1,988 results match your criteria azide-alkyne cycloaddition

Molecules, the Ultimate Nanomotor: Linking Chemical Reaction Intermediates to their Molecular Diffusivity.

ACS Nano 2021 Sep 15. Epub 2021 Sep 15.

Center for Soft and Living Matter, Institute for Basic Science (IBS), Ulsan 44919, South Korea.

The intellectual community focused on nanomotors has recently become interested in extending these concepts to individual molecules. Here, we study a chemical reaction according to whose mechanism some intermediate species should speed up while others slow down in predictable ways, if the nanomotor hypothesis of boosted diffusion holds. Accordingly, we scrutinize the absolute diffusion coefficient () during intermediate steps of the catalytic cycle for the CuAAC reaction (copper-catalyzed azide-alkyne cycloaddition click reaction), using proton pulsed field-gradient nuclear magnetic resonance to discriminate between the diffusion of various reaction intermediates. Read More

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September 2021

Covalent Linkage of BODIPY-Photosensitizers to Anderson-type Polyoxometalates using CLICK Chemistry.

Chemistry 2021 Sep 14. Epub 2021 Sep 14.

Ulm University, Institute of Inorganic Chemistry I, Albert-Einstein-Allee 11, 89081, Ulm, GERMANY.

The covalent attachment of molecular photosensitizers (PS) to polyoxometalates (POMs) opens new pathways to PS-POM dyads for light-driven charge-transfer and charge-storage. Here we report a synthetic route for the covalent linkage of BODIPY-dyes to Anderson-type polyoxomolybdates using CLICK chemistry ( i.e. Read More

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September 2021

Recent progress on 1H-1,2,3-triazoles as potential antifungal agents.

Curr Top Med Chem 2021 Sep 13. Epub 2021 Sep 13.

Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001. India.

To overcome ever increasing cases of antifungal resistance and circumventing side effects and drug interactions related with currently available drugs has impelled the need to expedite the process of drug discovery and development of novel antifungals. 1,4-Disubstituted 1,2,3-triazole has gained tremendous interest in last two decades mainly because of its ease of synthesis via copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) and its broad spectrum of chemotherapeutic potential. 1,2,3-Triazole is an excellent pharmacophore which has been used as a bioisostere for obtaining libraries of new medicinally important scaffolds. Read More

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September 2021

Divergent Synthesis of Molecular Winch Prototypes.

Chemistry 2021 Sep 7. Epub 2021 Sep 7.

Université Toulouse III Paul Sabatier: Universite Toulouse III Paul Sabatier, Chimie, FRANCE.

We report the synthesis of conceptually new prototypes of molecular winches with the ultimate aim to investigate the work performed by a single ruthenium-based molecular motor anchored on a surface by probing its ability to pull a load upon electrically-driven directional rotation. According to a technomimetic design, the motor was embedded in a winch structure, with a long flexible polyethylene glycol chain terminated by an azide hook to connect a variety of molecular loads. The structure of the motor was first derivatized by means of two sequential cross-coupling reactions involving a penta(4-halogenophenyl)cyclopentadienyl hydrotris(indazolyl)borate ruthenium(II) precursor and the resulting benzylamine derivative was next exploited as key intermediate in the divergent synthesis of a family of nanowinch prototypes. Read More

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September 2021

Heteroacene-Based Amphiphile as a Molecular Scaffold for Bioimaging Probes.

Front Chem 2021 18;9:729125. Epub 2021 Aug 18.

Department of Chemistry and Biochemistry, University of Mississippi University, Oxford, MS, United States.

The challenges faced with current fluorescence imaging agents have motivated us to study two nanostructures based on a hydrophobic dye, 6-pyrrolo[3,2-:4,5-']bis [1,4]benzothiazine (TRPZ). TRPZ is a heteroacene with a rigid, pi-conjugated structure, multiple reactive sites, and unique spectroscopic properties. Here we coupled TRPZ to a tert-butyl carbamate (BOC) protected 2,2-bis(hydroxymethyl)propanoic acid (bisMPA) dendron via azide-alkyne Huisgen cycloaddition. Read More

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Glucose-Sensitive Core-Cross-Linked Nanoparticles Constructed with Polyphosphoester Diblock Copolymer for Controlling Insulin Delivery.

Bioconjug Chem 2021 Sep 1;32(9):2095-2107. Epub 2021 Sep 1.

College of Chemistry, Chemical Engineering and Materials Science, State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis, Soochow University, Suzhou 215123, P. R. China.

This work aims to construct biocompatible, biodegradable core-cross-linked and insulin-loaded nanoparticles which are sensitive to glucose and release insulin via cleavage of the nanoparticles in a high-concentration blood glucose environment. First, a polyphosphoester-based diblock copolymer (PBYP--Gluc)--PEEP was prepared via ring-opening copolymerization (ROP) and the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) in which PBYP and PEEP represent the polymer segments from 2-(but-3-yn-1-yloxy)-2-oxo-1,3,2-dioxaphospholane and 2-ethoxy-2-oxo-1,3,2-dioxaphospholane, respectively, and Gluc comes from 2-azidoethyl-β-d-glucopyranoside (Gluc-N) that grafted with PBYP. The structure and molecular weight of the copolymer were characterized by H NMR, P NMR, GPC, FT-IR, and UV-vis measurements. Read More

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September 2021

Evaluation of a photo-initiated copper(I)-catalyzed azide-alkyne cycloaddition polymer network with improved water stability and high mechanical performance as an ester-free dental restorative.

Dent Mater 2021 Aug 26. Epub 2021 Aug 26.

Department of Chemical and Biological Engineering, University of Colorado Boulder, 596 UCB, Boulder, CO, United States; Materials Science and Engineering Program, University of Colorado Boulder, 596 UCB, Boulder, CO, United States. Electronic address:

Objective: The objective is to develop and characterize an ester-free ether-based photo-CuAAC resin with high mechanical performance, low polymerization-induced stress compared with common BisGMA/TEGDMA (70/30) resins, and improved water stability in comparison to previously developed urethane-based photo-CuAAC resins.

Methods: Triphenyl-ethane-centered ether-linked tri-azide monomers were synthesized and co-photopolymerized with ether-linked tri-alkyne monomers under visible light irradiation using a copper(II) pre-catalyst and CQ/EDAB as the initiator. The ether-based CuAAC formulation was investigated for thermo-mechanical properties, polymerization kinetics and shrinkage stress, and flexural properties with respect to a conventional BisGMA/TEGDMA (70/30) dental resin. Read More

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Virus Infection Variability by Single-Cell Profiling.

Viruses 2021 Aug 9;13(8). Epub 2021 Aug 9.

Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.

Cell-to-cell variability of infection has long been known, yet it has remained one of the least understood phenomena in infection research. It impacts on disease onset and development, yet only recently underlying mechanisms have been studied in clonal cell cultures by single-virion immunofluorescence microscopy and flow cytometry. In this review, we showcase how single-cell RNA sequencing (scRNA-seq), single-molecule RNA-fluorescence in situ hybridization (FISH), and copper(I)-catalyzed azide-alkyne cycloaddition (click) with alkynyl-tagged viral genomes dissect infection variability in human and mouse cells. Read More

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Designed Artificial Protein Heterodimers With Coupled Functions Constructed Using Bio-Orthogonal Chemistry.

Front Chem 2021 4;9:733550. Epub 2021 Aug 4.

Molecular Biosciences Division, School of Biosciences, Cardiff University, Cardiff, United Kingdom.

The formation of protein complexes is central to biology, with oligomeric proteins more prevalent than monomers. The coupling of functionally and even structurally distinct protein units can lead to new functional properties not accessible by monomeric proteins alone. While such complexes are driven by evolutionally needs in biology, the ability to link normally functionally and structurally disparate proteins can lead to new emergent properties for use in synthetic biology and the nanosciences. Read More

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Access to 2,6-Dipropargylated BODIPYs as "Clickable" Congeners of Pyrromethene-567 Dye: Photostability and Synthetic Versatility.

Org Lett 2021 Sep 17;23(17):6801-6806. Epub 2021 Aug 17.

Instituto de Química Orgánica General, IQOG-CSIC, Juan de la Cierva 3, 28006, Madrid, Spain.

Hitherto unreported 2,6-dipropargyl-1,3,5,7-tetramethyl BODIPYs can be efficiently prepared by a Nicholas reaction/decomplexation protocol from 1,3,5,7-tetramethyl BODIPYs. The title compounds, which improve the BODIPY photostability by retaining their inherent photophysical and photochemical properties, can be engaged in efficient copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) "click-type" reactions with azido derivatives to provide all-BODIPY-triads or conjugated BODIPYs. Read More

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September 2021

Regiodivergent and stereoselective hydroxyazidation of alkenes by biocatalytic cascades.

iScience 2021 Aug 17;24(8):102883. Epub 2021 Jul 17.

Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, Generic Drug Research Center of Guizhou Province, Green Pharmaceuticals Engineering Research Center of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China.

Asymmetric functionalization of alkenes allows the direct synthesis of a wide range of chiral compounds. Vicinal hydroxyazidation of alkenes provides a desirable path to 1,2-azidoalcohols; however, existing methods are limited by the control of stereoselectivity and regioselectivity. Herein, we describe a dual-enzyme cascade strategy for regiodivergent and stereoselective hydroxyazidation of alkenes, affording various enantiomerically pure 1,2-azidoalcohols. Read More

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Controlled density glycodendron microarrays for studying carbohydrate-lectin interactions.

Org Biomol Chem 2021 Sep 13;19(34):7357-7362. Epub 2021 Aug 13.

Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), CSIC - Universidad de Sevilla, Av. Américo Vespucio 49, 41092 Seville, Spain.

Glycodendron microarrays with defined valency have been constructed by on-chip synthesis on hydrophobic indium tin oxide (ITO) coated glass slides and employed in lectin-carbohydrate binding studies with several plant and human lectins. Glycodendrons presenting sugar epitopes at different valencies were prepared by spotwise strain-promoted azide-alkyne cycloaddition (SPAAC) between immobilised cyclooctyne dendrons and azide functionalised glycans. The non-covalent immobilisation of dendrons on the ITO surface by hydrophobic interaction allowed us to study dendron surface density and SPAAC conversion rate by in situ MALDI-TOF MS analysis. Read More

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September 2021

Vitamin B - Peptide Nucleic Acid Conjugates.

Methods Mol Biol 2021 ;2355:65-82

Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw, Poland.

Vitamin B (cobalamin, Cbl) is an essential nutrient for all mammals and some bacteria. From a chemical point of view, it is a highly functionalized molecule, which enables conjugation at multiple positions and attachment of various cargoes. Both mammalian and bacterial cells have developed a specific transport pathway for the uptake of vitamin B, and as a consequence, cobalamin is an attractive candidate for the delivery of biologically relevant molecules into cells. Read More

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January 2021

Poly(hydrophobic amino acid) Conjugates for the Delivery of Multiepitope Vaccine against Group A Streptococcus.

Bioconjug Chem 2021 Aug 11. Epub 2021 Aug 11.

School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland 4072, Australia.

Peptide-based vaccines are composed of small, defined, antigenic peptide epitopes. They are designed to induce well-controlled immune responses. Multiple epitopes are often employed in these vaccines to cover strain variability of a pathogen. Read More

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Bioorthogonal chemistry in metal clusters: a general strategy for the construction of multifunctional probes for bioimaging in living cells and in vivo.

J Mater Chem B 2021 Sep 10;9(33):6614-6622. Epub 2021 Aug 10.

Department of Chemistry and Biology, Faculty of Environment and Life Science, Beijing University of Technology, Beijing, 100124, P. R. China.

Multifunctional bioimaging probes based on metal clusters have multiple characteristics of metal clusters and functional conjugates, and their development has broad application prospects in the fields of biomedical imaging and tumor diagnosis. However, current bioconjugation methods on metal clusters are time-consuming and have low reaction efficiency, which hinders the construction of bioimaging probes with multifunctional components. Here, we report a concise and promising design strategy to realize the simple and efficient introduction of functional conjugates through bioorthogonal reactions based on azido-functionalized metal clusters. Read More

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September 2021

Mechanical unfolding of ensemble biomolecular structures by shear force.

Chem Sci 2021 Aug 12;12(30):10159-10164. Epub 2021 Jul 12.

Department of Chemistry & Biochemistry and School of Biomedical Sciences, Advanced Materials and Liquid Crystal Institute, Kent State University Kent OH 44242 USA

Mechanical unfolding of biomolecular structures has been exclusively performed at the single-molecule level by single-molecule force spectroscopy (SMFS) techniques. Here we transformed sophisticated mechanical investigations on individual molecules into a simple platform suitable for molecular ensembles. By using shear flow inside a homogenizer tip, DNA secondary structures such as i-motifs are unfolded by shear force up to 50 pN at a 77 796 s shear rate. Read More

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Synthesis and preliminary evaluation of prostate-specific membrane antigen targeted upconversion nanoparticles as a first step towards radio/fluorescence-guided surgery of prostate cancer.

J Mater Chem B 2021 Aug 10. Epub 2021 Aug 10.

Université Clermont Auvergne, Inserm, Imagerie Moléculaire et Stratégies Théranostiques, UMR 1240, F-63000 Clermont-Ferrand, France.

Over the last decade, upconversion nanoparticles (UCNP) have been widely investigated in nanomedicine due to their high potential as imaging agents in the near-infrared (NIR) optical window of biological tissues. Here, we successfully develop active targeted UCNP as potential probes for dual NIR-NIR fluorescence and radioactive-guided surgery of prostate-specific membrane antigen (PSMA)(+) prostate cancers. We designed a one-pot thermolysis synthesis method to obtain oleic acid-coated spherical NaYF4:Yb,[email protected] core/shell UCNP with narrow particle size distribution (30. Read More

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Alginate modification via click chemistry for biomedical applications.

Carbohydr Polym 2021 Oct 19;270:118360. Epub 2021 Jun 19.

College of Life Sciences, Xinyang Normal University, Xinyang 464000, China. Electronic address:

Alginate biopolymers are characterized by favorable properties, of biocompatibility, degradability, and non-toxicity. However, the poor stability properties of alginate have limited its suitability for diverse applications. Recently, click chemistry has generated significant research interest due to its high reaction efficiency, high selectivity for a single product, harmless byproducts, and processing simplicity. Read More

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October 2021

IEDDA: An Attractive Bioorthogonal Reaction for Biomedical Applications.

Molecules 2021 Jul 30;26(15). Epub 2021 Jul 30.

Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.

The pretargeting strategy has recently emerged in order to overcome the limitations of direct targeting, mainly in the field of radioimmunotherapy (RIT). This strategy is directly dependent on chemical reactions, namely bioorthogonal reactions, which have been developed for their ability to occur under physiological conditions. The Staudinger ligation, the copper catalyzed azide-alkyne cycloaddition (CuAAC) and the strain-promoted [3 + 2] azide-alkyne cycloaddition (SPAAC) were the first bioorthogonal reactions introduced in the literature. Read More

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An Advanced 'clickECM' That Can be Modified by the Inverse-Electron-Demand Diels-Alder Reaction.

Chembiochem 2021 Aug 3. Epub 2021 Aug 3.

Reutlingen Research Institute, Reutlingen University, School of Applied Chemistry, Alteburgstr. 150, 72762, Reutlingen, Germany.

The extracellular matrix (ECM) represents the natural environment of cells in tissue and therefore is a promising biomaterial in a variety of applications. Depending on the purpose, it is necessary to equip the ECM with specific addressable functional groups for further modification with bioactive molecules, for controllable cross-linking and/or covalent binding to surfaces. Metabolic glycoengineering (MGE) enables the specific modification of the ECM with such functional groups without affecting the native structure of the ECM. Read More

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Thiazolidinone-linked1,2,3-triazoles with monoterpenic skeleton as new potential anticancer agents: Design, synthesis and molecular docking studies.

Bioorg Chem 2021 Jul 20;115:105184. Epub 2021 Jul 20.

Laboratoire de Synthèse Organique et Physico-Chimie Moléculaire, Département de Chimie, Faculté des Sciences, Semlalia B.P 2390, Marrakech 40001, Morocco. Electronic address:

A novel series of 1,2,3-triazole-thiazolidinone-carvone hybrid compounds has been designed and synthesized using the copper-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition (CuAAC) process based on (R)-Carvone-O-propargylated 5-hydroxybenzylidene-thiazolidin-4-one derivative as starting material. All compounds were characterized and identified based on their NMR and HRMS spectroscopic data. HMBC correlations confirm that under the CuAAC reaction conditions, only the 1,4-disubstituted triazole regioisomers were formed. Read More

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An Overview of Recent Advances in Biomedical Applications of Click Chemistry.

Bioconjug Chem 2021 08 28;32(8):1455-1471. Epub 2021 Jul 28.

Amity Institute of Virology and Immunology, Amity University, Noida 201313, Uttar Pradesh, India.

Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) is a modular and bio-orthogonal approach that is being adopted for the efficient synthesis of organic and bioorganic compounds. It leads to the selective formation of 1,4-disubstituted 1,2,3-triazole units connecting readily accessible building blocks via a stable and biocompatible linkage. The vast array of the bioconjugation applications of click chemistry has been attributed to its fast reaction kinetics, quantitative yields, minimal byproducts, and high chemospecificity and regioselectivity. Read More

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α-d-Mannoside ligands with a valency ranging from one to three: Synthesis and hemagglutination inhibitory properties.

Carbohydr Res 2021 Oct 8;508:108396. Epub 2021 Jul 8.

Department of Chemistry, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan.

Six mono-, di-, and trivalent α-d-mannopyranosyl conjugates built on aromatic scaffolds were synthesized in excellent yields by Cu(I) catalyzed azide-alkyne cycloaddition reaction (CuAAC). These conjugates were designed to have unique, flexible tails that combine a mid-tail triazole ring, to interact with the tyrosine gate, with a terminal phenyl group armed with benzylic hydroxyl groups to avoid solubility problems as well as to provide options to connect to other supports. Biological evaluation of the prepared conjugates in hemagglutination inhibition (HAI) assay revealed that potency increases with valency and the trivalent ligand 6d (HAI = 0. Read More

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October 2021

Tannic Acid: A green and efficient stabilizer of Au, Ag, Cu and Pd nanoparticles for the 4-Nitrophenol Reduction, Suzuki-Miyaura coupling reactions and click reactions in aqueous solution.

J Colloid Interface Sci 2021 Jul 8;604:281-291. Epub 2021 Jul 8.

College of polymer science and engineering, Sichuan University, Chengdu 610065, China. Electronic address:

Due to the good electrical, optical, magnetic, catalytic properties, transition metal nanoparticles (TMNPs) have been becoming more and more interesting in the fileds of environment, material, biomedicine, catalysis, and so on. Here, tannic acid (TA) is used as a green and efficient stabilizer to fabricate all kinds of TMNPs including AuNPs, AgNPs, CuNPs and PdNPs. These TMNPs possess small sizes ranging from 1 nm to 6 nm, which is conducive to several catalytic reactions in aqueous solution, such as 4-nitrophenol (4-NP) reduction, CuAAC reactions and Suzuki-Miyaura coupling reactions. Read More

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Your mother was right, washing matters: An alkyne-analog of ibuprofen reveals unwanted reactivity of aromatic compounds with proteins during copper-catalyzed click chemistry.

Bioorg Med Chem Lett 2021 Sep 13;48:128260. Epub 2021 Jul 13.

Department of Chemistry, University of Southern California, Los Angeles, CA 90089, United States; Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, United States. Electronic address:

Bioorthogonal chemistry, in particular the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), has enabled the robust identification of covalent protein targets of probes and drugs. Ibuprofen is commonly used pain and fever reducer and is sold as an enantiomeric racemate. Interestingly, the stereoisomers can be enzymatically converted through an ibuprofen-CoA thioester intermediate, which might non-specifically react with protein nucleophiles. Read More

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September 2021

Dinuclear Copper Complex Immobilized on a Janus-Type Material as an Interfacial Heterogeneous Catalyst for Green Synthesis.

ACS Appl Mater Interfaces 2021 Jul 11;13(28):33091-33101. Epub 2021 Jul 11.

Department of Chemistry, Technical University of Kaiserslautern, Erwin-Schrödinger-Street 54, Kaiserslautern 67663, Germany.

We herein describe a rational design of a heterogeneous catalyst composed of a dinuclear cuprate anion being immobilized electrostatically on one surface of Janus-type nanosheets while the other surface is decorated with highly hydrophobic octyl groups. The catalyst was found to be well dispersible in the organic phase of a biphasic aqueous/organic mixture. It was characterized by means of elemental analysis, atomic absorption spectroscopy, mass spectrometry, N absorption-desorption analysis, thermogravimetric analysis, scanning electron microscopy (SEM), and solid-state C and Si cross-polarization magic-angle spinning nuclear magnetic resonance spectroscopy. Read More

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Luminescent terpyridine appended geminal bisazide and bistriazoles: multinuclear Pt(II) complexes and AIPE-based DNA detection with the naked eye.

Dalton Trans 2021 Jul;50(29):10225-10236

Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal 741246, India.

We report square planar Pt(ii) complexes as luminescent biosensors for DNA detection in solution. The sensing is attributed to the aggregation induced bright red photoluminescence (AIPE) of the complexes in the presence of DNA that can be seen with the naked eye using only a 360 nm light source. Terpyridine appended luminescent geminal bistriazoles (L1-L4, from geminal bisazide A through azide-alkyne 'click' cycloaddition) with versatile chelating sites were explored for metal coordination and reaction with Pt(dmso)2Cl2 yielding tetranuclear and dinuclear complexes of Pt(ii) with different N∩N ligand environments. Read More

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Synthesis of new 1,4-disubstituted 1,2,3-triazoles using the CuAAC reaction and determination of their antioxidant activities.

An Acad Bras Cienc 2021 30;93(3):e20201672. Epub 2021 Jun 30.

Universidade Federal de Campina Grande, Centro de Educação e Saúde, Acesso Professora Maria Anita Furtado Coelho, s/n, 58175-000 Cuité, PB, Brazil.

This study describes the synthesis and antioxidant activity of new 1,4-disubstituted 1,2,3-triazoles. These compounds were generated semi-synthetically using the Cu(I)-catalysed azide-alkyne cycloaddition (CuAAC) reaction between ethyl 2-azidoacetate and terminal acetylenes derived from the natural products carvacrol, eugenol, isovanillin, thymol and vanillin. The products were obtained at 50 to 80% yield and characterised through several spectrographic techniques. Read More

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Synthesis of NaSO mediated cleavable affinity tag for labeling of O-GlcNAc modified proteins via azide-alkyne cycloaddition.

Bioorg Med Chem Lett 2021 Sep 3;48:128244. Epub 2021 Jul 3.

Joint National Laboratory for Antibody Drug Engineering, The First Affiliated Hospital of Henan University, School of Basic Medicine Science, Henan University, 475004 Kaifeng, China. Electronic address:

A facile and convergent procedure for the synthesis of azobenzene-based probe was reported, which could selectively release interested proteins conducted with sodium dithionite. Besides, the cleavage efficiency is closely associated with the structural features, in which an ortho-hydroxyl substituent is necessary for reactivity. In addition, the azobenzene tag applied in the AcGlcNAz-labled proteins demonstrated high efficiency and selectivity in comparison with Biotin-PEG-Alkyne, which provides a useful platform for enrichment of any desired bioorthogonal proteomics. Read More

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September 2021

[Advances in technologies for large-scale enrichment and identification of ribonucleic acid-protein complexes].

Se Pu 2021 Feb;39(2):105-111

Beijing Institute of Lifeomics, Beijing Proteome Research Center, National Center for Protein Sciences(Beijing), State Key Laboratory of Proteomics, Beijing 102206, China.

Ribonucleic acid (RNA) rarely exists alone in the cell. RNAs interact with a variety of proteins and form RNA-protein complexes (RP-complexes) in every step of their life cycle, from transcription to degradation. These RP-complexes play key roles in regulating a variety of physiological processes. Read More

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February 2021