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Supervised sequential pattern mining of event sequences in sport to identify important patterns of play: An application to rugby union.

PLoS One 2021 23;16(9):e0256329. Epub 2021 Sep 23.

RIKEN Center for Advanced Intelligence Project, Tokyo, Japan.

Given a set of sequences comprised of time-ordered events, sequential pattern mining is useful to identify frequent subsequences from different sequences or within the same sequence. However, in sport, these techniques cannot determine the importance of particular patterns of play to good or bad outcomes, which is often of greater interest to coaches and performance analysts. In this study, we apply a recently proposed supervised sequential pattern mining algorithm called safe pattern pruning (SPP) to 490 labelled event sequences representing passages of play from one rugby team's matches in the 2018 Japan Top League season. Read More

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September 2021

Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice.

Science 2021 Sep 23;373(6562):1537-1540. Epub 2021 Sep 23.

Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.

[Figure: see text]. Read More

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September 2021

Patients' Experience of New Technologies and Digitalization in Diabetes Care in Germany.

J Diabetes Sci Technol 2021 Sep 23:19322968211041377. Epub 2021 Sep 23.

Diabetes-Zentrum Mergentheim, Forschungsinstitut der Diabetes-Akademie Bad Mergentheim (FIDAM), Universität Bamberg, Germany.

Background: Little is little known about how people with diabetes experience advancing digitization and new technologies in diabetes.

Research Question: What are the attitudes of people with diabetes (or, in the case of children with diabetes, their parents) toward digitization and advancing technology in diabetology? What significant advantages and disadvantages do they see, and how do they assess current developments of digitization in diabetology (eg, hybrid closed-loop systems, do-It-Yourself (DIY) closed-loop systems, data protection, and data donation)?

Material And Method: 3,427 people with diabetes (47.7% female, 65. Read More

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September 2021

[The role of endothelial dysfunction for assessment of a rehab potential in the patients with acute stroke].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(8. Vyp. 2):66-70

Regional Clinical Hospital, Omsk, Russia.

Objective: The analysis of the endothelial reactivity in the acute stroke by it severity and determination of rehab potential.

Materials And Methods: Twenty-three patients with ischemic stroke, aged 50 to 80 years, who were treated in the regional vascular center of Omsk region, were studied. The severity of stroke and stroke outcome was assessed by NIHSS and the modified Rankin scale. Read More

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January 2021

Membrane scaffolds for matrix-induced autologous chondrocyte implantation in the knee: a systematic review.

Br Med Bull 2021 Sep 22. Epub 2021 Sep 22.

Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, SA, Italy.

Introduction: Chondral defects of the knee are common and their management is challenging.

Source Of Data: Current scientific literature published in PubMed, Google scholar, Embase and Scopus.

Areas Of Agreement: Membrane-induced autologous chondrocyte implantation (mACI) has been used to manage chondral defects of the knee. Read More

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September 2021

Antiviral Effectivity of Favipiravir Against Peste Des Petits Ruminants Virus Is Mediated by the JAK/STAT and PI3K/AKT Pathways.

Front Vet Sci 2021 6;8:722840. Epub 2021 Sep 6.

Department of Bioengineering, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, China.

Peste des petits ruminants virus (PPRV), belonging to the genus in the family , causes severe infectious disease in small ruminants and has been rapidly spreading in many parts of Africa, the Middle East, and Asia. Although vaccination is considered to be an effective means of controlling PPR, the heat-sensitive nature of the vaccines against PPRV greatly limits their application in areas with a hot climate. In the present study, we investigated the anti-PPRV effects of favipiravir and sought to identify the underlying mechanisms using the Vero cell line. Read More

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September 2021

Chlorothalonil induces the intestinal epithelial barrier dysfunction in Caco-2 cell-based in vitro monolayer model by activating MAPK pathway.

Acta Biochim Biophys Sin (Shanghai) 2021 Sep 22. Epub 2021 Sep 22.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.

The widespread use of chlorothalonil (CTL) has caused environmental residues and food contamination. Although the intestinal epithelial barrier (IEB) is directly involved in the metabolism and transportation of various exogenous compounds, there are few studies on the toxic effects of these compounds on the structure and function of IEB. The disassembly of tight junction (TJ) is a major cause of intestinal barrier dysfunction under exogenous compounds intake, but the precise mechanisms are not well understood. Read More

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September 2021

[Joint preservation in hip surgery].

Authors:
Joachim Grifka

Orthopade 2021 Sep 21. Epub 2021 Sep 21.

Orthopädische Klinik für die Universität Regensburg, Asklepios Klinikum Bad Abbach GmbH, Kaiser-Karl-V.-Allee 3, 93077, Bad Abbach, Deutschland.

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September 2021

Public health and expert failure.

Authors:
Roger Koppl

Public Choice 2021 Sep 17:1-24. Epub 2021 Sep 17.

Syracuse University, Syracuse, USA.

In a modern democracy, a public health system includes mechanisms for the provision of expert scientific advice to elected officials. The decisions of elected officials generally will be degraded by expert failure, that is, the provision of bad advice. The theory of expert failure suggests that competition among experts generally is the best safeguard against expert failure. Read More

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September 2021

Filling the knowledge gap: A suspect screening study for 1310 potentially persistent and mobile chemicals with SFC- and HILIC-HRMS in two German river systems.

Water Res 2021 Sep 10;204:117645. Epub 2021 Sep 10.

Department of Analytical Chemistry, Helmholtz Centre for Environmental Research - UFZ, Permoserstrasse 15, Leipzig 04318, Germany; University of Leipzig, Institute for Analytical Chemistry, Linnéstrasse 3, Leipzig 04103, Germany. Electronic address:

Persistent and mobile chemicals (PM chemicals) were searched for in surface waters by hydrophilic interaction liquid chromatography (HILIC) and supercritical fluid chromatography (SFC), both coupled to high resolution mass spectrometry (HRMS). A suspect screening was performed using a newly compiled list of 1310 potential PM chemicals to the data of 11 surface water samples from two river systems. In total, 64 compounds were identified by this approach. Read More

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September 2021

Halitosis, what experiences and methods apply Dutch dental hygienists.

Int J Dent Hyg 2021 Sep 21. Epub 2021 Sep 21.

SPOH ARTS - International Oral Health Psychology, Amsterdam, The Netherlands.

Objectives: The aim of this research is to gain more insight in the methods and experiences of dental hygienists in the Netherlands regarding the treatment of patients with halitosis.

Material And Methods: A total of 92 dental hygienists completed the questionnaire (consisting of 19 questions on personal and professional characteristics, clinical observation and treatment of halitosis, the referral of patients with halitosis, the presence and usefulness of a protocol). The questionnaire was distributed using a social media platform for dental professionals in oral health care from all over the Netherlands. Read More

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September 2021

Recreational N O use: just laughing or really bad news?

Addiction 2021 Sep 20. Epub 2021 Sep 20.

Department of Psychiatry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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September 2021

Evolution and progression of Barrett's oesophagus to oesophageal cancer.

Nat Rev Cancer 2021 Sep 20. Epub 2021 Sep 20.

Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge, Cambridge, UK.

Cancer cells are shaped through an evolutionary process of DNA mutation, cell selection and population expansion. Early steps in this process are driven by a set of mutated driver genes and structural alterations to the genome through copy number gains or losses. Oesophageal adenocarcinoma (EAC) and the pre-invasive tissue, Barrett's oesophagus (BE), provide an ideal example in which to observe and study this evolution. Read More

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September 2021

Development and preliminary evaluation of Chinese School-aged Children's Eating Behavior Scale.

J Health Popul Nutr 2021 Sep 20;40(1):41. Epub 2021 Sep 20.

Department of Health Statistics and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.

Background: The objective of this study was to develop a scale to assess eating behaviors of school-aged children (6-12 years old) in China.

Methods: To develop the scale, a literature review and qualitative interviews were conducted. The draft scale contained 115 items and went through three evaluations among three groups of caregivers (n = 140, 400, 700) selected from suburban and urban kindergartens in Xi'an, Hanzhong, and Yanan, China, from March 2017 to October 2018. Read More

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September 2021

The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation.

J Neuroinflammation 2021 Sep 20;18(1):215. Epub 2021 Sep 20.

Medical Faculty, Eye Center, University Hospital, University of Freiburg, Freiburg im Breisgau, Germany.

Background: Microglia cells represent the resident innate immune cells of the retina and are important for retinal development and tissue homeostasis. However, dysfunctional microglia can have a negative impact on the structural and functional integrity of the retina under native and pathological conditions.

Methods: In this study, we examined interferon-regulatory factor 8 (Irf8)-deficient mice to determine the transcriptional profile, morphology, and temporospatial distribution of microglia lacking Irf8 and to explore the effects on retinal development, tissue homeostasis, and formation of choroidal neovascularisation (CNV). Read More

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September 2021

Entrustment in physician-patient communication: a modified Delphi study using the EPA approach.

BMC Med Educ 2021 Sep 20;21(1):497. Epub 2021 Sep 20.

RARE Department, Islamic International Medical College, Riphah International University, Rawalpindi, Pakistan.

Background: Competency based curricula across the globe stress on the importance of effective physician patient communication. A variety of courses have been used to train physicians for this purpose. However, few of them link competencies with practice resulting in confusions in implementation and assessment. Read More

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September 2021

Application of a scheimpflug-based biomechanical analyser and tomography in the early detection of subclinical keratoconus in chinese patients.

BMC Ophthalmol 2021 Sep 20;21(1):339. Epub 2021 Sep 20.

Department of Ophthalmology, Peking University Third Hospital, Beijing, China.

Background: In vivo corneal biomechanics evaluation has been used to help screen early keratoconus in recent years. This study is to evaluate the value of a Scheimpflug-based biomechanical analyser combined with tomography in detecting subclinical keratoconus by distinguishing normal eyes from frank keratoconus (KC) and forme frusta keratoconus (FFKC) eyes in Chinese patients.

Methods: Study design: diagnostic test. Read More

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September 2021

[Inflammatory Bowel Disease - Challenges in the Workplace and Support for Coping with Disease].

Rehabilitation (Stuttg) 2021 Sep 20. Epub 2021 Sep 20.

Institut für Sozialmedizin und Epidemiologie, Universität zu Lübeck, Lübeck.

Purpose: Patients with inflammatory bowel diseases (IBD) are often impaired in their ability to be employed due to IBD symptoms. The aim of this study was to explore work-related problems and support requested by IBD patients and develop rehabilitation programs meeting their needs.

Methods: A total of 235 IBD patients (97 rehabilitants, 138 outpatients) completed a questionnaire assessing disease-specific impairments, work-related concerns and the need for support services. Read More

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September 2021

Pool water disinfection by ozone-bromine treatment: Assessing the disinfectant efficacy and the occurrence and in vitro toxicity of brominated disinfection by-products.

Water Res 2021 Sep 9;204:117648. Epub 2021 Sep 9.

German Environment Agency (UBA), Section Water Treatment, Schichauweg 58, Berlin 12307, Germany. Electronic address:

Pool water is continuously circulated and reused after an extensive treatment including disinfection by chlorination, ozonation or UV treatment. In Germany, these methods are regulated by DIN standard 19643. Recently, the DIN standard has been extended by a new disinfection method using hypobromous acid as disinfectant formed by introducing ozone into water with naturally or artificially high bromide content during water treatment. Read More

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September 2021

Two lymphomas in the same patient: A case report.

Rev Med Inst Mex Seguro Soc 2020 ;58(4):536-540

Universidad Autónoma de Chihuahua, Facultad de Medicina y Ciencias Biomédicas, Circuito Universitario Campus II, Departamento de Medicina. Chihuahua, Chihuahua, México.

IntroducciÓn: La asociación de forma sincrónica de un linfoma Hodgkin y un linfoma no Hodgkin en un mismo paciente es muy rara.

Caso ClÍnico: Varón de 68 años que comienza su padecimiento con adenomegalias cervicales y axilares. Se realiza biopsia escisional y se encuentra linfoma de Hodgkin de tipo celularidad mixta, por lo que se inicia quimioterapia. Read More

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January 2020

Effects of interval-based inpatient treatment for anorexia nervosa: An observational study.

Brain Behav 2021 Sep 20:e32362. Epub 2021 Sep 20.

Schoen Clinic Bad Staffelstein, Bad Staffelstein, Germany.

Objective: After inpatient treatment for anorexia nervosa (AN), many patients relapse and need to be readmitted. To obtain a sustained improvement, a pre-planned multistep inpatient procedure might help to improve the patient's skills in dealing with symptoms and transdiagnostic problems, thus decreasing symptoms of AN. However, no data have been reported for such interval treatment yet. Read More

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September 2021

Unilateral cerebral perfusion is gaining increased interest, but more evidence is still necessary.

Authors:
Paul P Urbanski

Eur J Cardiothorac Surg 2021 Sep 20. Epub 2021 Sep 20.

Department of Cardiovascular Surgery, Cardiovascular Clinic Bad Neustadt, Bad Neustadt, Germany.

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September 2021

An observational study of learning effects of peer-assisted learning tests in COVID-19 pandemic times.

J Dent Educ 2021 Sep 20. Epub 2021 Sep 20.

Department of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Erlangen, Germany.

Purpose: This study aimed to determine whether peer-assisted learning (PAL) is a more effective learning and test method in terms of oral- and maxillofacial surgery.

Material And Methods: In July 2020, a total of 267 students took a PAL-based exam on fictional patients with surgical issues, in which they had to evaluate two fellow students and were themselves evaluated by two fellow students. The students evaluated their experience with the PAL-based exam through a questionnaire which consisted of five given statements (answer possibilities: agree, disagree, neutral) and two questions (answer possibilities: better, equal, worse) to rate. Read More

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September 2021

Satisfaction, Preference and Injection Habits of Switching to 200 Units/ml Insulin Lispro Pen from 100 Units/ml: A Patient Survey in Germany.

Diabetes Ther 2021 Sep 20. Epub 2021 Sep 20.

Klinik und Poliklinik für Endokrinologie, Nephrologie, Rheumatologie, Universitätsklinikum Leipzig, Liebigstr. 20, 04103, Leipzig, Germany.

Introduction: The study was designed to assess patient satisfaction, preferences and injection habits for patients using insulin lispro 200 units/ml pen (IL200) compared to their previously used disposable 100 units/ml mealtime insulin pen ("MTI-100 pen") in Germany.

Methods: A site-based, cross-sectional study involving a self-reported survey and medical record extraction in patients with diabetes currently using IL200 for between 3 and 12 months and had previously used any disposable MTI-100 pen.

Results: Of 114 patients included, 83. Read More

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September 2021

[Osteoporotic fractures of the pelvic ring and their minimally invasive treatment options].

Authors:
Florian Faber

Orthopade 2021 Sep 20. Epub 2021 Sep 20.

Neurochirurgie, Orthopädie und Unfallchirurgie, Sektion Wirbelsäule, Orthopädische Universitätsklinik Regensburg, Asklepios Klinikum Bad Abbach, Kaiser Karl V. Allee 3, 93077, Bad Abbach, Deutschland.

The routine care of osteoporotic fractures of the pelvic ring requires a well-structured treatment algorithm in order to start a stage-appropriate treatment without delay. Nowadays, minimally invasive treatment methods are the gold standard. The minimally invasive dorsal techniques primarily include percutaneous sacroiliac screw osteosynthesis and internal spinopelvic fixation. Read More

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September 2021

Concept Mapping, an Effective Tool for Long-Term Memorization of Anatomy-A Quasi-Experimental Research Carried out among 1st Year General Medicine Students.

Eur J Investig Health Psychol Educ 2020 Mar 3;10(1):530-543. Epub 2020 Mar 3.

Department of Medical Informatics and Biostatistics, Faculty of General Medicine, Iuliu Hatieganu University of Medicine, 400012 Cluj-Napoca, Romania.

This study is part of a doctoral thesis conducted at the Faculty of Psychology of Babes-Bolyai University in collaboration with the University of Medicine, both from Cluj-Napoca, Romania. The starting point of the study was based on the eternal question of the medical student-"How should I learn to manage to retain so much information?" This is how learning through conceptual maps and learning by understanding has been achieved. In the study, a number of 505 students from the Faculty of General Medicine were randomly selected and divided into groups, to observe changes in the grades they obtained when learning anatomy with the concept mapping method vs. Read More

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Efficacy and safety of exogenous beta-hydroxybutyrate for preventive treatment in episodic migraine: A single-centred, randomised, placebo-controlled, double-blind crossover trial.

Cephalalgia 2021 Sep 20:3331024211043792. Epub 2021 Sep 20.

Division of Neuropaediatrics, University of Basel Children's Hospital, University of Basel, Switzerland.

Background: Several studies propose that brain energy deficit might be partially involved in the pathophysiology of migraine. Previously, studies demonstrated that ketogenic diet causes a substantial reduction in migraine frequency. Since the ketogenic diet is restricting and its adherence is difficult, we proposed to supplement ketone bodies exogenously to provide a prophylactic effect in migraineurs. Read More

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September 2021

Prognostic value of haemoglobin drop in patients with acute coronary syndromes.

Eur J Clin Invest 2021 Sep 20:e13670. Epub 2021 Sep 20.

Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.

Background: The prognostic value of in-hospital haemoglobin drop in patients with acute coronary syndrome (ACS) undergoing invasive therapy remains insufficiently investigated.

Materials And Methods: This observational study included 3838 patients with ACS with admission and in-hospital nadir haemoglobin values available. Haemoglobin drop was defined as a positive difference between admission and nadir haemoglobin values. Read More

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September 2021