1,534 results match your criteria balance board

Biobetters in patients with immune-mediated inflammatory disorders: An international Delphi consensus.

Autoimmun Rev 2021 May 8:102849. Epub 2021 May 8.

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; IBD center, Humanitas Research Hospital, IRCCS, Rozzano, Milan, Italy. Electronic address:

Several efforts have been made to improve the available therapeutic armamentarium of patients with immune-mediated inflammatory disorders (IMIDs) leading to the development of biobetters. To date, there is no commonly accepted definition of biobetters. Sixteen physicians with expertise in the field of IMIDs from eleven countries attended a virtual international consensus meeting to provide for the first time a definition of biobetter and to identify unmet needs on this topic. Read More

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Probable post-traumatic stress disorder and harmful alcohol use among male members of the British Police Forces and the British Armed Forces: a comparative study.

Eur J Psychotraumatol 2021 Mar 25;12(1):1891734. Epub 2021 Mar 25.

King's Centre for Military Health Research, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

: British Armed Forces' and Police Forces' personnel are trained to operate in potentially traumatic conditions. Consequently, they may experience post-traumatic stress disorder (PTSD), which is often comorbid with harmful alcohol use. : We aimed to assess the proportions, and associations, of probable PTSD and harmful alcohol use among a covariate-balanced sample of male military personnel and police employees. Read More

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Patient-reported outcomes from a randomized, double-blind, placebo controlled, phase III study of baricitinib placebo in patients with moderately to severely active rheumatoid arthritis and an inadequate response to methotrexate therapy: results from the RA-BALANCE study.

Ther Adv Musculoskelet Dis 2021 20;13:1759720X211006964. Epub 2021 Apr 20.

Department of Rheumatology and Immunity, Center of Clinical Immunology, Peking University People's Hospital, Xicheng District, Beijing, P.R. China.

Introduction: To assess the effect of baricitinib on patient-reported outcomes (PROs) in patients with moderately to severely active rheumatoid arthritis (RA) who had an inadequate response to methotrexate (MTX).

Methods: This was a 52-week, randomized, double-blind, placebo controlled, phase III study in patients with RA who had an inadequate response to MTX. Patients ( = 290) receiving stable background MTX were randomly assigned (1:1) to receive placebo or baricitinib 4 mg once daily with a primary endpoint at week 12. Read More

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Whole-body vibration training versus conventional balance training in patients with severe COPD-a randomized, controlled trial.

Respir Res 2021 May 4;22(1):138. Epub 2021 May 4.

Department of Pulmonary Rehabilitation, Philipps-University of Marburg, German Center for Lung Research, Malterhoeh 1, 83471 Schoenau Am Koenigssee, Marburg, Germany.

Background: Whole-body vibration training (WBV) performed on a vibration platform can significantly improve physical performance in patients with chronic obstructive pulmonary disease. It has been suggested that an important mechanism of this improvement is based on an improvement in balance. Therefore, the aim of this study was to investigate the effects of WBV compared to conventional balance training. Read More

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Innovative Simulation Roadmap for Faculty to Prepare Advanced Practice Registered Nurses for Entry Into Practice.

Nurs Educ Perspect 2021 Apr 30. Epub 2021 Apr 30.

About the Authors The authors are faculty at the Johns Hopkins School of Nursing, Baltimore, Maryland. Deborah W. Busch, DNP, CPNP, IBCLC, CNE, FAANP, is an assistant professor. JoAnne Silbert Flagg, DNP, CPNP, IBCLC, CNE, FAAN, is an associate professor. Brigit VanGraafeiland, DNP, CPNP, CNE, FAAN, is an assistant professor. Nancy G. Russell, DNP, MSN, FNP-BC, CNE, is an assistant professor. Elizabeth Sloand, PhD, CPNP, CNE, FAANP, FAAN, is a professor. Shawna Mudd, DNP, CRNP, CNE, is an associate professor. Kimberly Mclltrot, DNP, CRNP, CNE, FAANP, FAAN, is an assistant professor. Rita D'Aoust, PhD, ANP-BC, CNE, FAANP, FNAP, FAAN, is an associate professor. For more information, contact Dr. Busch at

Abstract: Advanced practice registered nurse (APRN) programs are challenged to provide clinical learning experiences that prepare graduates with the full continuum of expected competencies. Preparing the APRN in academia, in terms of didactic and clinical application for novice entry, is often a vexing balance between board certification preparedness and the actualities of clinical practice. This article presents an innovative strategy to examine the perplexing reflective question often asked by educators: Does the current approach for simulation development prepare our APRN students sufficiently for entry into practice, and is it current to what is occurring in practice? Read More

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Bioprospecting of Rhizosphere-Resident Fungi: Their Role and Importance in Sustainable Agriculture.

J Fungi (Basel) 2021 Apr 18;7(4). Epub 2021 Apr 18.

Applied Plant Pathology Laboratory, Department of Studies in Botany, University of Mysore, Manasagangotri, Mysuru 570006, Karnataka, India.

Rhizosphere-resident fungi that are helpful to plants are generally termed as 'plant growth promoting fungi' (PGPF). These fungi are one of the chief sources of the biotic inducers known to give their host plants numerous advantages, and they play a vital role in sustainable agriculture. Today's biggest challenge is to satisfy the rising demand for crop protection and crop yield without harming the natural ecosystem. Read More

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Symptoms of Medication Withdrawal in Parkinson's Disease: Considerations for Informed Consent in Patient-Oriented Research.

Pharmaceut Med 2021 Apr 29. Epub 2021 Apr 29.

Department of Neurology, Vanderbilt University Medical Center, 1161 21st Ave South A-0118, Nashville, TN, 37232, USA.

Introduction: Dopamine medication withdrawal in Parkinson's disease (PD) is commonly employed in clinical practice and can be required for participation in research studies. When asked to withdraw from medications, participants often enquire as to what symptoms they should expect.

Objectives: This study sought to improve the informed consent process by identifying patient-reported symptoms when dopamine treatment is withheld. Read More

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A Crisis-Responsive Framework for Medical Device Development Applied to the COVID-19 Pandemic.

Front Digit Health 2021 Mar 22;3. Epub 2021 Mar 22.

Greater Boston Pandemic Fabrication Team (PanFab) c/o Harvard-MIT Center for Regulatory Science, Harvard Medical School, Boston, MA, United States.

The disruption of conventional manufacturing, supply, and distribution channels during the COVID-19 pandemic caused widespread shortages in personal protective equipment (PPE) and other medical supplies. These shortages catalyzed local efforts to use nontraditional, rapid manufacturing to meet urgent healthcare needs. Here we present a crisis-responsive design framework designed to assist with product development under pandemic conditions. Read More

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Investigating GIPR (ant)agonism: A structural analysis of GIP and its receptor.

Structure 2021 Apr 21. Epub 2021 Apr 21.

Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen 2200, Denmark. Electronic address:

The glucose-dependent insulinotropic polypeptide (GIP) is a 42-residue metabolic hormone that is actively being targeted for its regulatory role of glycemia and energy balance. Limited structural data of its receptor has made ligand design tedious. This study investigates the structure and function of the GIP receptor (GIPR), using a homology model based on the GLP-1 receptor. Read More

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Oliceridine: A Novel Drug for the Management of Moderate to Severe Acute Pain - A Review of Current Evidence.

J Pain Res 2021 14;14:969-979. Epub 2021 Apr 14.

Department of Anesthesiology, Division of Women's Anesthesia, Duke University Medical Center, Durham, NC, 27710, USA.

Optimal pain relief requires a balance between adequate analgesia and risk of adverse effects. Opioids remain the cornerstone for managing moderate to severe pain, but are associated with opioid-induced respiratory depression (OIRD) and gastrointestinal complications. Opioids exert their analgesic effects predominantly via G-protein signaling, however, adverse effects including OIRD are mediated by the β-arrestin pathway. Read More

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Impact of prenatal maternal cytokine exposure on sex differences in brain circuitry regulating stress in offspring 45 years later.

Proc Natl Acad Sci U S A 2021 Apr;118(15)

Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032.

Stress is associated with numerous chronic diseases, beginning in fetal development with in utero exposures (prenatal stress) impacting offspring's risk for disorders later in life. In previous studies, we demonstrated adverse maternal in utero immune activity on sex differences in offspring neurodevelopment at age seven and adult risk for major depression and psychoses. Here, we hypothesized that in utero exposure to maternal proinflammatory cytokines has sex-dependent effects on specific brain circuitry regulating stress and immune function in the offspring that are retained across the lifespan. Read More

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Mechanistic interplay of various mediators involved in mediating the neuroprotective effect of daphnetin.

Pharmacol Rep 2021 Apr 16. Epub 2021 Apr 16.

Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.

Daphnetin is a 7, 8 dihydroxy coumarin isolated from different medicinal plants of the Thymelaeaceae family and exhibits copious pharmacological activities including neuroprotection, anti-cancer, anti-malarial, anti-inflammatory, anti-parasitic and anti-arthritic activity. It has been proved to be an effective neuroprotective agent in several preclinical animal studies and cell line examinations. It is found to interact with different cellular mediators and signaling pathways to confer protection against neurodegeneration. Read More

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Towards decoding the coupled decision-making of metabolism and epithelial-to-mesenchymal transition in cancer.

Br J Cancer 2021 Apr 15. Epub 2021 Apr 15.

Center for Theoretical Biological Physics and Department of Physics, Northeastern University, Boston, MA, USA.

Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis. A developmental programme known as epithelial-to-mesenchymal transition (EMT) plays a critical role during metastasis, promoting the loss of polarity and cell-cell adhesion and the acquisition of motile, stem-cell characteristics. Cells undergoing EMT or the reverse mesenchymal-to-epithelial transition (MET) are often associated with metabolic changes, as the change in phenotype often correlates with a different balance of proliferation versus energy-intensive migration. Read More

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Effect of East Asian atmospheric particulate matter deposition on bacterial activity and community structure in the oligotrophic Northwest Pacific.

Environ Pollut 2021 Apr 5;283:117088. Epub 2021 Apr 5.

College of Marine Life Sciences, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao, 266003, China; Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003, China.

Large amounts of anthropogenic East Asian (EA) particulate matters (PM), containing inorganic nutrients and organic matter, are deposited in the oligotrophic Northwest Pacific Ocean. However, the effects of such deposition on marine microbes remain unclear. In this study, the effect of EA PM deposition on marine bacteria was assessed by five on-board microcosm experiments, conducted in oligotrophic basins of the South China Sea. Read More

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Monetite-based composite cranial implants demonstrate long-term clinical volumetric balance by concomitant bone formation and degradation.

Acta Biomater 2021 Apr 12. Epub 2021 Apr 12.

Department of Materials Science and Engineering, Uppsala University, Uppsala, Sweden.

The use of calcium phosphates (CaPs) as synthetic bone substitutes should ideally result in a volumetric balance with concomitant bone formation and degradation. Clinical data on such properties is nevertheless lacking, especially for monetite-based CaPs. However, a monetite-based composite implant has recently shown promising cranial reconstructions, with both CaP degradation and bone formation. Read More

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Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS.

Mol Cell 2021 May 13;81(9):1905-1919.e12. Epub 2021 Apr 13.

Department of Molecular Biology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

Oxidative phosphorylation (OXPHOS) and glycolysis are the two major pathways for ATP production. The reliance on each varies across tissues and cell states, and can influence susceptibility to disease. At present, the full set of molecular mechanisms governing the relative expression and balance of these two pathways is unknown. Read More

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Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance.

Mol Cell 2021 Apr 6. Epub 2021 Apr 6.

Oncode Institute, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands; Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands; Department of Cell Biology, Erasmus University Medical Centre, 3015 CN, Rotterdam, the Netherlands. Electronic address:

DNA double-strand break (DSB) repair is mediated by multiple pathways. It is thought that the local chromatin context affects the pathway choice, but the underlying principles are poorly understood. Using a multiplexed reporter assay in combination with Cas9 cutting, we systematically measure the relative activities of three DSB repair pathways as a function of chromatin context in >1,000 genomic locations. Read More

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Effect of posture control training using virtual reality program on sitting balance and trunk stability in children with cerebral palsy.

NeuroRehabilitation 2021 ;48(3):247-254

Department of Physical Therapy, College of Health Science, Cheongju University, Cheongju, Republic of Korea.

Objective: We aimed to determine whether the posture control training in the sitting posture using virtual reality (VR) training program affects sitting balance and trunk stability in children with spastic cerebral palsy (CP).

Methods: The experiment was conducted for 4 weeks by randomly allocating 20 children with CP. The experimental group (n = 10) performed balance training in the sitting position using a VR training program, and the control group (n = 10) performed arm reach training in the sitting position. Read More

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January 2021

Regulatory experience of handling Risk Management Plans (RMPs) for medicinal products in the EU.

Expert Opin Drug Saf 2021 Apr 22:1-12. Epub 2021 Apr 22.

Medicines Authority, San Ġwann, Malta.

: Risk Management Plans (RMPs) aim to optimize a medicinal product's benefit/risk balance for the individual patient and the target population. Despite differences in regulatory RMP requirements between jurisdictions worldwide, their ultimate aim is to protect public health.: The review presents findings of different RMP requirements by different regulatory authorities and additional risk minimization measures (issued between January 2010 and December 2018) indicate how RMPs and additional risk minimization measures translate into actions to protect public health within the European Union (EU) member states and worldwide. Read More

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High Prevalence of Biofilms on Retrieved Implants from Aseptic Pseudarthrosis Cases.

Spine Surg Relat Res 2021 23;5(2):104-108. Epub 2020 Sep 23.

Department of Bioengineering and Orthopaedics Surgery, Colleges of Engineering and Medicine, University of Toledo, Toledo, USA.

Introduction: Recent literature has associated pseudarthrosis and pedicle screw loosening with subchronic infection at the pedicle of the vertebra. The positive culture results of a previous retrieval analysis show that such patients have a high frequency of bacterial contamination. The objective of this study is to visually capture the architecture of these undiagnosed infections, which have been described in other studies as biofilms on supposedly "aseptic" screw loosening. Read More

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September 2020

Sex differences in outcomes following less-invasive left ventricular assist device implantation.

Ann Cardiothorac Surg 2021 Mar;10(2):255-267

Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.

Background: Worse outcomes in women compared to men undergoing left ventricular assist device (LVAD) implantation remain an underestimated problem in heart failure (HF) patients. With device miniaturization, less-invasive LVAD implantation techniques have gained relevance, but their impact on outcomes in women is unknown. This study investigates sex-related differences in patients undergoing LVAD implantation through less-invasive procedures. Read More

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What Is Frailty? Perspectives from Chinese Clinicians and Older Immigrants in New Zealand.

J Cross Cult Gerontol 2021 Apr 8. Epub 2021 Apr 8.

University of Otago, Christchurch, New Zealand.

This qualitative study explores the meanings of frailty held by Chinese New Zealanders and Chinese health care professionals with the aim of identifying commonalities as well as potential differences. Two guided focus groups with Mandarin and Cantonese speaking older adults (n = 10), one individual interview with a English speaking older Chinese, and one focus group with Chinese New Zealand health care professionals (n = 7) were held to obtain views on frailty in older adults, followed by transcribing and a thematic qualitative analysis. Three main themes emerged: (1) Frailty is marked by ill-health, multiple chronic and unstable medical comorbidities, and is a linked with polypharmacy; (2) Frailty can involve physical weakness, decline in physical function such as reduced mobility or poor balance, and declining cognitive function; and (3) Frailty is associated with psychological and social health including depression, reduced motivation, social isolation, and loss of confidence. Read More

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Technology-Based Fall Risk Assessments for Older Adults in Low-Income Settings: Protocol for a Cross-sectional Study.

JMIR Res Protoc 2021 Apr 7;10(4):e27381. Epub 2021 Apr 7.

Department of Statistics and Data Science, University of Central Florida, Orlando, FL, United States.

Background: One-third of older adults have maladaptive fall risk appraisal (FRA), a condition in which there is a discrepancy between the level of fear of falling (FOF) and physiological fall risk (balance performance). Older adults who overestimate their physiological fall risk and report a high FOF are less likely to participate in physical activity. Limited data suggest that the association among FOF, body composition, and physical activity intensity differs by fear severity. Read More

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Zero-Balance Ultrafiltration during Cardiopulmonary Bypass Is Associated with Decreased Urine Output.

J Extra Corpor Technol 2021 Mar;53(1):27-37

SpecialtyCare, Brentwood, Tennessee; Congenital Heart Center, UF Health Shands Hospital, University of Florida, and Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Florida, Gainesville, Florida.

Zero-balance ultrafiltration (ZBUF) during cardiopulmonary bypass (CPB) has been purported to reduce pro-inflammatory mediators during cardiac surgery. However, its clinical benefit is equivocal and its effect on renal function unknown. The purpose of this study was to examine the effect of ZBUF on urine output in adult patients undergoing CPB. Read More

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The art and science of drug titration.

Ther Adv Drug Saf 2020 19;11:2042098620958910. Epub 2021 Jan 19.

University of Rhode Island College of Pharmacy, Kingston, RI, USA.

A "one-size-fits-all" approach has been the standard for drug dosing, in particular for agents with a wide therapeutic index. The scientific principles of drug titration, most commonly used for medications with a narrow therapeutic index, are to give the patient adequate and effective treatment, at the lowest dose possible, with the aim of minimizing unnecessary medication use and side effects. The art of drug titration involves the interplay of scientific drug titration principles with the clinical expertise of the healthcare provider, and an individualized, patient-centered partnership between the provider and the patient to review the delicate balance of perceived benefits and risks from both perspectives. Read More

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January 2021

Balance rehabilitation with a virtual reality protocol for patients with hereditary spastic paraplegia: Protocol for a clinical trial.

PLoS One 2021 1;16(4):e0249095. Epub 2021 Apr 1.

UTP- Universidade Tuiuti do Paraná, Curitiba, Paraná, Brazil.

Background: Neurodegenerative diseases are sporadic hereditary conditions characterized by progressive dysfunction of the nervous system. Among the symptoms, vestibulopathy is one of the causes of discomfort and a decrease in quality of life. Hereditary spastic paraplegia is a heterogeneous group of hereditary degenerative diseases involving the disorder of a single gene and is characterized by the progressive retrograde degeneration of fibers in the spinal cord. Read More

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Circadian rhythms and the gut microbiome synchronize the host's metabolic response to diet.

Cell Metab 2021 May 30;33(5):873-887. Epub 2021 Mar 30.

Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address:

The molecular circadian clock and symbiotic host-microbe relationships both evolved as mechanisms that enhance metabolic responses to environmental challenges. The gut microbiome benefits the host by breaking down diet-derived nutrients indigestible by the host and generating microbiota-derived metabolites that support host metabolism. Similarly, cellular circadian clocks optimize organismal physiology to the environment by influencing the timing and coordination of metabolic processes. Read More

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Chronic musculoskeletal pain and occupational aspects among Brazilian teachers.

Int J Occup Saf Ergon 2021 May 3:1-7. Epub 2021 May 3.

Department of Public Health, Universidade Estadual de Londrina, Brazil.

This study aimed to determine the association between working conditions and chronic musculoskeletal pain (CMP) in regions of the body in teachers. A cross-sectional study was performed with 958 teachers from Brazil. Outcomes were chronic pain in the upper limbs, lower back and lower limbs. Read More

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Rolling balance board of adjustable geometry as a tool to assess balancing skill and to estimate reaction time delay.

J R Soc Interface 2021 03 31;18(176):20200956. Epub 2021 Mar 31.

Department of Applied Mechanics, Budapest University of Technology and Economics, Budapest, Hungary.

The relation between balancing performance and reaction time is investigated for human subjects balancing on rolling balance board of adjustable physical parameters: adjustable rolling radius and adjustable board elevation . A well-defined measure of balancing performance is whether a subject can or cannot balance on balance board with a given geometry (, ). The balancing ability is linked to the stabilizability of the underlying two-degree-of-freedom mechanical model subject to a delayed proportional-derivative feedback control. Read More

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