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Association of the apoptotic marker APO1/Fas with children's predisposing factors for metabolic syndrome and with mean platelet volume.

J Pediatr Endocrinol Metab 2021 Aug 2. Epub 2021 Aug 2.

Laboratory of Biology and Biochemistry, Faculty of Health Sciences, Department of Nursing, University of Peloponnese, Tripoli, Greece.

Background: Apoptosis antigen 1/FAS receptor (APO1/Fas) signaling in endothelial cells plays a significant role in angiogenesis while increased mean platelet volume (MPV) is an important marker for platelet activation. We investigated the possible correlation between APO1/Fas and both metabolic parameters and platelet activity (indicated by the MPV) in a healthy pediatric population.

Methods: One hundred and eighty-five children, aged 5-17 years old, were enrolled in the study. Read More

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Cytomorphological spectrum of cysticercosis: a study of 26 cases.

Cytopathology 2021 Jul 31. Epub 2021 Jul 31.

Department Of Pathology, Atal Bihari Vajpayi Institute Of Medical Sciences & Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Background: Cysticercosis is a systemic parasitic disease caused by the larval stage of Taenia solium. It is the most common parasitic disease worldwide. Fine needle aspiration cytology plays an important role in prompt recognition of this disease. Read More

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Intraoperative Cochlear Nerve Monitoring for Vestibular Schwannoma Resection and Simultaneous Cochlear Implantation in Neurofibromatosis Type 2: A Case Series.

Oper Neurosurg (Hagerstown) 2021 Jul 31. Epub 2021 Jul 31.

Department of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

Background: Neurofibromatosis type 2 (NF2) often results in profound hearing loss and cochlear implantation is an emerging hearing rehabilitation option. However, cochlear implant (CI) outcomes in this population vary, and intraoperative monitoring to predict cochlear nerve viability and subsequent outcomes is not well-established.

Objective: To review the use of intraoperative electrically evoked cochlear nerve monitoring in patients with NF2 simultaneous translabyrinthine (TL) vestibular schwannoma (VS) resection and cochlear implantation. Read More

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The "Three on a Stick" Incision-A Curvilinear Solution for the Occipital and Suboccipital Region.

Oper Neurosurg (Hagerstown) 2021 Jul 31. Epub 2021 Jul 31.

Division of Neurosurgery, Schneider Children's Medical Center of Israel, Clalit Health System, Petah Tikva, Israel.

Background: Different conditions of the posterior fossa such as Chiari malformations, tumors, and arachnoid cysts require surgery through a suboccipital approach, for which a typical midline vertical linear incision is used. Curvilinear incisions have been carried in all other scalp regions other than the sub region for better cosmetic outcomes; a vertical curvilinear incision in the occipital and suboccipital region has not been reported.

Objective: To evaluate the cosmetic value and safety of the "3 on a stick" vertical suboccipital curvilinear incision. Read More

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Pilates improves physical performance and decreases risk of falls in older adults: a systematic review and meta-analysis.

Physiotherapy 2021 Jun 7;112:163-177. Epub 2021 Jun 7.

Universidad de Castilla La-Mancha, Health and Social Research Center, Cuenca, Spain; Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile.

Background: Falls are the leading cause of injury-related deaths in older adults. Physical exercise is a suitable strategy to reduce the risk of falls, but there is little research on the effectiveness of specific exercise modalities.

Objectives: To estimate the effectiveness of Pilates compared to habitual or non-exercise on physical performance and the risk of falls in older adults. Read More

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Management of nasal myiasis and type 2 diabetes mellitus: A rare case and review article.

Int J Surg Case Rep 2021 Jul 26;85:106244. Epub 2021 Jul 26.

Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Electronic address:

Background: Nasal myiasis is a nasal infestation caused by house fly larvae (maggot). It's a rare condition with only a few reported cases and no treatment consensus.

Case Presentation: A 54-year-old woman was admitted to the emergency unit with a complaint of larvae found in the left nasal cavity and bloody nasal discharge for 2 days. Read More

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Challenges in replicating secondary analysis of electronic health records data with multiple computable phenotypes: A case study on methicillin-resistant Staphylococcus aureus bacteremia infections.

Int J Med Inform 2021 Jul 16;153:104531. Epub 2021 Jul 16.

Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA. Electronic address:

Background: Replication of prediction modeling using electronic health records (EHR) is challenging because of the necessity to compute phenotypes including study cohort, outcomes, and covariates. However, some phenotypes may not be easily replicated across EHR data sources due to a variety of reasons such as the lack of gold standard definitions and documentation variations across systems, which may lead to measurement error and potential bias. Methicillin-resistant Staphylococcus aureus (MRSA) infections are responsible for high mortality worldwide. Read More

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High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials.

Mult Scler Relat Disord 2021 Jul 21;55:103159. Epub 2021 Jul 21.

Division of Neurology, Department of Medicine, St. Michael\220s Hospital, University of Toronto, ON M5B 1W8, Canada. Electronic address:

Background: Biotin may activate the acetyl-CoA-, 3-methylcrotonyl-CoA-, propionyl-CoA-, and pyruvate carboxylases to increase myelin repair and/or synthesis, and may enhance the production of adenosine triphosphate (ATP), which may be essential to prevent neurodegeneration. The purpose of this review was to determine the effectiveness and safety of high-dose biotin (HDB) in multiple sclerosis via a systematic review of randomized controlled trials.

Methods: We searched the following electronic databases for relevant articles: MEDLINE, CENTRAL, EMBASE, Scopus, and ClinicalTrials. Read More

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Theory of mind and its neuroanatomical correlates in people with multiple sclerosis.

Mult Scler Relat Disord 2021 Jul 20;55:103156. Epub 2021 Jul 20.

Department of Neurology, Nitobe Memorial Nakano General Hospital, 4-59-16, Chuo, Nakano-ku, Tokyo, 164-8607, Japan.

Background Theory of mind (ToM) is one of the several different concepts in social cognition and is defined as the ability to access the mental states of others or to adopt the point of view of others. Although studies have shown that ToM is impaired in people with multiple sclerosis (MS), the results based on individual ToM tasks are conflicting; some studies have shown deficits only in the 'Reading the Mind in the Eyes' Test (RMET), while others have reported poor performance in the Faux Pas Test (FPT) as well as RMET. Furthermore, little is known about the relationship between ToM performance and neuroanatomical characteristics in MS. Read More

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Multiple sclerosis incidence and prevalence in Poland: Data from administrative health claims.

Mult Scler Relat Disord 2021 Jul 22;55:103162. Epub 2021 Jul 22.

Department of Neurology, Jagiellonian University Medical College, Krakow, Poland; Department of Neurology, University Hospital in Krakow, Krakow, Poland.

Background: The detailed data concerning multiple sclerosis (MS) epidemiology in Poland are based on studies from few and less populated provinces. Therefore, we evaluated MS incidence and prevalence in Poland using electronic administrative health claims (AHCs) from the National Health Fund.

Methods: We retrospectively analyzed the AHC financial database collected from 2009 to 2019, encompassing all patients using public health resources. Read More

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A cross-sectional survey of cannabis use by people with MS in Oregon and Southwest Washington.

Mult Scler Relat Disord 2021 Jul 25;55:103172. Epub 2021 Jul 25.

Department of Neurology Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239 USA; Department of Neurology, Portland VA Health Care System, 3710 SW US Veterans Hospital Rd, Portland, OR, 97239, USA.

Background: Evidence supports that cannabinoids reduce self-reported spasticity and neuropathic pain in people with MS (PwMS), and legal access to cannabis for medical and recreational use continues to rise. However, there are limited data regarding patterns of cannabis use and perceived benefits of cannabis among PwMS in the US. This study describes the prevalence of cannabis use, routes of administration, perceived benefit of cannabis for MS, and characteristics associated with cannabis use and perception of benefit among a population of PwMS living in two states where cannabis is legal for both medical and recreational use. Read More

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Multiple sclerosis in Peru: National prevalence study using capture-recapture analysis.

Mult Scler Relat Disord 2021 Jul 12;55:103147. Epub 2021 Jul 12.

Asociación de pacientes con Esclerosis Múltiple en el Perú, Lima, Peru.

Background: There is scarce epidemiological data on Multiple Sclerosis (MS) in Latin America. National epidemiological studies are needed to guide the health policy related to MS.

Objective: To determine MS national prevalence in Peru and describe clinical and epidemiological characteristics of the disease. Read More

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Deliberate practice in resuscitation training using a feedback device, and the effects of the physical characteristics of the rescuer on the acquisition and retention of cardiopulmonary resuscitation skills: Randomized clinical trial.

Int Emerg Nurs 2021 Jul 28;58:101037. Epub 2021 Jul 28.

Fundación San Juan de Dios, Centro de Ciencias de la Salud San Rafael, Universidad de Nebrija, Paseo de La Habana, 70, 28036 Madrid, Spain; UNINPSI, Dpto. de Psicología, Universidad Pontificia Comillas, Madrid, Spain. Electronic address:

Background: Cardiopulmonary resuscitation (CPR) skills decline rapidly and rescuers' physical characteristics could impact on their performance. Our aim was to analyse the effects of deliberate practice using a feedback device (FD) on the CPR performance of nursing students prior to, immediately after, and three months after training, considering their physical characteristics.

Method: Sixty nursing students participated in this randomized clinical trial (control group n = 28; training group n = 32). Read More

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Elderly patients presenting to a rural hospital emergency department in inland Croatia - A retrospective study.

Int Emerg Nurs 2021 Jul 28;58:101035. Epub 2021 Jul 28.

Zagreb University of Applied Sciences, Mlinarska cesta 38, HR-10000 Zagreb, Croatia. Electronic address:

Background: Emergency departments are faced with a high influx of patients presenting for various complaints. The aim of the present study was to assess the basic characteristics of elderly patients presenting to a rural hospital emergency department in inland Croatia in 2017.

Methods: Retrospective data collected from the Hospital Information System and by analysis of medical records on patients presenting to emergency department in 2017 were used in the study. Read More

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Fifteen years of the proficiency testing program for HIV-1 viral load testing laboratories in China, 2005-2019.

J Clin Virol 2021 Jul 14;142:104911. Epub 2021 Jul 14.

National AIDS Reference Laboratory, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

Background: HIV-1 viral load (VL) testing is essential for monitoring the effects of antiretroviral therapy in HIV-infected patients. In order to identify factors that impact testing performance of HIV-1 VL testing laboratories, this study performed a retrospective analysis on data from the domestic HIV-1 VL proficiency testing (PT) program in China during 2005 to 2019.

Methods: Analysis was conducted on testing results of 155 PT panel specimens that were distributed to HIV-1 VL testing laboratories nationwide during 2005 to 2019. Read More

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Neurology trial registrations on ClinicalTrials.gov between 2007 and 2018: A cross-sectional analysis of characteristics, early discontinuation, and results reporting.

J Neurol Sci 2021 Jul 14;428:117579. Epub 2021 Jul 14.

Stanford University School of Medicine, Stanford, CA, United States of America.

Background: Increasing neurological disease burden and advancing treatment options require clinical trials to expand the evidence base of clinical care. We aimed to characterize neurology clinical trials registered between October 2007 and April 2018 and identify features associated with early discontinuation and results reporting.

Methods: We compared 16,994 neurology (9. Read More

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A positron emission tomography study of the serotonin1B receptor effect of electroconvulsive therapy for severe major depressive episodes.

J Affect Disord 2021 Jul 17;294:645-651. Epub 2021 Jul 17.

Department of Neuropsychiatry, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Background: Electroconvulsive therapy (ECT) is an effective treatment for depressive disorders, although its molecular mechanism of action is unknown. The serotonin 1B (5-HT) receptor is a potential target for treatment of depression and low 5-HT receptor binding in limbic regions has been reported in previous positron emission tomography (PET) studies of depression.

Methods: The objective of this longitudinal PET study was to examine the effect of ECT for depression on 5-HT receptor binding. Read More

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Workplace victimization and alcohol misuse among junior military personnel: Mediating the role of anger.

J Affect Disord 2021 Jul 17;294:638-644. Epub 2021 Jul 17.

Diretor of the King's Centre for Military Health Research, King's College London, London, United Kingdom.

Background: Workplace victimization is one of most serious problems for affecting alcohol misuse in junior military personnel (JMP) that has been largely overlooked in research attention. Studies on workplace victimization and alcohol misuse indicate anger as mediator. Workplace victimization may affect alcohol misuse (in)directly through the mediator. Read More

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Stress management versus cognitive restructuring in trauma-affected refugees - A follow-up study on a pragmatic randomised trial.

J Affect Disord 2021 Jul 16;294:628-637. Epub 2021 Jul 16.

Competence Centre for Transcultural Psychiatry, Mental Health Centre Ballerup, Mental Health Services of the Capital Region, Ballerup, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Background: There is a lack of research and consensus with respect to long-term effective treatments for trauma-affected refugees. The purpose of this follow-up study of a randomised clinical trial was to investigate the effectiveness of Stress Management (SM) versus Cognitive Restructuring (CR) in treating trauma-affected refugees, six and 18 months post-treatment, respectively.

Methods: From a total of 126 refugees with PTSD, the intention-to-treat sample in the original trial, 74 patients were present at the six-month follow-up (SM; n = 37, CR; n = 37) and 34 patients at the 18-month follow-up (SM; n = 14, CR; n = 20). Read More

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Posttraumatic stress in adult civilians exposed to violent conflict, war and associated human rights abuses in the Eastern Mediterranean Region: A systematic review and meta-analysis.

J Affect Disord 2021 Jun 26;294:605-627. Epub 2021 Jun 26.

Division of Clinical Psychological Intervention, Department of Education and Psychology, Freie Universität Berlin, Berlin, Germany.

Background: The Eastern Mediterranean Region (EMR) is the stage of the world's most violent conflicts and the origin of the largest refugee population worldwide. These conflicts can result in symptoms of posttraumatic stress (PTS). To date, no comprehensive meta-analysis on proportions of PTS in civilians from the EMR has been conducted. Read More

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An epidemiological study of externally determined and self-identified mental and physical disability across the spectrum of bipolar disorders.

J Affect Disord 2021 Jul 25;294:597-604. Epub 2021 Jul 25.

Centre for Mental Health, Swinburne University of Technology, Victoria, Australia. Electronic address:

Background: Studies exploring disability in bipolar disorder (BD) have primarily assessed clinical samples of full-threshold BD-I and BD-II alongside so-called objective criteria such as unemployment or receipt of government disability payments. This study extends research on disability by examining externally determined and self-identified disability in a community sample and by including subthreshold BD (BDS).

Methods: Data were extracted from the USA Collaborative Psychiatric Epidemiology Surveys about individuals who met recognized criteria for BD-I, BD-II and BDS who had completed self-ratings of physical and mental disability, comorbidities, and health risk factors (e. Read More

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Advancing health through research: A scoping review of and model for adjunctive psychosocial interventions to improve outcomes for perinatal women with bipolar disorder.

J Affect Disord 2021 Jul 18;294:586-591. Epub 2021 Jul 18.

Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, United States. Electronic address:

Background: We aimed to identify randomized clinical trials (RCTs) which evaluated the efficacy of adjunctive psychosocial interventions to improve outcomes during the perinatal period for women with bipolar disorder (BD).

Methods: We scanned the literature to identify RCTs evaluating the efficacy of adjunctive psychosocial therapies or interventions provided during the perinatal period to women with BD. We searched from 1946 to July 2020 using Embase, Ovid Medline, PsycINFO, and Scopus. Read More

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Added burden of major depressive disorder on cardiovascular morbidity and mortality among patients with cardiovascular disease and the modifying effects of antidepressants: A national retrospective cohort study.

J Affect Disord 2021 Jul 22;294:580-585. Epub 2021 Jul 22.

Department of Healthcare Administration, Asia University, Taiwan; Department of Psychology, Asia University, Taiwan. Electronic address:

Background: To evaluate the likelihood of a future cardiovascular event (i.e., in-hospital mortality or cardiovascular disease [CVD] complications/interventions) among patients with CVD and major depressive disorder (MDD) compared to those without MDD, and the antidepressant use on future cardiovascular events between the two groups. Read More

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The protective effect of isoflurane pretreatment on liver IRI by suppressing noncanonical pyroptosis of liver macrophages.

Int Immunopharmacol 2021 Jul 28;99:107977. Epub 2021 Jul 28.

Department of Hepatobiliary Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing 40010, China. Electronic address:

Background: Liver ischaemia-reperfusion injury (IRI) is a major complication in the perioperative period and often leads to liver failure and even systemic inflammation. Sufficient evidence has demonstrated that isoflurane has anti-inflammatory effects. We aimed to determine whether isoflurane pretreatment protects against liver IRI and to investigate the mechanisms involved in this protection. Read More

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Risk factors for irreversible airway obstruction after infant bronchiolitis.

Respir Med 2021 Jul 24;187:106545. Epub 2021 Jul 24.

Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland; Department of Paediatrics, Tampere University Hospital, Tampere, Finland.

Background: Increasing evidence shows that environmental factors in childhood play a role in development of irreversible airway obstruction. We evaluated early-life and preschool-age risk factors for irreversible airway obstruction in adolescence after bronchiolitis in infancy.

Methods: This study is a secondary analysis of data collected during prospective long-term follow-up of our post-bronchiolitis cohort. Read More

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The smpact of childhood maltreatment on the severity of childhood-related posttraumatic stress disorder in adults.

Child Abuse Negl 2021 Jul 28;120:105208. Epub 2021 Jul 28.

Department of Clinical Psychology, University of Amsterdam, Amsterdam, the Netherlands.

Background: Childhood maltreatment is relatively common and is related to a range of negative consequences, such as Posttraumatic Stress Disorder (PTSD). There are indications that various maltreatment types are related to PTSD severity, although not all types, such as emotional abuse, meet the PTSD Criterion-A.

Objective: The aim of the present study was to examine the relationship between 5 types of childhood maltreatment (i. Read More

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Growing up in the context of intimate partner violence: Experiences and meanings for adolescents in Chile.

Child Abuse Negl 2021 Jul 28;120:105220. Epub 2021 Jul 28.

Departamento de Psicología, Facultad de Ciencias Sociales, Universidad de Chile, Avenida Capitán Ignacio Carrera Pinto, 1045 Ñuñoa, Santiago, Chile.

Background: Growing up in the context of intimate partner violence (IPV) is associated with a range of mental health problems in childhood. A recent area of research in this field considers the perspectives of children and adolescents in understanding the phenomenon of IPV.

Objective: To explore the lived experiences of adolescents growing up in the context of IPV and the meanings they construct about the phenomenon. Read More

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Short carboxyl terminal parathyroid hormone peptides modulate human parathyroid hormone signaling in mouse osteoblasts.

Biochem Biophys Res Commun 2021 Jul 28;572:15-19. Epub 2021 Jul 28.

Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic Rochester, 200 First Street Southwest, Rochester, MN, 55905, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic Rochester, 200 First Street Southwest, Rochester, MN, 55905, USA. Electronic address:

Background: Novel human parathyroid hormone (hPTH) peptides of unknown biological activity have recently been identified in the serum of subjects with normal renal function, chronic renal failure, and end-stage renal disease through the application of liquid chromatography-high resolution mass spectrometry.

Purpose: of experiments: To determine the bioactivity of these peptides, we synthesized hPTH28-84, hPTH38-84, and hPTH45-84 peptides by solid phase peptide synthesis and tested their bioactivity in MC3T3-E1 mouse osteoblasts, either individually or together with the native hormone, hPTH1-84, by assessing the accumulation of 3´,5´-cyclic adenosine monophosphate (cAMP) and the induction of alkaline phosphatase activity.

Results: Increasing doses of hPTH1-84 (1-100 nM) increased the accumulation of cAMP and alkaline phosphatase activity in osteoblasts. Read More

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Do clinical criteria based on PROMIS outcomes identify acceptable symptoms and function for patients with musculoskeletal problems.

Musculoskelet Sci Pract 2021 Jul 5;55:102423. Epub 2021 Jul 5.

George Fox University, Newberg, OR, USA.

Background: Understanding how symptoms influence patient judgements of their health informs providers where to direct care. Patient reported physical outcomes (physical function, pain interference) and self-efficacy of symptom management (SEsm)) predict a patient's health state (i.e. Read More

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