Br J Clin Pharmacol 2021 Sep 8. Epub 2021 Sep 8.
Department of Anesthesiology, Shidong Hospital of Shanghai, University of Shanghai for Science and Technology, Shanghai, China.
Background: Propofol may result in hypotension, bradycardia, and loss of protective reflexes, especially in elderly patients, while esketamine, a N-methyl-D-aspartate receptor antagonist, has analgesic, anaesthetic and sympathomimetic properties and is known to cause less cardiorespiratory depression. We hypothesized that esketamine may reduce the median effective concentration (EC ) of propofol and co-administration cause less likely to produce hypotension during gastrointestinal endoscopy in elderly patients.
Methods: Ninety elderly patients, aged 65-89 years, undergoing gastrointestinal endoscopy were randomly assigned into three groups: SK0 (control) group (0 mg/kg esketamine), SK0. Read More