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Prognostic value of ferroptosis-related genes in patients with lung adenocarcinoma.

Thorac Cancer 2021 May 12. Epub 2021 May 12.

Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin, China.

Background: The prevalence of lung adenocarcinomas (LUADs) has dramatically increased in recent decades. Ferroptosis is a process of iron-dependent regulatory cell death. It is still unclear whether the expression of ferroptosis-related genes (FRGs) is involved in the pathogenesis and survival of patients with LUAD. Read More

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Metallic Implants in MRI - Hazards and Imaging Artifacts.

Rofo 2021 May 12. Epub 2021 May 12.

Department for Radiology and Neuroradiology, Molecular Imaging North Competence Center (MOIN CC), Section Biomedical Imaging, University Hospital Schleswig-Holstein - Campus Kiel, Kiel University, Germany.

Background:  Magnetic resonance imaging (MRI) is an examination method for noninvasive soft tissue imaging without the use of ionizing radiation. Metallic implants, however, may pose a risk for the patient and often result in imaging artifacts. Due to the increasing number of implants, reducing these artifacts has become an important goal. Read More

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MRI-findings in idiopathic intracranial hypertension (Pseudotumor cerebri).

Rofo 2021 May 12. Epub 2021 May 12.

Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein - Campus Kiel, Germany.

Background:  Pseudotumor cerebri, also known as idiopathic intracranial hypertension, is a disorder of increased intracranial pressure of unknown etiology. Main symptom is headache which has a characteristic similar to other headache diseases, therefore the idiopathic intracranial hypertension often remains undetected. The incidence is 1/100 000 with the number of unreported cases being much higher. Read More

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Proposing an International Standard Accident Number for Interconnecting Information and Communication Technology Systems of the Rescue Chain.

Methods Inf Med 2021 May 12. Epub 2021 May 12.

Peter L. Reichertz Institute for Medical Informatics, TU Braunschweig and Hannover Medical School, Braunschweig, Germany.

Background:  The rapid dissemination of smart devices within the internet of things (IoT) is developing toward automatic emergency alerts which are transmitted from machine to machine without human interaction. However, apart from individual projects concentrating on single types of accidents, there is no general methodology of connecting the standalone information and communication technology (ICT) systems involved in an accident: systems for alerting (e.g. Read More

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Efficient Clinical Data Sharing Framework Based on Blockchain Technology.

Methods Inf Med 2021 May 12. Epub 2021 May 12.

Department of Information Management, National Chung Cheng University, Chia-Yi County, Taiwan.

Background:  While electronic health records have been collected for many years in Taiwan, their interoperability across different health care providers has not been entirely achieved yet. The exchange of clinical data is still inefficient and time consuming.

Objectives:  This study proposes an efficient patient-centric framework based on the blockchain technology that makes clinical data accessible to patients and enable transparent, traceable, secure, and effective data sharing between physicians and other health care providers. Read More

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In vitro evaluation of the anti-pathogenic activity of Okoubaka aubrevillei on the human gastrointestinal tract.

Z Gastroenterol 2021 May 12;59(5):423-437. Epub 2021 May 12.

Institute of Integrative Medicine, University of Witten/Herdecke, Germany.

Background:   is used in traditional West African medicine and in homeopathy for treatment and prevention of several gastrointestinal problems. The aim of this study was to evaluate the effect of repeated doses of two products (10 % ethanolic tincture, mother tincture (MT); 3 decimal potency, 3X) on the microbial activity of physiological human colon microbiota using a Simulator of the Human Intestinal Microbial Ecosystem (SHIME) and to investigate any preventive effect against infections with diarrhea-causing pathogens.

Methods:  Upon inoculation with fecal microbiota from a healthy donor, 4 parallel proximal colon compartments of the SHIME were treated either with MT, 3X, ethanol control or blank control for 7 days. Read More

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Homeopathic Treatment in Patients with Polycystic Ovarian Syndrome: A Case Series.

Homeopathy 2021 May 12. Epub 2021 May 12.

Dr. Anjali Chatterjee Regional Research Institute for Homoeopathy, Kolkata, West Bengal. Under CCRH, Ministry of AYUSH, Govt. of India, Kolkata, West Bengal, India.

Background And Objectives:  Polycystic ovary syndrome (PCOS) is a common heterogeneous endocrine disorder in women of reproductive age. It is characterized by various clinical presentations such as ovulatory dysfunction, polycystic ovaries, and hyperandrogenism. Considering the side effects associated with conventional treatment and the patients who fail to respond to these measures, there is a demand for a complementary therapy that would alleviate symptoms of PCOS without side effects. Read More

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[Function-based tests to determine the return-to-activity state in patients with non-specific low back pain].

Sportverletz Sportschaden 2021 May 12. Epub 2021 May 12.

Hochschule Furtwangen, Germany.

Background:  Most people with back pain suffer from non-specific low back pain, for which no specific reasons can be found. Two out of three have recurrent pain episodes. To reduce the likelihood of recurrence and long-lasting pain, functional tests are increasingly used to determine the current functional status. Read More

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Bigu-Style Fasting Affects Metabolic Health by Modulating Taurine, Glucose, and Cholesterol Homeostasis in Healthy Young Adults.

J Nutr 2021 May 12. Epub 2021 May 12.

Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.

Background: Dynamic orchestration of metabolic pathways during continuous fasting remains unclear.

Objective: We investigated the physiological effects of Bigu-style fasting and underlying metabolic reprogramming in healthy adults.

Methods: We conducted a 5-d Bigu trial in 43 healthy subjects [age 23. Read More

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Maternal Overweight and Obesity during Pregnancy Are Associated with Neonatal, but Not Maternal, Hepcidin Concentrations.

J Nutr 2021 May 12. Epub 2021 May 12.

Department of Pediatrics, Medical School, University of Michigan, Ann Arbor, MI, USA.

Background: Overweight or obesity among pregnant women may compromise maternal and neonatal iron status by upregulating hepcidin.

Objectives: This study determined the association of 1) maternal and neonatal iron status with maternal and neonatal hepcidin concentrations, and 2) maternal prepregnancy weight status with maternal and neonatal hepcidin concentrations.

Methods: We examined hematologic data from 405 pregnant women and their infants from the placebo treatment group of a pregnancy iron supplementation trial in rural China. Read More

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Polyhydroxybutyrate: A Useful Product of Chlorotic Cyanobacteria.

Microb Physiol 2021 May 12:1-11. Epub 2021 May 12.

Interfaculty Institute of Microbiology and Infection Medicine Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.

Polyhydroxybutyrate (PHB) is a carbon polymer with diverse functions, varying greatly on the organism producing it. This microreview describes the current knowledge about PHB metabolism, structure, and different physiological roles with a special focus on cyanobacteria. Despite the physiological function of PHB in the cyanobacterial phylum still being unknown, these organisms provide the unique opportunity to directly convert atmospheric CO2 into bioplastic using a solar-based process. Read More

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A Scoping Review on College Student Physical Activity: How Do Researchers Measure Activity and Examine Inequities?

J Phys Act Health 2021 May 11:1-9. Epub 2021 May 11.

Background: The purpose of this scoping review was to critically examine the design and quality of contemporary research involving college student physical activity participation, focusing on physical activity measurement, assessment of sociodemographic characteristics, and examination of inequities based on sociodemographic characteristics.

Methods: Systematic searches were conducted in 4 electronic databases.

Results: From 28,951 sources screened, data were extracted from 488 that met the inclusion criteria. Read More

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Changes in Physical Activity, Sleep, Mental Health, and Social Media Use During COVID-19 Lockdown Among Adolescent Girls: A Mixed-Methods Study.

J Phys Act Health 2021 May 11:1-9. Epub 2021 May 11.

Background: To suppress the transmission of coronavirus, many governments, including that of the island of Ireland, implemented a societal lockdown, which included school closures, limits on social gatherings, and time outdoors. This study aimed to evaluate changes in physical activity (PA), mental health, sleep, and social media use among adolescent girls during lockdown.

Methods: 281 female pupils (12-14 y) taking part in the ongoing Walking In Schools study on the island of Ireland self-reported PA, mental health, sleep, and social media use before (September-October 2019) and during lockdown (May-June 2020), via questionnaires. Read More

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Predictors of Health Information Seeking Behavior: A Systematic Review and Network Analysis.

J Med Internet Res 2021 May 12. Epub 2021 May 12.

The University of Sydney School of Pharmacy, Pharmacy and Bank Building A15, The University of Sydney, AU.

Background: People engage in health information seeking behavior (HISB) to support health outcomes. Being able to predict a person's behavior can inform the development of interventions to guide effective health information seeking. Obtaining a comprehensive list of the predictors of HISB through a systematic search of the literature and exploring the inter-relationship of these predictors are important first steps in this process. Read More

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Anti-CD20 antibody therapy and risk of infection in patients with demyelinating diseases.

Mult Scler Relat Disord 2021 May 1;52:102988. Epub 2021 May 1.

Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Background: Anti-CD20 antibody therapy may be associated with an increased risk of infections. We therefore investigated risk factors for infection in patients with demyelinating diseases treated with anti-CD20 antibody therapy.

Methods: In this retrospective uncontrolled study, patients ever treated with anti-CD20 antibodies at an academic clinic were identified through the Danish Multiple Sclerosis Registry (DMSR). Read More

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Matching-adjusted indirect treatment comparison of ozanimod versus teriflunomide for relapsing multiple sclerosis.

Mult Scler Relat Disord 2021 Apr 25;52:102972. Epub 2021 Apr 25.

Bristol Myers Squibb, 3551 Lawrenceville Rd., Princeton, NJ, 08540 USA.

Background: A growing number of immunomodulating disease-modifying therapies are available for treatment of relapsing multiple sclerosis (RMS). In the absence of randomized head-to-head trials, matching-adjusted indirect comparisons (MAICs) can be used to adjust for cross-trial differences and evaluate the comparative efficacy and safety of these agents. We used MAIC methodology to indirectly compare key outcomes with ozanimod (OZM) and teriflunomide (TERI) in the treatment of RMS. Read More

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Interventions to reduce preterm birth in pregnant women with psychosocial vulnerability factors-A systematic review.

Midwifery 2021 Apr 20;100:103018. Epub 2021 Apr 20.

Department of Health Science and Technology, Public Health and Epidemiology Group, Aalborg University, Niels Jernes Vej 14, 9220 Aalborg Øst, Denmark.

Objective: Pregnant women with psychosocial vulnerability factors face a higher risk of preterm birth, a heavier burden of perinatal morbidity and mortality and less social health equity. Prevention of preterm birth in this group has proved difficult, and more knowledge is needed to ensure evidence-based care and improve prevention. This study aimed to determine the effectiveness of preventive interventions to reduce preterm birth among pregnant women with psychosocial vulnerability factors. Read More

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Blood neutrophils from children with COVID-19 exhibit both inflammatory and anti-inflammatory markers.

EBioMedicine 2021 May 9;67:103357. Epub 2021 May 9.

División Infectología, Hospital General de Agudos Dr. Juan A. Fernández, Av. Cerviño 3356, CABA C1425, Argentina.

Background: Perhaps reflecting that children with COVID-19 rarely exhibit severe respiratory symptoms and often remain asymptomatic, little attention has been paid to explore the immune response in pediatric COVID-19. Here, we analyzed the phenotype and function of circulating neutrophils from children with COVID-19.

Methods: An observational study including 182 children with COVID-19, 21 children with multisystem inflammatory syndrome (MIS-C), and 40 healthy children was performed in Buenos Aires, Argentina. Read More

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The effect of highly inhomogeneous biphasic properties on mechanical behaviour of articular cartilage.

Comput Methods Programs Biomed 2021 Apr 22;206:106122. Epub 2021 Apr 22.

State Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, 710054, Xi'an, Shaanxi, China; Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, LS2 9JT, United Kingdom; Tribology Research Institute, School of Mechanical Engineering, Southwest Jiaotong University, 610031, Chengdu, Sichuan, China. Electronic address:

Background And Objective: Investigating the biomechanics of cartilage could help to understand the unique load-bearing property of the cartilage and optimize the scaffold design in tissue-engineering. It is important to model the cartilage as a highly inhomogeneous fibril-reinforced biphasic material to represent its complex composition and structure. The depth-dependent and strain-dependent properties of the cartilage would also play an important role in its mechanical behaviour. Read More

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Texture analysis based on U-Net neural network for intracranial hemorrhage identification predicts early enlargement.

Comput Methods Programs Biomed 2021 May 3;206:106140. Epub 2021 May 3.

Department of Anatomy, Anhui Medical University, 81 Meishan Road, Hefei 230032, China. Electronic address:

Background And Objective: Early hemorrhage enlargement in hypertensive cerebral hemorrhage indicates a poor prognosis. This study aims to predict the early enlargement of cerebral hemorrhage through the intelligent texture analysis of cerebral hemorrhage after segmentation.

Methods: A total of 54 patients with hypertensive intracerebral hemorrhage were selected and divided into enlarged hematoma (enlarged group) and non-enlarged hematoma (negative group). Read More

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Nomograms to Predict Overall and Cancer-Specific Survival in Gastric Signet-Ring Cell Carcinoma.

J Surg Res 2021 May 9;266:13-26. Epub 2021 May 9.

Department of General Surgery, The Third Affiliated Hospital of Wenzhou Medical University. Electronic address:

Background: The objective of our study was to develop and validate nomograms to predict the overall survival (OS) and cancer-specific survival (CSS) of patients with signet-ring cell carcinoma (SRCC) of the stomach.

Methods: Data were collected from the Surveillance, Epidemiology, and End Results (SEER) database. A total of 1781 patients were randomly allocated to a training set (n = 1335) and a validation set (n = 446). Read More

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The effect of cervical intervertebral disc degeneration on the motion path of instantaneous center of rotation at degenerated and adjacent segments: A finite element analysis.

Comput Biol Med 2021 May 4;134:104426. Epub 2021 May 4.

Department of Orthopaedic Surgery, Beijing Tiantan Hospital, Capital Medical University, No.119, South 4th Ring West Road, Fengtai District, Beijing, 100070, China; National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, Beijing, 100853, China. Electronic address:

Background: The motion path of instantaneous center of rotation (ICR) is a crucial kinematic parameter to dynamically characterize cervical spine intervertebral patterns of motion; however, few studies have evaluated the effect of cervical disc degeneration (CDD) on ICR motion path. The purpose of this study was to investigate the effect of CDD on the ICR motion path of degenerated and adjacent segments.

Method: A validated nonlinear three-dimensional finite element (FE) model of a healthy adult cervical spine was used. Read More

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Ventral striatal activation during reward differs between major depression with and without impaired mood reactivity.

Psychiatry Res Neuroimaging 2021 May 2;313:111298. Epub 2021 May 2.

Department of Psychology, Florida State University, 1107 West Call St, Tallahassee, FL 32304, United States.

Background: Recent efforts to classify subtypes of major depressive disorder marked by different psychophysiological indicators have identified blunted reward-related brain activation in gambling tasks as a characteristic linked specifically to depressed participants with impaired mood reactivity.

Methods: The current study compared individuals diagnosed with current depressive disorder (n = 26) with healthy controls (n = 24) regarding brain responses to gain and loss trials in an fMRI version of the "Doors" choice-feedback task. Study aims were to examine reward-related brain activation in relation to depression, depressive subtypes, and course of depression. Read More

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Acute knee clinics are effective in reducing delay to diagnosis following anterior cruciate ligament injury.

Knee 2021 May 9;30:267-274. Epub 2021 May 9.

Bradford Teaching Hospitals NHS Foundation Trust, Accident and Emergency Department MSK Service, Bradford Royal Infirmary, Bradford BD9 6DA, UK.

Background: Delays to diagnosis of anterior cruciate ligament (ACL) injury and specialist consultation continue to place patients at risk of early onset osteoarthritis. Incorporating acute knee clinics within a streamlined accident and emergency (A&E) pathway have shown potential in reducing delay but specific evaluative research is lacking. The aim of this service evaluation was to investigate the effectiveness of an acute knee clinic at one NHS Trust in the United Kingdom (UK), on reducing the delay to diagnosis of ACL injury and specialist consultation compared to a standard A&E pathway. Read More

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Health care utilisation and costs associated with different treatment protocols for newly diagnosed childhood acute lymphoblastic leukaemia: A population-based study in Ontario, Canada.

Eur J Cancer 2021 May 9;151:126-135. Epub 2021 May 9.

Institute for Health Policy, Evaluation and Management, University of Toronto, 155 College St, Toronto, ON, M5T 3MG, Canada; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, M4N 3M5, Canada; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Cir, Toronto, ON, M5S 1A8, Canada.

Background: Although different treatment protocols for childhood acute lymphoblastic leukaemia (ALL) all achieve high cure rates, their health care utilisation and costs have not been rigorously compared.

Methods: Disease, treatment, and outcome data were chart abstracted for all children with ALL in Ontario, Canada, diagnosed 2002-2012. Linkage to population-based databases identified health care utilisation. Read More

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Combined healthy lifestyle and depressive symptoms: a meta-analysis of observational studies.

J Affect Disord 2021 Apr 26;289:144-150. Epub 2021 Apr 26.

Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan. Electronic address:

Background: To systematically summarize the association between combined lifestyle (at least three factors, including but not limited to smoking, drinking, physical activity, body mass index, diet) and depressive symptoms by a meta-analysis in general populations.

Methods: Multiple electronic databases were searched for observational studies investigating combined lifestyle factors and depressive symptoms published before September 2020. Pooled risk estimates were calculated using random-effects models. Read More

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Structural neuroimaging phenotypes of a novel multi-gene risk score in youth bipolar disorder.

J Affect Disord 2021 Apr 28;289:135-143. Epub 2021 Apr 28.

University of Toronto, Toronto, ON, Canada; Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Background: Bipolar disorder (BD) is among the most heritable psychiatric disorders, particularly in early-onset cases, owing to multiple genes of small effect. Here we examine a multi-gene risk score (MGRS), to address the gap in multi-gene research in early-onset BD.

Methods: MGRS was derived from 34 genetic variants relevant to neuropsychiatric diseases and related systemic processes. Read More

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Internet-based cognitive assessment tool: Sensitivity and validity of a new online cognition screening tool for patients with bipolar disorder.

J Affect Disord 2021 Apr 27;289:125-134. Epub 2021 Apr 27.

Digital Health Section, Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark; Copenhagen Center for Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.

Background: The International Society for Bipolar Disorders Targeting Cognition Task Force recommends the Screen for Cognitive Impairment in Psychiatry (SCIP) to screen for cognitive impairment in bipolar disorder. However, SCIP must be administered by a healthcare professional, which is often impossible due to time and resource constraints. Web-based, self-administered cognition screening tools may enable assessment and monitoring of patients' cognition at a much larger scale to a reduced cost. Read More

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Depressive and stress symptoms in insomnia patients predict group cognitive-behavioral therapy for insomnia long-term effectiveness: A data-driven analysis.

J Affect Disord 2021 Apr 24;289:117-124. Epub 2021 Apr 24.

Sleep Disorder Center, San Raffaele Hospital Milan, Italy.

Background: Insomnia Disorder is characterized by high degree of phenotypic heterogeneity, that might influence treatment response.

Methods: 123 of 294 insomnia patients initially recruited (66.7% females, age=40. Read More

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Individual and neighbourhood socioeconomic measures and the risk of non-central nervous system solid tumours in children: A nationwide register-based case-control study in Denmark.

Cancer Epidemiol 2021 May 9;73:101947. Epub 2021 May 9.

Danish Cancer Society Research Center, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark; Department of Environmental Science, Aarhus University, Frederiksborgvej 399, P.O. Box 358, 4000 Roskilde, Denmark.

Background: The aetiology for most solid tumours in childhood is largely unknown. The lack of evidence concerns also the relationship between socioeconomic position (SEP) and risk of childhood solid tumours other than in the central nervous system (CNS). We sought to access the association between individual and neighbourhood SEP measures and risk of childhood non-CNS solid tumours in Denmark and to evaluate whether associations varied by measure of SEP, time point of SEP assessment (during pregnancy versus before diagnosis) and tumour type. Read More

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