1,229 results match your criteria aya patients


Incidence Patterns and Outcomes of Ewing Sarcoma in South Korea (1999-2017): A Retrospective Analysis Using Korea Central Cancer Registry Data.

Cancer Res Treat 2021 Jul 20. Epub 2021 Jul 20.

Division of Cancer Registration and Surveillance, National Cancer Center, Goyang, Korea.

Purpose: Due to low incidence, epidemiologic data of Ewing sarcoma in the Asian population are scarce. We aimed to examine the incidence pattern and outcome of patients with Ewing sarcoma in the Republic of Korea.

Materials And Methods: Data of patients with Ewing sarcoma diagnosed between 1999 and 2017 were obtained from the Korea Central Cancer Registry (KCCR). Read More

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A call to action: Antiracist patient engagement in adolescent and young adult oncology research and advocacy.

Future Oncol 2021 Jul 15. Epub 2021 Jul 15.

Department of Gastrointestinal Oncology, Intermountain Healthcare, Murray, UT 84107, USA.

Amidst the concurrent global crises of coronavirus disease 2019 (COVID-19), uprisings against Anti-Black racism and police brutality, as well as anti-Asian racism and violence, the field of medicine found itself simultaneously called upon to respond as essential workers in the public health devastation of COVID-19, and as representatives of healthcare institutions wrought with the impacts of systemic racism. Clinicians, researchers, and advocates in adolescent and young adult (AYA) oncology, must come together in authentic activism to begin the work of creating structural change to advance antiracist approaches to patient engagement in AYA oncology research and advocacy. Critical review of existing practices is needed to ensure that ethical and effective research methods are employed when engaging with racial and ethnic minority AYA patients with cancer, who may be particularly vulnerable and exploited in the current context. Read More

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Feasibility and acceptability of a home-based resistance training intervention in adolescent and young adult hematopoietic cell transplant survivors.

Pediatr Blood Cancer 2021 Jul 14:e29206. Epub 2021 Jul 14.

Cancer and Blood Disorders Center, Seattle Children's Hospital, Seattle, Washington, USA.

Background: Adolescent and young adult (AYA) hematopoietic cell transplantation (HCT) survivors are at increased risk of metabolic syndrome and lean body mass (LBM) deficits. Resistance training (RT) is a potential intervention to improve LBM, metabolic fitness, and reduce risk of cardiovascular disease.

Procedure: Eligible participants ages 13-39 years, 80-120 days post-HCT, transfusion independent, and prednisone dose ≤1 mg/kg/day were approached. Read More

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Mortality in patients treated for COVID-19 in the emergency department of a tertiary care hospital during the first phase of the pandemic: Derivation of a risk model for emergency departments.

Emergencias 2021 08;33(4):273-281

Área de Urgencias, Hospital Clinic, Barcelona, España. Universitat de Barcelona, España.

Objectives: To develop a risk model to predict 30-day mortality after emergency department treatment for COVID-19.

Material And Methods: Observational retrospective cohort study including 2511 patients with COVID-19 who came to our emergency department between March 1 and April 30, 2020. We analyzed variables with Kaplan Meier survival and Cox regression analyses. Read More

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Poor-Prognosis Metastatic Cancers in Adolescents and Young Adults: Incidence Patterns, Trends, and Disparities.

JNCI Cancer Spectr 2021 Jun 27;5(3):pkab039. Epub 2021 Apr 27.

Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.

Background: For adolescents and young adults (AYAs, aged 15-39 years) with cancer, metastatic disease at diagnosis is the strongest predictor of mortality, but its associations with age and sociodemographic factors are largely unexplored.

Methods: Using Surveillance, Epidemiology, and End Results Program data from 2000 to 2016, we collected incident cases of poor-prognosis metastatic cancer (5-year survival < 50%) and compared the proportion, incidence, time trends, and incidence rate ratios for race and ethnicity, sex, and socioeconomic status among AYAs, middle-aged adults (aged 40-64 years) and older adults (aged 65-79 years).

Results: From 2000 to 2016, a total of 17 210 incident cases of poor-prognosis metastatic cancer were diagnosed in AYAs, 121 274 in middle-aged adults, and 364 228 in older adults. Read More

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Survey design and analysis considerations when utilizing misclassified sampling strata.

BMC Med Res Methodol 2021 Jul 11;21(1):145. Epub 2021 Jul 11.

Department of Biostatistics, Vanderbilt University Medical Center, Nashville, USA.

Background: A large multi-center survey was conducted to understand patients' perspectives on biobank study participation with particular focus on racial and ethnic minorities. In order to enrich the study sample with racial and ethnic minorities, disproportionate stratified sampling was implemented with strata defined by electronic health records (EHR) that are known to be inaccurate. We investigate the effect of sampling strata misclassification in complex survey design. Read More

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The BNT162b2 mRNA COVID-19 vaccine in adolescents and young adults with cancer: A monocentric experience.

Eur J Cancer 2021 Jun 23;154:30-34. Epub 2021 Jun 23.

Department of Pediatric Immunology, Hematology and Oncology, Children Hospital of La Timone, AP-HM, Marseille, France; SMARTc Unit, Centre de Recherche en Cancérologie de Marseille, Inserm U1068, Aix Marseille Univ, Marseille France. Electronic address:

Background And Aims: COVID-19 infection in paediatric patients with cancer is severe or critical in 20% of the patients. It can therefore directly affect paediatric patients with cancer and/or their care. We aimed at evaluating the safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine in adolescents and young adults (AYA) with solid tumour. Read More

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Acute Lymphoblastic Leukemia in Adolescents and Young Adults: A Polish Perspective.

J Adolesc Young Adult Oncol 2021 Jul 7. Epub 2021 Jul 7.

Poznan University of Medical Sciences, Poznań, Poland.

Acute lymphoblastic leukemia (ALL) is a disease that affects immature lymphocytes in the blood and presents a high prevalence rate in children and adolescent young adult (AYA) populations (15-39 years). AYAs are a unique group who face a significant therapeutic disadvantage when treated with the adult regimen, as evident with lower remission rates, whereas the opposite is true in children. A recent study by EUROCARE-5 showed a marked decrease with age in 5 years relative to survival outcomes based on cancer registries of 27 European countries: 85. Read More

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Solution-focused brief therapy for adolescent and young adult cancer patients in China: a pilot randomized controlled trial.

J Psychosoc Oncol 2021 Jul 7:1-18. Epub 2021 Jul 7.

Department of Medicine, University of Chicago, Chicago, IL, USA.

Objective: This pilot clinical trial investigated solution-focused brief therapy (SFBT) for psychological distress among adolescent and young adult (AYA) patients with cancer in China.

Methods: Fifty Chinese AYA patients diagnosed with cancer were randomized into the treatment group (SFBT) and control group (active control). Psychological distress was measured by the brief symptom inventory and hope was measured by the Herth-Hope-Index. Read More

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Oral etoposide as a single agent in childhood and young adult cancer in England: Still a poorly evaluated palliative treatment.

Pediatr Blood Cancer 2021 Jul 6:e29204. Epub 2021 Jul 6.

National Cancer Registration and Analysis Service (NCRAS), Public Health England, London, UK.

Background: Oral etoposide is commonly used in palliative treatment of childhood and young adult cancer without robust evidence. We describe a national, unselected cohort of young people in England treated with oral etoposide using routinely collected, population-level data.

Methods: Patients aged under 25 years at cancer diagnosis (1995-2017) with a treatment record of single-agent oral etoposide in the Systemic AntiCancer Dataset (SACT, 2012-2018) were identified, linked to national cancer registry data using NHS number and followed to 5 January 2019. Read More

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Factors affecting the resolution of acute non-infectious anterior scleritis.

Br J Ophthalmol 2021 Jul 1. Epub 2021 Jul 1.

Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA.

Background/aims: Tumor necrosis factor alpha (TNF-⍺) inhibitors are increasingly being used to treat scleritis, however, their efficacy has not been compared to older treatments. Additionally, few studies have assessed differences in the course of scleritis among different patient groups. We identify demographic factors, comorbidities and treatments associated with the resolution of acute scleritis. Read More

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Whole Lung Irradiation after High-Dose Busulfan/Melphalan in Ewing Sarcoma with Lung Metastases: An Italian Sarcoma Group and Associazione Italiana Ematologia Oncologia Pediatrica Joint Study.

Cancers (Basel) 2021 Jun 3;13(11). Epub 2021 Jun 3.

Paediatric Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milano, Italy.

Purpose: To analyze toxicity and outcome predictors in Ewing sarcoma patients with lung metastases treated with busulfan and melphalan (BU-MEL) followed by whole-lung irradiation (WLI).

Methods: This retrospective study included 68 lung metastatic Ewing Sarcoma patients who underwent WLI after BU-MEL with autologous stem cell transplantation, as part of two prospective and consecutive treatment protocols. WLI 12 Gy for <14 years old and 15 Gy for ≥14 years old patients were applied at least eight weeks after BU-MEL. Read More

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A Retrospective 5-Year Single Center Study Highlighting the Risk of Cancer Predisposition in Adolescents and Young Adults.

Cancers (Basel) 2021 Jun 17;13(12). Epub 2021 Jun 17.

Paediatrics and Adolescent Medicine, University Medical Center Augsburg, 86156 Augsburg, Germany.

The knowledge of inherited cancer susceptibility opens a new field of cancer medicine. We conducted a retrospective single-center cohort study. Data of AYA cancer patients registered between January 2014 and December 2018 were analyzed. Read More

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Biopsychosocial Factors Associated with Supportive Care Needs in Canadian Adolescent and Young Adult Cancer Survivors.

J Clin Med 2021 Jun 15;10(12). Epub 2021 Jun 15.

Cancer Rehabilitation and Survivorship, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada.

Adolescents and young adults (AYAs) represent an overlooked population in cancer survivorship care. Identifying the needs of AYAs can guide the development of tailored programs for this population. We conducted a cross-sectional descriptive analysis to identify biopsychosocial factors associated with AYA post-treatment supportive care needs and unmet needs using data obtained from the Experiences of Cancer Patients in Transitions Study of the Canadian Partnership Against Cancer, in collaboration with cancer agencies in the 10 Canadian provinces. Read More

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Secondary Breast Cancer Sociodemographic Characteristics and Survival by Age Group.

Ann Surg Oncol 2021 Jun 29. Epub 2021 Jun 29.

Division of Hematology and Oncology, Center for Oncology Hematology Outcomes Research and Training (COHORT), University of California Davis School of Medicine, Sacramento, CA, USA.

Background: Secondary cancers account for 16% of all new cancer diagnoses, with breast cancer (BC) the most common secondary cancer. We have shown that secondary BC has unique characteristics and decreased survival compared with primary BC in adolescent and young adults (AYA; 15-39 years old). However, older BC populations are less well studied. Read More

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Screening for distress and needs: Findings from a multinational validation of the Adolescent and Young Adult Psycho-Oncology Screening Tool with newly diagnosed patients.

Psychooncology 2021 Jun 23. Epub 2021 Jun 23.

Division of Oncology, Leeds Institute of Medical Research, School of Medicine, The University of Leeds, Leeds, UK.

Objective: Adolescents and young adults (AYAs) diagnosed with cancer commonly experience elevated psychological distress and need appropriate detection and management of the psychosocial impact of their illness and treatment. This paper describes the multinational validation of the Distress Thermometer (DT) for AYAs recently diagnosed with cancer and the relationship between distress and patient concerns on the AYA-Needs Assessment (AYA-NA).

Methods: AYA patients (N = 288; 15-29 years, M  = 21. Read More

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Iodine-125 radioactive seed brachytherapy as a treatment for spine and bone metastases: A systematic review and meta-analysis.

Surg Oncol 2021 Jun 10;38:101618. Epub 2021 Jun 10.

Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

Aim: To evaluate the analgesic efficacy, safety, and local tumor control of iodine-125 (I) seed brachytherapy (BT) for the management of spine and bone metastases.

Methods: A systematic literature search was conducted using PubMed, the Cochrane Library, and Scopus databases. Data regarding patient demographics, tumor characteristics, procedural parameters, and clinical outcomes were extracted and analyzed. Read More

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Capturing the financial hardship of cancer in military adolescent and young adult patients: A conceptual framework.

J Psychosoc Oncol 2021 Jun 21:1-18. Epub 2021 Jun 21.

Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.

Objective: Examine whether an existing conceptual framework for understanding financial hardship following a cancer diagnosis captures experiences among military adolescent and young adult (AYA) patients.

Methodological Approach: Investigators conducted focus groups and key informant interviews (n = 24) with active-duty military AYA cancer patients, their spouses, cancer care providers, and commanders at a military medical center and military post.

Findings: Content analysis and thematic abstraction revealed that military AYA cancer patients' experiences of financial hardship occur within material, psychosocial, and behavioral domains that are situated within the contextual influences of AYA development and military culture. Read More

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Incidence of Cancer in Adolescents and Young Adults in Jordan, 2000-2017.

JCO Glob Oncol 2021 Jun;7:934-946

Department of Pathology and Laboratory Medicine, King Hussein Cancer Center, Amman, Jordan.

Purpose: The epidemiology of cancer in adolescents and young adults (AYAs) is distinct and underinvestigated. Therefore, we investigated the incidence of cancer in AYAs in Jordan.

Patients And Methods: We accessed all records submitted to the Jordan Cancer Registry between 2000 and 2017. Read More

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Pediatric oncology clinician communication about sexual health with adolescents and young adults: A report from the children's oncology group.

Cancer Med 2021 Jun 15. Epub 2021 Jun 15.

Cancer and Blood Disease Institute, Children's Hospital Los Angeles, USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA.

Background: Sexual health (SH) is an important concern for adolescents and young adults (AYAs). This study determined current SH communication practices, barriers, and additional resources needed among pediatric oncology clinicians who treat AYAs.

Methods: A cross-sectional survey was developed by the Children's Oncology Group (COG) AYA Committee and sent to pediatric oncologists (n = 1,987; 85. Read More

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Work ability and cognitive impairments in young adult cancer patients: associated factors and changes over time-results from the AYA-Leipzig study.

J Cancer Surviv 2021 Jun 12. Epub 2021 Jun 12.

Department of Medical Psychology and Medical Sociology, University of Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany.

Purpose: Although young adults represent a significant portion of the working population, little is known about the work ability and cognitive impairments in adolescent and young adult (AYA) cancer patients (including the long-term course) following cancer treatment.

Methods: As part of the AYA-Leipzig study, we surveyed AYA cancer survivors (aged 18-39 years at diagnosis; time since diagnosis ≤ 4 years, including all cancer diagnoses) at two time points (t2 = 12 months after t1). Work ability (Work Ability Index, WAI-r) and cognitive impairments (Copenhagen Psychosocial Questionnaire, COPSOQ) were compared at both time points. Read More

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Outcome of childhood acute lymphoblastic leukemia treatment in a single center in Brazil: A survival analysis study.

Cancer Rep (Hoboken) 2021 Jun 11:e1452. Epub 2021 Jun 11.

Clinical Medicine Post-Graduation Program, College of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Background: Acute lymphoblastic leukemia (ALL) is the most common neoplasm in childhood. The probability of current overall survival (OS) is around 90% in developed countries. There are few studies that demonstrate the results in Brazil. Read More

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Access to care and worsening eating disorder symptomatology in youth during the COVID-19 pandemic.

J Eat Disord 2021 Jun 10;9(1):69. Epub 2021 Jun 10.

Division of Adolescent and Young Adult Medicine, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.

Background: Shelter-in-place orders and social distancing guidelines, in response to the COVID-19 pandemic, have limited traditional face-to-face interactions and led to many clinical providers transitioning to the use of videoconferencing platforms. The present study aims to assess how the COVID-19 pandemic has impacted adolescents'/young adults' (AYA) eating disorder (ED)-related care, and how access to, changes in, perceived disruptions to, and quality of care are associated with ED thoughts and behaviors.

Methods: AYA enrolled in the RECOVERY study, a pre-existing web-based longitudinal study, and completed a COVID-19-specific survey (n = 89). Read More

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The global, regional, and national burden of cancer among adolescents and young adults in 204 countries and territories, 1990-2019: a population-based study.

J Hematol Oncol 2021 Jun 9;14(1):89. Epub 2021 Jun 9.

Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Pok Fu Lam, Hong Kong.

Background: Accurate appraisal of burden of adolescents and young adults (AYAs) cancers is crucial to informing resource allocation and policy making. We report on the latest estimates of burden of AYA cancers in 204 countries and territories between 1990 and 2019 in association with socio-demographic index (SDI).

Patients And Methods: Estimates from the Global Burden of Disease study 2019 were used to analyse incidence, mortality, and disability-adjusted life years (DALYs) due to AYA cancers at global, regional, and national levels by sex. Read More

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Multidisciplinary Management of Adolescent and Young Adult Patients with Hodgkin Lymphoma.

Curr Treat Options Oncol 2021 Jun 7;22(7):64. Epub 2021 Jun 7.

Mayo Clinic Division of Hematology and Medical Oncology, Phoenix, AZ, USA.

Opinion Statement: Successful management of adolescent and young adult patients with Hodgkin lymphoma (HL) requires a multidisciplinary approach to care with special attention paid to the unique medical, logistical, and psychosocial challenges faced by this group. The emotional and social changes and big life transitions that occur between the ages of 15 and 39 result in a broad scope of supportive care needs that differ from children or adults in similar circumstances. Currently, care of adolescent and young adult (AYA) patients with HL may be fractured across the pediatric-adult cancer care continuum resulting in this group being less well studied than pediatric or adult patients in general. Read More

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Adolescents' and Young Adults' Ability to Self-Screen for Contraindications to Hormonal Contraception and the Role of Chronic Illness.

J Adolesc Health 2021 Jun 3. Epub 2021 Jun 3.

Indiana University School of Medicine, Department of Pediatrics/Adolescent Medicine, Indianapolis, Indiana.

Purpose: Multiple states allow pharmacists to prescribe hormonal contraception but can have age restrictions. The study objective was to examine how age influences adolescents' and young adults' (AYAs) ability to self-report potential contraindications to hormonal contraception compared with physician reports (our "gold standard").

Methods: Between February 2017 and August 2018, girls aged 14-21 years and their physicians were recruited in outpatient adolescent primary and subspecialty care clinics. Read More

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Prevalence of patients with lysosomal storage disorders and peroxisomal disorders: A nationwide survey in Japan.

Mol Genet Metab 2021 Jul 12;133(3):277-288. Epub 2021 May 12.

Advanced Clinical Research Center, Southern Tohoku Research Center for Neuroscience, Kanagawa, Japan.

Introduction: Lysosomal storage disorders and peroxisomal disorders are rare diseases caused by the accumulation of substrates of the metabolic pathway within lysosomes and peroxisomes, respectively. Owing to the rarity of these diseases, the prevalence of lysosomal storage disorders and peroxisomal disorders in Japan is unknown. Therefore, we conducted a nationwide survey to estimate the number of patients with lysosomal storage disorders and peroxisomal disorders in Japan. Read More

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Comprehensive Assessment of Incidence, Risk Factors, and Mechanisms of Impaired Medical and Psychosocial Health Outcomes among Adolescents and Young Adults with Cancer: Protocol of the Prospective Observational COMPRAYA Cohort Study.

Cancers (Basel) 2021 May 13;13(10). Epub 2021 May 13.

Department of Medical Oncology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

Adolescent and young adult (AYA) cancer patients suffer from delay in diagnosis, and lack of centralized cancer care, age-adjusted expertise, and follow-up care. This group presents with a unique spectrum of cancers, distinct tumor biology, cancer risk factors, developmental challenges, and treatment regimens that differ from children and older adults. It is imperative for advances in the field of AYA oncology to pool data sources across institutions and create large cohorts to address the many pressing questions that remain unanswered in this vulnerable population. Read More

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Photon or Proton Therapy for Adolescent and Young Adult Tumors Focused on Long-Term Survivors.

Cureus 2021 Apr 22;13(4):e14627. Epub 2021 Apr 22.

Department of Radiation Oncology, University of Tsukuba Hospital, Tsukuba, JPN.

Background This study was conducted to evaluate late toxicities in adolescent and young adult (AYA) patients who received photon or proton therapy. Methodology A total of 106 AYA patients who received proton and photon therapy and were followed-up for more than two years were retrospectively evaluated. The median age of patients was 22 years (range, 15-29 years). Read More

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Adolescent and young adult neuro-oncology: a comprehensive review.

Neurooncol Pract 2021 Jun 18;8(3):236-246. Epub 2021 Feb 18.

Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

Adolescent and young adult (AYA; ages 15-39) patients represent a population that experiences significant challenges in cancer care and research, exemplified by poorer clinical outcomes as well as unmet psychosocial and reproductive health needs. Despite central nervous system (CNS) tumors being one of the most common malignancies diagnosed in the age group, there is a clear paucity of AYA CNS tumor-specific publications, especially those related to the unique psychosocial and reproductive health needs of this population of patients. In this review, we examine various aspects of AYA oncological care including tumor biology, clinical outcome, clinical trials enrollment rate, site of care, unique psychosocial needs, and oncofertility. Read More

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