1,093 results match your criteria atrophy iris


Longitudinal phenotypic study of late-onset retinal degeneration due to a founder variant c.562C>A p.(Pro188Thr) in the gene.

Ophthalmic Genet 2021 May 5:1-12. Epub 2021 May 5.

Department of Ophthalmology, Ghent University Hospital, Ghent, Belgium.

: Late-onset retinal degeneration (L-ORD) is a rare autosomal dominant retinal dystrophy related to gene variants.: Twenty-six patients (21-81 years) with L-ORD due to c.562C>A p. Read More

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Optic Nerve Aplasia.

J Neuroophthalmol 2021 Apr 14. Epub 2021 Apr 14.

Philadelphia College of Osteopathic Medicine (BDS), Philadelphia, Pennsylvania; Pediatric Ophthalmology and Ocular Genetics (BDS, SHY), Wills Eye Hospital, Philadelphia, Pennsylvania; Pediatric Ophthalmology (BEG), Helen DeVos Children's Hospital, Grand Rapids, Michigan; The Rotterdam Eye Hospital (JTHNF), Rotterdam, the Netherlands; Cullen Eye Institute (LSB), Baylor College of Medicine, Houston, Texas; Department of Pediatric Ophthalmology (MB), LV Prasad Eye Institute, Hyderabad, India; Ophthalmology Unit (SG), Ricardo Gutiérrez Children Hospital, Buenos Aires, Argentina; Cataract and Laser Institute of Southern Oregon PC (TR), Medford, Oregon; Flaum Eye Institute and Golisano Children's Hospital (AVL), University of Rochester, New York, New York.

Objective: Optic nerve aplasia (ONA) is a rare ocular anomaly. We report ophthalmologic, systemic, and genetic findings in ONA.

Methods: Patients were identified through an International Pediatric Ophthalmology listserv and from the practice of the senior author. Read More

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Classification criteria for varicella zoster virus anterior uveitis.

Am J Ophthalmol 2021 Apr 9. Epub 2021 Apr 9.

the Department of Medicine, Texas A&M University, College Station, TX, USA.

Purpose: To determine classification criteria for varicella zoster virus (VZV) anterior uveitis DESIGN: Machine learning of cases with VZV anterior uveitis and 8 other anterior uveitides.

Methods: Cases of anterior uveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on the diagnosis, using formal consensus techniques. Cases were split into a training set and a validation set. Read More

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Classification criteria for herpes simplex virus anterior uveitis.

Am J Ophthalmol 2021 Apr 9. Epub 2021 Apr 9.

the Department of Medicine, Texas A&M University, College Station, TX, USA.

Purpose: To determine classification criteria for herpes simplex virus (HSV) anterior uveitis DESIGN: : Machine learning of cases with HSV anterior uveitis and 8 other anterior uveitides.

Methods: Cases of anterior uveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on the diagnosis, using formal consensus techniques. Cases were split into a training set and a validation set. Read More

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Classification criteria for Fuchs uveitis syndrome.

Am J Ophthalmol 2021 Apr 9. Epub 2021 Apr 9.

Department of Medicine, Texas A&M University, College Station, TX, USA.

Purpose: To determine classification criteria for Fuchs uveitis syndrome.

Design: Machine learning of cases with Fuchs uveitis syndrome and 8 other anterior uveitides.

Methods: Cases of anterior uveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on the diagnosis, using formal consensus techniques. Read More

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Iridoschisis: Spectrum of Presentation.

Middle East Afr J Ophthalmol 2020 Oct-Dec;27(4):224-227. Epub 2021 Jan 19.

Department of Ophthalmology, Dr. Shroff's Charity Eye Hospital, New Delhi, India.

Purpose: The purpose of the study was to report a small case series of patients with iridoschisis seen at our hospital over a period of 5 years.

Methods: Retrospective review of all those files over the past 5 years whereby the diagnosis of iridoschisis/iris atrophy/iris fibrils in anterior chamber (AC) was made.

Results: In our case series, the average age at presentation was 49 years (range: 23-85 years). Read More

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January 2021

Uveitis-Glaucoma-Hyphema Syndrome: Clinical Features and Differential Diagnosis.

Ocul Immunol Inflamm 2021 Apr 1:1-6. Epub 2021 Apr 1.

Rome Eye Hospital, Rome, Italy.

to study the clinical features of uveitis-glaucoma-hyphema (UGH) syndrome, particularly those useful for a differential diagnosis from unilateral hypertensive acute anterior uveitis. A retrospective chart review was conducted on the clinical features of 9 patients with UGH syndrome. These features were then compared with those detected in 50 patients with unilateral hypertensive acute anterior uveitis. Read More

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Distinguishing Features of Anterior Uveitis Caused by Herpes Simplex Virus, Varicella-Zoster Virus, and Cytomegalovirus.

Am J Ophthalmol 2021 Mar 25;227:191-200. Epub 2021 Mar 25.

Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (H.T, N.H, M.I, M.M). Electronic address:

Purpose: To determine distinguishing features of the clinical characteristics of anterior uveitis (AU) caused by herpes simplex virus (HSV), varicella-zoster virus (VZV), and cytomegalovirus (CMV).

Design: Retrospective, multicenter case series.

Methods: Consecutive patients with herpetic AU examined at 11 tertiary centers in Japan between January 2012 and December 2017 and who were followed for ≥3 months were evaluated. Read More

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The Spinal Muscular Atrophy Health Index: Italian validation of a disease-specific outcome measure.

Neuromuscul Disord 2021 Feb 9. Epub 2021 Feb 9.

Pediatric Neurology, Università Cattolica del Sacro Cuore, Rome, Italy.

Patient report outcome measures in Spinal Muscular Atrophy (SMA) represent a potential complement to observer rated scales which can be used to better understand treatment response. We developed, translated and validated an Italian version of the Spinal Muscular Atrophy Health Index (SMAHI), a disease-specific, patient reported outcome measure questionnaire, designed to estimate the patients' perception of disease burden. Test-retest reliability was assessed in 37 patients (16 children aged 12-17 and 21 adults) and was excellent in both cohorts. Read More

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February 2021

Intravitreal rituximab monotherapy for management of eyes with vitreoretinal lymphoma: initial experience from India.

Int Ophthalmol 2021 Mar 17. Epub 2021 Mar 17.

L&T Ocular Pathology Department, Medical Research Foundation, 18 College Road, Chennai, Tamilnadu, 600006, India.

Purpose: To evaluate treatment outcomes and complications of intravitreal rituximab (IVR) monotherapy for eyes with vitreoretinal lymphoma (VRL).

Methods: Patients diagnosed with 'isolated primary VRL' or 'VRL with remission of systemic disease' and treated with IVR (1 mg/0.1 ml) between June 2014 and June 2019 were included in this retrospective, interventional case series. Read More

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Ocular phenotypes in a mouse model of impaired glucocerebrosidase activity.

Sci Rep 2021 Mar 16;11(1):6079. Epub 2021 Mar 16.

Departments of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.

Mutations in the GBA1 gene encoding glucocerebrosidase (GCase) are linked to Gaucher (GD) and Parkinson's Disease (PD). Since some GD and PD patients develop ocular phenotypes, we determined whether ocular phenotypes might result from impaired GCase activity and the corresponding accumulation of glucosylceramide (GluCer) and glucosylsphingosine (GluSph) in the Gba1 knock-in (Gba KI/KI; "KI") mouse. Gba KI mice developed age-dependent pupil dilation deficits to an anti-muscarinic agent; histologically, the iris covered the anterior part of the lens with adhesions between the iris and the anterior surface of the lens (posterior synechia). Read More

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Implantation of retropupillary iris-claw lenses: A review on surgical management and outcomes.

Acta Ophthalmol 2021 Mar 8. Epub 2021 Mar 8.

Department of Ophthalmology, Oslo University Hospital, Oslo, Norway.

Iris-claw lenses have gained increasing popularity over the last years and are by many surgeons regarded as viable options in eyes with insufficient capsular or zonular support. The iris-claw lens has two haptics with fine fissures for folding (enclavating) the mid-peripheral part of the iris stroma and can either be placed in front of or posterior to the iris. In particular, the retropupillary implantation has been increasingly chosen probably due to having an anatomical position similar to that of the crystalline lens. Read More

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Iris clues in ACG.

Int Ophthalmol 2021 May 23;41(5):1959-1964. Epub 2021 Feb 23.

Centre for Sight, New Delhi, Delhi NCR, India.

Primary angle closure glaucoma is a major cause of visual morbidity in Asia, which hosts 80% of the worldwide cases. In India, primary angle closure glaucoma (PACG) comprises almost 50% of adult glaucomas in hospital setting with its asymptomatic presentation predominating at 80%. Early diagnosis is critical to prevent the blinding trajectory of this disease, which is purported to cause twice as much blindness compared to open angle glaucoma. Read More

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Long-Term Outcomes of Ophthalmic and Retinal Artery Occlusion After Cosmetic Facial Filler Injection.

Aesthet Surg J 2021 Feb 22. Epub 2021 Feb 22.

Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.

Background: Ophthalmic artery occlusion (OAO) and retinal artery occlusion (RAO) after facial filler injection have become increasingly significant due to the increment of cosmetic injection procedures for aesthetic purposes.

Objectives: To analyze the long-term visual outcomes and complications of cosmetic facial filler related OAO and RAO.

Methods: This single center, retrospective case series included 17 eyes of 16 filler related OAO or RAO patients with a follow-up period of one year or longer. Read More

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February 2021

Is 20/20 visual outcome a reality in rubella cataract? - Prognostic factors in children with cataract associated with congenital rubella syndrome.

Indian J Ophthalmol 2021 Mar;69(3):598-602

Department of Pediatric Ophthalmology and Strabismus, M M Joshi Eye Institute, Hubli, Karnataka, India.

Purpose: The aim of this study ws to evaluate prognostic factors associated with final visual outcome in patients with congenital cataract associated with congenital rubella syndrome.

Methods: A prospective interventional analysis of preoperative systemic and ocular features of 56 eyes of 28 seropositive infants of less than 12 months presenting to us with bilateral cataract was performed. All infants were surgically treated with cataract extraction, posterior capsulorhexis, and anterior vitrectomy followed by visual rehabilitation. Read More

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Atypical free-floating iridociliary pigmented epithelial cysts and secondary glaucoma in a caiman (Caiman latirostris).

Vet Ophthalmol 2021 Feb 16. Epub 2021 Feb 16.

The Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.

We describe a case of chronic ocular trauma that resulted in fixed and free-floating, pigmented epithelial iridociliary cysts, inflammation, and secondary glaucoma in a caiman (Caiman latirostris). A 20- to 25-year-old male caiman was presented with phthisis bulbi in the right eye, and congested episcleral vessels, corneal leukoma, disorganized anterior chamber, multifocal anterior synechia, and elevated intraocular pressure in the left eye. Ocular ultrasound of the left eye revealed round structures dispersed in the anterior and posterior chambers and vitreous cavity. Read More

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February 2021

Iris Manifestations in Inadequately Treated Chronic Recurrent Vogt-Koyanagi-Harada Disease.

Ocul Immunol Inflamm 2021 Feb 9:1-7. Epub 2021 Feb 9.

Department of Ophthalmology, University of Medicine 1, Yangon, Myanmar.

: To describe the iris changes in chronic recurrent Vogt-Koyanagi-Harada Disease (VKH): Retrospective case series. Clinical features of 3 VKH patients who developed bilateral depigmentation of the iris are described.: Patients had delayed diagnosis and inadequately treated chronic recurrent VKH. Read More

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February 2021

Four mutations in MITF, SOX10 and PAX3 genes were identified as genetic causes of waardenburg syndrome in four unrelated Iranian patients: case report.

BMC Pediatr 2021 Feb 8;21(1):70. Epub 2021 Feb 8.

Department of Genetics, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Background: Waardenburg syndrome (WS) is a rare genetic disorder. The purpose of this study was to investigate clinical and molecular characteristics of WS in four probands from four different Iranian families.

Case Presentation: The first patient was a 1-year-old symptomatic boy with congenital hearing loss and heterochromia iridis with a blue segment in his left iris. Read More

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February 2021

Development of neovascular glaucoma after intraocular surgery in Pierson syndrome.

Ophthalmic Genet 2021 Feb 8:1-3. Epub 2021 Feb 8.

Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

: To report a patient with Pierson syndrome who presented with neovascular glaucoma (NVG) after cataract surgery.: Retrospective case report.: A 17-year old monocular female presented with sudden onset of pain and decreased vision in the right eye. Read More

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February 2021

Novel mechanism of decreased iris vasculature density after cosmetic iris implants.

BMJ Case Rep 2021 Feb 4;14(2). Epub 2021 Feb 4.

Cleveland Clinic Cole Eye Institute, Cleveland, Ohio, USA.

A 25-year-old man presented with decreased vision in both eyes, approximately 4 years following bilateral bright ocular cosmetic iris implantation. On examination, he was found to have bilateral elevated intraocular pressures, anterior chamber cells and flare, chronic peripheral anterior synechiae and significantly reduced endothelial cell counts. Ultrasound biomicroscopy demonstrated compression of the peripheral iris, resulting in synechial angle closure in both eyes. Read More

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February 2021

A PITX2 splice-site mutation in a family with Axenfeld-Rieger syndrome leads to decreased expression of nuclear PITX2 protein.

Int Ophthalmol 2021 Apr 25;41(4):1503-1511. Epub 2021 Jan 25.

Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Purpose: Axenfeld-Rieger syndrome (ARS) is an autosomal dominant disorder characterized by ocular anterior segment abnormalities. In the current study, we describe clinical and genetic findings in a Chinese ARS pedigree.

Methods: An ARS pedigree was recruited and patients were given comprehensive ophthalmic examinations and general physical examinations. Read More

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Ocular hypertension in Axenfeld-Rieger Syndrome.

Rom J Ophthalmol 2020 Oct-Dec;64(4):455-458

Institut Català de Retina, Barcelona, Spain.

to describe a clinical case of ocular hypertension (OHT) in Axenfeld-Rieger Syndrome (ARS). Observational case report of a 43-year-old woman with background of OHT. The data was collected originally with a standardized electronic medical record. Read More

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December 2020

Variable phenotype of Knobloch syndrome due to biallelic mutations in children.

Eur J Ophthalmol 2020 Nov 25:1120672120977343. Epub 2020 Nov 25.

Department of Ophthalmology, Hadassah University Medical Center, Faculty of Medicine, Hebrew University, Jerusalem, Israel.

Purpose: Knobloch syndrome is a rare, recessively inherited disorder classically characterized by high myopia, retinal detachment, and occipital encephalocele. Our aim is to report the clinical and genetic findings of four Israeli children affected by Knobloch syndrome.

Methods: Retrospective study of four patients diagnosed with Knobloch syndrome, who underwent full ophthalmic examination, electroretinography, and neuroradiologic imaging. Read More

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November 2020

Prostaglandin-Associated Periorbitopathy in Children and Young Adults with Glaucoma.

Ophthalmol Glaucoma 2020 Jul - Aug;3(4):288-294. Epub 2020 Apr 3.

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina. Electronic address:

Objective: To evaluate for relative palpebral and orbital changes after long-term unilateral exposure to prostaglandin analogues (PGAs) in patients with childhood glaucoma.

Design: Prospective cross-sectional cohort study.

Participants: A total of 29 patients with history of childhood glaucoma, who were treated unilaterally with PGAs for at least 12 months. Read More

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Ocular Injury Caused by the Sprayed Venom of the Asian Giant Hornet ().

Case Rep Ophthalmol 2020 May-Aug;11(2):430-435. Epub 2020 Aug 6.

Department of Ophthalmology, School of Medicine, Fujita Health University, Toyoake, Japan.

This report presents the details of a case of sight-threatening injury in the right eye of a 77-year-old man which was caused by the venom of the Asian giant hornet (). The patient was not stung, rather the venom was sprayed into his eye. Although the injured eye was washed as a first aid treatment, persistent corneal defect, corneal endothelial decompensation, iris atrophy, pupil dilation, and mature cataract were observed and a hand movement visual acuity was recorded 8 weeks after the injury. Read More

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Quantitative Analysis of the Iris Surface Smoothness by Anterior Segment Optical Coherence Tomography in Fuchs Uveitis.

Ocul Immunol Inflamm 2020 Sep 23:1-6. Epub 2020 Sep 23.

Retina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Objective: To demonstrate the value of "smoothness index (SI)" as a novel tool for quantitative analysis of iris surface findings in unilateral Fuchs' uveitis (FU).

Methods: Both phakic eyes from patients with unilateral FU as well as healthy control subjects underwent anterior segment optical coherence tomography (AS-OCT). The ImageJ software was used for calculating the SI. Read More

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September 2020

Unilateral iridoschisis.

J Fr Ophtalmol 2020 Dec 10;43(10):1103-1104. Epub 2020 Sep 10.

Department of ophthalmology, Military teaching hospital Med-V, Rabat, Morocco.

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December 2020

Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography.

Clin Ophthalmol 2020 11;14:2265-2270. Epub 2020 Aug 11.

Department of Dermatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Background: Vitiligo is a common skin condition affecting 0.5-2% of the population. The exact etiology of the condition is unknown, but the result is autoimmune destruction of melanocytes. Read More

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Ocular Manifestations of Sickle Cell Disease in Different Genotypes.

Ophthalmic Epidemiol 2021 Jun 6;28(3):185-190. Epub 2020 Aug 6.

Department of Special Surgery, The University of Jordan Hospital, The University of Jordan, Amman, Jordan.

Background: Sickle cell disease (SCD) is a multisystemic disorder with variable systemic involvement which varies according to genotype. In this study, our aim is to compare ocular complications between HbSS, HbSC, HbS/β+ thalassemia, HbS/β0 thalassemia, SS alpha thalassemia, and S/β0 + alpha thalassemia genotypes.

Methods: Data of patients included in this study was recruited from the Cooperative Study of Sickle Cell Disease (CSSCD). Read More

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