2021 Apr 21.

Shanghai Collaborative Innovation for Aquatic Animal Genetics and Breeding, Shanghai Ocean University, Shanghai, China.

Oreochromis niloticus RAS-association domain family 4 (rassf4) was specifically expressed in the ovaries. Immunohistochemistry results showed that Rassf4 was located in follicular cells. The methylation percentages of the promoter region (-734/-1012) of rassf4 in the ovaries and testes were 13. Read More

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A multidrug resistance-associated protein inhibitor is a potential enhancer of the benzyl isothiocyanate-induced apoptosis induction in human colorectal cancer cells.

J Biochem Mol Toxicol 2021 Apr 21:e22791. Epub 2021 Apr 21.

Graduate School of Environmental and Life Science, Okayama University, Okayama, Japan.

The increasing drug efflux through the ATP-binding cassette (ABC) transporters is the most plausible mechanism that mediates resistance to the anticancer phytochemicals, such as benzyl isothiocyanate (BITC), as well as chemotherapy drugs. To identify a potential component to overcome this resistance by combinatory utilization, we focused on multidrug resistance-associated proteins (MRPs) pumping various drug metabolites with glutathione as well as the organic anions. The pharmacological treatment of an MRP inhibitor, MK571, significantly potentiated the BITC-induced antiproliferation, coincided with the enhanced accumulation of BITC and glutathione in human colorectal cancer HCT-116 cells. Read More

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In silico screening using bulk and single-cell RNA-seq data identifies RIMS2 as a prognostic marker in basal-like breast cancer: A retrospective study.

Medicine (Baltimore) 2021 Apr;100(16):e25414

Department of Thyroid Surgery.

Abstract: Single-cell RNA-seq has become a powerful tool to understand tumor cell heterogenicity. This study tried to screen prognosis-related genes in basal-like breast tumors and evaluate their correlations with cellular states at the single-cell level.Bulk RNA-seq data of basal-like tumor cases from The Cancer Genome Atlas-Breast Cancer (TCGA-BRCA) and single-cell RNA-seq from GSE75688 were retrospectively reviewed. Read More

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Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains.

Proc Natl Acad Sci U S A 2021 Apr;118(17)

Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215;

Insulin and insulin-like growth factor 1 (IGF-1) receptors share many downstream signaling pathways but have unique biological effects. To define the molecular signals contributing to these distinct activities, we performed global phosphoproteomics on cells expressing either insulin receptor (IR), IGF-1 receptor (IGF1R), or chimeric IR-IGF1R receptors. We show that IR preferentially stimulates phosphorylations associated with mammalian target of rapamycin complex 1 (mTORC1) and Akt pathways, whereas IGF1R preferentially stimulates phosphorylations on proteins associated with the Ras homolog family of guanosine triphosphate hydrolases (Rho GTPases), and cell cycle progression. Read More

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PCA062, a P-cadherin targeting antibody-drug-conjugate, displays potent anti-tumor activity against P-cadherin-expressing malignancies.

Mol Cancer Ther 2021 Apr 20. Epub 2021 Apr 20.

Disease Area Oncology, Novartis Institutes for BioMedical Research

The cell surface glycoprotein P-cadherin (PCAD) is highly expressed in a number of malignancies, including those arising in the epithelium of the bladder, breast, esophagus, lung and upper aerodigestive system. PCA062 is a P-cadherin specific antibody drug conjugate (ADC) that utilizes the clinically validated SMCC-DM1 linker-payload to mediate potent cytotoxicity in cell lines expressing high levels of P-cadherin in vitro, while displaying no specific activity in P-cadherin negative cell lines. High cell surface P-cadherin is necessary, but not sufficient, to mediate PCA062 cytotoxicity. Read More

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A laminin-based local regulatory network in the testis that supports spermatogenesis.

Semin Cell Dev Biol 2021 Apr 17. Epub 2021 Apr 17.

The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; Institute of Reproductive Medicine, Nantong University School of Medicine, Nantong, Jiangsu 226001, China. Electronic address:

In adult rat testes, the basement membrane is structurally constituted by laminin and collagen chains that lay adjacent to the blood-testis barrier (BTB). It plays a crucial scaffolding role to support spermatogenesis. On the other hand, laminin-333 comprised of laminin-α3/ß3/γ3 at the apical ES (ectoplasmic specialization, a testis-specific cell-cell adherens junction at the Sertoli cell-step 8-19 spermatid interface) expressed by spermatids serves as a unique cell adhesion protein that forms an adhesion complex with α6ß1-integrin expressed by Sertoli cells to support spermiogenesis. Read More

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Specific bioactivity of IL-22 in intestinal cells as revealed by the expression of IL-22RA1 in mandarin fish, Siniperca chuatsi.

Dev Comp Immunol 2021 Apr 17:104107. Epub 2021 Apr 17.

School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong Province, 266109, China; State Key Laboratory of Freshwater Ecology and Biotechnology, And Key Laboratory of Aquaculture Disease Control, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei Province, 430072, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong Province, 266237, China; The Innovation Academy of Seed Design, Chinese Academy of Sciences, Wuhan, China. Electronic address:

IL-22, a multifunctional cytokine, acts as an important regulator in host immunity in mammals. IL-22 homologues have been characterized in several species of fish, with its expression found in multiple tissues/cells in fish, but its target cells have not been fully analyzed. In the present research, different organ/tissue isolated cells were examined for the expression of IL-22 and the induced IL-22 responses in mandarin fish. Read More

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Adaptive cell invasion maintains lateral line organ homeostasis in response to environmental changes.

Dev Cell 2021 Apr 13. Epub 2021 Apr 13.

Stowers Institute for Medical Research, Kansas City, MO 64110, USA. Electronic address:

Mammalian inner ear and fish lateral line sensory hair cells (HCs) detect fluid motion to transduce environmental signals. Actively maintained ionic homeostasis of the mammalian inner ear endolymph is essential for HC function. In contrast, fish lateral line HCs are exposed to the fluctuating ionic composition of the aqueous environment. Read More

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The bone microenvironment increases phenotypic plasticity of ER breast cancer cells.

Dev Cell 2021 Apr;56(8):1100-1117.e9

Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; McNair Medical Institute, Baylor College of Medicine, BCM600, One Baylor Plaza, Houston, TX 77030, USA. Electronic address:

Estrogen receptor-positive (ER) breast cancer exhibits a strong bone tropism in metastasis. How the bone microenvironment (BME) impacts ER signaling and endocrine therapy remains poorly understood. Here, we discover that the osteogenic niche transiently and reversibly reduces ER expression and activities specifically in bone micrometastases (BMMs), leading to endocrine resistance. Read More

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Nucleoprotein-enriched diet enhances the protein synthesis pathway and satellite cell activation via ERK1/2 phosphorylation in the unloaded rat muscle.

Exp Physiol 2021 Apr 20. Epub 2021 Apr 20.

Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma-ku, Kobe, Hyogo, 654-0142, Japan.

New Findings: What is the central question of this study? The purpose of this study was to determine if the nucleotides in a nucleoprotein diet could ameliorate the unloading-associated decrease in soleus muscle mass and fiber size. What is the main finding and its importance? The results indicate that the nucleotides in the nucleoprotein-enriched diet could ameliorate the unloading-associated decrease in type I fiber size and muscle mass most likely due to the activation of protein synthesis pathways and satellite cell proliferation and differentiation via ERK1/2 phosphorylation. Thus nucleotide supplementation appears to be an effective countermeasure for muscle atrophy. Read More

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Reaching out in anticipation: bacterial membrane extensions represent a permanent investment in polysaccharide sensing and utilization.

Environ Microbiol 2021 Apr 19. Epub 2021 Apr 19.

Pharmaceutical Biotechnology, Institute of Pharmacy, University Greifswald, 17487, Greifswald, Germany.

Outer membrane extensions are common in many marine bacteria. However, the function of these surface enlargements or extracellular compartments is poorly understood. Using a combined approach of microscopy and subproteome analyses, we therefore examined Pseudoalteromonas distincta ANT/505, an Antarctic polysaccharide degrading gamma-proteobacterium. Read More

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On the 3D Correlation between Myofibroblast Shape and Contraction.

J Biomech Eng 2021 Apr 20. Epub 2021 Apr 20.

James T. Willerson Center for Cardiovascular Modeling and Simulation, The Oden Institute for Computational Engineering and Sciences, Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.

Cell shape is known to correlate closely with stress-fiber geometry and function, and is thus a critical feature of cell biophysical state. However, the relationship between myofibroblast shape and contraction is complex, even as well in regards to steady-state contractile level (basal tonus). At present, the relationship between myofibroblast shape and basal tonus in 3D is poorly understood. Read More

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Chlorophyll development in mature lysigenous and schizogenous root aerenchymas provides evidence of continuing cortical cell viability.

New Phytol 1994 Mar;126(3):493-497

Department of Applied Biology, University of Hull, Hull HU6 7RX, UK.

The'greening'of mature aerenchymatous adventitious roots of Phragmrtes auttralis (Cav.) Trin. ex Steudel, rice, maize, Atorm calamus L. Read More

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A light and electron microscope study of rhizoid-ascomycete associations and flagelliform axes in British hepatics with observations on the effects of the fungi on host morphology.

New Phytol 1991 Jun;118(2):233-257

School of Biological Sciences, Queen Mary and Westfield College, London, E1 4NS, UK.

Ascomycetous fungi, identified by the presence of simple septa and Woronin bodies, form a range of highly specialized associations with the unicellular rhizoids of 46 (16.2%) of the 284 species of British liverworts. The majority of these are in the two jungermannialian suborders Lepidoziineae and Cephaloziineae. Read More

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New Phytol 1987 Jan;105(1):57-65

Department of Botany, University of Nijmegen, Toernooiveld, 6525 ED Nijmegen, The Netherlands.

Initiation and formation of floral buds was studied on explants of Nicotiana tabacum. During the first stage of development (0 to 4 d), protrusions are formed at the basal side of the explant as a result of cell divisions in both sub-epidermal and epidermal cell layers. The second stage (4 to 7 d) is characterized by the formation of tracheary centres inside the protrusions followed by the formation of floral primordia at the surface of the protrusions. Read More

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January 1987

Subterranean gametophytic axes in the primitive liverwort Haplomitrium harbour a unique type of endophytic association with aseptate fungi.

New Phytol 2003 Oct;160(1):185-197

Dipartimento di Scienze ambientali, Seconda Università di Napoli, via A. Vivaldi 43, 81100 Caserta, Italy.

•  Haplomitrium, a primitive liverwort taxon with only remote affinities to other liverwort groups, develops root-like subterranean axes harbouring fungal endophytes. Here we report on the fungal association in H. gibbsiae and H. Read More

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October 2003

Chlamydomonas reinhardtii as a eukaryotic photosynthetic model for studies of heavy metal homeostasis and tolerance.

M Hanikenne

New Phytol 2003 Aug;159(2):331-340

Genetics of Microorganisms, Department of Life Sciences, B22, University of Liège, B4000 Liège, Belgium.

The green alga Chlamydomonas reinhardtii is a useful model of a photosynthetic cell. This unicellular eukaryote has been intensively used for studies of a number of physiological processes such as photosynthesis, respiration, nitrogen assimilation, flagella motility and basal body function. Its easy-to-manipulate and short life cycle make this organism a powerful tool for genetic analysis. Read More

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Discriminating 'DRESS minor' from 'DRESS major': facial oedema aligns to the severe phenotype.

J Am Acad Dermatol 2021 Apr 16. Epub 2021 Apr 16.

Department of Dermatology, King's College Hospital, Denmark Hill, London, SE5 9RS, U.K.

Background: DRESS is a cutaneous and systemic drug allergy disorder. Patients exist on a severity spectrum with some developing a mild form of the disorder which fails to meet the RegiSCAR diagnostic criteria for DRESS.

Objective: We sought to determine if there were any cutaneous or dermatopathological features which discriminate between the mild form of DRESS ('DRESS minor') and the severe phenotype ('DRESS major'). Read More

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