46,085 results match your criteria atypical clinical

Aortic Angiosarcoma in Association with Endovascular Aneurysm Repair: Case Report and Review of the Literature.

Am J Case Rep 2021 Jun 12;22:e931740. Epub 2021 Jun 12.

Division of Clinical Pathology, Niigata University Faculty of Medicine, Niigata, Japan.

BACKGROUND Primary aortic sarcoma often poses diagnostic challenges for pathologists and clinicians because of a very low incidence and controversy over nomenclature and definition. We report a case of aortic angiosarcoma in association with a graft. We also conducted a clinicopathological review of cases of primary aortic sarcomas associated with implanted grafts. Read More

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How I Diagnose Angioimmunoblastic T-Cell Lymphoma.

Am J Clin Pathol 2021 Jun 12. Epub 2021 Jun 12.

Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Objectives: Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma derived from T-follicular helper cells. For pathologists, diagnosing AITL may be challenging due to its wide clinical and histopathologic spectrum, which can mimic a variety of reactive and neoplastic processes.

Methods: We summarize and discuss the clinicopathologic features of AITL, emphasizing diagnostic tools available to the practicing pathologist. Read More

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Clinical and functional characterization of atypical KRAS/NRAS mutations in metastatic colorectal cancer.

Clin Cancer Res 2021 Jun 11. Epub 2021 Jun 11.

Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center

Purpose: Mutations in () predict lack of anti-EGFR efficacy in metastatic colorectal cancer (mCRC). However, it is unclear if all mutations have similar impact and atypical mutations beyond those in standard guidelines exist.

Experimental Design: We reviewed 7 tissue and 1 cfDNA cohorts of 9485 patients to characterize atypical variants. Read More

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Evaluation of liver enzyme elevations and hepatotoxicity in patients treated with checkpoint inhibitor immunotherapy.

PLoS One 2021 11;16(6):e0253070. Epub 2021 Jun 11.

Toronto Centre for Liver Disease, University Health Network, Toronto, Canada.

Background And Aims: Immune checkpoint inhibitors (ICI) are increasingly used in cancer therapy. Elevated liver enzymes frequently occur in patients treated with ICI but evaluation is poorly described. We sought to better understand causes of liver enzyme elevation, investigation and management. Read More

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Meningioma preceding CASPR2 antibody limbic encephalitis with a stroke mimic: A case report.

Medicine (Baltimore) 2021 Jun;100(23):e26241

Department of Neurology, Weifang People's Hospital (The First Affiliated Hospital of Weifang Medical University), Weifang, Shandong, China.

Rationale: Todd paralysis (a stroke-like presentation in some patients with epilepsy) caused by limbic encephalitis (LE) is not easily distinguished from acute ischemic stroke by clinicians in the emergency room.

Patient Concerns: We report a contactin-associated protein-like 2-antibody (CASPR2-Ab)-positive patient who presented with atypical LE.

Diagnoses: CASPR2-Ab-positive LE was the presumed diagnosis. Read More

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KCNT1-related epilepsies and epileptic encephalopathies: phenotypic and mutational spectrum.

Brain 2021 Jun 11. Epub 2021 Jun 11.

Pediatric Neurology Department, Lyon University Hospital, 69500 Bron, France.

Variants in KCNT1, encoding a sodium-gated potassium channel (subfamily T member 1), have been associated with a spectrum of epilepsies and neurodevelopmental disorders. These range from familial autosomal dominant or sporadic sleep-related hypermotor epilepsy ((AD)SHE) to epilepsy of infancy with migrating focal seizures (EIMFS) and include developmental and epileptic encephalopathies (DEE). This study aims to provide a comprehensive overview of the phenotypic and genotypic spectrum of KCNT1 mutation-related epileptic disorders in 248 individuals, including 66 unpreviously published and 182 published cases, the largest cohort reported so far. Read More

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An atypical ear nodule.

Indian J Dermatol Venereol Leprol 2021 May 8:1-2. Epub 2021 May 8.

Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.

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Imaging side effects and complications of chemotherapy and radiation therapy: a pictorial review from head to toe.

Insights Imaging 2021 Jun 10;12(1):76. Epub 2021 Jun 10.

IRCCS Istituto Ortopedico Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy.

Newer biologic drugs and immunomodulatory agents, as well as more tolerated and effective radiation therapy schemes, have reduced treatment toxicity in oncology patients. However, although imaging assessment of tumor response is adapting to atypical responses like tumor flare, expected changes and complications of chemo/radiotherapy are still routinely encountered in post-treatment imaging examinations. Radiologists must be aware of old and newer therapeutic options and related side effects or complications to avoid a misinterpretation of imaging findings. Read More

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The Efficacy and Safety of Carbon Ion Radiotherapy for Meningiomas: A Systematic Review and Meta-Analysis.

Front Oncol 2021 25;11:620534. Epub 2021 May 25.

Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.

Objective: The purpose of this systematic review and meta-analysis is to evaluate the efficacy and safety of carbon ion radiotherapy (CI-RT) in improving meningioma by comparing photon and protons radiotherapy.

Methods: A comprehensive search for relevant studies published until March 17, 2021, was conducted in PubMed, the Cochrane Library, Chinese Biomedical Literature Database and EMBASE. Statistical analyses were performed with R 4. Read More

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A Conservative Management Approach for Unusual Presentation of Oral Actinomycosis.

Qamar Hashem

Case Rep Dent 2021 18;2021:5570758. Epub 2021 May 18.

Clinical Dental Sciences Department/Endodontic Division College of Dentistry, Princes Noura Bint Abdulrahman University, Riyadh, Saudi Arabia.

Actinomycosis is gram-positive saprophytic infection that is characterized by chronic suppurative and granulomatous lesion. It could be found in the oral cavity, lungs, colon, and genital area. In the oral cavity, it is commonly associated with infected root canals presented as persistent infections. Read More

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Non-S Sickling Hemoglobin Variants: Historical, Genetic, Diagnostic, and Clinical Perspectives.

Oman Med J 2021 May 31;36(3):e261. Epub 2021 May 31.

Department of Pediatrics, Aminu Kano Teaching Hospital, Kano State, Nigeria.

Apart from hemoglobin-S (HbS), there are other Hb variants (non-S sickling Hb variants) that cause sickle cell disease. However, the profiles of these non-S sickling Hb variants have neither been collated nor harmonized. A literature search revealed 14 non-S sickling Hb variants (HbC-Harlem, HbC-Ziguinchor, HbS-Travis, HbS-Antilles, HbS-Providence, HbS-Oman, HbS-Cameroon, HbS-South End, Hb Jamaica Plain, HbC-Ndjamena, HbS-Clichy, HbS-San Martin, HbS-Wake, and HbS-São Paulo). Read More

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Genetic and Metabolite Variability in One-Carbon Metabolism Applied to an Insulin Resistance Model in Patients With Schizophrenia Receiving Atypical Antipsychotics.

Front Psychiatry 2021 25;12:623143. Epub 2021 May 25.

Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI, United States.

Patients with schizophrenia are at high risk of pre-mature mortality due to cardiovascular disease (CVD). Our group has completed studies in pharmacogenomics and metabolomics that have independently identified perturbations in one-carbon metabolism as associated with risk factors for CVD in this patient population. Therefore, this study aimed to use genetic and metabolomic data to determine the relationship between folate pharmacogenomics, one-carbon metabolites, and insulin resistance as measured using the homeostatic model assessment for insulin resistance (HOMA-IR) as a marker of CVD. Read More

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Diagnostic Approaches for Large Vessel Vasculitides.

Open Access Rheumatol 2021 1;13:153-165. Epub 2021 Jun 1.

Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium.

The large vessel vasculitides comprise giant cell arteritis (GCA), Takayasu arteritis (TAK), and chronic periaortitis. The diagnostic approach to these conditions involves the correct use and interpretation of clinical criteria, imaging techniques, and, in case of GCA, temporal artery biopsy. Ultrasound, magnetic resonance imaging (MRI), and computed tomography (CT) reveal a homogeneous, concentric, thickening of the arterial wall. Read More

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Behavioral Therapy for Tremor or Dystonia Affecting Voice in Speakers with Hyperkinetic Dysarthria: A Systematic Review.

J Voice 2021 Jun 7. Epub 2021 Jun 7.

Department of Physical Medicine & Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Think + Speak Lab, Shirley Ryan AbilityLab, Chicago, Illinois.

Introduction: Hyperkinetic dysarthria is characterized by atypical involuntary movements within the speech mechanism that may affect the respiratory, laryngeal, pharyngeal-oral, or velopharyngeal-nasal subsystems and may alter speech production. Although articulatory impairments are commonly considered in hyperkinetic dysarthria, speakers with hyperkinetic dysarthria may also present with changes in voice quality, pitch, and loudness. In approximately 70% of speakers with hyperkinetic dysarthria, these voice alterations are associated with tremor or dystonia. Read More

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Amnion epithelial cells are an effective source of factor H and prevent kidney complement deposition in factor H-deficient mice.

Stem Cell Res Ther 2021 Jun 10;12(1):332. Epub 2021 Jun 10.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via GB Camozzi 3, 24020, Ranica, Bergamo, Italy.

Complement factor H (FH) is the main plasma regulator of the alternative pathway of complement. Genetic and acquired abnormalities in FH cause uncontrolled complement activation amplifying, with the consequent accumulation of complement components on the renal glomeruli. This leads to conditions such as C3 glomerulopathy (C3G) and atypical hemolytic uremic syndrome (aHUS). Read More

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Clinical features of NK/T-cell EBV-associated LPD manifested as gastrointestinal symptoms in patients with normal immunity: a case report and literature review.

BMC Gastroenterol 2021 Jun 10;21(1):254. Epub 2021 Jun 10.

Department of Gastroenterology, The Second Xiangya Hospital, Changsha, 410011, Hunan, China.

Background: Epstein-Barr virus (EBV)-associated NK/T-cell lymphoproliferative disorder (LPD) involving the gastrointestinal tract is rarely observed in individuals with normal immunity. The atypical clinical, colonoscopic manifestations often confuse clinicians, leading to misdiagnosis and delays in the treatment.

Case Presentation: Herein, we reported on a single case of a patient with gastrointestinal symptoms. Read More

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Diagnostic interpretation of non-contrast qualitative MR imaging features for characterisation of uterine leiomyosarcoma.

Br J Radiol 2021 Jun 11:20210115. Epub 2021 Jun 11.

Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, UK.

Objective: To assess the value of non-contrast MRI features for characterisation of uterine leiomyosarcoma (LMS) and differentiation from atypical benign leiomyomas.

Methods: This study included 57 atypical leiomyomas and 16 LMS which were referred preoperatively for management review to the specialist gynae-oncology multidisciplinary team meeting. Non-contrast MRIs were retrospectively reviewed by five independent readers (three senior, two junior) and a five-level Likert score (1-low/5-high) was assigned to each mass for likelihood of LMS. Read More

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Machine learning accurately classifies neural responses to rhythmic speech vs. non-speech from 8-week-old infant EEG.

Brain Lang 2021 Jun 7;220:104968. Epub 2021 Jun 7.

Centre for Neuroscience in Education, Department of Psychology, University of Cambridge, UK.

Currently there are no reliable means of identifying infants at-risk for later language disorders. Infant neural responses to rhythmic stimuli may offer a solution, as neural tracking of rhythm is atypical in children with developmental language disorders. However, infant brain recordings are noisy. Read More

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Adaptation and psychometric validation of Hindi version of the Behavioural Emotion Regulation Questionnaire.

Asian J Psychiatr 2021 Jun 5;62:102730. Epub 2021 Jun 5.

Department of Clinical Psychology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, 560029, India.

Background: The Behavioural Emotion Regulation Questionnaire (BERQ; Kraaij and Garnefski, 2019) is a recently developed tool which assesses behavioural strategies for emotion regulation.

Aim: The present study aimed at validating the factor structure and psychometric properties of the Hindi version of the BERQ (BERQ-H) in a sample of Indian population.

Method: A community sample of n = 358 individuals completed the Hindi version of the Behavioural Emotion Regulation Questionnaire, Patient Health Questionnaire-9, Generalized Anxiety Disorder Scale-7, and the Kessler Psychological Distress Scale (K-10). Read More

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Evaluation of UMELISA CHAGAS™ with the incorporation of new monomeric and chimeric peptides representative of different regions of Trypanosoma cruzi

Biomedica 2021 05 31;41(Supl. 1):113-120. Epub 2021 May 31.

Centro de Inmunoensayo, La Habana, Cuba.

Introduction: Most people with Chagas disease develop specific antibodies against Trypanosoma cruzi. In early infection, IgM antibodies against T. cruzi are produced and later replaced for IgG antibodies during the course of the disease. Read More

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Emergent Admissions to the Epilepsy Monitoring Unit in the Setting of COVID-19 Pandemic-related, State-mandated Restrictions: Clinical Decision Making and Outcomes.

Neurodiagn J 2021 Jun 10:1-9. Epub 2021 Jun 10.

Department of NeurologyUniversity of Texas Southwestern Medical Center, Dallas, Texas.

Due to the coronavirus disease 2019 (COVID-19) pandemic, the state of Texas-limited elective procedures to conserve beds and personal protective equipment (PPE); therefore, between March 22 and May 18, 2020, admission to the epilepsy monitoring unit (EMU) was limited only to urgent and emergent cases. We evaluated clinical characteristics and outcomes of these patients who were admitted to the EMU. Nineteen patients were admitted (one patient twice) with average age of 36. Read More

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Talaromyces marneffei infection in non-HIV-infected patients in mainland China.

Mycoses 2021 Jun 10. Epub 2021 Jun 10.

Department of Dermatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Background: Talaromyces marneffei, formerly known as Penicillium marneffei, is a significant emerging pathogenic fungus in Southeast Asia which can generate life-threatening systemic infections. Human Immunodeficiency Virus (HIV) infection is considered as the most underlying disease among systemic infections. However, infections due to T. Read More

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Severe speech impairment is a distinguishing feature of FOXP1-related disorder.

Dev Med Child Neurol 2021 Jun 9. Epub 2021 Jun 9.

Murdoch Children's Research Institute, Parkville, VIC, Australia.

Aim: To delineate the speech and language phenotype of a cohort of individuals with FOXP1-related disorder.

Method: We administered a standardized test battery to examine speech and oral motor function, receptive and expressive language, non-verbal cognition, and adaptive behaviour. Clinical history and cognitive assessments were analysed together with speech and language findings. Read More

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A Systematic Review and Meta-Analysis of Autoantibodies for Diagnosis and Prognosis in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy.

Front Neurosci 2021 24;15:637336. Epub 2021 May 24.

Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China.

To review the available evidence on sensitivity and specificity of anti-NF155 antibody detection in diagnosing a specific subset of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and to calculate the frequencies of different autoantibodies to paranodal proteins. Diagnosis of CIDP relies on clinical and neurophysiologic criteria and lacks useful diagnostic biomarkers. A subset of CIDP patients exhibit atypical clinical phenotypes and impaired response to conventional treatments. Read More

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Fumarate Hydratase Deficiency Should be Considered in the Differential Diagnosis of Uterine and Extrauterine Smooth Muscle Tumors of Uncertain Malignant Potential (STUMP).

Int J Gynecol Pathol 2021 Jun 9. Epub 2021 Jun 9.

Department of Pathology, Stanford University School of Medicine, Stanford, California.

Fumarate hydratase-deficient leiomyomas (dFH leiomyomas) often display atypical pathologic features yet exhibit a benign clinical course. Recent data suggest that dFH leiomyomas may be misclassified as smooth muscle tumors of uncertain malignant potential, a category that encompasses a heterogenous subgroup of uterine neoplasms with smooth muscle differentiation and atypical features that impart ambiguity regarding their expected clinical behavior. dFH leiomyomas can be seen in the context of hereditary leiomyomatosis and renal cell carcinoma syndrome or in the sporadic setting. Read More

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Are Lung Ultrasound Findings in COVID-19 Pneumonia Typical or Specific?

Praxis (Bern 1994) 2021 Jun;110(8):421-425

Emergency Medicine, San Luigi Gonzaga University Hospital, Torino, Italy.

The application of point-of-care lung ultrasound (LUS) in the first diagnosis and management of Corona Virus Disease 2019 (COVID-19) has gained a great interest during a pandemic that is undermining even the most advanced health systems. LUS demonstrated high sensitivity in the visualization of the interstitial signs of the typical pneumonia complicating the infection. However, although this disease gives typical lung alterations, the same LUS signs observed in COVID-19 pneumonia can be detected in other common pulmonary conditions. Read More

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COVID-19 Infection and Acute Kidney Injury: Cause or Complication?

Blood Purif 2021 Jun 9:1-4. Epub 2021 Jun 9.

San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy.

Management of COVID-19 infection is the trend topic in the scientific community and case identification is a key step to contain the pandemic. While pneumonia and acute respiratory distress syndrome represent the typical severe manifestations of the disease, atypical presentations pose significant diagnostic and therapeutic challenges for physicians, especially when diagnostic tests are repeatedly negative. Clinical picture of COVID-19 patients is often complicated by bacterial infections or thrombotic events. Read More

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Clinical optochin resistant Streptococcus pneumoniae and Streptococcus pseudopneumoniae strains in Tunisia.

J Infect Dev Ctries 2021 May 31;15(5):672-677. Epub 2021 May 31.

Habib Bourguiba University Hospital, Sfax, Tunisia.

Introduction: Streptococcus pneumoniae can be responsible for severe human infections. Optochin resistance has been a potential cause of misidentification of pneumococcus and other members of the mitis group. Hence, rapid and easy optochin resistant (Optr) S. Read More

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Pterygium: an update on pathophysiology, clinical features, and management.

Ther Adv Ophthalmol 2021 Jan-Dec;13:25158414211020152. Epub 2021 May 31.

Ophthalmic Research Center, Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pterygium is a relatively common ocular surface disease. The clinical aspects and the treatment options have been studied since many years ago, but many uncertainties still exist. The core pathologic pathway and the role of heredity in the development of pterygium are still attractive fields for the researchers. Read More

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Real-World Medication Treatment Patterns for Long-Term Care Residents with Dementia-Related Psychosis.

Gerontol Geriatr Med 2021 Jan-Dec;7:23337214211016565. Epub 2021 May 31.

New York Medical College, Valhalla, NY, USA.

This study evaluated treatment patterns and factors associated with medication treatment changes in residents with dementia-related psychosis in a long-term care (LTC) setting. A retrospective database cohort study was conducted using the national PharMerica database and included dementia residents with or without incident psychosis. Treatment patterns were assessed and a multivariate logistic regression model was used to identify factors associated with any treatment change (discontinuation, switch, or sporadic use) in dementia-related psychosis therapy. Read More

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