9,688 results match your criteria average retinal


Detection of fixation points using a small visual landmark for brain-computer interfaces.

J Neural Eng 2021 Jun 15. Epub 2021 Jun 15.

Dept. of Biomedical Engineering, Tianjin University, School of Precision Instrument and Opto-Electronics Engineering, Tianjin 300072, Tianjin, 300072, CHINA.

Abstract- Objective: The speed of visual brain-computer interfaces (v-BCIs) has been greatly improved in recent years. However, the traditional v-BCI paradigms require users to directly gaze at the intensive flickering items, which would cause severe problems such as visual fatigue and excessive visual resource consumption in practical applications. Therefore, it is imperative to develop a user-friendly v-BCI. Read More

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Vitrectomy With Silicone Oil Tamponade and Without Internal Limiting Membrane Peeling for the Treatment of Myopic Foveoschisis With High Risk of Macular Hole Development.

Front Med (Lausanne) 2021 28;8:648540. Epub 2021 May 28.

Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Department of Ophthalmology, Peking University People's Hospital, Beijing, China.

To explore the efficiency and safety of the surgical procedure of pars plana vitrectomy (PPV) with silicone oil (SO) tamponade and without internal limiting membrane (ILM) peeling for myopic foveoschisis (MF) eyes with high risk of macular hole formation. Three eyes (three patients) with MF and foveal detachment were enrolled into the study. Comprehensive preoperative ophthalmological assessments, including best corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT) were performed on the eyes. Read More

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Blood Vessel Segmentation of Fundus Retinal Images Based on Improved Frangi and Mathematical Morphology.

Comput Math Methods Med 2021 26;2021:4761517. Epub 2021 May 26.

College of Communication and Information Engineering, Xi'an University of Science and Technology, Xi'an 710054, China.

An improved blood vessel segmentation algorithm on the basis of traditional Frangi filtering and the mathematical morphological method was proposed to solve the low accuracy of automatic blood vessel segmentation of fundus retinal images and high complexity of algorithms. First, a global enhanced image was generated by using the contrast-limited adaptive histogram equalization algorithm of the retinal image. An improved Frangi Hessian model was constructed by introducing the scale equivalence factor and eigenvector direction angle of the Hessian matrix into the traditional Frangi filtering algorithm to enhance blood vessels of the global enhanced image. Read More

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Evaluation of Retinal Nerve Fiber Layer Thickness and Optic Nerve Head Parameters in Obstructive Sleep Apnoea Patients.

Korean J Ophthalmol 2021 Jun 4;35(3):223-230. Epub 2021 Jun 4.

Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia.

Purpose: To study the retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) parameters in obstructive sleep apnoea (OSA) patients and their relationship with severity of the disease.

Methods: A cross-sectional, hospital-based study. Fifty-four OSA subjects and 54 controls were recruited. Read More

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Changes of Neuroretinal Rim and Retinal Nerve Fiber Layer Thickness Assessed by Optical Coherence Tomography After Filtration Surgery in Glaucomatous Eyes.

Clin Ophthalmol 2021 3;15:2335-2344. Epub 2021 Jun 3.

Ludwig-Maximilians University, Eye Clinic, Campus Innenstadt, Munich, D-80336, Germany.

Purpose: Lowering the intraocular pressure (IOP) in patients with primary open-angle glaucoma (POAG) with filtration surgery can induce morphological changes to the bulbus and structures of the retina. In this study, we have evaluated changes of Bruch's membrane-based parameters and retinal nerve fiber layer (RNFL) derived by spectral-domain optical coherence tomography (SD-OCT) in eyes that have undergone glaucoma filtration surgery.

Patients And Methods: SD-OCT imaging of the optic nerve head (ONH) and of the RNFL was performed in 54 eyes of 54 patients with medically uncontrolled POAG before and after IOP-lowering surgery (trabeculectomy or deep sclerectomy). Read More

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ETOILE: Real-World Evidence of 24 Months of Ranibizumab 0.5 mg in Patients with Visual Impairment Due to Diabetic Macular Edema.

Clin Ophthalmol 2021 3;15:2307-2315. Epub 2021 Jun 3.

Novartis Pharma SAS, Rueil-Malmaison, France.

Purpose: To evaluate the real-world effectiveness of intravitreal ranibizumab 0.5 mg (Lucentis) in improving visual acuity (VA) in adults with decreased VA due to diabetic macular edema (DME).

Patients And Methods: Real-world prospective observational 24-month study. Read More

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Validating Ellipsoid Zone Area Measurement With Multimodal Imaging in Choroideremia.

Transl Vis Sci Technol 2021 May;10(6):17

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alberta, Canada.

Purpose: To assess en face ellipsoid zone (EZ) maps of remaining retinal structure as outcome measures for the future clinical research in patients with choroideremia.

Methods: Twenty eyes from 12 patients with a confirmed genetic diagnosis of choroideremia were included retrospectively from a single site. From spectral domain-optical coherence tomography volume scans, slabs including the EZ were manually segmented to create the en face EZ maps. Read More

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Model Structure Uncertainty in the Characterization and Growth of Geographic Atrophy.

Transl Vis Sci Technol 2021 May;10(6)

Department of Surgery, Ophthalmology, University of Melbourne, Parkville, Victoria, Australia.

Purpose: To identify the most suitable model for assessing the rate of growth of total geographic atrophy (GA) by analysis of model structure uncertainty.

Methods: Model structure uncertainty refers to unexplained variability arising from the choice of mathematical model and represents an example of epistemic uncertainty. In this study, we quantified this uncertainty to help identify a model most representative of GA progression. Read More

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Loss of Rbfox1 Does Not Affect Survival of Retinal Ganglion Cells Injured by Optic Nerve Crush.

Front Neurosci 2021 24;15:687690. Epub 2021 May 24.

Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA, United States.

Rbfox1 is a multifunctional RNA binding protein that regulates alternative splicing, transcription, mRNA stability and translation. Its roles in neurogenesis and neuronal functions are well established. Recent studies also implicate Rbfox1 in the regulation of gene networks that support cell survival during stress. Read More

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Macular sensitivity assessment and fixation analysis using microperimetry in children with retinopathy of prematurity.

Br J Ophthalmol 2021 Jun 9. Epub 2021 Jun 9.

Ophthalmology Department, Ankara University Faculty of Medicine, Ankara, Turkey.

Background/aims: To investigate retinal sensitivity and fixation stability using microperimetry in children with retinopathy of prematurity (ROP).

Methods: Observational case series. Totally 51 preterm children who had been followed for ROP were examined in three groups (n=17 in each group). Read More

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The Retinal Ganglion Cell Response to Blast-Mediated Traumatic Brain Injury Is Genetic Background Dependent.

Invest Ophthalmol Vis Sci 2021 Jun;62(7):13

Department of Ophthalmology and Visual Sciences, Carver College of Medicine, The University of Iowa, Iowa City, IA, United States.

Purpose: The purpose of this study was to examine the influence of genetic background on the retinal ganglion cell (RGC) response to blast-mediated traumatic brain injury (TBI) in Jackson Diversity Outbred (J:DO), C57BL/6J and BALB/cByJ mice.

Methods: Mice were subject to one blast injury of 137 kPa. RGC structure was analyzed by optical coherence tomography (OCT), function by the pattern electroretinogram (PERG), and histologically using BRN3A antibody staining. Read More

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Gender of Award Recipients in Major Ophthalmology Societies.

Am J Ophthalmol 2021 Jun 5. Epub 2021 Jun 5.

Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

Purpose: To assess the gender distribution of major ophthalmology society awards.

Design: Retrospective, observational study.

Methods: The study population included award recipients from nine ophthalmological societies: American Academy of Ophthalmology (AAO), American Association for Pediatric Ophthalmology and Strabismus (AAPOS), American Glaucoma Society (AGS), American Society of Cataract and Refractive Surgery (ASCRS), American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS), American Society of Retina Specialists (ASRS), American Uveitis Society (AUS), Cornea Society, and North American Neuro-Ophthalmology Society (NANOS). Read More

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[Minimally invasive vitrectomy for the treatment of severe proliferative diabetic retinopathy].

Zhonghua Yan Ke Za Zhi 2021 Jun;57(6):440-446

Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Tianjin 300384, China.

To report the efficacy and safety of minimally invasive vitrectomy for the treatment of severe proliferative diabetic retinopathy (PDR) and the effect of preoperative retinal photocoagulation on prognosis. Case-series study and cohort study. This study included 48 severe PDR patients (53 eyes). Read More

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The role of retinal fluid location in atrophy and fibrosis evolution of patients with neovascular age-related macular degeneration long-term treated in real world.

Acta Ophthalmol 2021 Jun 4. Epub 2021 Jun 4.

Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clínica Universidad de Navarra, Pamplona, Spain.

Purpose: To assess the effect of clinical factors on the development and progression of atrophy and fibrosis in patients with neovascular age-related macular degeneration (nAMD) receiving long-term treatment in the real world.

Methods: An ambispective 36-month multicentre study, involving 359 nAMD patients from 17 Spanish hospitals treated according to the Spanish Vitreoretinal Society guidelines, was designed. The influence of demographic and clinical factors, including the presence and location of retinal fluid, on best-corrected visual acuity (BCVA) and progression to atrophy and/or fibrosis were analysed. Read More

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Outer retina reconstruction following inverted internal limiting membrane flap technique for large macular holes.

Saudi J Ophthalmol 2020 Jul-Sep;34(3):160-166. Epub 2021 Feb 27.

Department of Ophthalmology, Eye Foundation Retina Institute, Ikeja, Lagos, Nigeria.

Purpose: The aim of this study is to investigate the outer retina reconstruction using postoperative spectral domain optical coherence tomography (SD OCT) in large diameter macular holes (MHs) treated with the inverted internal limiting membrane (ILM) flap technique.

Methods: A retrospective study of 14 consecutive eyes that had vitrectomy and inverted ILM flap technique for MHs with a base diameter of 400 μ or greater. Preoperative and postoperative SD OCT images were assessed for MH closure and for outer retina presence; represented by the external limiting membrane (ELM) and ellipsoid zone (EZ), in the subfoveal and parafoveal areas. Read More

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February 2021

Optical coherence tomography angiography microvascular changes in diabetics without diabetic retinopathy.

Saudi J Ophthalmol 2020 Jul-Sep;34(3):156-159. Epub 2021 Feb 27.

Department of Ophthalmology, FSI Hospital, Tunis, Tunisie.

Purpose: The purpose of this study was to analyze the retinal vasculature of diabetic eyes without clinical retinopathy in order to detect microvascular abnormalities, comparing them to that of healthy nondiabetic control eyes.

Methods: This is a prospective, cross-sectional study including 40 patients (76 eyes). Twenty patients (40 eyes) were diabetics with no diabetic retinopathy group (NDRG). Read More

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February 2021

Hydroxychloroquine dosing and toxicity: A real-world experience in Saudi Arabia of 63 patients.

Saudi J Ophthalmol 2020 Jul-Sep;34(3):151-155. Epub 2021 Feb 27.

The Eye Center and The Eye Foundation for Research in Ophthalmology, King Saud University, Riyadh, Saudi Arabia.

Purpose: To assess the ocular toxicity in patients on high doses of hydroxychloroquine (HCQ) per weight, as per the latest American Academy of Ophthalmology (AAO) screening guidelines for HCQ toxicity.

Methods: This is a multi-center study looking at consecutive patients attending the ophthalmology clinics at a tertiary hospital and a private clinic in Saudi Arabia. A data collection sheet was used to collect patient's information regarding the dose per body weight, duration of HCQ use and any risk factors associated with the use of the medication as per the latest AAO guidelines for HCQ screening. Read More

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February 2021

Evaluating Reading Performance in Different Preferred Retinal Loci in Persian-Speaking Patients with Age-Related Macular Degeneration.

J Curr Ophthalmol 2021 Jan-Mar;33(1):48-55. Epub 2021 Mar 26.

Department of Basic Sciences, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To evaluate reading performance in different preferred retinal loci (PRLs) using a Persian version of a Minnesota Low Vision Reading (MNREAD) chart in Persian-speaking patients with age-related macular degeneration (AMD).

Methods: In this cross-sectional study, 35 patients with AMD were assessed. The reading performance was investigated by the MNREAD chart without using low vision aids. Read More

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Central Macular Thickness in Diabetic Macular Edema.

Acta Endocrinol (Buchar) 2020 Oct-Dec;16(4):417-425

Medipol University, Medicine School, Department of Ophthalmology, Istanbul, Turkey.

Context: Retinal microvascular dysfunction differs in macular edema lesions in the two eyes of the same patient with diabetic retinopathy.

Objective: To evaluate the relationship between central macular thickness (CMT) and metabolic/systemic factors including anthropometric and laboratory findings, in patients with regressed diabetic retinopathy and a history of pars plana vitrectomy (PPV) combined with internal limiting membrane peeling in one eye.

Subjects And Methods: Forty-two eyes with PPV and the same patients' fellow 42 eyes (without PPV) included this study. Read More

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Corneal hysteresis as a risk factor for optic nerve head surface depression and retinal nerve fiber layer thinning in glaucoma patients.

Sci Rep 2021 Jun 3;11(1):11677. Epub 2021 Jun 3.

Department of Ophthalmology, Huizhou Municipal Central Hospital, No.41, Eling North Road, Huizhou, 516001, China.

To evaluate the role of corneal hysteresis (CH) as a risk factor for progressive ONH surface depression and RNFL thinning measured by confocal scanning laser ophthalmoscopy (CSLO) and spectral-domain optical coherence tomography (SD-OCT), respectively in glaucoma patients. Prospective study. A total of 146 eyes of 90 patients with glaucoma were recruited consecutively. Read More

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Identification of multiple noise sources improves estimation of neural responses across stimulus conditions.

eNeuro 2021 Jun 1. Epub 2021 Jun 1.

Department of Physiology & Biophysics, University of Washington, Seattle, WA 98195

Most models of neural responses are constructed to reproduce the average response to inputs but lack the flexibility to capture observed variability in responses. The origins and structure of this variability have significant implications for how information is encoded and processed in the nervous system, both by limiting information that can be conveyed and by determining processing strategies that are favorable for minimizing its negative effects. Here, we present a new modeling framework that incorporates multiple sources of noise to better capture observed features of neural response variability across stimulus conditions. Read More

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Questionnaire for the assessment of adherence barriers of intravitreal therapy: the ABQ-IVT.

Int J Retina Vitreous 2021 Jun 2;7(1):43. Epub 2021 Jun 2.

Universitäts-Augenklinik Tübingen, Elfriede-Aulhorn-Straße 7, 72076, Tübingen, Germany.

Objective: To develop and validate a questionnaire for the investigation of non-adherence (NA) barriers in patients receiving intravitreal injection (IVT).

Design: Questionnaire development and cross-sectional patient survey combined with a retrospective medical chart review.

Participants: German patients with neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME) receiving anti-vascular endothelial growth factor (anti-VEGF) treatment via IVT. Read More

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Distribution and internal correlations of corneal astigmatism in cataract patients.

Sci Rep 2021 Jun 1;11(1):11514. Epub 2021 Jun 1.

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin Medical University, Tianjin, 300384, China.

The aim of the study is to explore the distribution patterns and internal correlations of the morphological parameters of the cornea in patients with age-related cataract. The Pentacam HR was used to measure anterior corneal astigmatism (ACA), posterior corneal astigmatism (PCA), total corneal astigmatism (TCA) and keratometric corneal astigmatism (KCA). With age, the proportion of with-the-rule (WTR) ACA decreased from 65. Read More

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Corneal Toxicity of Intravitreal Methotrexate Used for the Treatment of Proliferative Vitreoretinopathy in Silicone Oil-Filled Eyes: A Case Series.

Cornea 2021 Jun 1. Epub 2021 Jun 1.

University of California, San Francisco, Department of Ophthalmology, San Francisco, CA; and Zuckerberg San Francisco General Hospital and Trauma Center, Department of Ophthalmology, San Francisco, CA.

Purpose: The purpose of this study was to evaluate the corneal toxicity of intravitreal methotrexate used for the prevention of proliferative vitreoretinopathy (PVR).

Methods: In this retrospective case series, eyes with recurrent retinal detachment secondary to PVR were treated with intravitreal injections of 400 μg methotrexate at an average frequency of every 7 days after vitrectomy with silicone oil tamponade. Corneas were examined for corneal epitheliopathy by slit-lamp biomicroscopy before each injection. Read More

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Brolucizumab for Choroidal Neovascular Membrane with Pigment Epithelial Tear and Subretinal Fluid.

J Clin Med 2021 May 30;10(11). Epub 2021 May 30.

Service d'Ophtalmologie, Centre Hospitalier Universitaire de la Croix-Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, 69004 Lyon, France.

The aim of this study was to determine the utility of brolucizumab in the management of choroidal neovessels (CNV) with a retinal pigment epithelial (RPE) tear and subretinal fluid. We used a case series of patients with CNV who developed an RPE tear either spontaneously or following an intravitreal injection. All patients received intravitreal brolucizumab as primary or switch therapy. Read More

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Glaucoma Progression after Delivery in Patients with Open-Angle Glaucoma Who Discontinued Glaucoma Medication during Pregnancy.

J Clin Med 2021 May 19;10(10). Epub 2021 May 19.

Department of Ophthalmology, Institute of Vision Research, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.

In this retrospective study, clinical characteristics and glaucoma progression of open-angle glaucoma (OAG) patients who discontinued intraocular pressure (IOP)-lowering medication during pregnancy were investigated. Glaucoma progression was determined using either serial visual field tests or optic disc/retinal nerve fiber layer (RNFL) photographs. Age, number of previous pregnancies, diagnosis, average IOP, IOP fluctuation, visual field mean deviation, pattern standard deviation, and RNFL thickness were examined, and their association with glaucoma progression was determined using linear regression analysis. Read More

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Permeability of the Retina and RPE-Choroid-Sclera to Three Ophthalmic Drugs and the Associated Factors.

Pharmaceutics 2021 May 4;13(5). Epub 2021 May 4.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Korea.

In this study, Retina-RPE-Choroid-Sclera (RCS) and RPE-Choroid-Sclera (CS) were prepared by scraping them off neural retina, and using the Ussing chamber we measured the average time-concentration values in the acceptor chamber across five isolated rabbit tissues for each drug molecule. We determined the outward direction permeability of the RCS and CS and calculated the neural retina permeability. The permeability coefficients of RCS and CS were as follows: ganciclovir, 13. Read More

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Repeatability of Spectral Domain Optical Coherence Tomography Measurements of Bruch's Membrane Opening-Minimum Rim Width in Epiretinal Membrane Patients with Peripapillary Involvement.

J Clin Med 2021 May 21;10(11). Epub 2021 May 21.

Department of Ophthalmology, Gyeongsang National University Changwon Hospital, Changwon 51472, Korea.

The Bruch's membrane opening-minimum rim width (BMO-MRW) is a recently introduced parameter of the neuroretinal rim. We analyzed the repeatability of spectral-domain optical coherence tomography (SD-OCT) measurements of BMO-MRW in epiretinal membrane (ERM) patients with peripapillary involvement, since the surface around the optic disc is distorted in such patients. BMO-MRW and retinal nerve fiber layer (RNFL) thickness measurements were performed using SD-OCT in prospectively enrolled ERM patients and age-matched healthy control individuals. Read More

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Changes in each retinal layer and ellipsoid zone recovery after full-thickness macular hole surgery.

Sci Rep 2021 May 31;11(1):11351. Epub 2021 May 31.

Department of Ophthalmology, Konyang University College of Medicine, Konyang University Hospital, #158 Gwanjeodong-ro, Seo-gu, Daejeon, 35365, Republic of Korea.

To analyze the changes in each retinal layer and the recovery of the ellipsoid zone (EZ) after full-thickness macular hole (FTMH) surgery. Patients who underwent surgery for FTMH were included. Spectral-domain optical coherence tomography (SD-OCT) was performed preoperatively and postoperatively at 1, 3, 6, 9, and 12 months. Read More

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Translaminar Pressure Difference and Ocular Perfusion Pressure in Glaucomatous Eyes with Different Optic Disc Sizes.

J Ophthalmic Vis Res 2021 Apr-Jun;16(2):171-177. Epub 2021 Apr 29.

Department of Ophthalmology, Irmandade da Santa Casa de Misericordia de Sao Paulo, Sao Paulo, Brazil.

Purpose: Intracranial pressure (ICP) and ocular perfusion pressure (OPP) are both involved with the pathogenesis of glaucoma. The orbital ICP determines a retrolaminar counter pressure that is antagonistic to the intraocular pressure (IOP). The purpose of this study is to evaluate whether the translaminar pressure difference (TLPD) and the OPP varies in glaucoma patients with different optic disc sizes. Read More

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