2,582 results match your criteria average hypoxia


Extracellular Vesicles from Adipose-Derived Stem Cells Promote Diabetic Wound Healing via the PI3K-AKT-mTOR-HIF-1α Signaling Pathway.

Tissue Eng Regen Med 2021 Sep 20. Epub 2021 Sep 20.

Institute of Burn, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, People's Republic of China.

Background: Impaired potential of hypoxia-mediated angiogenesis lead poor healing of diabetic wounds. Previous studies have shown that extracellular vesicles from adipose derived stem cells (ADSC-EVs) accelerate wound healing with unelucidated mechanism. However, it is not yet clear about the underlying mechanism of ADSC-EVs in regulating the hypoxia-related PI3K/AKT/mTOR signaling pathway of vascular endothelial cells in diabetic wounds. Read More

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September 2021

Fetal Heart Rate Fragmentation.

Front Pediatr 2021 1;9:662101. Epub 2021 Sep 1.

Centre for Health Technology and Services Research (CINTESIS), Faculty of Medicine University of Porto, Porto, Portugal.

Intrapartum fetal monitoring's primary goal is to avoid adverse perinatal outcomes related to hypoxia/acidosis without increasing unnecessary interventions. Recently, a set of indices were proposed as new biomarkers to analyze heart rate (HR), termed HR fragmentation (HRF). In this work, the HRF indices were applied to intrapartum fetal heart rate (FHR) traces to evaluate fetal acidemia. Read More

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September 2021

Roxadustat for the Maintenance Treatment of Anemia in Patients with End-Stage Kidney Disease on Stable Dialysis: A European Phase 3, Randomized, Open-Label, Active-Controlled Study (PYRENEES).

Adv Ther 2021 Sep 19. Epub 2021 Sep 19.

Department of Nephrology, Collegium Medicum of the Jagiellonian University, Krakow, Poland.

Introduction: Roxadustat is an orally administered hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for the treatment of anemia of chronic kidney disease (CKD). This European, phase 3, randomized, open-label, active-controlled study investigated efficacy and safety of roxadustat in patients with end-stage kidney disease on dialysis for at least 4 months.

Methods: Patients were randomized to switch from an erythropoiesis-stimulating agent (ESA) (epoetin alfa or darbepoetin alfa) to roxadustat three times/week or to continue their previous ESA. Read More

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September 2021

[Adherence to hypothermia guidelines in newborns with hypoxic-ischemic encephalopathy].

An Pediatr (Barc) 2021 Sep 14. Epub 2021 Sep 14.

Neurología Neonatal, Fundación NeNe, Madrid, España.

Introduction: We do not have population data in Spain on the application of therapeutic hypothermia (TH). The objective was to examine adherence to management standards during TH of infants with hypoxic-ischemic encephalopathy (HIE).

Method: Multicenter observational cohort study from the beginning of TH (year 2010) in 5 hospitals in a Spanish region, until year 2019. Read More

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September 2021

Running exercise with end-expiratory breath holding up to the breaking point induces large and early fall in muscle oxygenation.

Eur J Appl Physiol 2021 Sep 16. Epub 2021 Sep 16.

UFR de Santé, Médecine et Biologie Humaine, Université Paris 13, Bobigny, France.

Purpose: The goal of this study was to assess the effects of repeated running bouts with end-expiratory breath holding (EEBH) up to the breaking point on muscle oxygenation.

Methods: Eight male runners participated in three randomised sessions each including two exercises on a motorised treadmill. The first exercise consisted in performing 10-12 running bouts with EEBH of maximum duration either (separate sessions) at 60% (active recovery), 80% (passive recovery) or 100% (passive recovery) of the maximal aerobic velocity (MAV). Read More

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September 2021

Moving on up: Vertical distribution shifts in rocky reef fish species during climate-driven decline in dissolved oxygen from 1995 to 2009.

Glob Chang Biol 2021 Sep 16. Epub 2021 Sep 16.

Marine Science Institute, University of California, Santa Barbara, CA, USA.

Anthropogenic climate change has resulted in warming temperatures and reduced oxygen concentrations in the global oceans. Much remains unknown on the impacts of reduced oxygen concentrations on the biology and distribution of marine fishes. In the Southern California Channel Islands, visual fish surveys were conducted frequently in a manned submersible at three rocky reefs between 1995 and 2009. Read More

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September 2021

Chronic inflammation-induced senescence impairs immunomodulatory properties of synovial fluid mesenchymal stem cells in rheumatoid arthritis.

Stem Cell Res Ther 2021 Sep 14;12(1):502. Epub 2021 Sep 14.

College of Veterinary Medicine, Gyeongsang National University, Jinju, 52828, Republic of Korea.

Background: Although the immunomodulatory properties of mesenchymal stem cells (MSCs) have been highlighted as a new therapy for autoimmune diseases, including rheumatoid arthritis (RA), the disease-specific characteristics of MSCs derived from elderly RA patients are not well understood.

Methods: We established MSCs derived from synovial fluid (SF) from age-matched early (average duration of the disease: 1.7 years) and long-standing (average duration of the disease: 13. Read More

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September 2021

Genomic variation in captive deer mouse (Peromyscus maniculatus) populations.

BMC Genomics 2021 Sep 14;22(1):662. Epub 2021 Sep 14.

Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.

Background: Deer mice (genus Peromyscus) are the most common rodents in North America. Despite the availability of reference genomes for some species, a comprehensive database of polymorphisms, especially in those maintained as living stocks and distributed to academic investigators, is missing. In the present study we surveyed two populations of P. Read More

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September 2021

PRE-RETINOPATHY OF TYPE 1 DIABETES IN THE CONTEXT OF FUNCTIONAL, STRUCTURAL AND MICROCIRCULATORY CHANGES IN THE MACULAR AREA.

Cesk Slov Oftalmol 2021 ;77(4):170-182

Aim: The authors assessed the development of intraocular changes in type 1 diabetes (T1DM) from the onset of the disease leading to diabetic retinopathy (DR). The quote: “There must be an intermediate stage between the physiological intraocular finding and the diabetic retinopathy itself “, (prof. Jan Vavřinec). Read More

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September 2021

Pulse oximetry adoption and oxygen orders at paediatric admission over 7 years in Kenya: a multihospital retrospective cohort study.

BMJ Open 2021 09 7;11(9):e050995. Epub 2021 Sep 7.

Health Services Unit, KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya.

Objectives: To characterise adoption and explore specific clinical and patient factors that might influence pulse oximetry and oxygen use in low-income and middle-income countries (LMICs) over time; to highlight useful considerations for entities working on programmes to improve access to pulse oximetry and oxygen.

Design: A multihospital retrospective cohort study.

Settings: All admissions (n=132 737) to paediatric wards of 18 purposely selected public hospitals in Kenya that joined a Clinical Information Network (CIN) between March 2014 and December 2020. Read More

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September 2021

Correlation of immunohistochemical expression of HIF-1alpha and IDH1 with clinicopathological and therapeutic data of moroccan glioblastoma and survival analysis.

Ann Med Surg (Lond) 2021 Sep 17;69:102731. Epub 2021 Aug 17.

Research's Pedagogic Unit of Pathological Anatomy, Laboratory of Pathological Anatomy. Research Team in Tumour Pathology, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco.

Introduction: Glioblastomas are aggressive primary intracranial tumours of the central nervous system causing significant mortality and morbidity worldwide.

Objective: This study aims to evaluate the prognostic value of tissue expression by immunostaining of hypoxia-inducible factor (HIF-1α), isocitrate dehydrogenase 1 (IDH1), and tumour protein p53 in glioblastoma in Moroccan patients. The association of HIF-1α, IDH1, and p53 expression with the clinicopathological data and overall patient survival (OS) was also evaluated. Read More

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September 2021

Association of obstructive sleep apnea severity with the composition of the upper airway microbiome.

J Clin Sleep Med 2021 Aug 31. Epub 2021 Aug 31.

Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.

Study Objectives: Although the airway mucosal system plays a pivotal role in the pathogenesis of obstructive sleep apnea (OSA), the underlying disease mechanism remains unclear. The microbiome greatly impacts human health and disease, particularly in the mucosa, where it can have direct interactions. In this study, we aimed to analyze the microbiome composition in the upper airway mucosa of individuals with and without OSA to identify potential disease severity-related microbial signatures. Read More

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Reversal of SARS-CoV2-Induced Hypoxia by Nebulized Sodium Ibuprofenate in a Compassionate Use Program.

Infect Dis Ther 2021 Aug 30. Epub 2021 Aug 30.

Instituto de Investigaciones en Ciencias de la Salud, Ciudad Universitaria, Córdoba, Argentina.

Introduction: Sodium ibuprofenate in hypertonic saline (NaIHS) administered directly to the lungs by nebulization and inhalation has antibacterial and anti-inflammatory effects, with the potential to deliver these benefits to hypoxic patients. We describe a compassionate use program that offered this therapy to hospitalized COVID-19 patients.

Methods: NaIHS (50 mg ibuprofen, tid) was provided in addition to standard of care (SOC) to hospitalized COVID-19 patients until oxygen saturation levels of > 94% were achieved on ambient air. Read More

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Predicting oxygen tension along the ureter.

Am J Physiol Renal Physiol 2021 08 30. Epub 2021 Aug 30.

Faculty of Engineering and Mathematical Sciences, University of Western Australia, Perth, Australia.

Continuous measurement of bladder urine oxygen tension (PO) is a new method to potentially detect renal medullary hypoxia in patients at risk of acute kidney injury (AKI). To assess its practicality, we developed a computational model of the peristaltic movement of a urine bolus along the ureter and the oxygen exchange between the bolus and ureter wall. This model quantifies the changes in urine PO as it transits from the renal pelvis to the bladder. Read More

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Blood Pressure Response in Miners Exposed to Chronic Intermittent Hypoxia in Chile.

Front Cardiovasc Med 2021 12;8:701961. Epub 2021 Aug 12.

Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.

Limited information is available on blood pressure (BP) behavior in workers exposed to chronic intermittent hypoxia (CIH), and even less is known regarding effects of CIH on 24-h ambulatory BP in those affected by arterial hypertension at sea level (SL). The aims of this study were to assess clinic and 24-h ambulatory BP at SL and at high altitude (HA; 3,870 m above SL) in workers exposed to CIH, and to compare BP response to HA exposure between normotensive and hypertensive workers. Nineteen normotensive and 18 pharmacologically treated hypertensive miners acclimatized to CIH were included, whose work was organized according to a "7 days-on-7 days-off" shift pattern between SL and HA. Read More

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The use of telemonitoring in managing the COVID pandemic: a pilot implementation study.

JMIR Form Res 2021 Aug 24. Epub 2021 Aug 24.

The Usher Institute, University of Edinburgh, Edinburgh, GB.

Background: Most people with COVID-19 self-manage at home. However, the condition can deteriorate quickly and some may develop serious hypoxia with relatively few symptoms. Early identification of deterioration allows effective management with oxygen and steroids. Read More

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Substantiation of Methods for Predicting Success in Artistic Swimming.

Int J Environ Res Public Health 2021 08 19;18(16). Epub 2021 Aug 19.

Department of Pedagogy, Kharkiv State Academy of Design and Arts, 61002 Kharkiv, Ukraine.

To develop a methodology for predicting success in artistic swimming based on a set of morphofunctional indicators and indices, 30 schoolgirls, average age (12.00 ± 0.22), were divided into two groups. Read More

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Adipose Tissue Hypoxia Correlates with Adipokine Hypomethylation and Vascular Dysfunction.

Biomedicines 2021 Aug 18;9(8). Epub 2021 Aug 18.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

Obesity is characterized by the accumulation of dysfunctional adipose tissues, which predisposes to cardiometabolic diseases. Our previous in vitro studies demonstrated a role of hypoxia in inducing adipokine hypomethylation in adipocytes. We sought to examine this mechanism in visceral adipose tissues (VATs) from obese individuals and its correlation with cardiometabolic risk factors. Read More

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Neurological Presentations of COVID-19: Characteristic Features in a Case Series of Hospitalized Patients from Abu Dhabi, UAE.

Biomed Res Int 2021 6;2021:5822259. Epub 2021 Aug 6.

Radiology Department, Sheikh Shakhbout Medical City, Abu Dhabi, UAE.

Background: COVID-19 patients can present with neurological manifestations in the form of headache, dizziness, hyposmia, myalgia, peripheral neuropathy, acute cerebrovascular disease, and encephalopathy. Neurological involvement could be due to virus-induced brain hypoxia, brain infection, or immune reaction. We aim to describe the neurological presentation of COVID-19 patients and study their neuroimaging findings and disease outcome. Read More

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Gender Differences in Idiopathic Pulmonary Fibrosis: Are Men and Women Equal?

Front Med (Lausanne) 2021 5;8:713698. Epub 2021 Aug 5.

Centre Constitutif de Référence des Maladies Pulmonaires Rares, AP-HP, Service de Pneumologie, Hôpital Avicenne, Bobigny, France.

Idiopathic pulmonary fibrosis (IPF) is characterized by a male predominance. The aim of the study was to explore gender differences in a well-designed French multicentre prospective IPF cohort (COhorte FIbrose, COFI) with a 5-year follow-up. Between 2007 and 2010, 236 patients with incident IPF were included in COFI. Read More

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Can hypoxia-inducible factor-1α overexpression discriminate human colorectal cancers with different microsatellite instability?

Genes Genet Syst 2021 Aug 21. Epub 2021 Aug 21.

Department of Gastrointestinal Cancer, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences.

Clinicopathological features of high-frequency microsatellite instability (MSI-H) colorectal cancers (CRCs) are different from low-frequency MSI (MSI-L) and microsatellite stable (MSS) CRCs. The clinical features of MSI-L cases are unknown, and although the tumors usually show instability for dinucleotide markers, evaluation based on dinucleotides alone could lead to the misclassification of MSI-L or MSS as MSI-H. In this research, we investigated the usefulness of hypoxia-inducible factor-1α (HIF-1α) expression to discriminate MSI-L from MSS and MSI-H in human CRC. Read More

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Renal Oxygenation (rSO2) Population Parameter Estimates in Premature Infants Routinely Monitored With Near-Infrared Spectroscopy.

Adv Neonatal Care 2021 Aug 19. Epub 2021 Aug 19.

Department of Physiological and Technological Nursing, College of Nursing, Augusta University, Augusta, Georgia (Drs Marin and Williams); Department of Pediatric Nephrology, Medical College of Georgia, Augusta University, Augusta, Georgia (Dr Mansuri); Department of Pediatrics, Division of Neonatology, Medical College of Georgia, Augusta University, Augusta, Georgia (Drs Mundy, Cockfield, Mann, and Stansfield); and Vascular Biology Center, Augusta University, Augusta, Georgia (Dr Stansfield).

Background: Currently, reference ranges for renal oxygenation measured by near-infrared spectroscopy (NIRS) in preterm infants beyond the first days of life are lacking, especially those born prior to 29 weeks' gestation. Population estimates of renal oxygenation (rSO2) levels among preterm infants over time have yet to be established, leading to reluctance in clinical application.

Purpose: To characterize the distribution and estimate population parameters for renal oxygenation measured by NIRS during the first 14 days of life among preterm infants. Read More

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Clusters of cause specific neonatal mortality and its association with per capita gross domestic product: A structured spatial analytical approach.

PLoS One 2021 17;16(8):e0255882. Epub 2021 Aug 17.

Escola Paulista de Medicina-Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.

Background: Infant mortality rate is a measure of population health and neonatal mortality account for great proportion of these deaths. Underdevelopment might be associated to higher neonatal mortality risk due to assistant related factors. Spatial and temporal distribution of mortality help identifying and developing strategies for interventions. Read More

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ROS-Responsive Selenium-Containing Carriers for Coencapsulation of Photosensitizer and Hypoxia-Activated Prodrug and Their Cellular Behaviors.

Macromol Biosci 2021 Aug 12:e2100229. Epub 2021 Aug 12.

Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials and Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.

The integration of hypoxia-activated chemotherapy with photodynamic therapy (PDT) has newly become a potent strategy for tumor treatment. Herein, a reactive oxygen species (ROS)-responsive drug carriers ([email protected]/mPEG-b-PSe NPs) are fabricated based on the amphiphilic selenium-containing methoxy poly(ethylene glycol)-polycarbonate (mPEG-b-PSe), the hydrophobic photosensitizer (PS), and hypoxia-activated prodrug Banoxantrone (AQ4N). The obtained nanoparticles are spherical with an average diameter of 100 nm as characterized by transmission electron microscope (TEM) and dynamic laser scattering (DLS) respectively. Read More

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The Term Newborn: Evaluation for Hypoxic-Ischemic Encephalopathy.

Clin Perinatol 2021 Aug;48(3):681-695

Department of Neonatology, NICN, Sharp Mary Birch Hospital for Women and Newborns, 8555 Aero Drive #104, San Diego, CA 92123, USA.

Neonatal encephalopathy due to perinatal hypoxia-ischemia (hypoxic-ischemic encephalopathy [HIE]) occurs at a rate of 1 to 3 per 1000 live births. Therapeutic hypothermia is the standard of care and the only currently available therapy to reduce the risk of death or disability in newborns with moderate to severe HIE. Hypothermia therapy needs to be initiated within 6 hours after birth in order to provide the best chance for neuroprotection. Read More

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Altered Brain Networks in Chronic Obstructive Pulmonary Disease: An Electroencephalography Analysis.

Clin EEG Neurosci 2021 Jul 28:15500594211035942. Epub 2021 Jul 28.

Department of Neurology, Korea University College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.

. Limited data are available regarding brain networks in patients with chronic obstructive pulmonary disease (COPD). Here, we investigated brain networks in COPD using graph theoretical analysis of electroencephalography data. Read More

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Phase 3 Study of Roxadustat to Treat Anemia in Non-Dialysis-Dependant CKD.

Kidney Int Rep 2021 Jul 17;6(7):1810-1828. Epub 2021 Apr 17.

Astellas Pharma Europe B.V., Leiden, The Netherlands.

Introduction: Roxadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that has demonstrated safety and efficacy versus placebo in phase III trials in patients with anemia of chronic kidney disease (CKD) who were not on dialysis (NDD).

Methods: This was a phase III, active-controlled, multicenter, partially randomized, open-label study in Japanese patients with NDD CKD. Patients who had used recombinant human erythropoietin or darbepoetin alfa (DA) before conversion were randomized to roxadustat or DA (comparative arms). Read More

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The correlation between the STOP-Bang score and oxygen saturation during spinal anesthesia with dexmedetomidine sedation.

Anesth Pain Med (Seoul) 2021 Jul 15;16(3):305-311. Epub 2021 Jul 15.

Department of Anesthesiology and Pain Medicine, Busan Central Hospital, Busan, Korea.

Background: The STOP-Bang questionnaire is a simple screening tool with high sensitivity for the detection of severe obstructive sleep apnea. Predicting airway obstruction would allow the safe management of sedative patients to prevent intraoperative hypoxia. This study was designed to check the correlation between the STOP-Bang score and oxygen saturation (SpO2) during sedation and confirm the availability of the STOP-Bang questionnaire as a preoperative exam for predicting the incidence of hypoxia in sedative patient management. Read More

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Degradation and Aging of Terrestrial Organic Carbon within Estuaries: Biogeochemical and Environmental Implications.

Environ Sci Technol 2021 08 18;55(15):10852-10861. Epub 2021 Jul 18.

Frontiers Science Center for Deep Ocean Multispheres and Earth System, and Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao 266100, China.

Estuaries are action zones for organic carbon (OC) degradation and aging. These processes influence the nature of terrestrial OC (OC) export and the magnitude of OC burial in marginal seas, with important environmental implications such as CO release and hypoxia. In this study, we determined the contents and carbon isotopic compositions (C and C) of bulk OC and fatty acids (FAs) as well as the sedimentological characteristics of suspended particulate matter (SPM) samples collected from two sites over four seasons and of surface sediment samples from three sites in the Pearl River estuary (PRE) to evaluate processes controlling OC degradation and aging along an estuarine gradient. Read More

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Genome-Wide DNA Methylation Changes Associated With High-Altitude Acclimatization During an Everest Base Camp Trek.

Front Physiol 2021 28;12:660906. Epub 2021 Jun 28.

Department of Anthropology, University of California, Los Angeles, Los Angeles, CA, United States.

The individual physiological response to high-altitude hypoxia involves both genetic and non-genetic factors, including epigenetic modifications. Epigenetic changes in hypoxia factor pathway (HIF) genes are associated with high-altitude acclimatization. However, genome-wide epigenetic changes that are associated with short-term hypoxia exposure remain largely unknown. Read More

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