57,847 results match your criteria autism

What is my child telling me? Reducing stress, increasing competence and improving psychological well-being in parents of children with a developmental disability.

Res Dev Disabil 2021 May 12;114:103984. Epub 2021 May 12.

Central Queensland University, Australia. Electronic address:

High levels of stress in parents of children with a developmental disability have been extensively documented. These heightened stress levels seem independent of diagnosis and are better explained by the level of challenging behavior of the children. Furthermore, the relationship between stress level and difficult behavior appears reciprocal. Read More

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Sleep disturbances in autism spectrum disorder without intellectual impairment: relationship with executive function and psychiatric symptoms.

Sleep Med 2021 Apr 22;83:106-114. Epub 2021 Apr 22.

Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain; Group of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institute (VHIR), Barcelona, Catalonia, Spain; Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain; Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.

The autism spectrum disorder (ASD) is a neurodevelopmental condition, frequently accompanied by medical and psychiatric pathology. One of the most commonly found problems associated with ASD is sleep disturbances, which are estimated to affect approximately 80% of the people with ASD, not only during childhood but also in the adolescence and adult stages. Nevertheless, the relationship of these sleep difficulties with autism severity, as well as other associated impairments such as executive functioning and psychiatric disorders (eg, depression), has not yet been widely studied. Read More

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The role of context in verbal humor processing in autism.

J Exp Child Psychol 2021 May 12;209:105166. Epub 2021 May 12.

Developmental Neurocognition Laboratory, Birkbeck College, University of London, London WC1E 7HX, UK.

Difficulties in processing humor have been associated with individuals with autism. The current study investigated whether humor comprehension and appreciation could be augmented in children with autism by providing contextual support suggesting that humor was to be expected. A verbally presented riddle task was used in which participants were assessed for their subjective ratings and comprehension of the materials. Read More

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How children with neurodevelopmental disorders can benefit from the neurocognitive effects of exercise.

Neurosci Biobehav Rev 2021 May 12. Epub 2021 May 12.

University of Tsukuba, Tsukuba, Japan.

Exercise is an integral part of children's lives, and research in educational settings has found that regular engagement promises improvements in executive function (i.e. top-down control of goal-directed behavior). Read More

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Vitamin A supplementation ameliorates motor incoordination via modulating RORα in the cerebellum in a valproic acid-treated rat autism model with vitamin A deficiency.

Neurotoxicology 2021 May 12. Epub 2021 May 12.

Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China; Chongqing Key Laboratory of Child Nutrition and Health, Chongqing, China. Electronic address:

Motor dysfunctions are common comorbidities among autism spectrum disorder (ASD) patients. Abnormal cerebellar development throughout critical periods may have an effect on motor functions and result in motor impairments. Vitamin A (VA) plays a crucial role in the developing process of the nervous system. Read More

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Children with ASD: A Pilot Study.

J Autism Dev Disord 2021 May 15. Epub 2021 May 15.

Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, 28029, Madrid, Spain.

While advances in intensive neonatal care have greatly improved survival rates among preterm infants, incidence of neurodevelopmental disorders in this group is still high, with autism spectrum disorder (ASD) being one of the most frequent. To this end, we conducted a social-communication intervention aimed at investigating efficacy in social-communicative skills. Eighteen children (preterm and full-term with ASD and preterm children) aged 18 through 20 months participated in the study. Read More

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Parental Views of Families of Children with Autism Spectrum Disorder and Developmental Disorders During the COVID-19 Pandemic.

J Autism Dev Disord 2021 May 15. Epub 2021 May 15.

Beach Center On Disability, University of Kansas, Haworth Hall, Room 3102, 1200 Sunnyside Avenue, Lawrence, KS, 66045-7534, USA.

The COVID-19 pandemic, the infection caused by the novel coronavirus detected in December 2019 by World Health Organization (WHO), has detrimentally impacted human life in a variety of areas. Many concepts including outbreak, pandemic, and quarantine have been an inseparable part of our lives. This kind of dialectic change naturally affects persons with autism spectrum disorder (ASD) and developmental disorders (DD) and their families. Read More

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Social attention as a cross-cultural transdiagnostic neurodevelopmental risk marker.

Autism Res 2021 May 15. Epub 2021 May 15.

Neurological Disorders Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.

The primary objectives of this study were to evaluate the structure and age-related stability of social attention in English and Arabic-speaking youth and to compare social attention between children with autism spectrum disorder (ASD), other developmental disabilities (DD), and typically-developing controls. Eye-tracking data were collected from US (N = 270) and Qatari (N = 242) youth ages 1-17, including children evaluated for possible ASD. Participants viewed 44 stimuli from seven social paradigms. Read More

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Specification of oxytocinergic and vasopressinergic circuits in the developing mouse brain.

Commun Biol 2021 May 14;4(1):586. Epub 2021 May 14.

Instituto de Neurociencias CSIC-UMH, San Juan de Alicante, Alicante, Spain.

Oxytocin (OXT) and arginine vasopressin (AVP) support a broad range of behaviors and homeostatic functions including sex-specific and context-appropriate social behaviors. Although the alterations of these systems have been linked with social-related disorders such as autism spectrum disorder, their formation and developmental dynamics remain largely unknown. Using novel brain clearing techniques and 3D imaging, we have reconstructed the specification of oxytocinergic and vasopressinergic circuits in the developing mouse brain with unprecedented cellular resolution. Read More

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Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry.

Commun Biol 2021 May 14;4(1):574. Epub 2021 May 14.

Roche Pharma Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases, Roche Innovation Center Basel, Basel, Switzerland.

Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Read More

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Children with Cerebral Palsy and Unmet Need for Care Coordination.

J Dev Behav Pediatr 2021 May 12. Epub 2021 May 12.

Research Department, Children's Specialized Hospital, New Brunswick, NJ; Physiatry Section, Children's Specialized Hospital, Mountainside, NJ; Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, NJ; Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.

Objective: To examine the physical and functional health of children with cerebral palsy (CP) and determine the prevalence and correlates of unmet need for health care coordination among this population.

Methods: We analyzed data from the 2016 to 2018 National Survey of Children's Health (n = 102,341). Bivariate and multivariable analyses were conducted to compare the prevalence of chronic health conditions, functional disabilities, and care coordination among children with and without CP. Read More

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Early Observation of Red Flags in 12-Month-Old Infant Siblings Later Diagnosed With Autism Spectrum Disorder.

Am J Speech Lang Pathol 2021 May 14:1-10. Epub 2021 May 14.

Department of Clinical Sciences, Florida State University, Tallahassee.

Purpose Valid and reliable screening tools are needed to improve early detection and optimize developmental outcomes for toddlers at risk for autism spectrum disorder (ASD). The current study aimed to evaluate the utility of the Systematic Observation of Red Flags (SORF) for ASD at 12 months of age in a sample of high-risk infant siblings of children with ASD. Method As part of a prospective, longitudinal study, we examined the sensitivity and specificity of the SORF at 12 months for predicting a diagnosis of ASD at 24 months in a sample of 122 infants, 31 of whom were diagnosed with ASD. Read More

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Attentional shift within and between faces: Evidence from children with and without a diagnosis of autism spectrum disorder.

PLoS One 2021 14;16(5):e0251475. Epub 2021 May 14.

Department of Developmental and Social Psychology, University of Padova, Padova, Italy.

Evidence of attentional atypicalities for faces in Autism Spectrum Disorders (ASD) are far from being confirmed. Using eye-tracking technology we compared space-based and object-based attention in children with, and without, a diagnosis of ASD. By capitalizing on Egly's paradigm, we presented two objects (2 faces and their phase-scrambled equivalent) and cued a location in one of the two objects. Read More

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Social communication disorder and behavioural addiction: Case report and clinical implications.

J Behav Addict 2021 May 13. Epub 2021 May 13.

1Psychiatry and Mental Health Department, CHU de Nantes, Nantes, France.

Background: Social communication disorder (SCD) is a neurodevelopmental disorder that includes communication difficulties. Literature linking SCD and addictions is scarce, and there are only a few case reports regarding the co-occurrence of addiction and autism disorder spectrum, and only one of them addressed behavioural addictions.

Case Presentation: We report MC's case, who displayed an SCD and sexual addiction (SA). Read More

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Functional connectivity-based prediction of Autism on site harmonized ABIDE dataset.

IEEE Trans Biomed Eng 2021 May 14;PP. Epub 2021 May 14.

Objective: The larger sample sizes available from multi-site publicly available neuroimaging data repositories makes machine-learning based diagnostic classification of mental disorders more feasible by alleviating the curse of dimensionality. However, since multi-site data are aggregated post-hoc, i.e. Read More

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Testing a Model of Sexual Minority Orientation in Individuals with Typical Development, the Broad Autism Phenotype, and Autism Spectrum Disorder.

J Autism Dev Disord 2021 May 14. Epub 2021 May 14.

The Virginia Consortium Program in Clinical Psychology, 555 Park Avenue, Norfolk, VA, 23504, USA.

Individuals with Autism Spectrum Disorder (ASD) and the Broad Autism Phenotype (BAP) are more likely than individuals with typical development (TD) to report a sexual minority orientation (e.g., Bejerot and Eriksson, PLoS ONE 9:1-9, 2014; DeWinter et al. Read More

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Impact of COVID-19 on Community Participation and Mobility in Young Adults with Autism Spectrum Disorders.

J Autism Dev Disord 2021 May 14. Epub 2021 May 14.

Rutgers Center for Advanced Infrastructure and Transportation, Rutgers University, 100 Brett Road #118, Piscataway, NJ, 08554, USA.

Transportation and mobility for community participation is difficult for persons with Autism Spectrum Disorders (ASD) under normal circumstances, but the impact of COVID-19 made access even more challenging. Researchers used a single-subject design to examine patterns of change from before and after the COVID-19 pandemic in community mobility and participation as measured by GPS and daily participation questionnaires. Participants were young adults with ASD between the ages of 21 and 27 (4 males, 2 females) who were enrolled in a subsequent study. Read More

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Lifestyle changes and risk of cancer: experience from the Swedish women's lifestyle and health cohort study.

Acta Oncol 2021 May 14:1-8. Epub 2021 May 14.

International Agency for Research on Cancer, Lyon, France.

Background: The impact of lifestyle changes on cancer risk is yet to be elucidated. We investigated this issue in the Swedish Women's Lifestyle and Health Cohort Study.

Material And Methods: We measured changes by comparing two questionnaires, filled in 1991/92 and 2003. Read More

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Congenital chromoanagenesis in the routine postnatal chromosomal microarray analyses.

Am J Med Genet A 2021 May 14. Epub 2021 May 14.

The Human Genome and Stem Cell Research Center, Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.

Chromosomal microarray analyses (CMA) have greatly increased both the yield and diagnostic accuracy of postnatal analysis; it has been used as a first-tier cytogenetic test in patients with intellectual disability, autism spectrum disorder, and multiple congenital abnormalities. During the last 15 years, we performed CMA in approximately 8,000 patients with neurodevelopmental and/or congenital disorders, of which 13 (0.16%) genetically catastrophic complex chromosomal rearrangements were identified. Read More

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Current practice and adaptations being made for people with autism admitted to in-patient psychiatric services across the UK.

BJPsych Open 2021 May 14;7(3):e102. Epub 2021 May 14.

Cornwall Intellectual Disability Epilepsy Research (CIDER) Cornwall Partnership NHS Foundation Trust, UK; and University of Plymouth Medical School, UK.

Background: A significant number of people with autism require in-patient psychiatric care. Although the requirement to adequately meet the needs of people with autism in these settings is enshrined in UK law and supported by national guidelines, little information is available on current practice.

Aims: To describe characteristics of UK in-patient psychiatric settings admitting people with autism. Read More

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Nutmegs and wild nutmegs: An update on ethnomedicines, phytochemicals, pharmacology, and toxicity of the Myristicaceae species.

Phytother Res 2021 May 13. Epub 2021 May 13.

Agrotechnology and Rural Development Division, CSIR-North East Institute of Science & Technology, Jorhat, 785006, Assam, India.

Prized medicinal spice true nutmeg is obtained from Myristica fragrans Houtt. Rest species of the family Myristicaceae are known as wild nutmegs. Nutmegs and wild nutmegs are a rich reservoir of bioactive molecules and used in traditional medicines of Europe, Asia, Africa, America against madness, convulsion, cancer, skin infection, malaria, diarrhea, rheumatism, asthma, cough, cold, as stimulant, tonics, and psychotomimetic agents. Read More

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A network analysis of interoception, self-awareness, empathy, alexithymia, and autistic traits.

Eur Arch Psychiatry Clin Neurosci 2021 May 13. Epub 2021 May 13.

Neuropsychology and Applied Cognitive Neuroscience Laboratory, Institute of Psychology, Chinese Academy of Sciences; CAS Key Laboratory of Mental Health, Institute of Psychology, 16 Lincui Road, Beijing, 100101, China.

Altered interoception has been consistently found in people with autism spectrum disorder (ASD), and this impairment may contribute to social cognitive dysfunctions. However, little is known regarding the intercorrelations between interoceptive sensibility, autistic, alexithymic, empathic, and self-related traits. We recruited 1360 non-clinical college students and adults to investigate the complex inter-relationship between these variables using network analysis. Read More

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'Investigating longitudinal associations between parent reported sleep in early childhood and teacher reported executive functioning in school-aged children with autism'.

Sleep 2021 May 14. Epub 2021 May 14.

Montreal Neurological Institute, Azrieli Centre for Autism Research, McGill University, Montreal, Canada.

Up to 80% of children with autism spectrum disorder (ASD) experience sleep disturbance. Poor sleep impairs executive functioning (EF), a lifelong difficulty in ASD. Evidence suggests EF difficulties in ASD are exacerbated by poor sleep. Read More

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A mini-review: Bridging the gap between autism spectrum disorder and pain comorbidities.

Can J Pain 2020 Dec 30;4(4):37-44. Epub 2020 Dec 30.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

Background: Pain is a complex neurobiological response with a multitude of causes; however, patients with autism spectrum disorder (ASD) often report chronic pain with no known etiology. Recent research has been aimed toward identifying the causal mechanisms of pain in mouse and human models of ASD. In recent years, efforts have been made to better document and explore secondary phenotypes observed in ASD patients in the clinic. Read More

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December 2020

Self-compassion, ego-resiliency, coping with stress and the quality of life of parents of children with autism spectrum disorder.

PeerJ 2021 3;9:e11198. Epub 2021 May 3.

Institute of Psychology, University of Silesia, Katowice, Silesia, Poland.

Background: The literature shows a fairly coherent picture of the types of difficulties parents face. Adaptive both coping styles and resources, such as self-compassion and ego-resiliency, indicated as important predictors of the quality of life among parents of children with autism spectrum disorder. The aim of the study was to determine the links between self-compassion and ego-resiliency, coping with stress and quality of life among parents of children with autism spectrum disorder in a Polish sample ( = 76). Read More

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The autistic-like behaviors development during weaning and sexual maturation in VPA-induced autistic-like rats is accompanied by gut microbiota dysbiosis.

PeerJ 2021 3;9:e11103. Epub 2021 May 3.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, P. R. China.

Researches on gut microbiota in autism have mostly focused on children, but the dynamic changes of gut microbiota from weaning to adulthood were still not clear because of the difficulty of diagnosing autism. In this study, autistic-like rats indued by valproate (VPA) were tracked from weaning (end of breastfeeding; four weeks old) to sexual maturation (food; eight weeks old). Autistic-like rats were found to show obvious developmental disorders. Read More

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Genetic Overlap Between Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Gene.

Front Neurosci 2021 27;15:649588. Epub 2021 Apr 27.

Department of Psychology, The Chinese University of Hong Kong, Hong Kong, China.

Recent findings indicated a high comorbidity between attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), as well as shared genetic influences on them. The latter might contribute at least partly to the former clinical scenario. This study aimed at investigating whether genes were potential pleiotropic genes to the two said disorders, underlying their genetic overlap. Read More

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Genomic selection signatures in autism spectrum disorder identifies cognitive genomic tradeoff and its relevance in paradoxical phenotypes of deficits versus potentialities.

Sci Rep 2021 May 13;11(1):10245. Epub 2021 May 13.

Human Molecular Genetics Lab, Neurobiology and Genetics Division, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, 695014, India.

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterized by paradoxical phenotypes of deficits as well as gain in brain function. To address this a genomic tradeoff hypothesis was tested and followed up with the biological interaction and evolutionary significance of positively selected ASD risk genes. SFARI database was used to retrieve the ASD risk genes while for population datasets 1000 genome data was used. Read More

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Bayonet-shaped language development in autism with regression: a retrospective study.

Mol Autism 2021 May 13;12(1):35. Epub 2021 May 13.

Research Center of the CIUSSS-NIM, Hôpital Rivière-Des-Prairies, 7070, Boul. Perras, Montreal, QC, H2E 1A4, Canada.

Background: Language delay is one of the major referral criteria for an autism evaluation. Once an autism spectrum diagnosis is established, the language prognosis is among the main parental concerns. Early language regression (ELR) is observed by 10-50% of parents but its relevance to late language level and socio-communicative ability is uncertain. Read More

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The impact of caregiver stigma on real-life social experience of Taiwanese adolescents with autism spectrum disorder.

Autism 2021 May 13:13623613211004329. Epub 2021 May 13.

Northumbria University, UK.

Lay Abstract: Caregivers of people with autism spectrum disorder commonly experience stigma. As a result, they may avoid contact with others, in turn, influencing their child's social participation. This study aimed to explore the impact of stigma perceived by the caregivers on the everyday social experience of Taiwanese adolescents with autism spectrum disorder. Read More

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