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Experience of Peer Bloggers Using a Social Media Website for Adolescents With Depression or Anxiety: Proof-of-Concept Study.

JMIR Form Res 2021 Jul 22;5(7):e26183. Epub 2021 Jul 22.

Division of Adolescent and Young Adult Medicine, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States.

Background: Supporting Our Valued Adolescents (SOVA) is a moderated and anonymous social media website intervention. SOVA ambassadors are adolescents and young adults (AYA) asked to write monthly blog posts and comments on others' posts on topics surrounding mental health.

Objective: This study aims to understand the feasibility and acceptability of peer blogging for a moderated mental health intervention website and explore whether bloggers-AYA who self-report symptoms of depression and anxiety-experience potential benefits. Read More

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Vaginal collagen I and III changes after carbon dioxide laser application in postmenopausal women with the genitourinary syndrome: a pilot study.

Climacteric 2021 Jul 22:1-9. Epub 2021 Jul 22.

Department of Obstetrics and Gynecology, University of Zaragoza Faculty of Medicine, Zaragoza, Spain.

Objective: The aim of the study was to evaluate the clinical response and collagen remodeling in the vaginal wall after three sessions of carbon dioxide (CO) laser application.

Methods: Fourteen postmenopausal women with vulvovaginal atrophy, aged 45-65 years and sexually active, were evaluated with clinical questionnaires, gynecological examinations and histological techniques before and after 20 weeks of treatment (ClinicalTrials.gov NCT03939078). Read More

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Associations of Seasonal Variations and Meteorological Parameters with Incidences of Upper and Lower Gastrointestinal Bleeding.

J Gastroenterol Hepatol 2021 Jul 21. Epub 2021 Jul 21.

School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.

Background: Previous studies have demonstrated the seasonal variations of non-variceal upper gastrointestinal bleeding (UGIB), but there is scanty data on lower gastrointestinal bleeding (LGIB) and the association with other meteorological parameters.

Methods: We included all patients hospitalized for UGIB and LGIB between 2009 and 2018 in Hong Kong. The monthly age- and sex-standardized GIB incidences were fitted to meteorological data including average temperature (AT), maximum temperature (MaxT), minimum temperature (MinT), temperature range (TR), average precipitation, average atmospheric pressure (AtomP) and average relative humidity after adjusting for prescriptions of aspirin, proton pump inhibitors and Helicobacter pylori eradication therapy using the autoregressive integrated moving average (ARIMA) model. Read More

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Cost-effectiveness of artificial intelligence monitoring for active tuberculosis treatment: A modeling study.

PLoS One 2021 21;16(7):e0254950. Epub 2021 Jul 21.

Los Angeles County Department of Public Health, Tuberculosis Control Program, Los Angeles, California, United States of America.

Background: Tuberculosis (TB) incidence in Los Angeles County, California, USA (5.7 per 100,000) is significantly higher than the U.S. Read More

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Modelling monthly influenza cases in Malaysia.

PLoS One 2021 21;16(7):e0254137. Epub 2021 Jul 21.

Department of Mathematical Science, Universiti Teknologi Malaysia, Skudai, Malaysia.

The increasing trend in the number new cases of influenza every year as reported by WHO is concerning, especially in Malaysia. To date, there is no local research under healthcare sector that implements the time series forecasting methods to predict future disease outbreak in Malaysia, specifically influenza. Addressing the problem could increase awareness of the disease and could help healthcare workers to be more prepared in preventing the widespread of the disease. Read More

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Scarcity of resources and inequity in access are frequently reported ethical issues for physiotherapists internationally: an observational study.

BMC Med Ethics 2021 Jul 20;22(1):97. Epub 2021 Jul 20.

UniSA Allied Health and Human Performance, University of South Australia, GPO Box 2471, Adelaide, SA, 5001, Australia.

Background: Little is known about the ethical situations which physiotherapists encounter internationally. This lack of knowledge impedes the ability of the profession to prepare and support physiotherapists in all world regions in their ethical practice. The purpose of the study was to answer the following research questions: What types of ethical issues are experienced by physiotherapists internationally? How frequently are ethical issues experienced by physiotherapists internationally? Can the frequency and type of ethical issue experienced by physiotherapists be predicted by sociodemographic, educational or vocational variables?

Methods: An observational study was conducted in English using an online survey from October 2018 to May 2019. Read More

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Regional disparity of certified teaching hospitals on physicians' workload and wages, and popularity among medical students in Japan.

Environ Health Prev Med 2021 Jul 20;26(1):75. Epub 2021 Jul 20.

Department of Epidemiology and Health Policy, School of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Background: Regional disparities in the working conditions of medical doctors have not been fully assessed in Japan. We aimed to clarify these differences in hospital characteristics: doctors' workload, wages, and popularity among medical students by city population sizes.

Methods: We targeted 423 teaching hospitals certified by the Japanese Society of Internal Medicine and assessed the working conditions of physicians specializing in internal medicine. Read More

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Excess all-cause mortality and COVID-19-related mortality: a temporal analysis in 22 countries, from January until August 2020.

Int J Epidemiol 2021 Jul 20. Epub 2021 Jul 20.

Israel Center of Disease Control, Ministry of Health, Ramat Gan, Israel.

Background: This study aimed to investigate overall and sex-specific excess all-cause mortality since the inception of the COVID-19 pandemic until August 2020 among 22 countries.

Methods: Countries reported weekly or monthly all-cause mortality from January 2015 until the end of June or August 2020. Weekly or monthly COVID-19 deaths were reported for 2020. Read More

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Modelling costs of community-based HIV self-testing programmes in Southern Africa at scale: an econometric cost function analysis across five countries.

BMJ Glob Health 2021 Jul;6(Suppl 4)

Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, UK.

Background: Following success demonstrated with the HIV Self-Testing AfRica Initiative, HIV self-testing (HIVST) is being added to national HIV testing strategies in Southern Africa. An analysis of the costs of scaling up HIVST is needed to inform national plans, but there is a dearth of evidence on methods for forecasting costs at scale from pilot projects. Econometric cost functions (ECFs) apply statistical inference to predict costs; however, we often do not have the luxury of collecting large amounts of location-specific data. Read More

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COVID-19 Precautionary Measures and Type 1 Diabetes Patients in Saudi Arabia.

Prim Care Diabetes 2021 Jul 15. Epub 2021 Jul 15.

Division of Endocrinology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Electronic address:

Aim: To minimize the spread of COVID-19, the Kingdom of Saudi Arabia (KSA) enforced a nationwide lockdown. We aimed to explore whether the manner in which Saudi patients with type 1 diabetes (T1D) manage their disease has changed during this unparalleled lockdown.

Methods: An online survey exploring the effect of lockdown on T1D outcomes was distributed among T1D patients residing in KSA during lockdown. Read More

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PTSD in the Year Following Sexual Assault: A Meta-Analysis of Prospective Studies.

Trauma Violence Abuse 2021 Jul 19:15248380211032213. Epub 2021 Jul 19.

7991York University, Toronto, Ontario, Canada.

Objective: Sexual assault is associated with higher rates of posttraumatic stress disorder (PTSD) than other traumas, and the course of PTSD may differ by trauma type. However, the course of PTSD after sexual assault has not been summarized. The aim of this meta-analysis was to identify the prevalence and severity of PTSD and changes to the average rate of recovery in the 12 months following sexual assault. Read More

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Food security, obesity, and meat-derived carcinogen exposure in US adults.

Food Chem Toxicol 2021 Jul 15;155:112412. Epub 2021 Jul 15.

College of Human Sciences, Auburn University, USA. Electronic address:

Risk for colorectal cancer (CRC) is increased in adults with poor diet quality, low socioeconomic status, and increased body mass index (BMI). Cooked meats contain high contents of mutagenic compounds related to CRC risk. To explore differences in meat-based carcinogen exposure, a 99-item Qualtrics survey was issued to 1648 US adults. Read More

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Variability in end-of-life healthcare use in patients with osteoarthritis: a population-based matched cohort study.

Osteoarthritis Cartilage 2021 Jul 14. Epub 2021 Jul 14.

Clinical Epidemiology Unit, Department of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden.

Purpose: To investigate the patterns of healthcare use (HCU) at the last year of life in persons with osteoarthritis (OA).

Methods: Using linked registers, we identified persons aged≥ 65 years who died during 2003-2014 and were resided in the Skåne region during 5-year prior to death. Among these, we randomly matched decedents with a principal OA diagnosis prior to the last year of life (OA cohort, n=17,993) with up to 4 comparators without OA by sex, age at death, and year of death (n=59,945). Read More

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Implementation of Biopsychosocial Supported-Self-Management for Chronic Primary Orofacial Pain including Temporomandibular Disorders: a Theory, Person and Evidence-Based Approach.

J Oral Rehabil 2021 Jul 17. Epub 2021 Jul 17.

School of Dentistry, Faculty of Medicine & Health, University of Leeds, Leeds, UK.

Background: Aims of the study were to: Implement supported self-management for chronic primary orofacial pain in a clinical setting. Evaluate its impact on consultation rates, pain-severity, interference-with-life and patient experience.

Methods: 66 patients with chronic primary orofacial pain received the intervention at a facial pain clinic at Leeds Dental Institute, UK. Read More

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Cohort Selection in Utero Against Male Twins and Childhood Cancers: A Population-Based Register Study.

Cancer Epidemiol Biomarkers Prev 2021 Jul 16. Epub 2021 Jul 16.

Program in Public Health, University of California, Irvine.

Background: Cancer ranks as the second leading cause of death among children aged 1 to 14 years in the US. Previous research finds that strong cohort selection in utero against males precedes a reduction in live-born males considered frail. We examine whether such cohort selection in utero may similarly affect the frequency of childhood cancers among male live births. Read More

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Impacts of the COVID-19 epidemic on the department of stomatology in a tertiary hospital: A case study in the General Hospital of the Central Theater Command, Wuhan, China.

Community Dent Oral Epidemiol 2021 Jul 16. Epub 2021 Jul 16.

Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden.

Objective: The impact of the worldwide COVID-19 pandemic on the dental community is evident. Dental education programmes and academic activities have suffered from the ramifications of the pandemic. This study aimed to depict the impacts of the COVID-19 epidemic on the clinical services and academic activities in the department of stomatology of a tertiary hospital in Wuhan, China. Read More

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Impact of Galcanezumab on Total Pain Burden: A Post Hoc Analysis of a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study in Patients with Episodic Cluster Headache.

J Pain Res 2021 8;14:2059-2070. Epub 2021 Jul 8.

Eli Lilly and Company, Indianapolis, IN, USA.

Purpose: In a phase 3 study, galcanezumab significantly reduced the frequency of episodic cluster headache attacks across weeks 1-3 (primary endpoint) compared with placebo. However, multiple pain dimensions may contribute to the total burden of episodic cluster headache pain. This post hoc analysis assessed the impact of galcanezumab on the total pain burden of episodic cluster headache using a composite measure. Read More

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The Impact of the COVID-19 Pandemic on the Number of Adolescents/Young Adults Seeking Eating Disorder-Related Care.

J Adolesc Health 2021 Jul 12. Epub 2021 Jul 12.

Division of Adolescent/Young Adult Medicine, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.

Purpose: The COVID-19 pandemic has led to the development and worsening of eating disorder (ED) symptoms in adolescents and young adults. In order to examine COVID-19-related trends in ED care-seeking at our institution.

Methods: We used interrupted time series regression to examine pre- and postpandemic monthly summary data of the following: (1) ED-related inpatient admissions for medical stabilization; (2) ED-related hospital bed-days; (3) completed outpatient ED assessments; and (4) ED outpatient care-related inquiries at a children's hospital in Boston, MA. Read More

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Assessment of Knowledge and Attitude of Cataract and Their Associated Factors Among Adults in Arba Minch Zuria Woreda, Southern Ethiopia.

Clin Ophthalmol 2021 6;15:2913-2920. Epub 2021 Jul 6.

School of Public Health, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia.

Background: Cataract is the major cause of reversible blindness and visual impairment in developing countries. It has been assumed that there is poor access to information related to the cause, prevention, and treatment of cataract in developing countries. There is also a paucity of data on knowledge and attitude towards cataract in Ethiopia. Read More

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The Relationship between Body Appreciation and Self-Esteem and Associated Factors among Omani University Students: An Online Cross-Sectional Survey.

J Obes 2021 23;2021:5523184. Epub 2021 Jun 23.

College of Nursing, Sultan Qaboos University, Muscat, Oman.

Background: Given the rapid pace of globalization and the fact that the Sultanate of Oman is experiencing a significant impact of social media on specifying appearance norms among youth in the country, research into positive body images and self-esteem among young individuals has become a national priority. Whilst body image has been well studied across cultures, both positive body image and the relationship between positive body image and self-esteem among Omani youth have been neglected. The aim of the study was to investigate the relationship between positive body image and self-esteem and associated sociodemographic factors among Omani university students based on gender. Read More

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Residual malaria in Jazan region, southwestern Saudi Arabia: the situation, challenges and climatic drivers of autochthonous malaria.

Malar J 2021 Jul 13;20(1):315. Epub 2021 Jul 13.

Saudi Centre for Disease Prevention and Control, Ministry of Health, Jazan, Kingdom of Saudi Arabia.

Background: Saudi Arabia and Yemen are the only two countries in the Arabian Peninsula that are yet to achieve malaria elimination. Over the past two decades, the malaria control programme in Saudi Arabia has successfully reduced the annual number of malaria cases, with the lowest incidence rate across the country reported in 2014. This study aims to investigate the distribution of residual malaria in Jazan region and to identify potential climatic drivers of autochthonous malaria cases in the region. Read More

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Sociodemographic changes in emergency department visits due to alcohol during COVID-19.

Drug Alcohol Depend 2021 Jun 30;226:108877. Epub 2021 Jun 30.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; ICES, Ottawa, Ontario, Canada; Bruyère Research Institute, Ottawa, Ontario, Canada; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

Introduction: Little detailed sociodemographic information is available about how alcohol use and associated health care visits have changed during COVID-19. Therefore, we assessed how rates of emergency department (ED) visits due to alcohol have changed during COVID-19 by age and sex and for individuals living in urban and rural settings and low and high-income neighborhoods.

Methods: Our cohort included 13,660,516 unique Ontario residents between the ages of 10-105. Read More

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Home environmental assessments and modification delivered by occupational therapists to reduce falls in people aged 65 years and over: the OTIS RCT.

Health Technol Assess 2021 Jul;25(46):1-118

York Trials Unit, Department of Health Sciences, University of York, York, UK.

Background: Falls and fall-related fractures are highly prevalent among older people and are a major contributor to morbidity and costs to individuals and society. Only one small pilot trial has evaluated the effectiveness of a home hazard assessment and environmental modification in the UK. This trial reported a reduction in falls as a secondary outcome, and no economic evaluation was undertaken. Read More

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Healthcare resource utilization and cost among patients treated for early-stage triple-negative breast cancer.

Future Oncol 2021 Jul 13. Epub 2021 Jul 13.

West Cancer Center, 7945 Wolf River Boulevard, Germantown, TN 38138, USA.

This retrospective, observational study examined real-world healthcare resource utilization (HCRU) and costs in 308 patients diagnosed with early-stage (II-IIIB) triple-negative breast cancer between 1 March 2008 and 31 March 2016. HCRU and costs were evaluated for two time periods: from neoadjuvant treatment start date to surgery (Time 1) and after surgery to recurrence or death (Time 2). The sample included 236 patients who received neoadjuvant treatment without subsequent adjuvant treatment (Neo) and 72 patients who received neoadjuvant treatment followed by adjuvant treatment (Neo + adj). Read More

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Comorbidity, lifestyle factors, and sexual satisfaction among Chinese cancer survivors.

Cancer Med 2021 Jul 13. Epub 2021 Jul 13.

Key Lab of Health Technology Assessment of National Health Commission and Key Lab of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, China.

Objectives: This study aims to explore the prevalence of sexual satisfaction among Chinese cancer survivors, and explore the association of sexual satisfaction with comorbidity and lifestyle factors.

Methods: A cross-sectional study was performed among 3996 Chinese cancer survivors recruited at Shanghai Cancer Rehabilitation Club from March to April 2017. Data were collected through self-reported questionnaires. Read More

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Pattern and determinants of COVID-19 infection and mortality across countries: An ecological study.

Heliyon 2021 Jul 8;7(7):e07504. Epub 2021 Jul 8.

Ministry of Health and Population, Egypt.

Background: This work aimed to identify the mathematical model and ecological determinants of COVID-19 infection and mortality across different countries during the first six months of the pandemic.

Methodology: In this study, authors used the online available data sources of randomly selected 18 countries to figure out potential determinants of COVID-19 transmissibility and mortality. The studied variables were environmental factors (daily average temperature, daily humidity), socioeconomic attributes (population age structure, count and density, human development index, per capita income (PCI), gross domestic product, internet coverage) mobility trends and chronic diseases. Read More

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Results of patients with neovascular age-related macular degeneration managed by a treat-extend-stop protocol without recurrence.

Graefes Arch Clin Exp Ophthalmol 2021 Jul 12. Epub 2021 Jul 12.

Retina Consultants of Orange County, 301 W. Bastanchury Ave #285, Fullerton, CA, 92835, USA.

Purpose: To assess vision, injection quantity, initial lesion size, and final anatomic status in patients with nAMD completing the treat-extend-stop (TES) protocol.

Methods: Patients with nAMD received ≥ 3 monthly anti-VEGF injections followed by 1-2 week injection interval extensions, with intra/subretinal fluid resolution on SD-OCT, to 12 weeks. With quiescent disease, and 2 quarterly injections, patients were monitored alone beginning at 4 weeks extending by 1-2 week intervals until quarterly monitoring. Read More

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Association between socioeconomic status and chronic obstructive pulmonary disease in Jiangsu province, China: a population-based study.

Chin Med J (Engl) 2021 Jun 22;134(13):1552-1560. Epub 2021 Jun 22.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China.

Background: Chronic obstructive pulmonary disease (COPD) is a common public health problem worldwide. Recent studies have reported that socioeconomic status (SES) is related to the incidence of COPD. This study aimed to investigate the association between SES and COPD among adults in Jiangsu province, China, and to determine the possible direct and indirect effects of SES on the morbidity of COPD. Read More

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Reindeer Anthrax in the Russian Arctic, 2016: Climatic Determinants of the Outbreak and Vaccination Effectiveness.

Front Vet Sci 2021 24;8:668420. Epub 2021 Jun 24.

Federal Research Center for Virology and Microbiology, Nizhny Novgorod Research Veterinary Institute - Branch of Federal Research Center for Virology and Microbiology, Nizhny Novgorod, Russia.

The Yamal Peninsula in the Russian Federation experienced a massive outbreak of anthrax in reindeer () in July-August 2016, with 2,650 (6.46% of the total susceptible population) animals infected, of which 2,350 died (case fatality rate of 88.67%). Read More

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Strength Training Intensity and Volume Affect Performance of Young Kayakers/Canoeists.

Front Physiol 2021 24;12:686744. Epub 2021 Jun 24.

Division of Training and Movement Sciences, Research Focus Cognitive Sciences, University of Potsdam, Potsdam, Germany.

Purpose: The aim of this study was to compare the effects of moderate intensity, low volume (MILV) vs. low intensity, high volume (LIHV) strength training on sport-specific performance, measures of muscular fitness, and skeletal muscle mass in young kayakers and canoeists.

Methods: Semi-elite young kayakers and canoeists ( = 40, 13 ± 0. Read More

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