5,492 results match your criteria autopsy rate


Putrefaction in the pandemic: a comparative study of the frequency of advanced decomposition change in coronial autopsies since the start of the COVID-19 pandemic.

J Clin Pathol 2021 Sep 17. Epub 2021 Sep 17.

Cellular Pathology, Imperial College Healthcare NHS Trust, London, UK.

Aims: The aim of this study is to evaluate whether there has been a significant change in the frequency of markedly decomposed bodies having coronial autopsies since the UK's first COVID-19 lockdown.

Methods: We compared coronial autopsies (n=263) performed by one pathologist at a central London mortuary in the 1 year before and after 23 March 2020 by analysing their autopsy reports and coronial documentation.

Results: We have shown that there has been a significant increase of 70. Read More

View Article and Full-Text PDF
September 2021

A large lipoma of the descending colon: A rare case report.

Radiol Case Rep 2021 Nov 1;16(11):3396-3399. Epub 2021 Sep 1.

Department of Radiology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, VietNam.

Colon lipoma is a rare benign disease in the gastrointestinal tract with an incidence rate of approximately 0.035%-4.4%. Read More

View Article and Full-Text PDF
November 2021

Technical and interpretive pitfalls of postmortem CT: Five examples of errors revealed by autopsy.

J Forensic Sci 2021 Sep 7. Epub 2021 Sep 7.

Chiba University Center for Education and Research in Legal Medicine, Chiba, Japan.

Image acquisition of dead bodies, particularly using postmortem computed tomography (PMCT), has become common in forensic investigations worldwide. Meanwhile, in countries such as Japan which have an extremely low rate of autopsy, PMCT is being increasingly used in the clinical field to certify the cause of death (COD) without performing an autopsy or toxicological tests, even in cases of unnatural death. Additionally, these PMCT images are predominantly interpreted by clinical personnel such as emergency physicians or clinicians who are not trained in PMCT interpretation and who work for the police, that is, the so-called police doctors. Read More

View Article and Full-Text PDF
September 2021

Fascin as a useful marker for cancer-associated fibroblasts in invasive lung adenocarcinoma.

Medicine (Baltimore) 2021 Sep;100(35):e27162

Department of Molecular Pathology, Tokyo Medical University, Japan.

Abstract: Cancer-associated fibroblasts (CAFs) have been attracting attention in recent years, but their nature has not been fully elucidated. Although CAFs have been recognized as an important therapeutic target, therapeutic agents have not been developed to date. CAFs are characterized by their high migration rate and involvement in epithelial-to-mesenchymal transition with some displaying a dendritic morphology that is reminiscent of fascin expression. Read More

View Article and Full-Text PDF
September 2021

Utilization of oral check-up data of autopsy cases.

J Forensic Leg Med 2021 Aug 24;83:102245. Epub 2021 Aug 24.

Department of Forensics Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 602-8566, Japan. Electronic address:

The maintenance of oral health contributes to the overall health of an individual. Similar to the Adult Dental Health Survey in the UK, the Survey of Dental Diseases (SDD) is being conducted in Japan. However, our routine oral examination of autopsy cases showed that the oral cavities of the autopsied bodies were unhealthy as compared to the SDD data. Read More

View Article and Full-Text PDF

Use of verbal autopsy for establishing causes of child mortality in camps for internally displaced people in Mogadishu, Somalia: a population-based, prospective, cohort study.

Lancet Glob Health 2021 09;9(9):e1286-e1295

Institute for Global Health, University College London, London, UK.

Background: People in humanitarian emergencies are likely to experience excess mortality but information on the causes of death is often unreliable or non-existent. This study aimed to provide evidence on the causes of death among children younger than 5 years in camps for internally displaced people in southern Somalia, during periods of protracted displacement and emergency influx amid the 2017 drought and health emergency.

Methods: We did a prospective, cohort study in 25 camps in the Afgooye corridor, on the outskirts of Mogadishu, Somalia. Read More

View Article and Full-Text PDF
September 2021

Sudden death due to leukostasis in a subject with undiagnosed chronic lymphocytic leukemia.

Forensic Sci Med Pathol 2021 Aug 20. Epub 2021 Aug 20.

Department of Pathology, State University of New York, Upstate Medical University, 13202, Syracuse, NY, USA.

Sudden death due to leukostasis and lymphocyte thrombi in patients with chronic hematologic malignancies is rare. Leukostasis is characterized by highly elevated leukemic cell count and decreased tissue perfusion symptoms, leading to severe complications and even death. Chronic lymphocytic leukemia (CLL) is a chronic lymphoproliferative disorder that shows a highly heterogeneous clinical course, ranging from indolent form to very aggressive disease. Read More

View Article and Full-Text PDF

The coronary artery calcification severity on postmortem CT could be a clue for the diagnosis of sudden cardiac death.

J Forensic Leg Med 2021 Aug 8;82:102227. Epub 2021 Aug 8.

Department of Forensic Medicine, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan. Electronic address:

About two-thirds of sudden deaths are sudden cardiac deaths (SCD), and ischemic heart disease (IHD) accounts for 60% of these. Although an autopsy needs to be performed to prove SCD, the forensic autopsy rate is very low in Japan. To diagnose the cause of death, postmortem computed tomography (PMCT) is often performed. Read More

View Article and Full-Text PDF

Could ante-mortem computed tomography be useful in forensic pathology of traumatic intracranial haemorrhage?

Afr J Lab Med 2021 29;10(1):1040. Epub 2021 Jul 29.

Department of Forensic Pathology, Faculty of Health Sciences, University of Limpopo, Polokwane, South Africa.

Background: Imaging techniques have proven valuable in forensic pathology practice, with computed tomography being preferred for forensic use. In the era of virtual autopsy and a low- to middle-income, resource-constrained country, a question arises as to whether ante-mortem computed tomography (ACT) could be cost-effective by reducing the number of invasive autopsies performed.

Objective: The objective of this study was to assess the usefulness of ACT in forensic pathology by examining discrepancy rates between ACT scans and autopsy findings in cases of deceased individuals with traumatic intracranial haemorrhages and assess factors associated with discrepancies. Read More

View Article and Full-Text PDF

Autopsies and quality of cause of death diagnoses.

SAGE Open Med 2021 4;9:20503121211037169. Epub 2021 Aug 4.

Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.

Objective: The consequences of a low autopsy rate are not considered in determining the cause of death.

Method: We have analyzed the Cause of Death Register of the Swedish National Board of Health and Welfare since it started 1969 to and including 2016 to visualize the decline in the frequency of clinical autopsies over time and evaluated the effect on the quality of the cause of death diagnoses.

Results: Over the five decades studied, the frequency of clinical autopsies declined from almost 40% to less than 5%. Read More

View Article and Full-Text PDF

Vaccine Induced Immune Thrombotic Thrombocytopenia Causing a Severe Form of Cerebral Venous Thrombosis With High Fatality Rate: A Case Series.

Front Neurol 2021 30;12:721146. Epub 2021 Jul 30.

Faculty of Medicine, Institute of Clinical Medicine, University in Oslo, Oslo, Norway.

During a 2-week period, we have encountered five cases presenting with the combination of cerebral venous thrombosis (CVT), intracerebral hemorrhage and thrombocytopenia. A clinical hallmark was the rapid and severe progression of disease in spite of maximum treatment efforts, resulting in fatal outcome in for 4 out of 5 patients. All cases had received ChAdOx1 nCov-19 vaccine 1-2 weeks earlier and developed a characteristic syndrome thereafter. Read More

View Article and Full-Text PDF

Baseline renal dysfunction determines mortality following parathyroidectomy in primary hyperparathyroidism: analysis of Indian PHPT registry.

J Bone Miner Metab 2021 Aug 15. Epub 2021 Aug 15.

Division of Endocrinology, Diabetes, and Bone & Mineral Disorders, Bone & Mineral Research Laboratory, Henry Ford Hospital, Detroit, MI, USA.

Introduction: Primary hyperparathyroidism (PHPT) in India is mostly symptomatic with renal and skeletal complications. Evidence on mortality outcomes following parathyroidectomy from India, where the disease is predominantly symptomatic is limited.

Material And Methods: This was a prospective study to evaluate mortality outcomes in the Indian PHPT registry over the past 25 years (n = 464). Read More

View Article and Full-Text PDF

Dementia in the Forensic Setting: Diagnoses Obtained Using a Condensed Protocol at the Office of Chief Medical Examiner, New York City.

J Neuropathol Exp Neurol 2021 Sep;80(8):724-730

From the Department of Pathology, Uniformed Services University F. Edward Hébert School of Medicine and Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA (DSP); and Department of Forensic Medicine, New York University Grossman School of Medicine and New York City Office of Chief Medical Examiner, New York City, New York, USA (RDF).

Individuals with dementia may come to forensic autopsy, partly because of non-natural deaths (e.g. fall-related), and/or concerns of abuse/neglect. Read More

View Article and Full-Text PDF
September 2021

Fast Progression in Amyotrophic Lateral Sclerosis Is Associated With Greater TDP-43 Burden in Spinal Cord.

J Neuropathol Exp Neurol 2021 Sep;80(8):754-763

From the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.

Upper and lower motor neuron pathologies are critical to the autopsy diagnosis of amyotrophic lateral sclerosis (ALS). Further investigation is needed to determine how the relative burden of these pathologies affects the disease course. We performed a blinded, retrospective study of 38 ALS patients, examining the association between pathologic measures in motor cortex, hypoglossal nucleus, and lumbar cord with clinical data, including progression rate and disease duration, site of symptom onset, and upper and lower motor neuron signs. Read More

View Article and Full-Text PDF
September 2021

Application of (Diptera, Calliphoridae) to Postmortem Interval Estimation in Southwest China: A Case Report.

Fa Yi Xue Za Zhi 2021 Jun;37(3):338-343

Guizhou Police College, Guiyang 550005, China.

Abstract: Insect samples found on human corpses can provide the information important to estimating the minimum postmortem interval (PMI). A female cadaver, found in a deserted factory in Chongqing of China, was confirmed as a homicide case after the forensic investigation and autopsy. Determining the time of death was difficult due to the inconsistent degree of decomposition in different parts of the decedent. Read More

View Article and Full-Text PDF

Pulmonary tumor embolism: A retrospective study over a 30-year period.

PLoS One 2021 11;16(8):e0255917. Epub 2021 Aug 11.

Department of Pathology and Laboratory Medicine, Rhode Island Hospital and The Alpert Medical School of Brown University, Providence, RI, United States of America.

Background: Pulmonary tumor embolism (PTE) is difficult to detect before death, and it is unclear whether the discrepancy between antemortem clinical and postmortem diagnosis improves with the advance of the diagnostic technologies. In this study we determined the incidence of PTE and analyzed the discrepancy between antemortem clinical and postmortem diagnosis.

Methods: We performed a retrospective autopsy study on patients with the history of malignant solid tumors from 1990 to 2020 and reviewed all the slides of the patients with PTE. Read More

View Article and Full-Text PDF

Data-Driven vs Consensus Diagnosis of MCI: Enhanced Sensitivity for Detection of Clinical, Biomarker, and Neuropathologic Outcomes.

Neurology 2021 Aug 10. Epub 2021 Aug 10.

Veterans Affairs San Diego Healthcare System, San Diego, CA.

Objective: Given prior work demonstrating that mild cognitive impairment (MCI) can be empirically differentiated into meaningful cognitive subtypes, we applied actuarial methods to comprehensive neuropsychological data from the University of California San Diego (UCSD) Alzheimer's Disease Research Center (ADRC) in order to identify cognitive subgroups within nondemented ADRC participants, and to examine cognitive, biomarker, and neuropathological trajectories.

Methods: Cluster analysis was performed on baseline neuropsychological data (n=738; mean age=71.8). Read More

View Article and Full-Text PDF

Occupational mortality in the New Mexico oil and gas industry.

J Forensic Sci 2021 Aug 7. Epub 2021 Aug 7.

School of Medicine, University of New Mexico, Albuquerque, NM, USA.

New Mexico's oil and natural gas industry has the second highest occupational fatality rate among oil and gas workers in the nation. There is currently limited data available regarding the top contributing factors to occupational mortality specific to the state's oil and gas industry. This study seeks to understand causes of mortality among oil and gas workers in New Mexico between 2008 and 2018. Read More

View Article and Full-Text PDF

Causes and circumstances of maternal death: a secondary analysis of the Community-Level Interventions for Pre-eclampsia (CLIP) trials cohort.

Lancet Glob Health 2021 09 29;9(9):e1242-e1251. Epub 2021 Jul 29.

Department of Obstetrics and Gynaecology, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada; Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. Electronic address:

Background: Incomplete vital registration systems mean that causes of death during pregnancy and childbirth are poorly understood in low-income and middle-income countries. To inform global efforts to reduce maternal mortality, we compared physician review and computerised analysis of verbal autopsies (interpreting verbal autopsies [InterVA] software), to understand their agreement on maternal cause of death and circumstances of mortality categories (COMCATs) in the Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomised trials.

Methods: The CLIP trials took place in India, Pakistan, and Mozambique, enrolling pregnant women aged 12-49 years between Nov 1, 2014, and Feb 28, 2017. Read More

View Article and Full-Text PDF
September 2021

Causes of preterm and low birth weight neonatal mortality in a rural community in Kenya: evidence from verbal and social autopsy.

BMC Pregnancy Childbirth 2021 Jul 29;21(1):536. Epub 2021 Jul 29.

Centre for Clinical Research, Kenya Medical Research Institute, P.O Box 54840 00200, Nairobi, Kenya.

Background: Under-five mortality in Kenya has declined over the past two decades. However, the reduction in the neonatal mortality rate has remained stagnant. In a country with weak civil registration and vital statistics systems, there is an evident gap in documentation of mortality and its causes among low birth weight (LBW) and preterm neonates. Read More

View Article and Full-Text PDF

Neonatal mortality rates, characteristics, and risk factors for neonatal deaths in Ghana: analyses of data from two health and demographic surveillance systems.

Glob Health Action 2021 01;14(1):1938871

Mother and Infant Research Unit, School of Health Sciences, University of Dundee, Dundee, UK.

Background: Reducing neonatal mortality rates (NMR) in developing countries is a key global health goal, but weak registration systems in the region stifle public health efforts.

Objective: To calculate NMRs, investigate modifiable risk factors, and explore neonatal deaths by place of birth and death, and cause of death in two administrative areas in Ghana.

Methods: Data on livebirths were extracted from the health and demographic surveillance systems in Navrongo (2004-2012) and Kintampo (2005-2010). Read More

View Article and Full-Text PDF
January 2021

Institutional guidelines on maternal care and investigations following antepartum stillbirth - a national survey.

BMC Pregnancy Childbirth 2021 Jul 24;21(1):528. Epub 2021 Jul 24.

Department of Obstetrics and Gynecology, Division of Feto-Maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Background: Antepartum stillbirth, i.e., intrauterine fetal death (IUFD) above 24 weeks of gestation, occurs with a prevalence of 2. Read More

View Article and Full-Text PDF

Strong association between insufficient plasma exchange and fatal outcomes in Japanese patients with immune-mediated thrombotic thrombocytopenic purpura.

Int J Hematol 2021 Oct 22;114(4):415-423. Epub 2021 Jul 22.

Department of Blood Transfusion Medicine, Nara Medical University, 840 Shijo-Cho, Kashihara, 634-8522, Japan.

Plasma exchange (PEX) using fresh frozen plasma has considerably reduced the mortality rate in patients with immune-mediated thrombotic thrombocytopenic purpura (iTTP). However, some patients still do not survive even with treatment, but little information is available regarding which treatment these patients received. This study was conducted to obtain this information in 240 patients who met the current iTTP diagnostic criteria and completed at least 30 days of follow-up except for deceased cases. Read More

View Article and Full-Text PDF
October 2021

Sensitive and Specific Immunohistochemistry Protocol for Nucleocapsid Protein from All Common SARS-CoV-2 Virus Strains in Formalin-Fixed, Paraffin Embedded Tissues.

Methods Protoc 2021 Jul 10;4(3). Epub 2021 Jul 10.

Department of Pathology, Medical College of Wisconsin, TBRC-C4980, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA.

Human coronavirus disease 2019 (COVID-19) is a life-threatening and highly contagious disease caused by coronavirus SARS-CoV-2. Sensitive and specific detection of SARS-CoV-2 viral proteins in tissues and cells of COVID-19 patients will support investigations of the biologic behavior and tissue and cell tropism of this virus. We identified commercially available affinity-purified polyclonal antibodies raised against nucleocapsid and spike proteins of SARS-CoV-2 that provide sensitive and specific detection of the virus by immunohistochemistry in formalin-fixed, paraffin-embedded tissue. Read More

View Article and Full-Text PDF

Effect of seasonal succession of algal communities on fouling of MF membrane.

J Environ Sci Health A Tox Hazard Subst Environ Eng 2021 19;56(8):912-919. Epub 2021 Jul 19.

National Institute of Ecology, Choongnam, Republic of Korea.

An emerging threat to membrane application is the seasonal proliferation of algae in water sources such as rivers, reservoirs and lakes. This study investigated the link between feed parameters and the membrane performance of a pilot-scale microfiltration (MF) plant for 7 months. The seasonal succession of algae in relation to temperature dynamics was monitored. Read More

View Article and Full-Text PDF

Histopathologic survey on lung necropsy specimens of 15 patients who died from COVID-19: A large study from Iran with a high rate of anthracosis.

Med J Islam Repub Iran 2021 17;35:63. Epub 2021 May 17.

Department of Internal Medicine, School of Medicine, Rasool Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran.

In the pandemic era of Coronavirus disease 19 (COVID-19), one of the most important issues is the nature of real pathological events that occur during disease course in different parts of the body. There are several ways to know more about COVID-related histopathological events,such as tissue sampling which means biopsy from the tissues of either livepeople or necropsy/autopsy of people who died from COVID-19. We conducted an original study for assessing histopathological findings of lung necropsy samples collected from 15 Iranian patients. Read More

View Article and Full-Text PDF

Uterine scar rupture at the site of the placenta accreta presenting as a case of sudden death.

Autops Case Rep 2021 8;11:e2020226. Epub 2020 Dec 8.

All India Institute of Medical Sciences, Department of Forensic Medicine and Toxicology, Raipur, Chhattisgarh, India.

Uterine rupture during pregnancy is a known complication of placenta accreta. This paper presents a case of sudden maternal death in the 27 week of gestation due to a ruptured uterine scar at the site of placenta accreta with a short inter-pregnancy period of 6 months with previous two C-sections. Autopsy findings revealed a massive hemoperitoneum and a thinned out anterolateral uterine wall. Read More

View Article and Full-Text PDF
December 2020

Evolution of the fabric of cardiovascular science: Saga of an enduring process of refinement.

Ann Cardiol Angeiol (Paris) 2021 Jul 14. Epub 2021 Jul 14.

Department of Anatomy, All India Institute of Medical Sciences, Phulwarisharif, Patna, Bihar, India.

Background: The core elements of cardiovascular science have been established by scholarly pursuits of numerous scientists across centuries. In this article, we have tried to trace the evolutionary journey of cardiovascular science from a rudimentary form in ancient period to a robust scientific discipline in modern times.

Methods: A literature search of relevant, peer-reviewed, published articles was undertaken from indexed databases (Medline & Pubmed, Scopus, Embase, CINAHL Plus, Web of Science and Google Scholar). Read More

View Article and Full-Text PDF