26,105 results match your criteria average plasma

Profile of the single-use, multiple-pass protein A adsorber column in immunoadsorption.

Vox Sang 2021 Sep 20. Epub 2021 Sep 20.

Institute of Transfusion Medicine and Haemotherapy, University of Wuerzburg, Wuerzburg, Germany.

Background And Objectives: Immunoadsorptions (IA) are used to remove autoantibodies from the plasma in autoimmune disorders. In this study, we evaluated the effects of a single-use, recombinant staphylococcal protein A-based immunoadsorber on blood composition of the patient.

Materials And Methods: In a cohort of patients with myasthenia gravis or stiff-person syndrome, essential parameters of blood cell count, coagulation, clinical chemistry or plasma proteins and immunoglobulins (Ig) were measured before and after IA (n = 11). Read More

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September 2021

Growth performance, nutrient digestibility, blood parameters, and carcass characteristics by lambs fed an oregano and cobalt blend.

Animal 2021 Sep 17;15(10):100365. Epub 2021 Sep 17.

Key Laboratory for Sheep, Goat and Cattle Germplasm and Straw Feed in Gansu Province, Gansu Academy of Agricultural Science, Lanzhou, Gansu 730070, China; Institute of Agricultural and Economic Informant Ion, Gansu Academy of Agricultural Sciences, Lanzhou, Gansu 730070, China.

Shifting ruminal fermentation via feeding a blend of oregano (Organum vulgare L.) essential oils and Co-lactate (EOC; Rum-A-Fresh, Ralco, Inc. Marshall, MN) could improve lamb growth and carcass performance. Read More

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September 2021

Blood products with autologous transfusion versus allogeneic transfusion in cardiac surgery patients.

Rev Med Inst Mex Seguro Soc 2020 ;58(4):417-427

Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Hospital General "Dr. Gaudencio González Garza", Servicio de Cirugía Cardiotorácica y Asistencia Circulatoria. Ciudad de México, México.

IntroducciÓn: Ante la alta frecuencia de transfusiones alogénicas en cirugía cardiaca, que exponen a los pacientes a los riesgos asociados a la transfusión, surge la transfusión autóloga como una alternativa.

Objetivo: Comparar el uso de hemocomponentes con transfusión autóloga frente a transfusión alogénica en pacientes sometidos a cirugía cardiaca con derivación cardiopulmonar.

Material Y MÉtodos: Estudio de cohorte prospectiva analítica de 26 pacientes sometidos a cirugía cardiaca con derivación cardiopulmonar, que se dividieron en dos grupos: grupo de estudio (n = 13), en el que se realizó transfusión autóloga, y grupo de control (n = 13), en el que solo se realizó transfusión alogénica. Read More

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January 2020

Highly Enhanced Thermoelectric and Mechanical Properties of Bi-Sb-Te Compounds by Carrier Modulation and Microstructure Adjustment.

ACS Appl Mater Interfaces 2021 Sep 20. Epub 2021 Sep 20.

Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China.

BiSbTe + wt % CuS ( = 0, 0.03, 0.05, and 0. Read More

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September 2021

Association Between COVID-19 Outcomes and Patient Characteristics: A Study in an Inner-City Community Hospital.

Cureus 2021 Aug 17;13(8):e17255. Epub 2021 Aug 17.

Internal Medicine, Saint Francis Medical Center, Seton Hall University Hackensack Meridian School of Medicine, Trenton, USA.

Background It has been shown that certain hematological conditions, such as lymphopenia and thrombocytopenia, are associated with increased severity and mortality from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, a majority of the previous data came from large institutional centers with high academic output. We aimed to explore the association between patient's characteristics, hematological parameters, and outcomes in admitted persons with coronavirus disease 2019 (COVID-19) at our community hospital in an inner city. Read More

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The differences in energy metabolism and redox status between sows with short and long farrowing duration.

Animal 2021 Sep 16;15(10):100355. Epub 2021 Sep 16.

Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, No. 211, Huimin Road, Wenjiang District, Chengdu 611130, Sichuan, People's Republic of China. Electronic address:

Farrowing duration is a crucial factor affecting survival of piglets and health of sows, and is highly correlated with the incidence of stillbirth. The present study assessed the metabolic characteristics of sows with short farrowing duration (SFD) or long farrowing duration (LFD). A total of 20 Yorkshire sows were screened from 60 sows and were retrospectively allocated into SFD (211 min on average, n = 10) or LFD (388 min on average, n = 10) group. Read More

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September 2021

Heavy Metals in the Blood Serum and Feces of Mugger Crocodile (Crocodylus palustris) in Sistan and Baluchistan Province, Iran.

Biol Trace Elem Res 2021 Sep 18. Epub 2021 Sep 18.

School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

This study was conducted to measure concentrations of cadmium (Cd), lead (Pb), arsenic (As), mercury (Hg), copper (Cu), chromium (Cr), and iron (Fe) in blood serum and feces of mugger crocodile (Crocodylus palustris) and in water and sediment of their habitat (Negour site, Chabahar County in Sistan and Baluchistan Province, Iran). Heavy metal contents in crocodile serum and feces, water, and sediments were analyzed by inductively coupled plasma optical emission spectrometry (ICP-OES spectrometer-Spectro Genesis). The highest levels of heavy metals in the mugger crocodile's serum were Fe > Hg > Pb > Cr > Cu > Cd > As, respectively. Read More

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September 2021

Chip-based microfluidics on-line with inductively coupled plasma - mass spectrometry for standard dilution analysis.

Anal Chim Acta 2021 Sep 6;1179:338830. Epub 2021 Jul 6.

Environmental Chemical Processes Laboratory, Department of Chemistry, University of Crete, Voutes Campus, Heraklion, 70013, Greece. Electronic address:

Microfluidics coupled on-line with ICP-MS detection can be combined with powerful quantitation procedures that take advantage of internal standardization and standard additions, such as the recently introduced Standard Dilution Analysis (SDA). Although so far used at mL min flow rates, here we demonstrate that SDA can be conveniently employed with a microfluidic chip-based ICP-MS system to improve determination accuracy for various sample types, including water, biological and cell digest samples, analyzed at μL min flow rates. The efficient coupling of a microfluidic chip to ICP-MS was accomplished using a combination of commercially available components, including a pneumatic high-efficiency nebulizer and a spray chamber designed to allow for the addition of a laminar flow makeup gas. Read More

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September 2021

Factors Associated With Gestational Diabetes Mellitus: A Cross-Sectional Study.

Cureus 2021 Aug 11;13(8):e17113. Epub 2021 Aug 11.

Obstetrics and Gynaecology, Isra University, Hyderabad, PAK.

Introduction The absence of tolerance in the levels of carbohydrates at the onset or at the time of pregnancy amongst females is known as gestational diabetes mellitus (GDM). This study is designed to determine the frequency of GDM and factors responsible for GDM to assess the actual magnitude of the outcome. Furthermore, it allows for developing strategies to minimize morbidities and improve the pregnancy outcome by early diagnosis and timely management, which can help reduce the frequency of GDM. Read More

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Letrozole, an aromatase inhibitor, improves seminal parameters and hormonal profile in aged endangered Markhoz bucks.

Anim Biosci 2021 Aug 25. Epub 2021 Aug 25.

Department of Animal Science, Faculty of Agriculture, University of Kurdistan, Sanandaj 661715175, Iran.

Objective: Letrozole, a potent aromatase inhibitor, is known to have the potential to modify male reproductive function by altering sex hormone levels. This study aimed to evaluate the semen and testicular characteristics and hormonal profile of aged Mrakhoz bucks (Capra hircus) treated with letrozole.

Methods: Twelve Markhoz male goats, aged between 4. Read More

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Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Protracted Alcohol Withdrawal Symptoms in Male Alcohol-Dependent Patients.

Front Psychiatry 2021 30;12:678594. Epub 2021 Aug 30.

Department of Nursing, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.

Protracted alcohol withdrawal symptoms (PAWS), characterized by the presence of substance-specific signs and symptoms (including anxiety, irritability, mood instability, insomnia, and cravings), make alcohol abstinence difficult and increase the risk of relapse in recovering alcoholics. The goal of this study was to evaluate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) on PAWS and plasma brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and leptin levels in patients with alcohol dependency. A total of 114 patients with alcohol dependence were randomly divided into two groups: the treatment group and the control group. Read More

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Clinicopathological characteristics and prognosis of hepatitis B associated membranous nephropathy and idiopathic membranous nephropathy complicated with hepatitis B virus infection.

Sci Rep 2021 Sep 15;11(1):18407. Epub 2021 Sep 15.

Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China.

The main objective of this study is to analyze the clinical and pathological features and prognosis of patients with Hepatitis B associated membranous nephropathy (HBV-MN) and idiopathic membranous nephropathy (IMN) complicated with hepatitis B virus (HBV) infection. This study will provide more basis for diagnosis and prognosis evaluation. A total of 50 patients with HBV-MN were included in this study. Read More

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September 2021

A Broad Range High-Throughput Assay for Lenvatinib Using Ultra-High Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry With Clinical Application in Patients With Hepatocellular Carcinoma.

Ther Drug Monit 2021 Oct;43(5):664-671

Department of Clinical Pharmacy, Oita University Hospital; and.

Background: Lenvatinib is increasingly being selected as the first-line treatment for unresectable hepatocellular carcinoma (HCC) based on the results of the REFLECT trial. However, early discontinuation of lenvatinib because of adverse effects is a frequent occurrence. Hence, lenvatinib is a difficult drug for use in the clinical setting. Read More

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October 2021

The Effect of Clozapine on Self-reported Duration of Sleep and Its Interaction With 23 Other Medications: A 5-Year Naturalistic Study.

J Clin Psychopharmacol 2021 Sep-Oct 01;41(5):534-539

From the Cambridgeshire and Peterborough NHS Foundation Trust.

Background: Sedation is a common and incapacitating clozapine adverse effect, but the factors associated with sedation and its pharmacological management remain poorly studied.

Methods: We conducted a retrospective cohort study based on deidentified electronic clinical records of clozapine-treated patients from the secondary mental health care provider for Cambridgeshire and Peterborough, United Kingdom. We first evaluated cross-sectionally the influence of clozapine dose, clozapine, and norclozapine plasma levels on self-reported hours slept, as a proxy for sedation, using bivariate correlation and then the longitudinal effect of changes in clozapine dose and other 23 medications using linear mixed effect models. Read More

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September 2021

Toxic masculinity in red blood cell units? Testosterone therapy in blood donors revisited.

Transfusion 2021 Sep 14. Epub 2021 Sep 14.

Vitalant Research Institute, Denver, Colorado, USA.

Background: FDA guidelines limit the use of blood from donors taking testosterone replacement therapy (TRT) to red blood cell (RBC) concentrates, whereas plasma and platelets are discarded. The purpose of this study is to bring awareness to above-average free testosterone concentrations in RBC units from TRT donors.

Study Design: We quantified the concentrations of free (bioavailable; pg/ml) and total (protein bound and free; ng/dl) testosterone in plasma (frozen within 24 h) and supernatants from 42-day stored leukocyte-reduced RBC units from 17 TRT male donors and 17 matched controls (no TRT). Read More

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September 2021

C-X-C Motif Chemokine Ligand 16 Is a Potent Predictor of Outcomes in Dialysis Patients.

Am J Nephrol 2021 Sep 10:1-10. Epub 2021 Sep 10.

Center for Kidney Disease, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Introduction: C-X-C motif chemokine ligand 16 (CXCL16) is an inflammatory marker that has been found to be predictive of outcomes in patients with cardiovascular disease. Our previous work has also demonstrated its relation to cardiac injury in dialysis patients. However, it is yet unclear whether there is an association between CXCL16 and adverse outcomes in dialysis patients. Read More

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September 2021

Comparison of the effectiveness of screening methods for the diagnosis of gestational diabetes mellitus in pregnant women: A cross-sectional study.

Int J Clin Pract 2021 Sep 13:e14857. Epub 2021 Sep 13.

Department of Medical Biochemistry, Okmeydanı Training and Research Hospital, Istanbul, Turkey.

Objective: The methods and criteria used for gestational diabetes mellitus (GDM) screening in pregnant women are updated by the relevant organisations in certain periods. We aimed to compare the efficiency of GDM screening tests in pregnant women and to investigate the reasons of different prevalence values reported in the literature.

Materials And Methods: In this retrospective cross-sectional study, a total of 2406 pregnant women who were admitted to the obstetric outpatient clinic for screening GDM, were included. Read More

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September 2021

Clinical and Molecular Characterizations of Papillary Thyroid Cancer in Children and Young Adults: a Multicenter Retrospective Study.

Thyroid 2021 Sep 13. Epub 2021 Sep 13.

Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, 71140, Department of Head and Neck Surgery, Shanghai, China;

Background Papillary thyroid carcinoma (PTC) is a rare malignancy in children and young adults (CAYA). It often presents with aggressive disease patterns and advanced stages, which are clinically distinct from those in adult patients. Here, we sought to characterize and better understand the clinical variants of PTC in CAYA and explore the underlying mechanisms. Read More

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September 2021

Treatment with bone maturation and average lifespan of HPP model mice by AAV8-mediated neonatal gene therapy via single muscle injection.

Mol Ther Methods Clin Dev 2021 Sep 12;22:330-337. Epub 2021 Jun 12.

Department of Biochemistry and Molecular Biology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan.

Hypophosphatasia (HPP) is an inherited skeletal disease characterized by defective bone and tooth mineralization due to a deficiency in tissue-nonspecific alkaline phosphatase (TNALP). Patients with the severe infantile form of HPP may appear normal at birth, but their prognosis is very poor. To develop a practical gene therapy for HPP, we endeavored to phenotypically correct TNALP knockout ( ) mice through adeno-associated virus type 8 (AAV8) vector-mediated, muscle-directed, TNALP expression. Read More

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September 2021

Diclofenac toxicity in susceptible bird species results from a combination of reduced glomerular filtration and plasma flow with subsequent renal tubular necrosis.

PeerJ 2021 23;9:e12002. Epub 2021 Aug 23.

Department of Paraclinical Science, University of Pretoria, Onderstepoort, Pretoria, South Africa.

Diclofenac caused the death of millions of vultures on the Asian subcontinent. Other non-steroidal anti-inflammatory drugs (NSAIDs) have since also been shown to be toxic to vultures with the exception of meloxicam. For this study, we evaluated the effect of diclofenac on renal uric acid transport and glomerulus filtration in an acute toxicity model. Read More

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Georgian Med News 2021 Jul-Aug(316-317):16-21

1National Institute of Surgery and Transplantology of the NAMS of Ukraine name after А.А. Shalimov, Kyiv; Ukraine.

The goal of this study was to analyze the effectiveness of pancreatogastrostomy at the stage of reconstruction by assessing its technical aspects and analysis of the frequency of postoperative complications. The article represents results of the study held with a total of 35 pancreatoduodenectomies performed, followed by reconstruction pancreatogastrostomy. The average patients age was 53. Read More

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September 2021

Migration in times of pandemic: SARS-CoV-2 infection among the Warao indigenous refugees in Belém, Pará, Amazonia, Brazil.

BMC Public Health 2021 09 13;21(1):1659. Epub 2021 Sep 13.

Secretaria de Saúde do Município de Belém (SESMA), Belem, Brazil.

Background: The emergence of the new causative agent of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the city of Wuhan, China, in December 2019, and its spread worldwide, led the World Health Organization (WHO) to declare a pandemic. The disease has caused high mortality among traditional populations and the most socially vulnerable groups such indigenous and refugees. The present study aims to investigate the prevalence of anti-SARS-CoV-2 IgG antibodies in the population of Venezuelan indigenous Warao refugees residing in private and public shelters in the city of Belem, capital of Para State, in the Brazilian Amazon. Read More

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September 2021

Sensitive quantification of free pazopanib using ultra-high performance liquid chromatography coupled to tandem mass spectrometry and assessment of clinical application.

J Pharm Biomed Anal 2021 Sep 4;206:114348. Epub 2021 Sep 4.

Department of Clinical Pharmacy, Oita University Hospital, Yufu-shi, Oita, Japan.

Pazopanib is widely used to treat renal cell carcinomas and soft tissue tumors in Japan. Although several reports demonstrated the usefulness of therapeutic drug monitoring (TDM) of pazopanib, those studies measured only total pazopanib concentration. For drugs with high protein binding rates such as pazopanib, measuring free concentrations may be clinically more useful than measuring total concentrations. Read More

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September 2021

Surface modification and improvements of wicking properties and dyeability of grey jute-cotton blended fabrics using low-pressure glow discharge air plasma.

Heliyon 2021 Aug 28;7(8):e07893. Epub 2021 Aug 28.

Department of Chemical Engineering, Universitas Riau, Pekanbaru, 28293, Indonesia.

Herein, we reported the improvements of wicking properties and dyeability of the jute-cotton blended (40:60) fabrics due to the effect of low-pressure glow discharge (LPGD) air plasma under selected exposure times. The microscopic features, functional groups, wettability, contact angles, wetting area, wicking rates, and reflectance values of the jute-cotton blended fabrics were analyzed using numerous experimental techniques. The scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) techniques were used to investigate the morphological and compositional modifications of plasma-treated jute blended cotton fabrics. Read More

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Effects of Exergames and Protein Supplementation on Body Composition and Musculoskeletal Function of Prefrail Community-Dwelling Older Women: A Randomized, Controlled Clinical Trial.

Int J Environ Res Public Health 2021 Sep 3;18(17). Epub 2021 Sep 3.

Postgraduate Program in Physical Education, Prevention and Rehabilitation in Physiotherapy Department, Federal University of Paraná, Curitiba 81531-900, PR, Brazil.

This study aimed to investigate the effects of exergames and protein supplementation on the body composition and musculoskeletal function of pre-frail older women. Methods: A randomized controlled clinical trial was conducted with 90 pre-frail older women (71.2 ± 4. Read More

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September 2021

Elastography and Metalloproteinases in Patients at High Risk of Preterm Labor.

J Clin Med 2021 Aug 29;10(17). Epub 2021 Aug 29.

Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-081 Lublin, Poland.

Preterm birth (PTB) is the leading cause of perinatal morbidity and mortality. Its etiopathology is multifactorial; therefore, many of the tests contain the assessment of the biochemical factors and ultrasound evaluation of the cervix in patients at risk of preterm delivery. The study aimed at evaluating the socioeconomic data, ultrasound examinations with elastography, plasma concentrations of MMP-8 and MMP-9 metalloproteinases, and vaginal secretions in the control group as well as patients with threatened preterm delivery (high-risk patients). Read More

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Stainless Steel Surface Nitriding in Open Atmosphere Cold Plasma: Improved Mechanical, Corrosion and Wear Resistance Properties.

Materials (Basel) 2021 Aug 26;14(17). Epub 2021 Aug 26.

Electronics and Computer Department, Faculty of Electrical Engineering and Computer Science, Transilvania University of Brasov, 29 Eroilor Blvd., 500036 Brasov, Romania.

This work presents preliminary results regarding improving the mechanical, wear and protective properties (hardness, coefficient of friction, corrosion resistance) of AISI 304 stainless steel surfaces by open atmosphere cold plasma surface treatment method. Comparative evaluations of the morphological, corrosion resistance, mechanical and tribological properties for different periods of treatment (using N gas for cold plasma generation in an open atmosphere) were performed. AFM surface analyses have shown significant surface morphology modifications (average roughness, FWHM, surface skewness and kurtosis coefficient) of the treated samples. Read More

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[Hearing dynamics in acute traumatic perforation of the tympanic membrane after application of blood plasma enriched with platelet growth factors].

Vestn Otorinolaringol 2021 ;86(4):23-30

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Russia.

Objective: The article considers the possibility of treating patients with acute traumatic perforation of the eardrum with a single application of blood plasma enriched with platelet-derived growth factors in the perforation area. As a result of the studies, it was found that the acceleration of its closure and the restoration of hearing.

Material And Methods: The study included 43 patients with unilateral acute PBP of various etiologies (Table 1). Read More

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September 2021

Caffeine co-ingested with carbohydrate on performance recovery in national-level paddlers: a randomized, double-blind, crossover, placebo-controlled trial.

J Sports Med Phys Fitness 2021 Sep 9. Epub 2021 Sep 9.

Department of Physical Education Studies, Brandon University, Brandon, Manitoba, Canada.

Background: Caffeine enhances muscle glycogen re-synthesis post exercise; however, the next-day effects on recovery are unknown. The present study aimed to examine the effects of carbohydrate (CHO) supplementation with or without caffeine (CAF) 24-h following exhaustive exercise on time trial performance in elite paddling athletes.

Methods: Nine highly trained male paddlers (21 ± 2 y) completed three experimental trials in a randomized, double-blind, crossover manner. Read More

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September 2021

The median effective concentration of propofol with different doses of esketamine during gastrointestinal endoscopy in elderly patients: a randomized controlled trial.

Br J Clin Pharmacol 2021 Sep 8. Epub 2021 Sep 8.

Department of Anesthesiology, Shidong Hospital of Shanghai, University of Shanghai for Science and Technology, Shanghai, China.

Background: Propofol may result in hypotension, bradycardia, and loss of protective reflexes, especially in elderly patients, while esketamine, a N-methyl-D-aspartate receptor antagonist, has analgesic, anaesthetic and sympathomimetic properties and is known to cause less cardiorespiratory depression. We hypothesized that esketamine may reduce the median effective concentration (EC ) of propofol and co-administration cause less likely to produce hypotension during gastrointestinal endoscopy in elderly patients.

Methods: Ninety elderly patients, aged 65-89 years, undergoing gastrointestinal endoscopy were randomly assigned into three groups: SK0 (control) group (0 mg/kg esketamine), SK0. Read More

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September 2021