498,219 results match your criteria attention

"Clicking" fragment leads to novel dual-binding cholinesterase inhibitors.

Bioorg Med Chem 2021 Jun 7;42:116269. Epub 2021 Jun 7.

National Medicines Institute, Chełmska 30/34, 00-725 Warsaw, Poland; National Centre for Nuclear Research, 05-400 Otwock-Świerk, Poland.

Cholinesterase inhibitors are potent therapeutics in the treatment of Alzheimer's disease. Among them, dual binding ligands have recently gained a lot of attention. We discovered novel dual-binding cholinesterase inhibitors, using "clickable" fragments, which bind to either catalytic active site (CAS) or peripheral anionic site (PAS) of the enzyme. Read More

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Lectins: Biological significance to biotechnological application.

Carbohydr Res 2021 Jun 8;506:108367. Epub 2021 Jun 8.

Department of Microbiology, Sikkim University, India. Electronic address:

Lectins are a set of non-enzymatic carbohydrate binding proteins appearing in all domains of life. They function to recognize, interact and bring about reversible binding of a specific sugar moiety present in a molecule. Since glycans are ubiquitous in nature and are an essential part of various biological process, the lectins are been investigated to understand the profile of these versatile but complex glycan molecule. Read More

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Exosome-based hybrid nanostructures for enhanced tumor targeting and hyperthermia therapy.

Colloids Surf B Biointerfaces 2021 Jun 8;205:111915. Epub 2021 Jun 8.

Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea. Electronic address:

Recently, natural exosomes have attracted attention as an ideal drug carrier to overcome the limitations of existing drug delivery systems which are toxicity induction and low cancer-targeting performance. In this study, we propose an exosome-based hybrid nanostructure (EHN) with improved targeting ability and therapeutic efficacy against colorectal cancer by using exosomes isolated from the tumor cell line as a drug carrier. The proposed EHN can have high biocompatibility by using exosomes, a biologically derived material, and show improved targeting performance by adding a tumor-targeting ligand (folic acid). Read More

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Progress in the study of D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) reversing multidrug resistance.

Colloids Surf B Biointerfaces 2021 Jun 8;205:111914. Epub 2021 Jun 8.

Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, PR China. Electronic address:

Currently, multidrug resistance (MDR) is one of the major reasons for failure in clinical cancer chemotherapy. Overexpression of the ATP binding cassette (ABC) transporter P-glycoprotein (P-gp), which significantly increases the efflux of anticancer drugs from tumor cells, enhances MDR. In the past few decades, four generations of P-gp inhibitors have appeared. Read More

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Neural correlates of irritability in a community sample of children.

J Affect Disord 2021 Jun 5;292:223-226. Epub 2021 Jun 5.

Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Australia; School of Psychology, Deakin University, Geelong, Australia.

Irritability has been associated with aberrant patterns of neural activation, yet little is known about structural brain correlates of irritability. As such, we aimed to investigate associations between irritability and gray matter volume (GMV) in a community sample of children enriched for irritability. The sample comprised children (n=162) aged 9-11 years with and without Attention-Deficit/Hyperactivity Disorder (ADHD), participating in a cohort study with magnetic resonance imaging data available. Read More

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Acute and chronic toxicity of microcystin-LR and phenanthrene alone or in combination to the cladoceran (Daphnia magna).

Ecotoxicol Environ Saf 2021 Sep 12;220:112405. Epub 2021 Jun 12.

State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, 73 East Beijing Road, Nanjing 210008, China. Electronic address:

Hazardous substances, such as microcystin-LR (MC-LR) and phenanthrene (Phe) are ubiquitous co-contaminants in eutrophic freshwaters, which cause harms to aquatic organisms. However, the risks associated with the co-exposure of aquatic biota to these two chemicals in the environment have received little attention. In this study, the single and mixture toxic effects of MC-LR and Phe mixtures were investigated in Daphnia magna after acute and chronic exposure. Read More

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September 2021

Emission tuning of highly efficient quaternary Ag-Cu-Ga-Se/ZnSe quantum dots for white light-emitting diodes.

J Colloid Interface Sci 2021 May 23;602:307-315. Epub 2021 May 23.

Institute for Electric Light Sources, School of Information Science and Technology, Fudan University, Shanghai 200433, China; Institute of Future Lighting, Academy for Engineering and Technology, Fudan University, Shanghai 200433, China; Zhongshan - Fudan Joint Innovation Center, Zhongshan 528437, China. Electronic address:

With the blooming development of zero-dimensional nanomaterials, I-III-VI alloying quantum dots (QDs) with outstanding photoelectrical properties have emerged to attract much attention as promising environmentally-friendly substitutions for conventional binary Cd-based QDs. In this work, a facile one-pot method was introduced to synthesize unreported quaternary Ag-Cu-Ga-Se/ZnSe (ACGSe/ZnSe) QDs. A relatively high photoluminescence quantum yield (PL QY) of 71. Read More

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Variations of antibiotic resistome in swine wastewater during full-scale anaerobic digestion treatment.

Environ Int 2021 Jun 12;155:106694. Epub 2021 Jun 12.

SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou 510006, China. Electronic address:

Anaerobic digesters have been widely used to treat wastewaters in livestock farms. With the increasing risk of antibiotic resistance originated from livestock husbandry, removal of antibiotics and antibiotic resistance genes (ARGs) via anaerobic digesters deserved more attention. Here we investigated the removal of antibiotics and ARGs in swine wastewater by three on-farm full-scale anaerobic digesters, including buried biogas digester (BBD), up-flow anaerobic sludge blanket (UASB) and high density polyethylene covered biogas digester (HDPE-BD). Read More

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Thromboembolic events associated with immune checkpoint inhibitors: A real-world study of data from the food and drug administration adverse event reporting system (FAERS) database.

Int Immunopharmacol 2021 Jun 12;98:107818. Epub 2021 Jun 12.

Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing Institute of Respiratory Medicine, Beijing 100020, China. Electronic address:

Background: Although there have been a few studies reporting thromboembolic events (TEEs) in patients treated with immune checkpoint inhibitors (ICIs), the detailed profile of the TEEs and the prothrombotic effects of ICIs remain mostly unknown.

Methods: Data from January 2004 to December 2019 in the FAERS database were retrieved. We investigated the clinical characteristics of the TEEs and conducted disproportionality analysis by using reporting odds ratios (ROR) to compare ICIs with the full database and other anti-cancer agents. Read More

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Facile and rapid detection of SARS-CoV-2 antibody based on a noncompetitive fluorescence polarization immunoassay in human serum samples.

Biosens Bioelectron 2021 Jun 5;190:113414. Epub 2021 Jun 5.

Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo, 060-8628, Japan; Innovative Research Centre for Preventive Medical Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan; Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan. Electronic address:

Antibody detection methods for viral infections have received broad attention due to the COVID-19 pandemic. In addition, there remains an ever-increasing need to quantitatively evaluate the immune response to develop vaccines and treatments for COVID-19. Here, we report an analytical method for the rapid and quantitative detection of SARS-CoV-2 antibody in human serum by fluorescence polarization immunoassay (FPIA). Read More

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A continuum model and simulations for large deformation of anisotropic fiber-matrix composites for cardiac tissue engineering.

J Mech Behav Biomed Mater 2021 Jun 7;121:104627. Epub 2021 Jun 7.

School of Engineering, Brown University, Providence, RI, United States; Center for Biomedical Engineering, Brown University, Providence, RI, United States. Electronic address:

Cardiac patch therapies promise to restore heart function and lower the risk of heart failure after heart attack. Fiber-matrix engineered tissue scaffolds have gained significant attention due to their tunable micro-structures, providing nonlinear mechanical properties similar to native anisotropic heart tissues. Mechanical properties of engineered scaffolds directly affect the stress fields generated inside and around the tissue scaffolds and have significant impact on the tissue functionality. Read More

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Technical framework for wastewater-based epidemiology of SARS-CoV-2.

Sci Total Environ 2021 Jun 11;791:148271. Epub 2021 Jun 11.

Department of Pharmaceutical & Biological Engineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, China. Electronic address:

Wastewater-based epidemiology (WBE) is expected to become a powerful tool to monitor the dissemination of SARS-CoV-2 at the community level, which has attracted the attention of scholars all over the world. However, there is not yet a standard protocol to guide its implementation. In this paper, we proposed a comprehensive technical and theoretical framework of relative quantification via qPCR for determining the virus abundance in wastewater and estimating the infection ratio in corresponding communities, which is expected to achieve horizontal and vertical comparability of the data using a human-specific biomarker as the internal reference. Read More

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Interactive regulation of laryngeal cancer and neuroscience.

Biochim Biophys Acta Rev Cancer 2021 Jun 12;1876(1):188580. Epub 2021 Jun 12.

Department of Pathology, Harbin Medical University Cancer Hospital, Harbin 150081, China. Electronic address:

Nerve fibres are distributed throughout the body along with blood and lymphatic vessels. The intrinsic morphological characteristics of nerves and the general characteristics of secretions in the tumour microenvironment provide a solid theoretical basis for exploring how neuronal tissue can influence the progression of laryngeal cancer (LC). The central nervous system (CNS) and the peripheral nervous system (PNS) jointly control many aspects of cancer and have attracted widespread attention in the study of the progression, invasion and metastasis of tumour tissue banks. Read More

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Ethnomedicine and Neuropsychopharmacology in Mesoamerica.

J Ethnopharmacol 2021 Jun 12:114243. Epub 2021 Jun 12.

Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, 09042, Monserrato CA, Italy. Electronic address:

Ethnopharmacological Relevance: The burden of disease caused by mental and neurological disorders is increasing globally, to a disproportionate degree in Latin America. In contrast to the many psychoactive plants with a use history in Mesoamerican cultures, the translation to the wider population of knowledge around numerous botanicals used contemporarily by indigenous Mesoamerican societies to treat psychological and neurological disorders did not receive the same attention.

Material And Methods: We used the previously published Mesoamerican Medicinal Plant Database to extract species and associated botanical drugs used as treatments for illnesses associated with the nervous system by Mesoamerican cultures in Belize, Guatemala, and Mexico. Read More

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Attention orienting to the eyes in violent female and male offenders: An eye-tracking study.

Biol Psychol 2021 Jun 12:108136. Epub 2021 Jun 12.

University of Tübingen, Department of Clinical Psychology and Psychotherapy, Tübingen, Germany; University Hospital Tübingen, Department of Psychiatry and Psychotherapy, Tübingen, Germany.

Attention to the eyes and eye contact form an important basis for the development of empathy and social competences including prosocial behavior. Thus, impairments in attention to the eyes of an interaction partner might play a role in the etiology of antisocial behavior and violence. For the first time, the present study extends investigations of eye gaze to a large sample (N = 173) including not only male but also female violent offenders and a control group. Read More

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Stimuli-responsive surfaces for switchable wettability and adhesion.

J R Soc Interface 2021 Jun 16;18(179):20210162. Epub 2021 Jun 16.

Centre of Advanced Structural Ceramics, Department of Materials, Imperial College London, London SW7 2AZ, UK.

Diverse unique surfaces exist in nature, e.g. lotus leaf, rose petal and rice leaf. Read More

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SIRT7: a sentinel of genome stability.

Open Biol 2021 Jun 16;11(6):210047. Epub 2021 Jun 16.

Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Shenzhen University International Cancer Center, Marshall Laboratory of Biomedical Engineering, Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen 518055, People's Republic of China.

SIRT7 is a class III histone deacetylase that belongs to the sirtuin family. The past two decades have seen numerous breakthroughs in terms of understanding SIRT7 biological function. We now know that this enzyme is involved in diverse cellular processes, ranging from gene regulation to genome stability, ageing and tumorigenesis. Read More

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Children with supracondylar humerus fractures have an increased risk of attention deficit hyperactivity disorder.

Acta Orthop Belg 2021 Mar;87(1):159-166

Children with attention deficit hyperactivity disorder (ADHD) have an increased risk of sustaining fractures during their preschool years. Supracondylar humerus fractures (SHFs) comprise the majority of fracture surgeries in the pediatric age range. We hypothesized that ADHD symptoms would be present in children with SHFs, and this characteristic trauma may be associated with an ADHD diagnosis. Read More

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Letter to the Editor: Risk Stratification in Patients With Child-Pugh B Cirrhosis and Acute Variceal Bleeding.

Hepatology 2021 Jun 15. Epub 2021 Jun 15.

Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China.

We recently read with great interest the article published by Yong Lv et al. in an issue of Hepatology. The authors demonstrated the risk stratification based on chronic liver failure consortium acute decompensation score in patients with child-pugh B cirrhosis and acute variceal bleeding. Read More

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Prevalence, drug resistance, and virulence genes of potential pathogenic bacteria in pasteurized milk of Chinese Fresh Milk Bar.

J Food Prot 2021 Jun 15. Epub 2021 Jun 15.

Qingdao Agricultural University College of Food Science and Engineering No.700 Changcheng Road, Chengyang District, Qingdao CHINA Qingdao 266109.

Fresh Milk Bar (FMB), an emerging dairy retail franchise, is used to instantly produce and sell pasteurized milk and other dairy products in China. However, the quality and safety of pasteurized milk in FMB have received little attention. The objective of this study is to investigate the prevalence, antimicrobial resistance, and virulence genes of Escherichia coli (E. Read More

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Insulin rapidly increases skeletal muscle mitochondrial ADP sensitivity in the absence of a high lipid environment.

Biochem J 2021 Jun 15. Epub 2021 Jun 15.

University of Guelph, Guelph, Canada.

Reductions in mitochondrial function have been proposed to cause insulin resistance, however the possibility that impairments in insulin signaling negatively affects mitochondrial bioenergetics has received little attention. Therefore, we tested the hypothesis that insulin could rapidly improve mitochondrial ADP sensitivity, a key process linked to oxidative phosphorylation and redox balance, and if this phenomenon would be lost following high-fat diet (HFD)-induced insulin resistance. Insulin acutely (60 minutes post I. Read More

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What's not in the news headlines or titles of Alzheimer disease articles? #InMice.

PLoS Biol 2021 Jun 15;19(6):e3001260. Epub 2021 Jun 15.

Casa de Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil.

There is increasing scrutiny around how science is communicated to the public. For instance, a Twitter account @justsaysinmice (with 70.4K followers in January 2021) was created to call attention to news headlines that omit that mice, not humans, are the ones for whom the study findings apply. Read More

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Do working conditions contribute differently to gender gaps in self-rated health within different occupational classes? Evidence from the Swedish Level of Living Survey.

Sara Kjellsson

PLoS One 2021 15;16(6):e0253119. Epub 2021 Jun 15.

Swedish Institute for Social Research, Stockholm University, Stockholm, Sweden.

Socioeconomic inequality in health among women is often referred to as smaller than health inequality among men. However, we know less about differences in health between men and women within the same socioeconomic groups. In this article the lack of attention to potential socioeconomic variation in gender health inequality is argued as unfortunate, as it can obscure how mechanisms, such as e. Read More

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Clinical Ethics Consultation during the First COVID-19 Lock Down in France: The "Commitment Model": Balancing General Questions and Individual Cases.

J Clin Ethics 2021 ;32(2):155-164

Centre d'éthique clinique, 27 Rue du Faubourg St. Jacques, 75014 Paris, France.

During the first outbreak of COVID-19, the French governmental advisory council on bioethics suggested the need to support healthcare providers with ad hoc "ethical support units." Several units engaged in such endeavors across the country. This article outlines some methodological considerations made by the Cochin Hospital Clinical Ethics Center (the Cec). Read More

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Going Backwards to Fill in the Missing Processes for Training and Evaluation of Clinical Bioethicists: What Has Been Needed for Decades to Move Real Professionalism Forward.

Evan G DeRenzo

J Clin Ethics 2021 ;32(2):149-154

John J. Lynch Center for Ethics, MedStar Washington Hospital Center, Washington, District of Columbia 20020 USA.

As the field of clinical bioethics has moved from its pioneers, who turned their attention to ethics problems in clinical medicine and clinical and animal research, to today's ubiquity of university degrees and fellowships in bioethics, there has been a steady drumbeat to professionalize the field. The problem has been that the necessary next steps-to specify the skills, knowledge, and personal and professional attributes of a clinical bioethicist, and to have a method to train and evaluate mastery of these standards-are lacking. Ordinarily, the path to professionalism in medicine starts with the intellectual pioneers. Read More

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A Closer Look at Feticide and Moral Distress.

Beth Epstein

J Clin Ethics 2021 ;32(2):124-126

University of Virginia School of Nursing, 202 Jeanette Lancaster Way, Charlottesville, Virginia 22903 USA.

Moral distress arises when healthcare providers recognize that a professional ethical obligation cannot be met due to constraints beyond their perceived or actual control. In this commentary, I expand a bit on the meaning and implications of moral distress identified among Israeli maternal-fetal medicine (MFM) physicians who participate in feticide. I examine briefly how exploring unmet professional obligations (for example, preventing harm), identifying who is burdened by the decisions of others, and drawing attention to what is owed to the woman, fetus, and physician may illuminate relevant ethical issues not currently considered in the calculus of late-term abortion decisions. Read More

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COVID-19 Information Dissemination: A Retrospective Analysis of the WeChat Communication Index.

J Med Internet Res 2021 Jun 10. Epub 2021 Jun 10.

School of Management, Weifang Medical University, Weifang, Shandong, CN.

Background: The COVID-19 outbreak has tremendously impacted the world. The number of the confirmed cases has continued to increase, causing damage to the society and the economy worldwide. The public pays close attention to the information on the pandemic and learns about the disease through various media outlets. Read More

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Multi-level Attention Network for Retinal Vessel Segmentation.

IEEE J Biomed Health Inform 2021 Jun 15;PP. Epub 2021 Jun 15.

Automatic vessel segmentation in the fundus images plays an important role in the screening, diagnosis, treatment, and evaluation of various cardiovascular and ophthalmologic diseases. However, due to the limited well-annotated data, varying size of vessels, and intricate vessel structures, retinal vessel segmentation has become a long-standing challenge. In this paper, a novel deep learning model called AACA-MLA-D-UNet is proposed to fully utilize the low-level detailed information and the complementary information encoded in different layers to accurately distinguish the vessels from the background with low model complexity. Read More

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Capsule Attention for Multimodal EEG-EOG Representation Learning With Application to Driver Vigilance Estimation.

IEEE Trans Neural Syst Rehabil Eng 2021 21;29:1138-1149. Epub 2021 Jun 21.

Driver vigilance estimation is an important task for transportation safety. Wearable and portable brain-computer interface devices provide a powerful means for real-time monitoring of the vigilance level of drivers to help with avoiding distracted or impaired driving. In this paper, we propose a novel multimodal architecture for in-vehicle vigilance estimation from Electroencephalogram and Electrooculogram. Read More

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Time-Driven Activity-Based Costing for Cataract Surgery in Canada: The Case of the Kensington Eye Institute.

Healthc Policy 2021 May;16(4):97-108

Director, Health System Strategy, Medtronic ULC, Brampton, ON.

Time-driven activity-based costing (TDABC) has received considerable attention globally as a way to measure value in healthcare systems. This study aimed to apply TDABC for cataract surgery at the Kensington Eye Institute (KEI). During a field evaluation, a detailed process map was created for cataract surgery at KEI. Read More

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