11,395 results match your criteria atypical antipsychotic

Development of an analytical method for the determination of pimavanserin and its impurities applying analytical quality by design principles as a risk-based strategy.

J Pharm Biomed Anal 2021 Apr 24;201:114091. Epub 2021 Apr 24.

Department of Analytical Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Marulića 19, 10000, Zagreb, Croatia. Electronic address:

Pimavanserin is an atypical antipsychotic indicated for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis. As it is a relatively new drug on the market, limited number of pharmacokinetic information and analytical methods are available. This paper presents an ultra-high performance chromatography for the simultaneous determination of pimavanserin and its four process impurities. Read More

View Article and Full-Text PDF

Association Between ApoA1 Gene Polymorphisms and Antipsychotic Drug-Induced Dyslipidemia in Schizophrenia.

Neuropsychiatr Dis Treat 2021 30;17:1289-1297. Epub 2021 Apr 30.

Department of Medical Laboratory, Huai'an Third People's Hospital, Huai'an, People's Republic of China.

Purpose: Dyslipidemia frequently occurs in schizophrenia patients treated with antipsychotic drugs (APDs), especially atypical APDs. Apolipoprotein A1 (ApoA1) plays a key role in lipid metabolism. The aim of this study was to investigate whether ApoA1 gene polymorphisms are associated with APD-induced dyslipidemia in schizophrenia patients. Read More

View Article and Full-Text PDF

Atypical antipsychotics: Managing adverse effects.

Perspect Psychiatr Care 2021 May 5. Epub 2021 May 5.

Department of Health and Community Systems, University of Pittsburgh, School of Nursing, Pittsburgh, Pennsylvania, USA.

Purpose: The purpose of this article is to provide an overview of common adverse effects and management strategies related to atypical antipsychotic use.

Conclusions: Atypical antipsychotics are commonly prescribed. While effective, atypical antipsychotics are associated with metabolic syndrome, extrapyramidal symptoms, and tardive dyskinesia, among others adverse effects. Read More

View Article and Full-Text PDF

Empagliflozin Effectively Attenuates Olanzapine-Induced Body Weight Gain in Female Wistar Rats.

Front Pharmacol 2021 19;12:578716. Epub 2021 Apr 19.

Department of Psychiatry and Neurology, Harvard Medical School and McLean Hospital, Belmont, MA, United States.

Atypical antipsychotic drugs are commonly associated with undesirable side effects including body weight gain (BWG) and metabolic deficits. Many pharmacological interventions have been tested in an attempt to minimize or prevent these side effects. Preliminary evidence suggests that antidiabetic drugs may be effective in attenuating antipsychotic-induced BWG. Read More

View Article and Full-Text PDF

Differential Effectiveness of Atypical Antipsychotics on Hallucinations: A Pragmatic Randomized Controlled Trial.

J Clin Psychopharmacol 2021 Apr 30. Epub 2021 Apr 30.

From the Division of Psychiatry NORMENT Centre of Excellence, Haukeland University Hospital Department of Clinical Medicine, Section of Psychiatry, Faculty of Medicine Department of Biological and Medical Psychology, University of Bergen Department of Addiction Medicine, Haukeland University Hospital Department of Clinical Psychology, University of Bergen, Bergen, Norway Medizinische Universität Innsbruck, Innsbruck, Austria TIPS Centre for Clinical Research in Psychosis, Psychiatric Division, Stavanger University Hospital Faculty of Health, Network for Medical Sciences, University of Stavanger, Stavanger Department of Mental Health, St Olav's University Hospital Department of Mental Health, Faculty of Medicine and Health Science, NTNU, Trondheim, Norway.

Background: Most studies investigating antipsychotic effectiveness report either total psychopathology or symptom cluster findings. Studies focusing on a separate symptom, such as hallucinations, a hallmark symptom in schizophrenia, are scarce.Therefore, the current study aims to compare the antihallucinatory effectiveness of 3 pharmacologically different antipsychotics: olanzapine, amisulpride, and aripiprazole. Read More

View Article and Full-Text PDF

Managing agitation during early recovery in adults with traumatic brain injury: an international survey.

Ann Phys Rehabil Med 2021 Apr 29:101532. Epub 2021 Apr 29.

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Australia; Monash-Epworth Rehabilitation Research Centre, Epworth Healthcare, Melbourne, Australia; Rehabilitation and Mental Health Division, Epworth Healthcare, Melbourne, Australia.

Background: Managing agitation is a significant challenge in the early stages of recovery after traumatic brain injury (TBI), and research investigating current practice during this period is lacking.

Objectives: This study examined how clinicians worldwide conceptualise, measure and manage agitation during early TBI recovery.

Methods: A cross-sectional anonymous online survey was distributed via email, newsletters, conferences and social media to clinicians involved in early TBI care worldwide. Read More

View Article and Full-Text PDF

Antipsychotic clozapine binding to alpha-2-macroglobulin protects interacting partners against oxidation and preserves the anti-proteinase activity of the protein.

Int J Biol Macromol 2021 Apr 28;183:502-512. Epub 2021 Apr 28.

Institute for Application of Nuclear Energy, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.

In this study, the interaction between clozapine, an atypical antipsychotic drug, and alpha-2-macroglobulin (αM), a multipurpose anti-proteinase, was investigated under simulated (patho) physiological conditions using multiple spectroscopic techniques and molecular modeling. It was found that αM binds clozapine with a moderate affinity (the binding constant of 0.9 × 10 M at 37 °C). Read More

View Article and Full-Text PDF

The Antipsychotic Risperidone Alters Dihydroceramide and Ceramide Composition and Plasma Membrane Function in Leukocytes In Vitro and In Vivo.

Int J Mol Sci 2021 Apr 10;22(8). Epub 2021 Apr 10.

Servicio de Bioquímica-Investigación, Hospital Universitario Ramón y Cajal, IRyCIS, 28034 Madrid, Spain.

Atypical or second-generation antipsychotics are used in the treatment of psychosis and behavioral problems in older persons with dementia. However, these pharmaceutical drugs are associated with an increased risk of stroke in such patients. In this study, we evaluated the effects of risperidone treatment on phospholipid and sphingolipid composition and lipid raft function in peripheral blood mononuclear cells (PBMCs) of older patients (mean age >88 years). Read More

View Article and Full-Text PDF

Severe Tachycardia Associated with Psychotropic Medications in Psychiatric Inpatients: A Study of Hospital Medical Emergency Team Activation.

J Clin Med 2021 Apr 6;10(7). Epub 2021 Apr 6.

Department of Psychiatry, Monash Health, Clayton, VIC 3168, Australia.

The use of antipsychotic medications is associated with side effects, but the occurrence of severe tachycardia (heart rate ≥ 130 per minute) is not well described. The aim of this study was to determine the frequency and strength of the association between antipsychotic use and severe tachycardia in an inpatient population of patients with mental illness, while considering factors which may contribute to tachycardia. We retrospectively analyzed data from 636 Medical Emergency Team (MET) calls occurring in 449 psychiatry inpatients in three metropolitan hospitals co-located with acute medical services, and used mixed-effects logistic regression to model the association between severe tachycardia and antipsychotic use. Read More

View Article and Full-Text PDF

Clozapine Response for Vocal Tics in Schizophrenic Patients: A Case Report With Literature Review.

Cureus 2021 Mar 25;13(3):e14111. Epub 2021 Mar 25.

Psychiatry, Interfaith Medical Center, Brooklyn, USA.

Antipsychotics have been documented in the literature as the most effective pharmacological treatment for tics thus far. Additionally, evidence in the literature has shown that typical and atypical antipsychotics are effective for the treatment of tic disorders in patients who are diagnosed with schizophrenia and other psychiatric illnesses. This evidence is typified as atypical antipsychotic medications, such as risperidone, aripiprazole, and olanzapine, have been documented as being effective for motor tics, particularly in Tourette's syndrome. Read More

View Article and Full-Text PDF

Atypical antipsychotics in the treatment of psychotic symptoms in Alzheimer's disease: a systematic review.

Int Clin Psychopharmacol 2021 Apr 23. Epub 2021 Apr 23.

Department of Psychiatry Department of Cellular and Molecular Biology Department of Medical Psychology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Introduction: With the advancement of Alzheimer's disease as well as other types of dementia, in addition to the cognitive decline, psychiatric symptoms have been outlined, including psychotic symptoms.

Objectives: The aim of the study is to review the available results on the antipsychotic treatment of Alzheimer's disease associated psychotic symptoms. The main objective of the study is to evaluate the efficacy of the treatment. Read More

View Article and Full-Text PDF

Case of paediatric catatonia precipitated by antipsychotic withdrawal in a child with autism spectrum disorder.

BMJ Case Rep 2021 Apr 23;14(4). Epub 2021 Apr 23.

Child and Adolescent Mental Health Services, Unit 6 Quin Road Business Park, Ennis, Ireland.

A 13-year-old girl with moderate intellectual disability and autism spectrum disorder (ASD) was admitted to the paediatric high-dependency unit following an 8-week history of altered mental status and motor behaviour. Her symptoms emerged followed shortly after discontinuation of risperidone, an atypical antipsychotic previously commenced to manage disruptive behaviour associated with ASD. On physical examination, the patient presented with negativism, grimacing, automatic obedience, waxy flexibility and ambitendency. Read More

View Article and Full-Text PDF

Quantitative Resting State Electroencephalography in Patients with Schizophrenia Spectrum Disorders Treated with Strict Monotherapy Using Atypical Antipsychotics.

Clin Psychopharmacol Neurosci 2021 May;19(2):313-322

Department of Psychiatry, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Objective: The effect of antipsychotic drugs on quantitative electroencephalography (EEG) has been mainly examined by the administration of a single test dose or among patients using combinations of other psychotropic drugs. We therefore investigated the effects of strict monotherapy with antipsychotic drugs on quantitative EEG among schizophrenia patients.

Methods: Data from 2,364 medical reports with EEG results from psychiatric patients admitted to the Hokkaido University Hospital were used. Read More

View Article and Full-Text PDF

The Antipsychotic Drug Clozapine Suppresses the RGS4 Polyubiquitylation and Proteasomal Degradation Mediated by the Arg/N-Degron Pathway.

Neurotherapeutics 2021 Apr 21. Epub 2021 Apr 21.

Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, 03080, Korea.

Although diverse antipsychotic drugs have been developed for the treatment of schizophrenia, most of their mechanisms of action remain elusive. Regulator of G-protein signaling 4 (RGS4) has been reported to be linked, both genetically and functionally, with schizophrenia and is a physiological substrate of the arginylation branch of the N-degron pathway (Arg/N-degron pathway). Here, we show that the atypical antipsychotic drug clozapine significantly inhibits proteasomal degradation of RGS4 proteins without affecting their transcriptional expression. Read More

View Article and Full-Text PDF

Resolution of enuresis with aripiprazole in children with psychiatric disorders: two case reports.

J Med Case Rep 2021 Apr 21;15(1):209. Epub 2021 Apr 21.

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialities "G. D'Alessandro", University of Palermo, via A. Giordano, Palermo, Italy.

Background: Aripiprazole is a third-generation atypical antipsychotic drug that acts as a stabilizer of the dopaminergic and serotonergic system. As partial agonist of the dopamine (D2) and serotonin (5-HT1A) receptors, it appears to be effective in reducing mania in patients with bipolar disorder, tics in Tourette Syndrome, aggression in schizophrenia and autism spectrum disorder. Enuresis has been reported among its side effects. Read More

View Article and Full-Text PDF

Real-world data analysis of the clinical and economic burden and risk factors in patients with major depressive disorder with an inadequate response to initial antidepressants.

J Med Econ 2021 Jan-Dec;24(1):589-597

School of Pharmacy, Sungkyunkwan University, Gyeonggi-do, Republic of Korea.

Aim: We aimed to determine the incidence of and identify the factors associated with treatment-resistant depression (TRD), psychiatric conditions, hospitalization, and cost in patients with major depressive disorder (MDD) who were treated using second-line strategies after an inadequate response to initial antidepressants (AD).

Materials And Methods: Using South Korean National Health Insurance claims data (1 January 2013 to 30 June 2018), we conducted a retrospective cohort analysis in newly treated patients with MDD who subsequently switched or added AD, or added atypical antipsychotics (AAPs) as a second-line treatment. We assessed the incidence of treatment-resistant depression (TRD), psychiatric conditions, and hospitalization for the first 2 years and costs in the third year. Read More

View Article and Full-Text PDF

Regulation of monoamine levels by typical and atypical antipsychotics in Caenorhabditis elegans mutant for nuclear distribution element genes.

Neurochem Int 2021 Apr 17;147:105047. Epub 2021 Apr 17.

Department of Pharmacology, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), Brazil; National Institute for Translational Medicine (INCT-TM, CNPq), Brazil. Electronic address:

Mammalian nuclear distribution genes encode proteins with essential roles in neuronal migration and brain formation during embryogenesis. The implication of human nuclear distribution genes, namely nudC and NDE1 (Nuclear Distribution Element 1)/NDEL1 (Nuclear Distribution Element-Like 1), in psychiatric disorders including schizophrenia and bipolar disorder, has been recently described. The partial loss of NDEL1 expression results in neuronal migration defects, while ndel1 null knockout (KO) leads to early embryonic lethality in mice. Read More

View Article and Full-Text PDF

Safety and Tolerability of Cariprazine in Patients with Schizophrenia: A Pooled Analysis of Eight Phase II/III Studies.

Neuropsychiatr Dis Treat 2021 7;17:957-970. Epub 2021 Apr 7.

Medical Division, Gedeon Richter Plc, Budapest, Hungary.

Background: Long-term treatment with antipsychotic agents is indicated for patients with schizophrenia, but treatment is associated with adverse events (AEs) that contribute to medication discontinuation and nonadherence. Understanding drug safety profiles is critical to avoid unwanted side effects. Cariprazine is a potent dopamine D/D receptor partial agonist that is approved for the treatment of adults with schizophrenia (EU, US) and acute manic/mixed and depressive episodes associated with bipolar I disorder (US). Read More

View Article and Full-Text PDF

HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry.

Transl Psychiatry 2021 Apr 12;11(1):214. Epub 2021 Apr 12.

Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.

The atypical antipsychotic clozapine is the only effective medication for treatment-resistant schizophrenia. However, it can also induce serious adverse drug reactions, including agranulocytosis and neutropenia. The mechanism by which it does so is largely unknown, but there is evidence for contributing genetic factors. Read More

View Article and Full-Text PDF

Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone.

Pharmacol Rep 2021 Apr 12. Epub 2021 Apr 12.

Department of Histology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, ul. Medyków 18, 40-752, Katowice, Poland.

Background: Adult neurogenesis observed both in the subventricular zone (SVZ) and hippocampus may be regulated and modulated by several endogenous factors, xenobiotics and medications. Classical and atypical antipsychotic drugs are able to affect neuronal and glial cell proliferation in the rat brain. The main purpose of this structural study was to determine whether chronic chlorpromazine treatment affects adult neurogenesis in the canonical sites of the rat brain. Read More

View Article and Full-Text PDF

Neural Autoantibodies in Cerebrospinal Fluid and Serum in Clinical High Risk for Psychosis, First-Episode Psychosis, and Healthy Volunteers.

Front Psychiatry 2021 26;12:654602. Epub 2021 Mar 26.

Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

The pathophysiological role of neural autoantibodies in acute psychotic disorders is receiving increased attention. However, there is still an ongoing debate, whether predominantly psychotic manifestations of autoimmune encephalitides exist that may remain undetected and, thus, untreated. Furthermore, it is discussed if such conditions can be diagnosed based on serum antibody results or if a reliable diagnosis requires additional cerebrospinal fluids (CSF) results. Read More

View Article and Full-Text PDF

Head-to-Head Comparison of Sedation and Somnolence Among 37 Antipsychotics in Schizophrenia, Bipolar Disorder, Major Depression, Autism Spectrum Disorders, Delirium, and Repurposed in COVID-19, Infectious Diseases, and Oncology From the FAERS, 2004-2020.

Front Pharmacol 2021 25;12:621691. Epub 2021 Mar 25.

Independent Neurophysiology Unit, Department of Psychiatry, Medical University of Lublin, Lublin, Poland.

Antipsychotic compounds are known to induce sedation somnolence and have expanded clinical indications beyond schizophrenia to regulatory approval in bipolar disorder, treatment-resistant depression, and is being repurposed in infectious diseases and oncology. However, the medical sciences literature lacks a comprehensive association between sedation and somnolence among a wide-range of antipsychotic compounds. The objective of this study is to assess the disproportionality of sedation and somnolence among thirty-seven typical and atypical antipsychotics. Read More

View Article and Full-Text PDF

[About diagnosis and therapy of bipolar disorder].

A N Barkhatova

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(3):155-159

Mental Health Research Center, Moscow, Russia.

The author describes diagnostic criteria and clinical symptoms of bipolar affective disorder (BAD) and summarizes the results of clinical studies on using modern antipsychotics to optimize BAD treatment. Preliminary recommendations for the use of aripiprazole in treatment of BAD, including exacerbation therapy and long-term maintenance therapy to prevent relapses, are presented. Read More

View Article and Full-Text PDF

Incidence of Corrected QT Prolongation With Concomitant Methadone and Atypical Antipsychotics in Critically Ill Children.

J Pediatr Pharmacol Ther 2021 31;26(3):271-276. Epub 2021 Mar 31.

Objective: To evaluate the safety of the combination of methadone and an atypical antipsychotic in PICU patients.

Methods: This was a retrospective observational cohort pilot study in a single-center PICU in an academic children's hospital. Children 1 month to 18 years of age were included if they received methadone, were then initiated on an atypical antipsychotic (i. Read More

View Article and Full-Text PDF

Atypical antipsychotics in the treatment of patients with a dual diagnosis of schizophrenia spectrum disorders and substance use disorders: the results of a randomized comparative study.

J Addict Dis 2021 Apr 9:1-20. Epub 2021 Apr 9.

Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia.

The article presents the results of a randomized comparative study of Aripiprazole and Quetiapine in the treatment of patients with a dual diagnosis: schizophrenia and substance use disorders. During the study, 90 of the 266 male patients were screened. Among them, 54 individuals (60%) had a previously established diagnosis of mental disorder and 36 patients (40%) had no established psychiatric diagnosis. Read More

View Article and Full-Text PDF

Obesogenic Behavior and Binge Eating Disorder in an Elderly Female with Schizophrenia.

J Obes Metab Syndr 2021 Apr 5. Epub 2021 Apr 5.

Department of Psychiatry, Aarupadai Veedu Medical College and Hospital, Puducherry, India.

Eating disorders, like binge eating, have a strong association with schizophrenia. Illness characteristics like disordered eating, cognition, and behavior can lead to eating disorders. Previous research highlighted the neurobiological structural similarity and the role of hormonal factors, like hypocretin, in the etiology of eating disorders in schizophrenia. Read More

View Article and Full-Text PDF

Characteristics of patients with major depressive disorder switching SSRI/SNRI therapy compared with those augmenting with an atypical antipsychotic in a real-world setting.

Curr Med Res Opin 2021 Apr 29:1-8. Epub 2021 Apr 29.

Janssen Research & Development LLC, Titusville, NJ, USA.

Background: Following a partial response of first-line antidepressant therapy for the treatment of major depressive disorder (MDD), there is a choice to augment treatment with another agent or switch to a different antidepressant.

Objective: To report the prevalence and compare the characteristics of patients switching from their initial selective serotonin reuptake inhibitor or serotonin-norepinephrine reuptake inhibitor (SSRI/SNRI) to a new SSRI/SNRI versus those augmenting SSRI/SNRI therapy with a second-generation antipsychotic (SGA).

Methods: MDD patients receiving first-line SSRI/SNRI treatment were identified from a large US-based claims database during 2000-2019. Read More

View Article and Full-Text PDF

Anticonvulsant and antipsychotic medications in the pharmacotherapy of panic disorder: a structured review.

Ther Adv Psychopharmacol 2021 21;11:20451253211002320. Epub 2021 Mar 21.

Clinical and Experimental Sciences, University of Southampton Faculty of Medicine; University Department of Psychiatry, Academic Centre, College Keep, 4-12 Terminus Terrace, Southampton, Hampshire, SO14 3DT, UK.

Background: As the remission rate of panic disorder (PD) achieved with conventional pharmacotherapy ranges between 20% and 50%, alternative psychopharmacological strategies are needed. We aimed to firstly review data regarding use of antipsychotic and non-benzodiazepine anticonvulsant medication in PD patients with or without comorbidities; secondly, to review data concerning reduction of panic symptoms during treatment of another psychiatric disorder with the same medications; and thirdly, to examine reports of anticonvulsant- or antipsychotic-induced new-onset panic symptomatology.

Methods: We performed a PubMed search (last day: 28 April 2020) of English-language studies only, combining psychopathological terms (e. Read More

View Article and Full-Text PDF

Low-Dose Aripiprazole-Induced Nocturnal Enuresis in a 9-Year-Old Boy: A Case Report and the Possible Underlying Mechanism.

Clin Neuropharmacol 2021 May-Jun 01;44(3):108-109

Child and Adolescent Psychiatry Department, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey.

Abstract: Aripiprazole is an atypical antipsychotic commonly used in the treatment of psychiatric disorders, such as schizophrenia, bipolar disorder, and irritability associated with autism spectrum disorder. Common adverse effects associated with aripiprazole usage in children and adolescents are nausea, vomiting, extrapyramidal adverse effects, akathisia, sedation, tremor, and increased appetite. Enuresis is one of the least expected adverse effects during aripiprazole use. Read More

View Article and Full-Text PDF