61 results match your criteria author "gemma


Author commentary on Emma C. Robbins et al.

Authors:

Endoscopy 2021 04 29;53(4):v19. Epub 2021 Mar 29.

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A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication?

PLoS Negl Trop Dis 2021 03 17;15(3):e0009144. Epub 2021 Mar 17.

WorldWide Antimalarial Resistance Network (WWARN), Oxford, United Kingdom.

Background: Oral ivermectin is a safe broad spectrum anthelminthic used for treating several neglected tropical diseases (NTDs). Currently, ivermectin use is contraindicated in children weighing less than 15 kg, restricting access to this drug for the treatment of NTDs. Here we provide an updated systematic review of the literature and we conducted an individual-level patient data (IPD) meta-analysis describing the safety of ivermectin in children weighing less than 15 kg. Read More

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Adjuvant Pertuzumab and Trastuzumab in Early HER2-Positive Breast Cancer in the APHINITY Trial: 6 Years' Follow-Up.

J Clin Oncol 2021 May 4;39(13):1448-1457. Epub 2021 Feb 4.

Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.

Purpose: APHINITY, at 45 months median follow-up, showed that pertuzumab added to adjuvant trastuzumab and chemotherapy significantly improved invasive disease-free survival (IDFS) (hazard ratio 0.81 [95% CI, 0.66 to 1. Read More

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Topological data analysis reveals genotype-phenotype relationships in primary ciliary dyskinesia.

Eur Respir J 2021 Jan 21. Epub 2021 Jan 21.

Primary Ciliary Dyskinesia Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Background: Primary ciliary dyskinesia (PCD) is a heterogeneous inherited disorder caused by mutations in approximately 50 cilia-related genes. PCD genotype-phenotype relationships have mostly arisen from small case series because existing statistical approaches to investigate relationships have been unsuitable for rare diseases.

Methods: We applied a topological data analysis (TDA) approach to investigate genotype-phenotype relationships in PCD. Read More

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January 2021

Oral cysteamine as an adjunct treatment in cystic fibrosis pulmonary exacerbations: An exploratory randomized clinical trial.

PLoS One 2020 28;15(12):e0242945. Epub 2020 Dec 28.

NovaBiotics Ltd, Aberdeen, United Kingdom.

Background: Emerging data suggests a possible role for cysteamine as an adjunct treatment for pulmonary exacerbations of cystic fibrosis (CF) that continue to be a major clinical challenge. There are no studies investigating the use of cysteamine in pulmonary exacerbations of CF. This exploratory randomized clinical trial was conducted to answer the question: In future pivotal trials of cysteamine as an adjunct treatment in pulmonary exacerbations of CF, which candidate cysteamine dosing regimens should be tested and which are the most appropriate, clinically meaningful outcome measures to employ as endpoints?

Methods And Findings: Multicentre double-blind randomized clinical trial. Read More

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January 2021

Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation.

Neurogastroenterol Motil 2021 Jun 2;33(6):e14050. Epub 2020 Dec 2.

NIHR Nottingham Biomedical Research Centre (BRC), Hospitals NHS Trust and the University of Nottingham, Nottingham University, Nottingham, UK.

Background: Chronic constipation is a prevalent disorder that affects patients' quality of life and consumes resources in healthcare systems worldwide. In clinical practice, it is still considered a challenge as clinicians frequently are unsure as to which treatments to use and when. Over a decade ago, a Neurogastroenterology & Motility journal supplement devoted to the investigation and management of constipation was published (2009; 21 (Suppl. Read More

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Types and Treatment of Hair Loss in Men and Women.

Authors:
Emma Coleman

Plast Surg Nurs 2020 Oct/Dec;40(4):222-235

Emma Coleman, RGN, is an aesthetic and dermatology registered general nurse, Kent, United Kingdom.

In this article, the author focuses on 4 common hair loss disorders that occur in both men and women. The author discusses research related to androgenetic alopecia, telogen effluvium, alopecia areata, and scarring alopecia and provides details on how to approach and manage these diseases according to patient gender. There are a range of tools and tests that can assist with the diagnostic process and help ensure that relevant and high standards of patient care are maintained. Read More

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December 2020

Still More to Understand in the Intersection Between Gender Diversity and Sexual Development.

Authors:
Jason Rafferty

Pediatrics 2020 12;146(6)

Thundermist Health Center, Woonsocket, Rhode Island; Hasbro Children's Hospital, Providence, Rhode Island; and Emma Pendleton Bradley Hospital, East Providence, Rhode Island

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December 2020

Genotype Predicts Outcomes in Fetuses and Neonates With Severe Congenital Long QT Syndrome.

JACC Clin Electrophysiol 2020 11 26;6(12):1561-1570. Epub 2020 Aug 26.

Joe DiMaggio Children's Hospital Heart Institute, Memorial Healthcare System, Hollywood, Florida, USA.

Objectives: This study sought to determine the relationship between long QT syndrome (LQTS) subtype (LTQ1, LTQ2, LTQ3) and postnatal cardiac events (CEs).

Background: LQTS presenting with 2:1 atrioventricular block or torsades de pointes in the fetus and/or neonate has been associated with risk for major CEs, but overall outcomes and predictors remain unknown.

Methods: A retrospective study involving 25 international centers evaluated the course of fetuses/newborns diagnosed with congenital LQTS and either 2:1 atrioventricular block or torsades de pointes. Read More

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November 2020

Biobank networking and globalisation: perspectives and practices of Australian biobanks.

Aust Health Rev 2021 Mar;45(2):214-222

Deceased. Formerly of Swinburne University of Technology, School of Health Sciences, Faculty of Health, Arts and Design, 427-451 Burwood Road, Hawthorn, Vic. 3122, Australia.

Objective This study examined the practices and attitudes of Australian biobanks regarding access to samples and data, as well as local and global networking with other biobanks. Methods This was a mixed-methods study, including an online survey of Australian biobank administrators and qualitative interviews with survey participants. The survey examined the criteria applied when considering requests to share or network. Read More

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Choreography-Specific Cross-Training and Conditioning Programs.

Authors:
Emma Faulkner

Phys Med Rehabil Clin N Am 2021 02 29;32(1):103-115. Epub 2020 Oct 29.

Atlanta Ballet, Atlanta Dance Medicine, TriHealth Physical Therapy, LLC, Department of Theater and Dance, Emory University, 215 Church Street Suite 101, Decatur, GA 30030, USA. Electronic address:

Because of increased choreographic demands, early specialization, multi-genre dancers, and high incidence of career-ending injuries, there is a need for enhanced training methodologies to address the unique needs of today's professional dancer. It is imperative for company directors, instructors, choreographers, and dance medicine practitioners to consider implementing the most specific conditioning and training programs to prepare their dancers to meet or exceed expectations without resultant injury. Quantifying effectiveness of choreography-specific training programs is an area for further research. Read More

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February 2021

Epiclomal: Probabilistic clustering of sparse single-cell DNA methylation data.

PLoS Comput Biol 2020 09 23;16(9):e1008270. Epub 2020 Sep 23.

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

We present Epiclomal, a probabilistic clustering method arising from a hierarchical mixture model to simultaneously cluster sparse single-cell DNA methylation data and impute missing values. Using synthetic and published single-cell CpG datasets, we show that Epiclomal outperforms non-probabilistic methods and can handle the inherent missing data characteristic that dominates single-cell CpG genome sequences. Using newly generated single-cell 5mCpG sequencing data, we show that Epiclomal discovers sub-clonal methylation patterns in aneuploid tumour genomes, thus defining epiclones that can match or transcend copy number-determined clonal lineages and opening up an important form of clonal analysis in cancer. Read More

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September 2020

Hypermethylated as Circulating Tumor DNA Marker for Disease Monitoring in Neuroblastoma.

JCO Precis Oncol 2020 14;4. Epub 2020 Apr 14.

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.

Purpose: Circulating tumor DNA (ctDNA) has been used for disease monitoring in several types of cancer. The aim of our study was to investigate whether ctDNA can be used for response monitoring in neuroblastoma.

Methods: One hundred forty-nine plasma samples from 56 patients were analyzed by quantitative polymerase chain reaction (qPCR) for total cell free DNA (cfDNA; albumin and β-actin) and ctDNA (hypermethylated ). Read More

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Author Correction: Low-molecular-weight-heparin increases Th1- and Th17-associated chemokine levels during pregnancy in women with unexplained recurrent pregnancy loss: a randomised controlled trial.

Sci Rep 2020 Jun 25;10(1):10600. Epub 2020 Jun 25.

Department of Clinical Immunology and Transfusion Medicine, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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Review of the Use of Platelet-Rich Plasma in the Treatment of Alopecia.

Authors:
Emma Coleman

Plast Surg Nurs 2020 Apr/Jun;40(2):68-72

Emma Coleman, RGN, is the founder of the Emma Coleman Skin Clinics, Kent, England.

Platelet-rich plasma (PRP) therapy is a new approach in dermatology and there is evidence to suggest that it provides excellent adjuvant treatment for nonscarring alopecia cases. There is evidence supporting the hypothesis that PRP therapy increases hair growth and thickness in patients with nonscarring alopecia. Studies including participants with scarring alopecia are limited and larger scale studies with tighter controls in PRP preparation, administration, and follow-up are needed to determine whether this is a clinically sound approach. Read More

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Non-surgical management of methamphetamine induced testicular ischemia.

Urol Case Rep 2020 Sep 3;32:101238. Epub 2020 May 3.

Urologist at Royal Perth Hospital, Victoria Square, Perth, 6000, Australia.

A rare case of methamphetamine induced testicular ischemia, a 35-year-old man with clinical and sonographic features of left epididymitis. However, Ultrasound incidentally showed a lack of vascularity of the right testicle despite being asymptomatic on the right hemi-scrotum. He was a known intravenous methamphetamine user, admitting his last injection was 4 h prior to his presentation. Read More

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September 2020

A cohort study of the service-users of online contraception.

BMJ Sex Reprod Health 2020 10 5;46(4):287-293. Epub 2020 May 5.

School of Population Health & Environmental Sciences, King's College London, London, UK.

Background: In January 2017, the first free service providing oral contraceptive pills (OCPs) ordered online and posted home became available in the London boroughs of Lambeth and Southwark - ethnically and socioeconomically diverse areas with high rates of unplanned pregnancy. There are concerns that online services can increase health inequalities; therefore, we aimed to describe service-users according to age, ethnicity and Index of Multiple Deprivation (IMD) quintile of area of residence and to examine the association of these with repeated use.

Methods: We analysed routinely collected data from January 2017 to April 2018 and described service-users using available sociodemographic factors and information on patterns of use. Read More

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October 2020

Correction to: Identifying Scoliosis in Population‑Based Cohorts: Automation of a Validated Method Based on Total Body Dual Energy X‑ray Absorptiometry Scans.

Calcif Tissue Int 2020 Aug;107(2):201

Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, Bristol, UK.

In the original version of the article, the co-author would like to add to the acknowledgements section to highlight their funding stream (EPSRC). The revised acknowledgements is given below. Read More

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Types and Treatment of Hair Loss in Men and Women.

Authors:
Emma Coleman

Plast Surg Nurs 2020 Jan/Mar;40(1):6-19

Emma Coleman, RGN, is an aesthetic and dermatology registered general nurse, Kent, United Kingdom.

In this article, the author focuses on 4 common hair loss disorders that occur in both men and women. The author discusses research related to androgenetic alopecia, telogen effluvium, alopecia areata, and scarring alopecia and provides details on how to approach and manage these diseases according to patient gender. There are a range of tools and tests that can assist with the diagnostic process and help ensure that relevant and high standards of patient care are maintained. Read More

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October 2020

Methamphetamine use in pregnancy, child protection, and removal of infants: Tertiary centre experience from Western Australia.

Midwifery 2020 Apr 18;83:102641. Epub 2020 Jan 18.

School of Allied Health. UWA, Australia. Electronic address:

The aim of this study is to explore factors that determine infant removal by Child Protective Services and placement in out of home care, for methamphetamine-using women receiving pregnancy care with Western Australia Women and Newborn Drug and Alcohol Service.

Method: A prospective cohort study of 112 methamphetamine-using women attending Women and Newborn Drug and Alcohol Service for pregnancy care from 2015 to 2018 was undertaken. Maternal methamphetamine use was assessed during each trimester of pregnancy using a standardised assessment tool. Read More

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Common mental disorders among young refugees in Sweden: The role of education and duration of residency.

J Affect Disord 2020 04 4;266:563-571. Epub 2020 Feb 4.

Department of Clinical Neuroscience, Division of Insurance Medicine, Karolinska Institutet, Stockholm, Sweden.

Background: Studies investigating risks of common mental disorders (CMDs) in refugee youth are sparse. The current study examined health care use due to CMDs in unaccompanied and accompanied refugee youth and Swedish-born, and the role of education and residency duration.

Methods: This longitudinal cohort study included 746,517 individuals (whereof 36,347 refugees) between 19 and 25 years, residing in Sweden in 2009. Read More

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Attention Deficit/Hyperactivity Disorder and risk for non-affective psychotic disorder: The role of ADHD medication and comorbidity, and sibling comparison.

Schizophr Res 2020 04 27;218:124-130. Epub 2020 Jan 27.

Department of Public Health Sciences, Division Public Health Epidemiology, Karolinska Institutet, Stockholm, Sweden; Center for Epidemiology and Community Medicine, Stockholm County Council, Stockholm, Sweden.

Attention Deficit/Hyperactivity Disorder (ADHD) is the most common psychiatric disorder in childhood. It is unclear whether ADHD increases the risk of non-affective psychotic disorder (NAPD). The study included a matched cohort, drawn from all born in Sweden 1987-1991 (n = 548,852). Read More

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Author Correction: Climate change, range shifts, and the disruption of a pollinator-plant complex.

Sci Rep 2019 Nov 20;9(1):17503. Epub 2019 Nov 20.

Department of Wildlife and Fisheries Sciences, Texas A&M University, 534 John Kimbrough Blvd., TAMU 2258, College Station, TX, 77843-2258, USA.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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November 2019

Expanding choice through online contraception: a theory of change to inform service development and evaluation.

BMJ Sex Reprod Health 2020 Apr 1;46(2):108-115. Epub 2019 Nov 1.

School of Population Health & Environmental Sciences, King's College London, London, UK.

Background: This study presents the theory of change underpinning an intervention to provide online contraceptive care in an inner London area with high rates of unplanned pregnancy. It aims to suggest attributes of an effective service and to identify key questions for its evaluation.

Methods: Thematic analysis of an online sexual and reproductive health programme funding application and 21 semi-structured interviews with a purposive sample of stakeholders selected to provide expertise in contraception and online health. Read More

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The author replies.

Authors:
Reinout A Bem

Pediatr Crit Care Med 2019 08;20(8):798

Pediatric Intensive Care Unit, Emma Children's Hospital, Amsterdam UMC, location AMC, University of Amsterdam, Amsterdam, The Netherlands.

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Fertility Preservation Outcomes and Considerations in Transgender and Gender-Diverse Youth.

Authors:
Jason Rafferty

Pediatrics 2019 09 5;144(3). Epub 2019 Aug 5.

Thundermist Health Centers, Woonsocket, Rhode Island; Hasbro Children's Hospital, Providence, Rhode Island; and Emma Pendleton Bradley Hospital, East Providence, Rhode Island

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September 2019

Correction to: Migalastat: A Review in Fabry Disease.

Drugs 2019 08;79(12):1363

Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

The article Migalastat: A Review in Fabry Disease, written by Emma H. McCafferty, Lesley J. Scott, was originally published Online First without open access. Read More

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