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Evaluating the monophyly of series (Cactaceae).

PhytoKeys 2021 28;177:25-42. Epub 2021 Apr 28.

Jardín Botánico, Instituto de Biología, Universidad Nacional Autónoma de México, Tercer Circuito Exterior, Ciudad Universitaria, Coyoacán, Ciudad de México 04510, Mexico.

(Cactaceae) taxonomy has been historically problematic due to the morphological variability and sympatry of the species. This has led to several proposals for infrageneric classification, including subgeneric, section and series categories. Mammillaria ser. Read More

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The Process of Managing the Children with Type 1 Diabetes in the Family: A Grounded Theory Study.

Iran J Nurs Midwifery Res 2021 Jan-Feb;26(1):25-33. Epub 2021 Jan 18.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Diabetes is a disease that affects all family members. Parents of children with type 1 diabetes are always concerned about all aspects of children's life. The aim of this study was to elucidate the process of managing children with diabetes in the family. Read More

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January 2021

The E2F transcription factor 2: What do we know?

Biosci Trends 2021 May 29;15(2):83-92. Epub 2021 Apr 29.

Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University, Ji'nan, China.

E2F transcription factor 2 (E2F2) is a member of the E2F family of transcription factors. The classical view is that some E2Fs act as "activators" and others "inhibitors" of cell cycle gene expression. However, the so-called "activator" E2F2 is particularly enigmatic, with seemingly contradictory roles in the cell cycle, proliferation, apoptosis, inflammation, and cell migration and invasion. Read More

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An experimental investigation of light emission produced in the process of positronium formation in matter.

Phys Chem Chem Phys 2021 May 5. Epub 2021 May 5.

Institut für Strahlenphysik/Institute of Radiation Physics, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstr. 400, 01328 Dresden, Germany.

The excess energy emitted during the positronium (Ps) formation in condensed matter may be released as light. Spectroscopic analysis of this light can be a new method of studying the electronic properties of materials. We report the first experimental attempt, according to our knowledge, to verify the existence of this emission process. Read More

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Metabolic Profiling of VOCs Emitted by Bacteria Isolated from Pressure Ulcers and Treated with Different Concentrations of Bio-AgNPs.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

Interdisciplinary Centre of Modern Technologies, Nicolaus Copernicus University in Toruń, 4 Wileńska St., 87-100 Toruń, Poland.

Considering the advent of antibiotic resistance, the study of bacterial metabolic behavior stimulated by novel antimicrobial agents becomes a relevant tool to elucidate involved adaptive pathways. Profiling of volatile metabolites was performed to monitor alterations of bacterial metabolism induced by biosynthesized silver nanoparticles (bio-AgNPs). , , and were isolated from pressure ulcers, and their cultures were prepared in the presence/absence of bio-AgNPs at 12. Read More

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A discussion on `Domain formation and phase transitions in the wurtzite-based heterovalent ternaries: a Landau theory analysis'.

Acta Crystallogr A Found Adv 2021 May 23;77(Pt 3):217-221. Epub 2021 Mar 23.

Structure and Dynamics of Energy Materials, Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, 14109 Berlin, Germany.

Heterovalent ternary nitrides are considered one of the promising classes of materials for photovoltaics, combining attractive physical properties with low toxicity and element abundance. One of the front-runner systems under consideration is ZnSnN. Although it is nominally a ternary compound, no clear crystallographic evidence for cation ordering has been observed so far. Read More

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Sildenafil 4.0-Integrated Synthetic Chemistry, Formulation and Analytical Strategies Effecting Immense Therapeutic and Societal Impact in the Fourth Industrial Era.

Pharmaceuticals (Basel) 2021 Apr 15;14(4). Epub 2021 Apr 15.

Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Sildenafil is a potent selective, reversible inhibitor of phosphodiesterase type 5 (PDE5) approved for the treatment of erectile dysfunction and pulmonary arterial hypertension. Whilst twenty years have passed since its original approval by the US Food and Drug Administration (USFDA), sildenafil enters the fourth industrial era catalyzing the treatment advances against erectile dysfunction and pulmonary hypertension. The plethora of detailed clinical data accumulated and the two sildenafil analogues marketed, namely tadalafil and vardenafil, signify the relevant therapeutic and commercial achievements. Read More

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Two Sides to One Story-Aroma Chemical and Sensory Signature of Lugana and Verdicchio Wines.

Molecules 2021 Apr 7;26(8). Epub 2021 Apr 7.

Department of Biotechnology, University of Verona, Villa Lebrecht, Via della Pieve 70, 37029 San Pietro in Cariano, Italy.

Lugana and Verdicchio are two Italian white wines with a Protected Designation of Origin (PDO) label. These two wine types are produced in different regions using the same grape variety. The aim of this work is to investigate the existence of volatile chemical markers that could help to elucidate differences between Lugana and Verdicchio wines both at chemical and sensory levels. Read More

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Bridging the Gap: The Influence of Foot and Ankle Pathomechanics in Total Knee Arthroplasty.

J Am Acad Orthop Surg 2021 Apr 26. Epub 2021 Apr 26.

From the Department of Orthopedic Surgery, Lenox Hill Hospital, New York, NY (Naylor, Seidman, and Scuderi), and Arthritis and Total Joint Specialists, Northside Hospital, Cumming, GA (Naylor).

Altered spinopelvic mechanics can have dramatic influences on the success of hip arthroplasty as seen with concomitant hip and spine disease. Interestingly, limited focus has been directed toward a similar codependent relationship between concurrent knee and foot deformities. By bridging this interdisciplinary gap, we attempt to explore the current understanding and clinical implications of concomitant knee and foot pathology while reviewing management options for addressing this unique yet ubiquitous patient population. Read More

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Post-exercise Cold Water Immersion Effects on Physiological Adaptations to Resistance Training and the Underlying Mechanisms in Skeletal Muscle: A Narrative Review.

Front Sports Act Living 2021 8;3:660291. Epub 2021 Apr 8.

Deakin University, Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Science, Geelong, VIC, Australia.

Post-exercise cold-water immersion (CWI) is a popular recovery modality aimed at minimizing fatigue and hastening recovery following exercise. In this regard, CWI has been shown to be beneficial for accelerating post-exercise recovery of various parameters including muscle strength, muscle soreness, inflammation, muscle damage, and perceptions of fatigue. Improved recovery following an exercise session facilitated by CWI is thought to enhance the quality and training load of subsequent training sessions, thereby providing a greater training stimulus for long-term physiological adaptations. Read More

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Development and Modification of Pre-miRNAs with a FRET Dye Pair for the Intracellular Visualization of Processing Intermediates That Are Generated in Cells.

Sensors (Basel) 2021 Mar 4;21(5). Epub 2021 Mar 4.

Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.

microRNAs (miRNAs) are small non-coding ribonucleic acids (RNAs), which regulate gene expression via the RNA interference (RNAi) system. miRNAs have attracted enormous interest because of their biological significance and disease relationship. In cell systems, the generation of miRNA is regulated by multiple steps: the transfer of primary miRNA from the nucleus to the cytosol, the generation of the precursor-miRNA (pre-miRNA), the production of double-stranded RNA from pre-miRNA by the Dicer, the interaction with protein argonaute-2 (AGO2), and the subsequent release of one strand to form miRISC with AGO2. Read More

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Physical Abilities in Low Back Pain Patients: A Cross-Sectional Study with Exploratory Comparison of Patient Subgroups.

Life (Basel) 2021 Mar 10;11(3). Epub 2021 Mar 10.

Institute for Physical Medicine, Physiko und Rheumatherapie, 3100 St. Pölten, Austria.

An abundance of literature has investigated the association between low back pain (LBP) and physical ability or function. It has been shown that LBP patients display reduced range of motion, decreased balance ability, impaired proprioception, and lower strength compared to asymptomatic persons. The aim of this study was to investigate the differences between LBP patients and healthy controls in terms of several physical abilities. Read More

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Social isolation and loneliness in old age: Exploring their role in mental and physical health.

Psychiatriki 2021 Mar 8;32(1):59-66. Epub 2021 Mar 8.

School of Psychology, Mediterranean College -University of Derby, Thessaloniki, Greece.

The current review has the ultimate scope to accurately define social isolation and loneliness while highlighting the serious repercussions on health and behavior. Daily hundreds of people across the globe report suffering from social isolation and loneliness; an over whelming feeling of emptiness, unworthiness and personal failure. Human beings are social species that have the need to nurture reliable and secure social settings to survive. Read More

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Next generation of immune checkpoint inhibitors and beyond.

J Hematol Oncol 2021 Mar 19;14(1):45. Epub 2021 Mar 19.

Division of Hematology and Oncology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

The immune system is the core defense against cancer development and progression. Failure of the immune system to recognize and eliminate malignant cells plays an important role in the pathogenesis of cancer. Tumor cells evade immune recognition, in part, due to the immunosuppressive features of the tumor microenvironment. Read More

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MALAT1 knockdown promoted cell viability and migration of LPS-treated MG-63 cells via sponging miR-212.

Genes Genomics 2021 May 16;43(5):523-531. Epub 2021 Mar 16.

Department of Osteology, Tianjin Hospital, No. 406, Jiefang South Road, Tianjin, 300211, China.

Background: Most fractures could heal after treatment, around 5-10 % of patients still develop delayed union and nonunion. Evidence has increasingly shown that abnormal expression of long noncoding RNAs is closely related to the occurrence and development of various diseases including fracture healing. However, evidence regarding the effect of MALAT1 on fracture healing remains limited. Read More

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Soluble inflammatory mediators of synoviocytes stimulated by monosodium urate crystals induce the production of oxidative stress, pain, and inflammation mediators in chondrocytes : Secretome of synoviocytes induces chondrocyte damage.

Clin Rheumatol 2021 Mar 16. Epub 2021 Mar 16.

Department of Rheumatic and Musculoskeletal Diseases, National Institute of Rehabilitation Luis Guillermo Ibarra-Ibarra, Mexico City, Mexico.

We hypothesized that the secretion of inflammatory mediators from synoviocytes affects the chondrocyte homeostasis of articular cartilage. This study was a preliminary attempt to elucidate the molecular mechanisms by which soluble mediators obtained from activated synoviocytes induce oxidative stress and inflammation in chondrocytes. We measured the concentrations of interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), nerve growth factor (NGF), superoxide anion (O), hydrogen peroxide (HO), and nitric oxide (NO) from articular human cells. Read More

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Using computable knowledge mined from the literature to elucidate confounders for EHR-based pharmacovigilance.

J Biomed Inform 2021 Mar 11;117:103719. Epub 2021 Mar 11.

University of Washington, Department of Biomedical Informatics and Medical Education, Seattle, WA, United States.

Introduction: Drug safety research asks causal questions but relies on observational data. Confounding bias threatens the reliability of studies using such data. The successful control of confounding requires knowledge of variables called confounders affecting both the exposure and outcome of interest. Read More

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Where next for laterality research? Looking back and looking forward.

Laterality 2021 Mar 11:1-6. Epub 2021 Mar 11.

School of Psychology, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

While paying attention to the recommendations of Ocklenburg, Berretz, Packheiser, and Friedrich (2020) in the target article, researchers in the field of laterality should attempt to: (1) solve the long-standing puzzle of the relationship between handedness and language lateralization; (2) further explore the genetic bases of manual and cerebral asymmetry and of their associations with psychiatric and neurodevelopmental conditions; (3) explore the adaptive significance of laterality for humans and non-humans and elucidate the relationships of asymmetry across species; and (4) embrace developing technologies to investigate the interaction between the hemispheres during the performance of everyday tasks. Read More

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Differences in Fatty Acid Oxidation between -Paclitaxel- and Solvent-Based Paclitaxel-Treated A549 Cells Based on Metabolomics.

ACS Omega 2021 Mar 15;6(8):5138-5145. Epub 2021 Feb 15.

School of Pharmacy, College of Medicine, National Taiwan University, 33 Linsen S. Road, Zhongzheng District, Taipei City 10050, Taiwan.

The pharmacokinetics, safety, and anticancer efficacy profiles of nanoparticle albumin-bound ()-paclitaxel formulations are superior to those of solvent-based paclitaxel formulations. The aims of the present study were to study the effects of -paclitaxel and solvent-based paclitaxel formulations on the metabolic profiles of the model cell line (A549) and attempt to elucidate the associated metabolic pathways. A mass spectrometry-based cell metabolomics approach and viability evaluation were used to explore the potential difference. Read More

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Multivariate quantitative genetic analysis of body weight traits in Corriedale sheep.

Trop Anim Health Prod 2021 Mar 6;53(2):197. Epub 2021 Mar 6.

Division of Animal Genetics and Breeding, FVSc & AH, SKUAST-K, Shuhama, Ganderbal, Kashmir, 190006 J&K, India.

In the present study, an attempt was made to elucidate the genetic parameters for body weight traits of lambs from Corriedale sheep population at different ages. Data were collected from 6874 lambs born over a span of 49 years from 1969 to 2017. The traits under study included body weight at birth (BW), weaning (WW), 6 months of age (6MW), 9 months of age (9MW) and yearling stage (YW). Read More

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Shifts in Ecological Dominance between Two Lepidopteran Species in Refuge Areas of Bt Cotton.

Insects 2021 Feb 12;12(2). Epub 2021 Feb 12.

Department of Entomology, Federal University of Grande Dourados (UFGD), Dourados 79825-070, Brazil.

Competition behavior involving agricultural pest species has long been viewed as a powerful selective force that drives ecological and phenotypic diversity. In this context, a Game Theory-based approach may be useful to describe the decision-making dilemma of a competitor with impacts to guarantee its superiority in terms of ecological dominance or sharing of the food resource with its competitor. In an attempt to elucidate the consequences of competitive dynamics for the ecological dominance of these species in refuge areas of Bt cotton, we conducted a study that was divided into two parts. Read More

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February 2021

Friend or Foe? Impacts of Dietary Xylans, Xylooligosaccharides, and Xylanases on Intestinal Health and Growth Performance of Monogastric Animals.

Animals (Basel) 2021 Feb 26;11(3). Epub 2021 Feb 26.

Department of Animal Science, North Carolina State University, Raleigh, NC 27695, USA.

This paper discusses the structural difference and role of xylan, procedures involved in the production of xylooligosaccharides (XOS), and their implementation into animal feeds. Xylan is non-starch polysaccharides that share a β-(1-4)-linked xylopyranose backbone as a common feature. Due to the myriad of residues that can be substituted on the polymers within the xylan family, more anti-nutritional factors are associated with certain types of xylan than others. Read More

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February 2021

Elucidating evolutionarily conserved mechanisms of diapause regulation using an in silico approach.

FEBS Lett 2021 Mar 2. Epub 2021 Mar 2.

Department of Biological Sciences, BITS Pilani KK Birla Goa Campus, Goa, India.

Embryonic diapause is an enigmatic phenomenon that appears in diverse species. Although regulatory mechanisms have been established, there is much to be discovered. Herein, we have made the first comprehensive attempt to elucidate diapause regulatory mechanisms using a computational approach. Read More

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Immunoproteomic analysis of Clostridium botulinum type B secretome for identification of immunogenic proteins against botulism.

Biotechnol Lett 2021 May 25;43(5):1019-1036. Epub 2021 Feb 25.

Zoology Department, Jiwaji University, Gwalior, Madhya Pradesh, India.

Objectives: To identify immunogenic proteins of C. botulinum type B secretome by immunoproteomic analysis.

Results: In the present study, an attempt was made to elucidate the vaccine candidates/diagnostic molecules against botulism using immuno proteomic approach. Read More

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Genomic epidemiology of a case cluster in Glasgow, Scotland, 2018.

Microb Genom 2021 03 23;7(3). Epub 2021 Feb 23.

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

In 2018, a cluster of two cases of cryptococcosis occurred at the Queen Elizabeth University Hospital (QEUH) in Glasgow, Scotland (UK). It was postulated that these cases may have been linked to pigeon droppings found on the hospital site, given there have been previous reports of associated with pigeon guano. Although some samples of pigeon guano taken from the site yielded culturable yeast from genera related to , they have since been classified as or spp. Read More

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Accelerated Fe Regeneration in an Effective Electro-Fenton Process by Boosting Internal Electron Transfer to a Nitrogen-Conjugated Fe(III) Complex.

Environ Sci Technol 2021 05 22;55(9):6042-6051. Epub 2021 Feb 22.

School of Chemical Science and Engineering, Shanghai Key Lab of Chemical Assessment and Sustainability, Key Laboratory of Yangtze River Water Environment, Tongji University, Siping Road 1239, Shanghai 200092, P. R. China.

The regeneration rate of Fe from Fe dictates the performance of the electro-Fenton (EF) process, represented by the amount of produced hydroxyl radicals (·OH). Current strategies for the acceleration of Fe regeneration normally require additional chemical reagents, to vary the redox potential of Fe/Fe. Here, we report an attempt at using the intrinsic property of the electrode to our advantage, i. Read More

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Symptomatic methemoglobinemia in a patient with metastatic clear cell renal cell carcinoma treated with pembrolizumab and axitinib combination therapy: a case report.

J Med Case Rep 2021 Feb 19;15(1):72. Epub 2021 Feb 19.

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.

Background: Combination regimens that include immune checkpoint (ICI) and vascular endothelial growth factor (VEGF) inhibition have opened the door to new treatment opportunities for patients with metastatic renal cell carcinoma (mRCC). While these treatment options have provided improved tolerability and better outcomes compared to older regimens, many patients still experience a myriad of treatment-related adverse events. Given that these regimens were recently approved for mRCC, the complete side effect profile may not be fully elucidated yet. Read More

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February 2021

Increasing Choices or Decreasing Hope? Explaining the Rising Prevalence of Depression From a Decision-Making Perspective.

Psychol Rep 2021 Feb 14:33294120988128. Epub 2021 Feb 14.

Department of Humanities and Social Sciences, Indian Institute of Technology, Kanpur.

In today's fast-moving society, we get a multitude of options available. However, choices once considered beneficial, are now being largely debated. In the face of rising prevalence of depression and being identified as the 'disease of modernity', this burden of increasing choices on the modern society needs to be re-evaluated. Read More

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February 2021

Long-Term Risk Factors for Intracranial In-Stent Restenosis From a Multicenter Trial of Stenting for Symptomatic Intracranial Artery Stenosis Registry in China.

Front Neurol 2020 26;11:601199. Epub 2021 Jan 26.

Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

For patients with symptomatic intracranial artery stenosis (sICAS), endovascular treatment has been shown to be feasible and safe in recent studies. However, in-stent restenosis (ISR) risks the recurrence of ischemic stroke. We attempt to elucidate the risk factors for ISR. Read More

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January 2021