8,509 results match your criteria bad outcome


Surgical outcomes with anatomic reduction of high-grade spondylolisthesis revisited: an analysis of 101 patients.

J Neurosurg Spine 2021 Sep 17:1-11. Epub 2021 Sep 17.

4Spine Center, Werner-Wicker-Clinic, Bad Wildungen, Germany.

Objective: The ideal strategy for high-grade L5-S1 isthmic spondylolisthesis (HGS) remains controversial. Critical questions include the impact of reduction on clinical outcomes, rate of pseudarthrosis, and postoperative foot drop. The scope of this study was to delineate predictors of radiographic and clinical outcome factors after surgery for HGS and to identify risk factors of foot drop. Read More

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September 2021

Association of age with the timing of acute spine surgery-effects on neurological outcome after traumatic spinal cord injury.

Eur Spine J 2021 Sep 17. Epub 2021 Sep 17.

Clinical and Experimental Spinal Cord Injury Research (Neuroparaplegiology), Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Purpose: To investigate the association of age with delay in spine surgery and the effects on neurological outcome after traumatic spinal cord injury (SCI).

Methods: Ambispective cohort study (2011-2017) in n = 213 patients consecutively enrolled in a Level I trauma center with SCI care in a metropolitan region in Germany. Age-related differences in the injury to surgery interval and conditions associated with its delay (> 12 h after SCI) were explored using age categories or continuous variables and natural cubic splines. Read More

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September 2021

Prognostic value of glomerular function estimated by Cockcroft-Gault creatinine clearance, MDRD-4, CKD-EPI and European Kidney Function Consortium equations in patients with acute coronary syndromes.

Clin Chim Acta 2021 Sep 13. Epub 2021 Sep 13.

Deutsches Herzzentrum München, Technische Universität München, Munich, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Germany.

Background: It remains unknown which equation used to assess the glomerular function is better for risk stratification in patients with acute coronary syndrome (ACS).

Methods: This study included 3985 patients with ACS. Glomerular function was assessed using 4 equations: the Cockcroft-Gault creatinine clearance (C-G), Modification of Diet in Renal Disease-4 (MDRD-4), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and European Kidney Function Consortium (EKFC) equations. Read More

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September 2021

Early platelet dysfunction in patients receiving extracorporeal membrane oxygenation is associated with mortality.

J Thromb Thrombolysis 2021 Sep 16. Epub 2021 Sep 16.

Department of Cardiology and Angiology I, University Heart Center Freiburg - Bad Krozingen, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Extracorporeal membrane oxygenation (ECMO) is used for patients with cardiopulmonary failure and is associated with severe bleeding and poor outcome. Platelet dysfunction may be a contributing factor. The aim of this prospective observational study was to characterize platelet dysfunction and its relation to outcome in ECMO patients. Read More

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September 2021

Improving the continuity and coordination of ambulatory care through feedback and facilitated dialogue-a study protocol for a cluster-randomised trial to evaluate the ACD study (Accountable Care in Germany).

Trials 2021 Sep 15;22(1):624. Epub 2021 Sep 15.

Department of Health Economics, Technical University of Munich, Georg-Brauchle-Ring 60/62, 80992, München, Germany.

Background: Patients in Germany are free to seek care from any office-based physician and can always ask for multiple opinions on a diagnosis or treatment. The high density of physicians and the freedom to choose among them without referrals have led to a need for better coordination between the multiple health professionals treating any given patient. The objectives of this study are to (1) identify informal networks of physicians who treat the same patient population, (2) provide these physicians with feedback on their network and patients, using routine data and (3) give the physicians the opportunity to meet one another in facilitated network meetings. Read More

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September 2021

Coronary revascularization in acute coronary syndrome: does the choice of the conduit matter?

J Cardiovasc Surg (Torino) 2021 Sep 14. Epub 2021 Sep 14.

Department of Cardiovascular Surgery, University Heart Center Freiburg, Bad Krozingen, Germany.

Background: Our retrospective study evaluates the impact on short - and long-term outcome according to the graft selection during emergency coronary revascularization surgery.

Methods: 339 Patients with acute coronary syndrome undergoing emergency coronary bypass surgery at our institution from 2008 until 2018 were analyzed using propensity score analysis. The primary endpoint was in-hospital survival. Read More

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September 2021

Study design and rationale of the pAtients pResenTing with cOngenital heaRt dIseAse Register (ARTORIA-R).

ESC Heart Fail 2021 Sep 12. Epub 2021 Sep 12.

A.O.U Cittá della Salute e della Scienza, Torino, Italy.

Aim: Due to improved therapy in childhood, many patients with congenital heart disease reach adulthood and are termed adults with congenital heart disease (ACHD). ACHD often develop heart failure (HF) as a consequence of initial palliative surgery or complex anatomy and subsequently require advanced HF therapy. ACHD are usually excluded from trials evaluating heart failure therapies, and in this context, more data about heart failure trajectories in ACHD are needed to guide the management of ACHD suffering from HF. Read More

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September 2021

The role of E-Cadherin expression in primary site of breast cancer.

Arch Gynecol Obstet 2021 Sep 12. Epub 2021 Sep 12.

Department of Obstetrics and Gynaecology, Breast Center and CCCLMU, LMU University Hospital, Marchioninistr. 15, 81377, Munich, Germany.

Purpose: The tumour's ability to metastasize is the major cause for fatal outcomes in cancer diseases. In breast cancer, aberrant E-Cadherin expression has been linked to invasiveness and poor prognosis.

Method: We assessed expression of E-Cadherin by immunohistochemistry in primary tumour tissue from 125 female breast cancer patients. Read More

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September 2021

Management of patients with medically intractable epilepsy and anterior temporal lobe encephaloceles.

J Neurosurg 2021 Sep 10:1-8. Epub 2021 Sep 10.

Departments of1Neurosurgery.

Objective: Temporal lobe encephaloceles (TLENs) are a significant cause of medically refractory epilepsy, but there is little consensus regarding their workup and treatment. This study characterizes these lesions and their role in seizures and aims to standardize preoperative evaluation and surgical management.

Methods: Patients with TLEN who had undergone resective epilepsy surgery from December 2015 to August 2020 at a single institution were included in the study. Read More

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September 2021

Snakebites in Rural Areas of Brazil by Race: Indigenous the Most Exposed Group.

Int J Environ Res Public Health 2021 Sep 5;18(17). Epub 2021 Sep 5.

Institute of Collective Health Studies, Federal University of Rio de Janeiro, Rio de Janeiro 21941-598, RJ, Brazil.

Animal stings are environmental hazards that threaten millions annually and cause a significant socioeconomic impact. Snakebite envenoming affects 2.7 million people globally every year, mostly the poorest and rural communities, with approximately 27,000 annual cases in Brazil. Read More

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September 2021

Effectiveness of a Three-Week Inpatient Pulmonary Rehabilitation Program for Patients after COVID-19: A Prospective Observational Study.

Int J Environ Res Public Health 2021 08 26;18(17). Epub 2021 Aug 26.

Bad Reichenhall Clinic, Centre for Rehabilitation, Pulmonology and Orthopedics, 83435 Bad Reichenhall, Germany.

For COVID-19 patients who remain symptomatic after the acute phase, pulmonary rehabilitation (PR) is recommended. However, only a few studies have investigated the effectiveness of PR, especially considering the duration between the acute phase of COVID-19 and the onset of rehabilitation, as well as the initial severity. This prospective observational study evaluated the efficacy of PR in patients after COVID-19. Read More

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18F-fluorodeoxyglucose positron-emitted tomography for predicting neurological outcome in hypoxic-ischemic encephalopathy.

Brain Inj 2021 Sep 9:1-9. Epub 2021 Sep 9.

School of Physical Medicine and Rehabilitation, University of Padua, Padua Italy.

: F-fluorodeoxyglucose positron-emitted tomography (FDG-PET) is a promising yet unexplored functional neuroimaging tool in the study and prognosis of hypoxic-ischemic encephalopathy (HIE) after cardiac arrest or respiratory failure. The present study aimed to correlate clinical data and FDG-PET scans for both analysis and prognostic use. : 24 patients from an intensive rehabilitation ward were retrospectively evaluated. Read More

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September 2021

Biatrial volume ratio predicts low voltage areas in atrial fibrillation.

Clin Cardiol 2021 Sep 8. Epub 2021 Sep 8.

School of Medicine - Cardiovascular Medicine, Boston University, Boston, Massachusetts, USA.

Background: Left atrial volume (LAV) and low voltage areas (LVAs) are acknowledged markers for worse rhythm outcome after ablation of atrial fibrillation (AF). Some studies reported the importance of increased right atrial volume (RAV) as a predictor for arrhythmia recurrences in AF patients.

Objective: To investigate association between the LAV/RAV ratio and LVAs presence. Read More

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September 2021

COVID-19 in a patient with sporadic lymphangioleiomyomatosis awaiting lung transplantation.

Respir Med Case Rep 2021 3;34:101505. Epub 2021 Sep 3.

Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan.

Coronavirus disease 2019 (COVID-19) is an emerging viral disease with a mortality that depends on the individual's condition. Underlying comorbidities are major risk factors for COVID-19-related morbidity and mortality. However, information regarding the clinical course of COVID-19 in patients with rare respiratory system diseases is lacking. Read More

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September 2021

Locus of control moderates the association of COVID-19 stress and general mental distress: results of a Norwegian and a German-speaking cross-sectional survey.

BMC Psychiatry 2021 09 6;21(1):437. Epub 2021 Sep 6.

Social Sciences, MF Norwegian School of Theology, Religion and Society, Oslo, Norway.

Background: An internal locus of control (LoC I) refers to the belief that the outcome of events in one's life is contingent upon one's actions, whereas an external locus of control (LoC E) describes the belief that chance and powerful others control one's life. This study investigated whether LoC I and LoC E moderated the relationship between COVID-19 stress and general mental distress in the general population during the early months of the COVID-19 pandemic.

Methods: This cross-sectional survey study analysed data from a Norwegian (n = 1225) and a German-speaking sample (n = 1527). Read More

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September 2021

The modification of cancer risk by chemicals.

Toxicol Res (Camb) 2021 Aug 12;10(4):800-809. Epub 2021 Jul 12.

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK.

Advances in understanding of the process of carcinogenesis have undermined the concept of chemicals being classifiable as either carcinogens or non-carcinogens. Elements of carcinogenesis are happening all the time and a proportion of cancers cannot be prevented, the 'bad luck hypothesis'. Although the proportion that can be prevented is disputed, it is important to continue efforts to reduce it. Read More

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Functional and hemodynamic results after transcatheter mitral valve leaflet repair with the PASCAL device depending on etiology in a real-world cohort.

J Cardiol 2021 Aug 31. Epub 2021 Aug 31.

Department of Cardiology, Cardiovascular Center Bad Neustadt, Von-Guttenberg-Straße 11, D-97616 Bad Neustadt a. d. Saale, Germany.

Background: The PASCAL system (Edwards Lifescience, Irvine, CA, USA) is a novel device for edge-to-edge treatment of mitral regurgitation (MR). The aim of our study was to examine the functional and hemodynamic outcome after repair of functional (FMR) and degenerative mitral regurgitation (DMR) using the PASCAL system in a real-world setting.

Methods: A total 92 consecutive patients with symptomatic MR 3+/4+ were treated in our institute using the PASCAL device. Read More

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Insights Into Genetics and Pathophysiology of Arrhythmogenic Cardiomyopathy.

Curr Heart Fail Rep 2021 Sep 3. Epub 2021 Sep 3.

Heart and Diabetes Center NRW, Erich and Hanna Klessmann Institute, University Hospital of the Ruhr-University Bochum, Georgstrasse 11, 32545, Bad Oeynhausen, Germany.

Purpose Of Review: Arrhythmogenic cardiomyopathy (ACM) is a genetic disease characterized by life-threatening ventricular arrhythmias and sudden cardiac death (SCD) in apparently healthy young adults. Mutations in genes encoding for cellular junctions can be found in about half of the patients. However, disease onset and severity, risk of arrhythmias, and outcome are highly variable and drug-targeted treatment is currently unavailable. Read More

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September 2021

Impact of implantation depth on outcomes of new-generation balloon-expandable transcatheter heart valves.

Clin Res Cardiol 2021 Sep 2. Epub 2021 Sep 2.

Department of Cardiology, Kerckhoff Heart Center, 61231, Bad Nauheim, Germany.

Background: Little is known about the impact of the ID on outcomes and device success using balloon-expandable devices. This study sought to analyze the impact of implantation depth (ID) on procedural outcomes.

Methods: In consecutive patients (n = 969) undergoing transfemoral TAVR with new-generation balloon-expandable prostheses, the mean ID (ID) was determined by aortography and categorized into low, correct, and high device position. Read More

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September 2021

COVID Pneumonia in the Elderly - Not a Basket Case Always.

J Assoc Physicians India 2021 Jun;69(6):11-12

Professor and Unit Head, Department of Medicine, TNMC and BYL Nair Hospital, Mumbai, Maharashtra.

COVID 19 is a respiratory disease, caused by a novel coronavirus, which was christened as SARSCoV2. It has spread rapidly all over the globe, leading to a pandemic with high mortality, due to the lack of pre-existing immunity. The elderly population (old-old ; > 75 years) has been increasingly affected with more severe respiratory symptoms, as compared to the young old (60-75 years) and middle aged patients, probably due to the increasing presence of comorbidities. Read More

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Role of hyperbaric oxygen in glioma: a narrative review.

Med Gas Res 2022 Jan-Mar;12(1):1-5

Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.

Gliomas are common brain mass with a high mortality rate. Patients with gliomas have a severely bad outcome, with an average survive duration less 15 months because of high recurrent rate and being resistant to radio-therapy and chemistry drugs therapy. Hyperbaric oxygen is extensively taken as an adjuvant treatment for various disease conditions. Read More

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September 2021

PY receptor blockers are anti-inflammatory drugs inhibiting both circulating monocytes and macrophages including THP-1 cells.

Sci Rep 2021 Aug 31;11(1):17459. Epub 2021 Aug 31.

Department of Cardiology and Angiology I, Faculty of Medicine, University Heart Center Freiburg - Bad Krozingen, University of Freiburg, Freiburg, Germany.

PY blockade improves patient outcomes after myocardial infarction. As well as antithrombotic effects, anti-inflammatory effects may contribute to this beneficial clinical outcome. Here we aimed to identify potential anti-inflammatory effects of PY receptor blockers on monocytes and macrophages. Read More

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Consensus-driven conceptual development of a standardized whole body-MRI scoring system for assessment of disease activity in juvenile idiopathic arthritis: MRI in JIA OMERACT working group.

Semin Arthritis Rheum 2021 Aug 15. Epub 2021 Aug 15.

Department of Diagnostic Imaging, Research Institute, The Hospital for Sick Children, Department of Medical Imaging, University of Toronto, Toronto, ON, Canada. Electronic address:

Objectives: Whole body-MRI is helpful in directing diagnostic and treatment approaches, and as a research outcome measure. We describe our initial consensus-driven phase towards developing a whole body-MRI scoring system for juvenile idiopathic arthritis.

Methods: An iterative approach using three rounds of anonymous Delphi surveys followed by a consensus meeting was used to draft the structure of the whole body-MRI scoring system, including the relevant anatomic joints and entheses for assessment, diagnostic item selection, definition and grading, and selection of appropriate MRI planes and sequences. Read More

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Outcomes of 10,312 patients treated with everolimus-eluting bioresorbable scaffolds during daily clinical practice - results from the European Absorb Consortium.

Catheter Cardiovasc Interv 2021 Aug 31. Epub 2021 Aug 31.

Medizinische Klinik I, University of Giessen, Giessen, Germany.

Objectives: To asses mid-term clinical outcomes of bioresorbable vascular scaffolds (BVS) for the treatment of coronary artery disease in a large-scale all-comers population.

Background: Several clinical settings are underrepresented in randomized studies investigating BVS against drug-eluting stents. Whether their results can be translated into the heterogeny patient population seen during daily routine requires further investigation. Read More

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An earlier role for intent in children's partner choice versus punishment.

J Exp Psychol Gen 2021 Aug 30. Epub 2021 Aug 30.

Department of Psychology and Neuroscience.

Among the many factors that influence our moral judgments, two are especially important: whether the person caused a bad outcome and whether they intended for it to happen. Notably, the weight accorded to these factors in adulthood varies by the type of judgment being made. For punishment decisions, intentions and outcomes carry relatively equal weight; for partner choice decisions (i. Read More

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An analysis of neurocognitive dysfunction in brain tumors.

Indian J Psychiatry 2021 Jul-Aug;63(4):377-382. Epub 2021 Aug 7.

Department of Neuro-Surgery, Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand, India.

Background: Neurocognitive dysfunction is an important issue in patients with frontal lobe lesions. These patients who may be in good neurological status may succumb to neurocognitive dysfunction, affecting their daily living and hampering the quality of life. This study aims to correlate pre- and post-operative neurocognitive dysfunction in patients with frontal lobe lesions. Read More

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Horizontal Aorta in Transcatheter Self-Expanding Valves: Insights From the HORSE International Multicentre Registry.

Circ Cardiovasc Interv 2021 Aug 30:CIRCINTERVENTIONS121010641. Epub 2021 Aug 30.

Cardiovascular Institute, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain (S.B., A.R., P.P.-F.).

Background: An increased degree of aortic angulation (AA) represents a challenging feature for bioprosthesis positioning. Whether AA has an impact on procedural outcomes of contemporary self-expanding valves remains unsettled. The aim of this study was to evaluate the impact of AA on procedural outcomes of transcatheter aortic valve replacement with contemporary self-expanding valves. Read More

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Early outcomes of patients with Marfan syndrome and acute aortic type A dissection.

J Thorac Cardiovasc Surg 2021 Jul 21. Epub 2021 Jul 21.

Department of Cardiac Surgery, Marfan Center, University Hospital Heidelberg, Heidelberg, Germany. Electronic address:

Background: Acute aortic Stanford type A dissection remains a frequent and life-limiting event for patients with Marfan syndrome. Outcome results in this high-risk group are limited.

Methods: The German Registry for Acute Aortic Dissection Type A collected the data of 56 centers between July 2006 and June 2015. Read More

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Contemporary Outcomes After Partial Resection Of Infected Aortic Grafts.

Ann Vasc Surg 2021 Aug 23. Epub 2021 Aug 23.

University of Patras, Patras, Greece.

Introduction: Aortic graft infection remains a considerable clinical challenge, and it is unclear which variables are associated with adverse outcomes among patients undergoing partial resection.

Methods: A retrospective, multi-institutional study of patients who underwent partial resection of infected aortic grafts from 2002-2014 was performed using a standard database. Baseline demographics, comorbidities, operative, and postoperative variables were recorded. Read More

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Breast cancer hypofractionated radiotherapy in 2-weeks with 2D technique: 5-year clinical outcomes of a phase 2 trial.

Rep Pract Oncol Radiother 2021 12;26(4):503-511. Epub 2021 Aug 12.

Department of Radiotherapy, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: To report clinical outcomes and late toxicities of a 2-week hypofractionated post-operative loco-regional radiotherapy in patients with breast cancer.

Materials And Methods: This trial was approved by the Institutional Ethics Committee and registered with gov, no. NCT02460744. Read More

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