7,924 results match your criteria average deficiency

Dietary Riboflavin Intake and Riboflavin Status in Young Adult Women Living in Metro Vancouver, Canada.

Curr Dev Nutr 2021 Apr 13;5(4):nzab021. Epub 2021 Mar 13.

Women and Kids Theme, South Australian Health and Medical Research Institute, and Discipline of Paediatrics, University of Adelaide, Adelaide, South Australia, Australia.

Background: Nutrition surveys suggest that <10% of Canadian adults have inadequate riboflavin intakes. However, biochemical riboflavin deficiency [erythrocyte glutathione reductase activity coefficient (EGRac) ≥1.40] has been reported in 41% of young adult women living in Metro Vancouver. Read More

View Article and Full-Text PDF

Toxicity and deleterious impacts of selenium nanoparticles at supranutritional and imbalance levels on male goldfish (Carassius auratus) sperm.

J Trace Elem Med Biol 2021 Apr 8;66:126758. Epub 2021 Apr 8.

Leibniz Institute for Natural Product Research and Infection Biology e.V. Hans-Knöll-Institute (HKI), Jena, Germany.

Background: Selenium has a major role in male reproduction and antioxidative mechanisms. Although deficiency of this element can result in damages to the body's organs, this metalloid can induce deleterious effects in organisms by causing oxidative stress. This study assessed the spermatotoxicity of selenium nanoparticles (SeNPs) in goldfish (Carassius auratus) based on genotoxicity, antioxidant status, sperm quality, and histopathology. Read More

View Article and Full-Text PDF

Impairment of Executive Functions Associated With Lower D-Serine Serum Levels in Patients With Schizophrenia.

Front Psychiatry 2021 29;12:514579. Epub 2021 Mar 29.

Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czechia.

A core symptom that is frequently linked with dysregulation of glutamatergic neurotransmission in regard to schizophrenia is impairment or damage of executive functioning as a component of cognitive deficiency. The amino acid D-serine plays the role of an endogenous coagonist at the glutamatergic -methyl-D-aspartate (NMDA) receptor glycine modulatory site. Considerably reduced serum levels of D-serine were found in patients suffering from schizophrenia compared with healthy control participants. Read More

View Article and Full-Text PDF

Etiologies, profile patterns and characteristics of children with short stature in Jordan.

J Pediatr Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.

Department of Pediatrics, The University of Jordan, Amman, Jordan.

Objectives: Childhood growth influences their social and psychological behavior, and abnormal growth may reflect underlying pathological etiologies. It is important to diagnose children with short stature as early as possible to be able to manage treatable causes. We aim to study etiologies and characteristics of short stature in children in Jordan. Read More

View Article and Full-Text PDF

Anaemia and its impact on colorectal cancer patients: how can we better optimize surgical outcomes?

ANZ J Surg 2021 Apr 13. Epub 2021 Apr 13.

Department of Colorectal Surgery, Western Health, Melbourne, Victoria, Australia.

Background: Anaemia is a common manifestation of colorectal cancer (CRC). However, appropriate workup prior to surgery and the effect of anaemia on outcomes have not been well defined. This study aimed to describe preoperative anaemia incidence, investigations performed, treatment and associated complications in a CRC surgical population at a single large tertiary institution in Australia. Read More

View Article and Full-Text PDF

The influence of TCM constitutions and neurocognitive function in elderly Macau individuals.

Chin Med 2021 Apr 13;16(1):32. Epub 2021 Apr 13.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China.

Background: Traditional Chinese medicine (TCM) constitution contributes to predicating disease occurrence and pathological progress. In this study, we investigate the correlation between TCM constitution and neurocognitive function in elderly Macau individuals.

Methods: A total of 313 older adults from elderly healthcare centers were recruited at random. Read More

View Article and Full-Text PDF

Does Iron Deficiency Affect the Heart in Children?

J Pediatr Hematol Oncol 2021 Apr 9. Epub 2021 Apr 9.

Departments of Pediatrics Pediatric Cardiology Pediatric Haemotology, Keciören Training and Research Hospital, Health Sciences University, Ankara, Turkey.

Introduction: It is well known that serum iron parameters are closely related to cardiovascular health. Iron deficiency may lead to significant cardiac problems, such as atrioventricular conduction abnormalities, and systolic and/or diastolic dysfunction. Studies related to the effect of iron deficiency on cardiac functions are limited in children. Read More

View Article and Full-Text PDF

Dietary intake and growth in children with Prader-Willi syndrome.

J Hum Nutr Diet 2021 Apr 9. Epub 2021 Apr 9.

Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland.

Background: The management of Prader-Willi Syndrome (PWS) requires strict dietary supervision to prevent obesity, avoid micronutrient deficiencies and ensure optimal growth. The present study aimed to examine the growth and dietary intake of children with PWS.

Methods: All children with genetically confirmed PWS attending Children's Health Ireland (CHI) at Tallaght (n = 44) were invited to participate. Read More

View Article and Full-Text PDF

[Cortexin administration due to improvement of cognitive and behavioral disorders in children and teenagers with epilepsy].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(3):127-131

Children's Regional Clinical Hospital, Belgorod, Russia.

Objective: To study the possibility of using the polypeptide drug cortexin for the treatment of cognitive, emotional and behavioral disorders in children and adolescents with epilepsy and to assess the efficacy and safety of the drug in this group of patients.

Materials And Methods: Eighty-six patients (41 girls and 45 boys) were examined at the age of 3 to 17 y.o. Read More

View Article and Full-Text PDF

Seasonal Changes in Vitamin D Levels of Healthy Children in Mid-Latitude, Asian Urban Area.

Pediatr Gastroenterol Hepatol Nutr 2021 Mar 4;24(2):207-217. Epub 2021 Mar 4.

Department of Pediatrics, Korea University Medical Center, Seoul, Korea.

Purpose: This study aimed to investigate the seasonal changes in vitamin D levels in a healthy pediatric population living in mid-latitude East Asian urban areas.

Methods: A pediatric population was selected from single secondary hospital visitors. Clinical data and serum vitamin D levels were collected retrospectively. Read More

View Article and Full-Text PDF

Treatment of maternal anemia by using oral iron drugs combined with diet therapy.

Pak J Pharm Sci 2020 Sep;33(5(Special)):2417-2422

No.2 Postpartum Department, Tengzhou Central People's Hospital, Tengzhou, China.

Iron deficiency anemia is a common nutritional deficiency disease in women during pregnancy, mainly due to the increased iron requirements of pregnant women and fetuses, resulting in a lack of iron elements necessary for the production of red blood cells, resulting in a decrease in the number of red blood cells and the symptoms of anemia; Causes chronic fetal hypoxia and affects the normal development of some important organs of the fetus. This article explores the clinical value of oral iron drugs combined with diet therapy for maternal anemia. Observed the changes of hemoglobin (Hb), red blood cell count (RBC), average hemoglobin concentration (McHc), serum iron (SI), transferrin saturation (TS) and other indicators of pregnant women before and after treatment and the differences in pregnancy outcomes. Read More

View Article and Full-Text PDF
September 2020

Vitamin D status in women with dichorionic twin pregnancies and their neonates: a pilot study in China.

BMC Pregnancy Childbirth 2021 Apr 8;21(1):279. Epub 2021 Apr 8.

International Collaborative Laboratory of Reproduction and Development of Chinese Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.

Background: Vitamin D deficiency is a global public health issue in women and children and is associated with adverse impacts on child growth, such as rickets. However, prior studies have mainly focused on measuring vitamin D levels in singleton pregnant women and their offspring, and very limited studies have revealed the prevalence of vitamin D deficiency in twin pregnant women and their offspring. The aim of this study was to investigate vitamin D levels in twin-pregnant women and their neonates. Read More

View Article and Full-Text PDF

Hereditary angioedema due to C1 inhibitor deficiency in Belarus: epidemiology, access to diagnosis and seven novel mutations in SERPING1 gene.

Clin Mol Allergy 2021 Apr 7;19(1). Epub 2021 Apr 7.

General Medicine Department, ASST-Fatebenefratelli-Sacco, Milan, Italy.

Background: Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare disease. Few states in developing countries have an adequate management of HAE, but none of them belongs to the former USSR area. This study analyses data from C1-INH-HAE patients from Belarus. Read More

View Article and Full-Text PDF

BH4-deficient hyperphenylalaninemia in Russia.

PLoS One 2021 6;16(4):e0249608. Epub 2021 Apr 6.

Research Centre for Medical Genetics, Moscow, Russia.

A timely detection of patients with tetrahydrobiopterin (BH4) -deficient types of hyperphenylalaninemia (HPABH4) is important for assignment of correct therapy, allowing to avoid complications. Often HPABH4 patients receive the same therapy as phenylalanine hydroxylase (PAH) -deficiency (phenylketonuria) patients-dietary treatment-and do not receive substitutive BH4 therapy until the diagnosis is confirmed by molecular genetic means. In this study, we present a cohort of 30 Russian patients with HPABH4 with detected variants in genes causing different types of HPA. Read More

View Article and Full-Text PDF

Exposure Assessment of Fluoride Intake Through Commercially Available Black Tea (Camellia sinensis L.) from Areas with High Incidences of Chronic Kidney Disease with Undetermined Origin (CKDu) in Sri Lanka.

Biol Trace Elem Res 2021 Apr 5. Epub 2021 Apr 5.

Department of Geography and Geosciences, GeoZentrum Nordbayern, Friedrich-Alexander University Erlangen-Nuremberg (FAU), Schlossgarten 5, 91054, Erlangen, Germany.

Fluoride is a beneficial trace element for human health as its deficiency and excess levels can cause detrimental health effects. In Sri Lanka, dry zone regions can have excessive levels of fluoride in drinking water and can cause dental and skeletal fluorosis. In addition to drinking water, traditional habits of tea consumption can cause an additional intake of fluoride in the population. Read More

View Article and Full-Text PDF

Association of Serum Vitamin D Levels and Stress Fractures in Collegiate Athletes.

Orthop J Sports Med 2020 Dec 9;8(12):2325967120966967. Epub 2020 Dec 9.

University of Arizona, Tucson, Arizona, USA.

Background: Low vitamin D levels along with high-intensity athletic training may put an athlete at increased risk for a stress fracture.

Purpose: To assess whether supplementation with vitamin D is associated with a reduced risk of stress fractures in college athletes. We also assessed differences in vitamin D levels among athletes participating in outdoor versus indoor sports. Read More

View Article and Full-Text PDF
December 2020

Nutrient Intake Adequacy from Food and Beverage Intake of US Children Aged 1-6 Years from NHANES 2001-2016.

Nutrients 2021 Mar 3;13(3). Epub 2021 Mar 3.

Medical and Scientific Affairs, RB|Mead Johnson Nutrition Institute, Evansville, IN 47721, USA.

The early years, between the ages of one and six, are a period of rapid physical, social and cognitive growth and a nutritionally adequate diet is an important factor for optimum development. We investigated the micronutrient adequacy and status of young US children aged 1-6 years ( = 9848) using 24-h dietary recall interviews completed by parents and caregivers participating in the National Health and Nutrition Examination Survey (NHANES) 2001-2016. data. Read More

View Article and Full-Text PDF

ATG4D is the main ATG8 delipidating enzyme in mammalian cells and protects against cerebellar neurodegeneration.

Cell Death Differ 2021 Apr 1. Epub 2021 Apr 1.

Departamento de Biología Funcional, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain.

Despite the great advances in autophagy research in the last years, the specific functions of the four mammalian Atg4 proteases (ATG4A-D) remain unclear. In yeast, Atg4 mediates both Atg8 proteolytic activation, and its delipidation. However, it is not clear how these two roles are distributed along the members of the ATG4 family of proteases. Read More

View Article and Full-Text PDF

Preoperative vitamin D deficiency is associated with increased risk of postoperative hypocalcemia after total thyroidectomy.

J Investig Med 2021 Mar 31. Epub 2021 Mar 31.

Department of Internal Medicine and Endocrinology, University of New Mexico Hospital, Albuquerque, New Mexico, USA.

Prior single-institution studies suggest that preoperative vitamin D deficiency (VDD) is associated with postoperative hypocalcemia and a prolonged length of hospital stay following total thyroidectomy. In this study, we employ a multi-institutional, de-identified electronic health records database to address this issue. We hypothesize that total thyroidectomy patients with preoperative VDD will be at an increased associated risk of postoperative hypocalcemia and hospitalization. Read More

View Article and Full-Text PDF

Effect of latitude on seasonal variations of vitamin D and some cardiometabolic risk factors: national food and nutrition surveillance.

East Mediterr Health J 2021 Mar 23;27(3):269-278. Epub 2021 Mar 23.

Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.

Background: Despite a remarkable reduction in the occurrence of many micronutrient deficiencies in most countries, vitamin D deficiency has remained a global problem. Age-adjusted disability-adjusted life years lost due to cardiovascular disease in the Eastern Mediterranean Region, including in the Islamic Republic of Iran, are higher than the global average.

Aims: To assess the effects of latitude and season on vitamin D status in the Iranian population and the association between vitamin D status and certain cardiometabolic risk factors. Read More

View Article and Full-Text PDF

The Association Between Ambient PM Exposure and Anemia Outcomes Among Children Under Five Years of Age in India.

Environ Epidemiol 2021 Feb 7;5(1):e125. Epub 2021 Jan 7.

St. John's Medical College, Bengaluru, India.

Anemia is highly prevalent in India, especially in children. Exposure to ambient fine particulate matter (PM) is a potential risk factor for anemia via. systemic inflammation. Read More

View Article and Full-Text PDF
February 2021

Interstitial Lung Disease in Common Variable Immunodeficiency.

Front Immunol 2021 11;12:605945. Epub 2021 Mar 11.

Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Interstitial lung disease (ILD) is a common complication in patients with common variable immunodeficiency (CVID) and often associated with other features, such as bronchiectasis and autoimmunity. As the ILD term encompasses different acute and chronic pulmonary conditions, the diagnosis is commonly made based on imaging features; histopathology is less frequently available. From a cohort of 637 patients with CVID followed at our center over 4 decades, we reviewed the data for 46 subjects (30 females, 16 males) who had lung biopsies with proven ILD. Read More

View Article and Full-Text PDF

Neurophysiological and ophthalmological findings of SPG7-related spastic ataxia: a phenotype study in an Irish cohort.

J Neurol 2021 Mar 27. Epub 2021 Mar 27.

National Ataxia Clinic, Department of Neurology, Tallaght University Hospital, Tallaght, Dublin 24, Ireland.

Background: Mutations in SPG7 are increasingly identified as a common cause of spastic ataxia. We describe a cohort of Irish patients with recessive SPG7-associated phenotype.

Methods: Comprehensive phenotyping was performed with documentation of clinical, neurophysiological, optical coherence tomography (OCT) and genetic data from individuals with SPG7 attending two academic neurology units in Dublin, including the National Ataxia Clinic. Read More

View Article and Full-Text PDF

Functional immune reconstitution early after allogeneic haematopoietic cell transplantation: A comparison of pre- and post-transplantation cytokine responses in stimulated whole blood.

Scand J Immunol 2021 Mar 26:e13042. Epub 2021 Mar 26.

Bone Marrow Transplant Unit, Department of Hematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

We aimed to use a novel standardized whole-blood stimulation system to evaluate differences in the functional immune reconstitution in patients early after allogeneic haematopoietic cell transplantation (HCT). Between April and September 2018, 30 patients undergoing HCT had whole blood samples collected around day -21 (day 0 being the day of haematopoietic cell infusion) and day +28. Whole blood was transferred to TruCulture assays comprising prefilled incubation tubes with cell culture medium and a standardized stimulus. Read More

View Article and Full-Text PDF

Seasonal patterns of bison diet across climate gradients in North America.

Joseph M Craine

Sci Rep 2021 Mar 25;11(1):6829. Epub 2021 Mar 25.

Jonah Ventures, 5485 Conestoga Ct #210, Boulder, CO, 80301, USA.

North American plains bison (Bison bison) have been reintroduced across their former range, yet we know too little about their current diet to understand what drove their past migrations as well as observed continental-scale variation in weight gain and reproduction. In order to better understand the seasonal diets of bison at the continental scale, bison fecal material was collected monthly from April to September in 2019 across 45 sites throughout the conterminous United States. Fecal material was analyzed for dietary quality using near infrared spectroscopy and dietary composition with DNA metabarcoding. Read More

View Article and Full-Text PDF

Simultaneous and proportional control of wrist and hand movements by decoding motor unit discharges in real time.

J Neural Eng 2021 Mar 24. Epub 2021 Mar 24.

Department of Mechanical Engineering, Shanghai Jiao Tong University State Key Laboratory of Mechanical System and Vibration, No. 800, Dongchuan Road, Shanghai, 200240, CHINA.

Surface electromyography (EMG) decomposition techniques can be used to establish human-machine interfacing (HMI), but most investigations are implemented offline due to the computational load of the approach. Here, we generalize the offline decomposition algorithm to identify the motor unit (MU) activities in real time, and we propose a MU-based approach for online simultaneous and proportional control of multiple motor tasks.High-density surface EMG signals recorded from forearm muscles were decomposed into motor unit spike trains (MUST) with the proposed decomposition method. Read More

View Article and Full-Text PDF

[Hereditary hemorrhagic telangiectasia: symptoms and diagnostic latency].

Laryngorhinootologie 2021 Mar 24. Epub 2021 Mar 24.

Klinik für Hals-Nasen-Ohrenheilkunde, Philipps-Universität Marburg, Germany.

Objective:  Patients with hereditary hemorrhagic Telangiectasia (HHT) suffer from a rare and systemic disease which is characterized by vascular malformations leading to a variety of different symptoms.

Material And Methods:  A retrospective review of patients who were referred to our new HHT Center of Excellence (HHT COE) for evaluation and treatment between April 2014 and August 2019 was performed.

Results:  235 patients were treated at the West German HHT Center. Read More

View Article and Full-Text PDF

The prevalence of anemia and iron deficiency among pregnant Ghanaian women, a longitudinal study.

PLoS One 2021 24;16(3):e0248754. Epub 2021 Mar 24.

Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America.

Background: Gestational iron deficiency (ID) can be deleterious to mother and fetus. However, iron status is not routinely measured during pregnancy in Ghana. Therefore, the scope of ID in this population is unknown. Read More

View Article and Full-Text PDF

Avoidance of iodine deficiency/excess during pregnancy in Hashimoto's thyroiditis.

Nuklearmedizin 2021 Mar 23. Epub 2021 Mar 23.

Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Purpose:  Hashimoto's thyroiditis is a common disease that also affects pregnant women. We analyzed to what extent the inflammatory process of Hashimoto's thyroiditis changes with iodine prophylaxis in pregnant women. The target for immunologic activity was levels of thyroid antibodies (TPO). Read More

View Article and Full-Text PDF

The association of vitamin D levels and insulin resistance.

Clin Nutr ESPEN 2021 Apr 3;42:325-332. Epub 2021 Feb 3.

Noncommunicable Diseases Research, Fasa University of Medical Sciences, Fasa, Iran; National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Objective: Vitamin D deficiency and insulin resistance have great prevalence in society. The latest studies indicate an inverse association between Vitamin D levels, insulin resistance, and Type 2 diabetes. The objective of this study was to investigate the effect of vitamin D status on insulin resistance. Read More

View Article and Full-Text PDF