543,574 results match your criteria autoimmune diseases


Kinase activity profiling reveals contribution of G-protein signaling modulator 2 deficiency to impaired regulatory T cell migration in rheumatoid arthritis.

J Autoimmun 2021 Sep 20;124:102726. Epub 2021 Sep 20.

Laboratory of Molecular Immunology, Division of Rheumatology and Clinical Immunology, Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Germany. Electronic address:

The ability of regulatory T (T) cells to migrate into inflammatory sites is reduced in autoimmune diseases, including rheumatoid arthritis (RA). The reasons for impaired T cell migration remain largely unknown. We performed multiplex human kinase activity arrays to explore possible differences in the post-translational phosphorylation status of kinase related proteins that could account for altered T cell migration in RA. Read More

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September 2021

Fluorescence-encoded Poly(methyl metharcylate) nanoparticles for a lateral flow assay detecting IgM autoantibodies in rheumatoid arthritis.

Anal Biochem 2021 Sep 20:114389. Epub 2021 Sep 20.

Brandenburg Technical University Cottbus - Senftenberg, Faculty of Natural Sciences, Universitätsplatz 1, D-01968 Senftenberg, Germany. Electronic address:

Rheumatoid arthritis (RA) belongs to the most often occurring autoimmune diseases in the world. For serological diagnosis, IgM auto-antibodies directed against the Fc portion of IgG referred to as rheumatoid factor are used as biomarkers. The autoantibody detection is usually done by ELISA. Read More

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September 2021

Association analysis of B7-H3 and B7-H4 gene single nucleotide polymorphisms in susceptibility to ankylosing spondylitis in eastern Chinese Han population.

Int J Immunogenet 2021 Sep 23. Epub 2021 Sep 23.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

This study was conducted to describe the association between the genetic variation of the recently identified immune checkpoint molecules B7-H3 and B7-H4, and the susceptibility to ankylosing spondylitis (AS). Two single nucleotide polymorphisms (SNPs) of B7-H3 gene and three SNPs of B7-H4 gene were genotyped in 649 AS patients and 646 age- and sex-matched healthy controls. Allele, genotype frequencies and different inheritance models were performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs), and the demographic and clinical parameters of patients were recorded. Read More

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September 2021

Absence of prostacyclin greatly relieves cyclophosphamide-induced cystitis and bladder pain in mice.

FASEB J 2021 Oct;35(10):e21952

Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan.

Cyclophosphamide (CP) has been widely used in the treatment of various malignancies and autoimmune diseases, but acrolein, a byproduct of CP, causes severe hemorrhagic cystitis as the major side effect of CP. On the other hand, a large amount of prostacyclin (PGI ) is produced in bladder tissues, and PGI has been shown to play a critical role in bladder homeostasis. PGI is biosynthesized from prostaglandin (PG) H , the common precursor of PGs, by PGI synthase (PTGIS) and is known to also be involved in inflammatory responses. Read More

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October 2021

Membrane-binding mechanism of the EEA1 FYVE domain revealed by multi-scale molecular dynamics simulations.

PLoS Comput Biol 2021 Sep 23;17(9):e1008807. Epub 2021 Sep 23.

Department of Biochemistry, University of Oxford, Oxford, United Kingdom.

Early Endosomal Antigen 1 (EEA1) is a key protein in endosomal trafficking and is implicated in both autoimmune and neurological diseases. The C-terminal FYVE domain of EEA1 binds endosomal membranes, which contain phosphatidylinositol-3-phosphate (PI(3)P). Although it is known that FYVE binds PI(3)P specifically, it has not previously been described of how FYVE attaches and binds to endosomal membranes. Read More

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September 2021

Clinical subgroup clustering analysis in a systemic lupus erythematosus cohort from Western Pennsylvania.

Eur J Rheumatol 2021 Jul 27. Epub 2021 Jul 27.

Division of Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.

Objective: Systemic lupus erythematosus (SLE) is a complex heterogenous autoimmune disease that can affect multiple organs. We performed clinical clustering analysis to describe a lupus cohort from the University of Pittsburgh Medical Center.

Methods: A total of 724 patients who met the American College of Rheumatology (ACR) classification criteria for SLE were included in this study. Read More

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The Kv1.3 K channel in the immune system and its "precision pharmacology" using peptide toxins.

Biol Futur 2021 Mar 6;72(1):75-83. Epub 2021 Feb 6.

Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 1 Egytem ter, Debrecen, 4032, Hungary.

Since the discovery of the Kv1.3 voltage-gated K channel in human T cells in 1984, ion channels are considered crucial elements of the signal transduction machinery in the immune system. Our knowledge about Kv1. Read More

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Biologia Futura: Emerging antigen-specific therapies for autoimmune diseases.

Biol Futur 2021 Mar 4;72(1):15-24. Epub 2021 Feb 4.

Department of Immunology, Eötvös Loránd University, Budapest, Hungary.

Autoimmune diseases are caused by breaking the central and/or peripheral tolerance against self, leading to uncontrolled immune response to autoantigens. The incidences of autoimmune diseases have increased significantly worldwide over the last decades; nearly 5% of the world's population is affected. The current treatments aim to reduce pain and inflammation to prevent organ damage and have a general immunosuppressive effect, but they cannot cure the disease. Read More

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Correction to: Spontaneous and Immune Checkpoint Inhibitor-Induced Autoimmune Diseases: Analysis of Temporal Information by Using the Japanese Adverse Drug Event Report Database.

Clin Drug Investig 2021 Sep 23. Epub 2021 Sep 23.

Laboratory of Regulatory Science, College of Pharmaceutical Sciences, Ritsumeikan University, 1‑1‑1 Noji‑Higashi, Kusatsu, Shiga, 525‑8577, Japan.

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September 2021

Pharmacokinetics and Safety of Intravenous and Subcutaneous Auto-injector Single-dose Belimumab in Healthy Chinese Volunteers: A phase 1, Randomized, Open-label Study.

Rheumatol Ther 2021 Sep 23. Epub 2021 Sep 23.

Department of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, 2901 Caolang Rd, Jinshan District, Shanghai, China.

Introduction: Belimumab is a recombinant human immunoglobulin G1λ monoclonal antibody indicated as an intravenous (IV) 10 mg/kg and subcutaneous (SC) 200-mg dose for the treatment of systemic lupus erythematosus (SLE). Belimumab 10 mg/kg IV has been approved for the treatment of patients with SLE in China. This phase 1 study investigated the pharmacokinetics (PK), safety, and tolerability of belimumab 200 mg SC and the approved IV formulation in a healthy Chinese population. Read More

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September 2021

Long-term efficacy and safety of canakinumab in patients with mevalonate kinase deficiency: results from the randomised Phase 3 CLUSTER trial.

Rheumatology (Oxford) 2021 Sep 23. Epub 2021 Sep 23.

Department of Pediatrics, University Medical Center Utrecht, Utrecht, the Netherlands.

Objectives: To evaluate the long-term efficacy and safety of canakinumab in patients with mevalonate kinase deficiency (MKD) during the open label extension (weeks 41-113) of the randomised controlled CLUSTER trial.

Methods: During a 72-week period, patients received open-label canakinumab 150 or 300 mg, every 4 or 8 weeks. The disease activity was evaluated every 8 weeks using physician global assessment (PGA) and counting the number of flares. Read More

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September 2021

Comment on: Herpes zoster following BNT162b2 mRNA Covid-19 vaccination in patients with autoimmune inflammatory rheumatic diseases: a case series. Reply.

Rheumatology (Oxford) 2021 Sep 23. Epub 2021 Sep 23.

Rheumatology Department, Tel Aviv Sourasky Medical Center affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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September 2021

Application of polysaccharide biopolymers as natural adsorbent in sample preparation.

Crit Rev Food Sci Nutr 2021 Sep 23:1-28. Epub 2021 Sep 23.

Institute of Electronic and Sensor Materials, TU Bergakademie, Freiberg, Germany.

Preparing samples for analyses is perhaps the most important part to analyses. The varied functional groups present on the surface of biopolymers bestow them appropriate adsorption properties. Properties like biocompatibility, biodegradability, presence of different surface functional group, high porosity, considerable absorption capacity for water, the potential for modification, etc. Read More

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September 2021

Health-promoting effects of bioactive compounds in blackcurrant (Ribes nigrum L.) Berries.

Rocz Panstw Zakl Hig 2021 ;72(3):229-238

Institute of Human Nutrition Sciences, Department of Dietetics, Warsaw University of Life Sciences (WULS-SGGW), Warsaw, Poland.

Blackcurrant (BC) is a well-known and appreciated berry fruit in our country and Poland is the largest BC producer among European Union countries and the second, after Russia, producer in the world. Due to the short shelf life of BC, its consumption in fresh form is relatively low , therefore the berries are processed into juices, jams, jellies, and freeze-dried products or alcoholic beverages. The high nutritional value of BC berries result from high content of bioactive compounds (among others, vitamin C, anthocyanins, pectins, organic acids, as well as polyunsaturated fatty acids contained in seeds of the fruit). Read More

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January 2021

[Side effects of longterm oral corticosteroid therapy].

Rev Prat 2021 Jun;71(6):587-596

Médecine interne et immunologie clinique, CHU de Rennes ; Inserm, Irset UMR 1085, université de Rennes-1, Rennes, France.

Side effects of long-term oral corticosteroid therapy. Systemic corticosteroid therapy has been used for over 70 years, and is still the cornerstone of the treatment of many conditions, in particular systemic, autoimmune or inflammatory diseases. Side effects of corticosteroids are numerous, and for most of them well known by prescribers. Read More

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Bioinformatics analyses of gene expression profile identify key genes and functional pathways involved in cutaneous lupus erythematosus.

Clin Rheumatol 2021 Sep 23. Epub 2021 Sep 23.

Department of Rheumatology and Immunology, The Affiliated Hospital of Hubei Minzu University, Enshi, Hubei Province, China.

Background: Lupus erythematosus is an autoimmune disease that causes damage to multiple organs ranging from skin lesions to systemic manifestations. Cutaneous lupus erythematosus (CLE) is a common type of lupus erythematosus (LE), but its molecular mechanisms are currently unknown. The study aimed to explore changes in the gene expression profiles and identify key genes involved in CLE, hoping to uncover its molecular mechanism and identify new targets for CLE. Read More

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September 2021

Anti-Ro/SSA Antibodies and the Autoimmune Long-QT Syndrome.

Front Med (Lausanne) 2021 6;8:730161. Epub 2021 Sep 6.

Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.

Autoimmunity is increasingly recognized as a novel pathogenic mechanism for cardiac arrhythmias. Several arrhythmogenic autoantibodies have been identified, cross-reacting with different types of surface proteins critically involved in the cardiomyocyte electrophysiology, primarily ion channels (autoimmune cardiac channelopathies). Specifically, some of these autoantibodies can prolong the action potential duration leading to acquired long-QT syndrome (LQTS), a condition known to increase the risk of life-threatening ventricular arrhythmias, particularly Torsades de Pointes (TdP). Read More

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September 2021

Driving CARs to BARs: The Winding Road to Specific Regulatory T Cells for Tolerance.

Authors:
David W Scott

Front Immunol 2021 6;12:742719. Epub 2021 Sep 6.

Department of Medicine (MED), Uniformed Services University of the Health Sciences, Bethesda, MD, United States.

Chimeric antigen receptor (CAR) transduced T cells have significantly improved cancer immunotherapy. Similarly, engineering regulatory T cells (Treg) with specific receptors to endow specificity and increase efficacy of Tregs holds great promise for therapy of a variety of adverse immune responses. In this review, we focus on our approaches using retroviral transduction of specific T-cell receptors, single chain variable fragments (scFv) or antigen in models of monogenic diseases, autoimmunity and allergy. Read More

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September 2021

TRIM21/Ro52 - Roles in Innate Immunity and Autoimmune Disease.

Front Immunol 2021 6;12:738473. Epub 2021 Sep 6.

Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.

TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's syndrome, systemic lupus erythematosus, and other rheumatic autoimmune diseases. Here, we summarise the structure and function of this enzyme, its roles in innate immunity, adaptive immunity and cellular homeostasis, the pathogenesis of autoimmunity against TRIM21, and the potential impacts of autoantibodies to this intracellular protein. Read More

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September 2021

Teaching Neuroimmunology to Undergraduate Students: Resource for Full Course or Modular Implementation.

Authors:
Junryo Watanabe

J Undergrad Neurosci Educ 2021 20;19(2):A163-A184. Epub 2021 Jun 20.

Biology Department, SUNY Oneonta, Oneonta, NY 13820.

This paper describes a course I designed to teach neuroimmunology to undergraduate students. In this course I incorporated many active learning strategies to help make it a student-centered class, where they developed communication skills, while reading and analyzing primary literature articles. As the field of neuroimmunology is relatively new, most textbooks in the field approached the subject from the perspective of neurology and autoimmune diseases. Read More

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Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases.

Nat Commun 2021 Sep 22;12(1):5565. Epub 2021 Sep 22.

Division Medical Inflammation Research, Dept. Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden.

Complex autoimmune diseases are sexually dimorphic. An interplay between predisposing genetics and sex-related factors probably controls the sex discrepancy in the immune response, but the underlying mechanisms are unclear. Here we positionally identify a polymorphic estrogen receptor binding site that regulates Cd2 expression, leading to female-specific differences in T cell-dependent mouse models of autoimmunity. Read More

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September 2021

Gut Microbiota and Autoimmune Diseases: a Charming Real World Together with Probiotics.

Curr Med Chem 2021 Sep 22. Epub 2021 Sep 22.

Emergency Department, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome. Italy.

Background: The role of gut microbiota in human disease is fascinating for hundreds of researchers worldwide. Many works have highlighted that gut microbiota modulates the immune system, and that its disruption can trigger autoimmune and inflammatory immune-mediated diseases. Probiotics are able to positively modify microbiota composition. Read More

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September 2021

The Underestimated Role of Mast Cells in the Pathogenesis of Rhinopathies.

Int Arch Allergy Immunol 2021 Sep 22:1-7. Epub 2021 Sep 22.

Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.

Mast cells (MCs) are involved in several biological processes, such as defense against pathogens, immunomodulation, tissue repair after injury, and angiogenesis. MCs have been shown to change from protective immune cells to potent pro-inflammatory cells, influencing the progression of many pathological conditions, including autoimmune diseases and cancers. The role of MCs in the pathogenesis of rhinopathies has often been underestimated, since previous studies have focused their attention on eosinophils and neutrophils, while MCs were considered involved exclusively in allergic rhinitis. Read More

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September 2021

Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling.

Cell Rep 2021 Sep;36(12):109726

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, and Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing, P.R. China. Electronic address:

Gut microbiota-mediated secondary bile acids (BAs) play an important role in energy balance and host metabolism via G protein-coupled receptors and/or nuclear receptors. Emerging evidence suggests that BAs are important for maintaining innate immune responses via these receptors. However, the effect of BAs on autoimmune uveitis is still unknown. Read More

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September 2021

Assessing the Risk Factors for Anxiety, Depression, and Posttraumatic Stress Disorder through the International Pemphigus and Pemphigoid Foundation.

J Eur Acad Dermatol Venereol 2021 Sep 22. Epub 2021 Sep 22.

University of Illinois at Chicago, Department of Dermatology, Chicago, Illinois, USA.

Autoimmune blistering diseases (AIBD) are associated with significant impact on quality of life with numerous associated psychiatric comorbidities. We sought to investigate disease-related risk factors for the development of depression, anxiety, and posttraumatic stress disorder (PTSD) in AIBD patients. A cross-sectional cohort study was conducted at the University of Illinois at Chicago with Institutional Review Board exemption. Read More

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September 2021

Differentiating Primary Sclerosing Cholangitis from Similar Diseases of Autoimmune Origin.

J Gastrointestin Liver Dis 2021 Sep 21;30(3):398-403. Epub 2021 Sep 21.

Faculty of Medicine, Masaryk University, Brno; Department of Pediatrics, University Hospital Brno, Brno; Central European Institute of Technology, Masaryk University, Brno, Czech Republic.

Background And Aims: Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease. Differential diagnostics can confuse it with immunoglobulin (Ig) G4-related sclerosing cholangitis (SC), an IgG4-related disease with clearly proven autoimmune origin. Differential diagnosis is made even more challenging because PSC with increased IgG4 levels (PSC-increased IgG4) also occurs. Read More

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September 2021

Early life adversity due to bereavement and inflammatory diseases in the next generation - a population study in transgenerational stress exposure.

Am J Epidemiol 2021 Sep 22. Epub 2021 Sep 22.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Emerging evidence suggests trauma experienced in childhood has negative transgenerational implications on offspring mental and physical health. The objective was to investigate whether early life adversity experienced as bereavement is associated with chronic inflammatory health in offspring. The study population included three generations of Swedish families with a base population of 453 516 children (G3) born 2001-2012. Read More

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September 2021

Tolosa-Hunt syndrome as initial presentation of Systemic Lupus Erythematosus.

Acta Neurol Taiwan 2021 Mar;30(1):39-42

Department of Ophthalmology, Chi Mei Medical Center, Tainan, Taiwan.

Purpose: Case presentation of newly diagnosed systemic lupus erythematosus (SLE) presenting initially as Tolosa-Hunt syndrome (THS).

Study Design: Retrospective clinical case.

Method: Case report. Read More

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Determinants for Control of Status Epilepticus in Patients with Anti-N-Methyl-D-Aspartate Receptor Encephalitis.

Acta Neurol Taiwan 2021 Mar;30(1):1-10

Stroke Center and Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.

Background: Treatment guideline for status epilepticus (SE) specifically in patients with anti-N-methyl- D-aspartate receptor (anti-NMDAR) encephalitis is insufficient. This study aimed to clarify the determinants for the control of SE in adult patients with anti-NMDAR encephalitis.

Methods: Medical records of all patients with anti-NMDAR encephalitis hospitalized between Jan. Read More

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