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Postoperative Streptococcus constellatus Bacteremia in a 75-Year-Old Patient with Pyometra: A Case Report.

Am J Case Rep 2021 Jun 24;22:e931167. Epub 2021 Jun 24.

Department of Medicine, Obstetrics and Gynecology Clinic, University of Udine, Udine, Italy.

BACKGROUND Pyometra is an accumulation of pus in the uterine cavity. It is rare in the general population but more common in elderly women. If diagnosed in the early stage, life-threating conditions may be avoided. Read More

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Silent Neurological Lesions Detected by Magnetic Resonance Imaging: Relationship to Hyperparathyroidism among End Stage Renal Disease Young Patients on Hemodialysis.

Int J Clin Pract 2021 Jun 24:e14569. Epub 2021 Jun 24.

Department of Neurology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Background: End-stage renal disease (ESRD) patients on hemodialysis (HD) suffer from several peripheral and central neurological complications. They are at high risk for developing silent neurological lesions (SNL) that may detected accidentally by magnetic resonance imaging (MRI). Many factors are implicated in the development of neurological deficits in ESRD patients on HD. Read More

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Knowledge, attitude and practice on usage and toxicity of local anaesthetic agents (LA) amongst health care professionals in obstetrics and gynaecology.

J Obstet Gynaecol 2021 Jun 24:1-4. Epub 2021 Jun 24.

Department of Obstetrics and Gynaecology, Worcestershire Acute Hospitals NHS Trust, Worcester, UK.

A sound knowledge of LA and their dosage is essential for effective anaesthesia and patient safety as LA toxicity could be potentially life-threatening and clinicians undertaking LA procedures must be competent in early recognition of toxicity and instigating remedial measures timely. This is a prospective national-level survey using self-administered questionnaires among health care professionals in Obstetrics and Gynaecology primarily based in Worcestershire Acute Hospital NHS Trust and further extended to other regions of the United Kingdom. The survey was focussed on evaluating the knowledge, attitude and practice (KAP) of the common local anaesthetic agents, their dosage, early recognition and management of LA systemic toxicity(LAST). Read More

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Screen-detected solid nodules: from detection of nodule to structured reporting.

Transl Lung Cancer Res 2021 May;10(5):2335-2346

Scienze Radiologiche, Department of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy.

Lung cancer screening (LCS) is gaining some interest worldwide after positive results from International trials. Unlike other screening practices, LCS is performed by an extremely sensitive test, namely low-dose computed tomography (LDCT) that can detect the smallest nodules in lung parenchyma. Up-to-date detection approaches, such as computer aided detection systems, have been increasingly employed for lung nodule automatic identification and are largely used in most LCS programs as a complementary tool to visual reading. Read More

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Letter to the Editor from Colle .

J Immunother Cancer 2021 Jun;9(6)

Sorbonne Université and Hospital Saint Antoine, Department of Medical rodiology, AP-HP, Paris, France.

In their article, Fucà highlight that early tumor shrinkage and depth of response predict the prognosis of patients with metastatic colorectal cancer (mCRC) microsatellite instability (MSI-H)/deficient mismatch repair (dMMR) treated by immune checkpoint inhibitors (ICI). We are surprised that no cases of pseudoprogression (PSPD) were reported in their study. PSPDs were described under ICI in patients treated for MSI/dMMR mCRC. Read More

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Spleen-preserving distal pancreatectomy following grade III pancreatic injury in a delayed presentation: a technical challenge.

BMJ Case Rep 2021 Jun 23;14(6). Epub 2021 Jun 23.

Department of Surgical Gastoenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Pancreatic injuries are often overlooked in view of subtle clinical signs, and high index of suspicion is required to manage these injuries. Management strategies vary depending on the grade of injury and associated solid organ injuries and vascular injuries. Early surgery is advised in patients with duct disruption to avoid complications related to duct disruption. Read More

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Evaluation of different DNA extraction methods and loop-mediated isothermal amplification primers for the detection of Mycobacterium ulcerans in clinical specimens.

BMC Infect Dis 2021 Jun 23;21(1):598. Epub 2021 Jun 23.

Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.

Background: Early diagnosis and treatment of Buruli ulcer is critical in order to avoid the debilitating effects of the disease. In this regard, the development of new diagnostic and point of care tools is encouraged. The loop-mediated isothermal amplification for the detection of Mycobacterium ulcerans represents one of the new tools with a good potential of being developed into a point of care test. Read More

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Harefuah 2021 Jun;160(6):377-381

Child Health and Sports Center, Meir Medical Center.

Introduction: McArdle disease (Glycogen storage disease type V) is a myopathy caused by an inherited deficit of muscle glycogen phosphorylase (PYGM). Since glycogen is an important fuel for muscular activity, people with McArdle's disease experience exercise intolerance. Dynamic or static vigorous exercise may lead to rhabdomyolysis, myoglobinuria and renal failure. Read More

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Polygenic Risk Score of Adolescent Idiopathic Scoliosis for Potential Clinical Use.

J Bone Miner Res 2021 Jun 22. Epub 2021 Jun 22.

Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan.

Adolescent idiopathic scoliosis (AIS) is a common disease causing three-dimensional spinal deformity in as many as 3% of adolescents. Development of a method that can accurately predict the onset and progression of AIS is an immediate need for clinical practice. Because the heritability of AIS is estimated as high as 87. Read More

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Early tibial component loosening of medial UKA after severe medial plateau SONK-report of three cases.

J Surg Case Rep 2021 Jun 17;2021(6):rjab242. Epub 2021 Jun 17.

Unort.E Hospital de Ortopedia, Londrina, PR, Brazil.

Spontaneous osteonecrosis or subchondral bone insufficiency fracture of the knee is a frequent injury in elderly female patients. The medial femoral condyle followed by the medial plateau is the most prevalent sites. When its evolution after conservative treatment is not favorable, medial unicompartimental arthroplasty is a surgical option with good results. Read More

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Neurodevelopmental signatures of narcotic and neuropsychiatric risk factors in 3D human-derived forebrain organoids.

Mol Psychiatry 2021 Jun 22. Epub 2021 Jun 22.

Center for Neurogenetics, Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, Cornell University, New York City, NY, USA.

It is widely accepted that narcotic use during pregnancy and specific environmental factors (e.g., maternal immune activation and chronic stress) may increase risk of neuropsychiatric illness in offspring. Read More

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Obtaining a faculty position in STEM at a research-intensive institution.

BMC Proc 2021 Jun 22;15(Suppl 2). Epub 2021 Jun 22.

Department of Medical Microbiology & Immunology, University of California, Davis, CA, USA.

Progressing from postdoctoral training to a STEM faculty appointment at a Research Intensive Institution (RII) is a daunting transition, and may be especially challenging to those who have followed a less-than-conventional path or whose peers have lost interest in academic careers. This article describes how to prepare for and progress through the application process for institutions in the USA, which takes approximately 1 year, including what to expect at each step and recommendations for a successful transition. The odds of success for any individual application are low, making good preparation and careful planning the more important, as does managing expectations to avoid becoming discouraged early in the process. Read More

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Koelreuteria paniculata invasiveness, yielding capacity and harvest date influence on biodiesel feedstock properties.

J Environ Manage 2021 Jun 20;295:113102. Epub 2021 Jun 20.

University of Novi Sad, Faculty of Agriculture, Trg Dositeja Obradovića 8, 21000, Novi Sad, Serbia. Electronic address:

Due to Koelreuteria paniculata Laxm., high abundance in Novi Sad (Serbia) and previously confirmed biodiesel feedstock suitability, this study aimed to assess generative potential and yield, assess K. paniculata invasive risk, and investigate the influence of harvesting periods on the oil content and quality. Read More

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GHRH secretion from a pancreatic neuroendocrine tumor causing gigantism in a patient with MEN1.

Endocrinol Diabetes Metab Case Rep 2021 Jun 1;2021. Epub 2021 Jun 1.

Department of Endocrinology, Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, UK.

Summary: A male patient with a germline mutation in MEN1 presented at the age of 18 with classical features of gigantism. Previously, he had undergone resection of an insulin-secreting pancreatic neuroendocrine tumour (pNET) at the age of 10 years and had subtotal parathyroidectomy due to primary hyperparathyroidism at the age of 15 years. He was found to have significantly elevated serum IGF-1, GH, GHRH and calcitonin levels. Read More

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Whether preoperative hysteroscopy increases the dissemination of endometrial cancer cells: A systematic review and meta-analysis.

J Obstet Gynaecol Res 2021 Jun 21. Epub 2021 Jun 21.

Department of Gynecologic Oncology, The First Hospital of Jilin University, Changchun, China.

Aim: To determine whether hysteroscopy (HSC) increases the risk of intraperitoneal dissemination in endometrial cancer patients.

Methods: We conducted a comprehensive review of multiple databases. Quality assessments of eligible studies were performed using the Newcastle-Ottawa and Jadad scales. Read More

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The psychological impact of threat and lockdowns during the COVID-19 pandemic: exacerbating factors and mitigating actions.

Transl Behav Med 2021 Jun 21. Epub 2021 Jun 21.

Centre for Trust, Peace, and Social Relations, Coventry University, UK.

In spring 2020, the COVID-19 pandemic was declared. The threat the pandemic poses as well as associated lockdown measures created challenging times for many. This study aimed to investigate the individual and social factors associated with low mental health, particularly perceived threat and lockdown measures, and factors associated with psychological well-being, particularly sense of control. Read More

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Percutaneous Endoscopic Gastrostomy in Children: An Update to the ESPGHAN Position Paper.

J Pediatr Gastroenterol Nutr 2021 Jun 22. Epub 2021 Jun 22.

Faculty of Medicine, University Children's Hospital, University of Ljubljana, Ljubljana, Slovenia KidZ Health Castle UZ Brussel, Brussels, Belgium Department of Human Pathology in Adulthood and Childhood "G. Barresi"- University of Messina, Italy Al Jalila Children's Specialty Hospital, Dubai, UAE Digestive Endoscopy and Surgery Unit, Bambino Gesù Children's Hospital IRCCS, Rome. Italy University Lille, CHU Lille, Infinite U1286, Lille, F-59000, France Children's Hospital Zagreb, University of Zagreb School of Medicine, Zagreb Croatia, University J.J. Strossmayer, School of Medicine, Osijek, Croatia Sheffield Children's Hospital NHS Foundation Trust, Sheffield, South Yorkshire, UK Université Libre de Bruxelles, Hôpital Universitaire des Enfants Reine Fabiola, Belgium University Children's Hospital Basel, Division of Pediatric Gastroenterology & Nutrition, University of Basel, Switzerland Maternal and Child Health Department, Sapienza, University of Rome, Italy Centro Hospitalar S. João, Porto, Portugal.

Background: The ESPGHAN position paper from 2015 on percutaneous endoscopic gastrostomy (PEG) required updating in the light of recent clinical knowledge and data published in medical journals since 2014.

Methods: A systematic review of medical literature from 2014 to 2020 was carried out. Consensus on the content of the manuscript, including recommendations, was achieved by the authors through electronic and virtual means. Read More

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The postoperative chest in lung cancer.

Clin Radiol 2021 Jun 18. Epub 2021 Jun 18.

Department of Thoracic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Most of the complications following lung cancer surgery occur in the early postoperative period and can result in significant morbidity and mortality. Delayed complications can also occur. Diagnosing these complications can be challenging because clinical manifestations are non-specific. Read More

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Feeding Tube Placement Following Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma.

Otolaryngol Head Neck Surg 2021 Jun 22:1945998211020302. Epub 2021 Jun 22.

Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.

Objective: To identify factors that may predict the need for feeding tubes in patients undergoing transoral robotic surgery (TORS) in the perioperative setting.

Study Design: Retrospective chart review.

Setting: Academic tertiary center. Read More

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Coronaviruses, cholesterol and statins: Involvement and application for Covid-19.

Biochimie 2021 Jun 18. Epub 2021 Jun 18.

Department of Endocrinology and Prevention of Cardiovascular Diseases, Institute of Cardiometabolism and Nutrition (ICAN), La Pitié-Salpêtrière Hospital, AP-HP, Paris, France. Electronic address:

The infectious power of coronaviruses is dependent on cholesterol present in the membranes of their target cells. Indeed, the virus enters the infected cell either by fusion or by endocytosis, in both cases involving cholesterol-enriched membrane microdomains. These membrane domains can be disorganized in-vitro by various cholesterol-altering agents, including statins that inhibit cell cholesterol biosynthesis. Read More

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Adverse Childhood Events and Substance Misuse in Men Who Perpetrated Intimate Partner Violence.

Int J Offender Ther Comp Criminol 2021 Jun 19:306624X211013519. Epub 2021 Jun 19.

Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.

Adverse childhood events related to violence suffered have developmental consequences such as the reproduction of such violence in intimate relationships and substance misuse in the later life trajectory. The objective of this study was to analyze the relationship between suffering adverse childhood events and excessive consumption of alcohol and drugs in 120 men, with a mean age of 40.51 years ( = 11. Read More

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Risk of Endometrial Cancer and Frequencies of Invasive Endometrial Procedures in Young Breast Cancer Survivors Treated With Tamoxifen: A Nationwide Study.

Front Oncol 2021 3;11:636378. Epub 2021 Jun 3.

Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Background: Although the guidelines recommend gynecological assessment and close monitoring for symptoms of endometrial cancer in postmenopausal breast cancer survivors taking tamoxifen (TAM), the risk of endometrial cancer in young breast cancer survivors has not yet been fully assessed. This study aimed to investigate the risk of developing endometrial cancer and the frequencies of gynecological examinations in young breast cancer survivors taking TAM in South Korea.

Methods: A nationwide retrospective cohort study was conducted using the Health Insurance Review and Assessment Service claims data. Read More

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Deceleration Assistance Mitigated the Trade-off Between Sense of Agency and Driving Performance.

Front Psychol 2021 2;12:643516. Epub 2021 Jun 2.

Department of Precision Engineering, The University of Tokyo, Tokyo, Japan.

Driving assistance technology has gained traction in recent years and is becoming more widely used in vehicles. However, drivers usually experience a reduced sense of agency when driving assistance is active even though automated assistance improves driving performance by reducing human error and ensuring quick reactions. The present study examined whether driving assistance can maintain human sense of agency during early deceleration in the face of collision risk, compared with manual deceleration. Read More

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Characterizing Brain Tumor Regions Using Texture Analysis in Magnetic Resonance Imaging.

Front Neurosci 2021 3;15:634926. Epub 2021 Jun 3.

School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China.

Purpose: To extract texture features from magnetic resonance imaging (MRI) scans of patients with brain tumors and use them to train a classification model for supporting an early diagnosis.

Methods: Two groups of regions (control and tumor) were selected from MRI scans of 40 patients with meningioma or glioma. These regions were analyzed to obtain texture features. Read More

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Calculations on compact disc cracking.

Philos Trans A Math Phys Eng Sci 2021 Aug 21;379(2203):20200292. Epub 2021 Jun 21.

Adelan, Weekin Works, 112 Park Hill Road, Harborne, West Midlands B15 9HD, UK.

The Griffith equation for brittle cracking has three problems. First, it applies to an infinite sheet whereas a laboratory test sample is typically near 100 × 100 mm. Second, it describes a central crack instead of the more dangerous and easily observable edge crack. Read More

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National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: III. The 2020 Treatment of Chronic GVHD Report.

Transplant Cell Ther 2021 Jun 11. Epub 2021 Jun 11.

Clinical Division of Hematology, Medical University of Graz, Graz, Austria. Electronic address:

Positive results from recent clinical trials have significantly expanded current therapeutic options for patients with chronic graft-versus-host disease (GVHD). However, new insights into the associations between clinical characteristics of chronic GVHD, pathophysiologic mechanisms of disease, and the clinical and biological effects of novel therapeutic agents are required to allow for a more individualized approach to treatment. The current report is focused on setting research priorities and direction in the treatment of chronic GVHD. Read More

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Analysis of risk factors for skin disorders caused by anti-epidermal growth factor receptor antibody drugs and examination of methods for their avoidance.

J Clin Pharm Ther 2021 Jun 17. Epub 2021 Jun 17.

Division of Clinical Pharmaceutics and Pharmacy Practice, Department of Clinical Pharmacy, School of Pharmacy, Iwate Medical University, Shiwa-gun, Japan.

What Is Known And Objective: Cancer drug treatment is often discontinued because of skin disorder aggravation. However, information on risk factors for skin disorders caused by anti-epidermal growth factor receptor (EGFR) antibody drugs is limited. The aim of this study was to analyse the factors associated with skin disorders caused by anti-EGFR antibody drugs and establish a method to minimize such aggravations. Read More

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Long-term cognitive and psychosocial outcomes in adults with phenylketonuria.

J Inherit Metab Dis 2021 Jun 18. Epub 2021 Jun 18.

Charles Dent Metabolic Unit, National Hospital for Neurology and Neurosurgery, London.

Previous studies have suggested that cognitive and psychosocial underfunctioning in early-treated adults with PKU may be explained by suboptimal adherence to dietary treatments, however these studies often employ small samples, with different outcome measures, definitions and cut-offs. Samples have also tended to comprise participants with a limited range of blood phenylalanine concentrations, and often individuals who may not have been treated early enough to avoid neurological damage. In this study, we explore the impact of lifetime dietary control, as indicated by blood phenylalanine concentrations in childhood, adolescence and adulthood, on long-term cognitive and psychosocial outcomes in a large sample of adults with PKU who were diagnosed by neonatal screening and commenced on dietary treatment within the first month of life. Read More

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Emergency Department Utilization Following Hepatopancreatic Surgery Among Medicare Beneficiaries.

J Gastrointest Surg 2021 Jun 18. Epub 2021 Jun 18.

Department of Surgery, The Ohio State University Wexner Medical Center and James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.

Background: Care delivered in hospital-based emergency departments (ED) is a target for cost savings. ED utilization following hepatopancreatic surgery remains poorly defined. We sought to define the rate of ED utilization following liver and pancreatic resection, as well as to identify factors associated with ED visits post-discharge. Read More

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ENaC and ROMK channels in the connecting tubule regulate renal K+ secretion.

J Gen Physiol 2021 Aug 18;153(8). Epub 2021 Jun 18.

Department of Physiology and Biophysics, Weill-Cornell Medical College, New York, NY.

We measured the activities of epithelial Na channels (ENaC) and ROMK channels in the distal nephron of the mouse kidney and assessed their role in the process of K+ secretion under different physiological conditions. Under basal dietary conditions (0.5% K), ENaC activity, measured as amiloride-sensitive currents, was high in cells at the distal end of the distal convoluted tubule (DCT) and proximal end of the connecting tubule (CNT), a region we call the early CNT (CNTe). Read More

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