94 results match your criteria atracurium local


Airway anesthesia with lidocaine for general anesthesia without using neuromuscular blocking agents in a patient with a history of anaphylaxis to rocuronium: a case report.

J Dent Anesth Pain Med 2020 Jun 24;20(3):173-178. Epub 2020 Jun 24.

Department of Anesthesiology and Pain Medicine, Dankook University College of Medicine, Cheonan, Korea.

We experienced a case of induction of general anesthesia without using neuromuscular blocking agents (NMBAs) in a 40-year-old woman with a history of anaphylaxis immediately after the administration of anesthetics lidocaine, propofol, and rocuronium to perform endoscopic sinus surgery 2 years before. The skin test showed a positive reaction to rocuronium and cis-atracurium. We induced general anesthesia without using NMBAs after inducing airway anesthesia with lidocaine (transtracheal injection and superior laryngeal nerve block). Read More

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[Influence of different local anesthetics on atracurium neuromuscular blockade on rats].

Rev Bras Anestesiol 2020 May - Jun;70(3):220-224. Epub 2020 May 12.

Universidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas, Departamento de Anestesiologia, Campinas, SP, Brasil.

Introduction: The association between Local Anesthetics (LAs) and Neuromuscular Blocking (NMB) drugs in clinical practice, and the possibility of interaction between these drugs has been investigated. LAs act on neuromuscular transmission in a dose-dependent manner and may potentiate the effects of NMB drugs.

Objective: The aim of this study was to evaluate, in an experimental model, the effect of lidocaine and racemic bupivacaine on neuromuscular transmission and the influence on neuromuscular blockade produced by atracurium. Read More

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Addition of dexmedetomidine, tramadol and neostigmine to lidocaine 1.5% increasing the duration of postoperative analgesia in the lower abdominal pain surgery among children: A double-blinded randomized clinical study.

Med Gas Res 2019 Jul-Sep;9(3):110-114

Department of Surgery, Arak University of Medical Sciences, Arak, Iran.

Pain is a common complication after surgery. Insufficient control of postoperative pain has adverse effects on the physiological, metabolic and psychological state of the child. The use of local analgesics and anesthetics alone cannot produce complete anesthesia and intraoperative comfort. Read More

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Anaesthesia, surgery, and life-threatening allergic reactions: epidemiology and clinical features of perioperative anaphylaxis in the 6th National Audit Project (NAP6).

Br J Anaesth 2018 Jul 21;121(1):159-171. Epub 2018 May 21.

Medicines and Healthcare products Regulatory Agency, London, UK.

Background: Anaphylaxis during anaesthesia is a serious complication for patients and anaesthetists.

Methods: The 6th National Audit Project (NAP6) on perioperative anaphylaxis collected and reviewed 266 reports of Grades 3-5 anaphylaxis over 1 yr from all NHS hospitals in the UK.

Results: The estimated incidence was ≈1:10 000 anaesthetics. Read More

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Life-threatening intraoperative anaphylaxis as a result of chlorhexidine present in Instillagel.

BMJ Case Rep 2017 Aug 21;2017. Epub 2017 Aug 21.

Department of Academic Vascular Surgery, Hull York Medical School, Hull, UK.

A 70-year-old man with left lower limb critical ischaemia was admitted to our vascular unit for a femoral-popliteal bypass. He had experienced a skin reaction to chlorhexidine 6 months previously during an angioplasty procedure. After intubation, once in the operating theatre, the patient had a urinary catheter inserted using Instillagel. Read More

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Effect of Local Ropivacaine on Hemodynamic Responses in Craniotomy Patients.

J Invest Surg 2018 Dec 22;31(6):464-468. Epub 2017 Aug 22.

a Faculty of Medicine, Department of Anesthesiology , Lorestan University of Medical Sciences , Khoramabad , Iran.

Background: Increased intracranial pressure (ICP) with hemodynamic is of major concern to anesthesiologists and surgeons in craniotomy surgery. Thus, the management of hemodynamic stability is essential in neuro-anesthesia. This study was performed to investigate the effect of local infiltration of 0. Read More

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December 2018

Utility of basophil activation testing to assess perioperative anaphylactic reactions in real-world practice.

Immun Inflamm Dis 2017 12 5;5(4):416-420. Epub 2017 Jun 5.

Department of Dermatology and Allergy Biederstein, Technische Universität München, Munich, Germany.

Introduction: Perioperative anaphylactic reactions due to drugs and substances associated with general anesthesia can potentially be life-threatening. The objective of this study was to investigate the significance of the basophil activation test (BAT) for allergy diagnosis work up.

Methods: A total of 14 patients (5 men, 9 women; mean age: 57. Read More

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December 2017

A preferential delivery method to investigate direct neuromuscular blockade effect of inhaled anesthetics on skeletal muscle.

Med Hypotheses 2017 Apr 22;101:67-68. Epub 2017 Feb 22.

Department of Anesthesiology, The First Affiliated Hospital of Chengdu Medical College, Xindu, Sichuan 610500, PR China. Electronic address:

Inhaled anesthetics can enhance the effect of neuromuscular blocker, but whether inhaled anesthetics such as sevoflurane have a direct effect on skeletal muscle contractility is unknown. Selectively blocking skeletal muscle may prevent the interference effect of central nervous system. So we decided to evaluate a local application of neuromuscular blocker (NMB) atracurium to prevent the general effect on skeletal muscle. Read More

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Effects of two different anesthetic methods on cellular immunity of patients after liver cancer resection.

J Biol Regul Homeost Agents 2016 Oct-Dec;30(4):1099-1106

Department of Anesthesiology, Cancer Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

This study aims to investigate the effects of epidural block in combination with general anesthesia and general anesthesia alone on the immune function of patients undergoing primary liver cancer resection. Twenty-four patients with liver cancer who received treatment in the Third Hospital of Harbin Medical University, Heilongjiang, China, were enrolled and randomly allocated into group A and group B, with 12 in each group. The data on the T lymphocyte subpopulation, pro-inflammatory cytokines and antiinflammatory cytokines were recorded before, immediately after and 24 h after liver cancer resection to compare differences and changes. Read More

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The novel use of different bupivacaine preparations with combined regional techniques for postoperative pain management in non-opioid-based laparoscopic inguinal herniorrhaphy.

J Clin Anesth 2016 Nov 8;34:403-6. Epub 2016 Jun 8.

Department of Anesthesiology, Richard L. Roudebush VA Medical Center, Indiana University School of Medicine, 1481 West Tenth Street, Indianapolis, IN 46202, USA. Electronic address:

Opioids are important for surgical pain control but may not be appropriate for patients with narcotic abuse histories or opioid intolerance. We describe a laparoscopic bilateral inguinal herniorrhaphy performed without perioperative or postoperative narcotics. Postoperative analgesia involves a novel technique using 2 different bupivacaine formulations that act synergistically to avoid lag time and provide extended pain relief during the acute surgical recovery phase. Read More

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November 2016

Longer Immediate Recovery Time After Anesthesia Increases Risk of Respiratory Complications After Laparotomy for Bariatric Surgery: a Randomized Clinical Trial and a Cohort Study.

Obes Surg 2015 Nov;25(11):2205-12

Department of Anesthesiology, UNESP-Universidade Estadual Paulista, Botucatu, SP, Brazil.

Background: We compared the effects of two anesthesia protocols in both immediate recovery time (IRT) and postoperative respiratory complications (PRCs) after laparotomy for bariatric surgery, and we determined the association between the longer IRT and the increase of PRC incidence.

Methods: We conducted the study in two stages: (i) in a randomized controlled trial (RCT), patients received either intervention (sevoflurane-remifentanil-rocuronium-ropivacaine) or control protocol (isoflurane-sufentanil-atracurium-levobupivacaine). All patients received general anesthesia plus continuous epidural anesthesia and analgesia. Read More

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November 2015

[Fetal cardiac interventions - are we ready for them?].

Ginekol Pol 2015 Apr;86(4):280-6

Objective: The aim of the study was to analyze types and methods of intrauterine fetal cardiac interventions performed between June 2011 and December 2013, and to assess the perinatal management of the neonates.

Methods: The program was developed after analysis of the available literature, practical individual training in Linz, Austria, and simulation of the procedure in a dissecting-room. The rules for anesthesia in pregnant women and their fetuses were developed. Read More

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Randomized clinical trial comparing two different techniques of local anesthesia (subcutaneous versus subcutaneous & deep infiltration) for postoperative pain in patients undergoing open appendecectomy.

J Egypt Soc Parasitol 2015 Apr;45(1):177-82

This study compared the postoperative analgesic effect of local anesthetic (LA) injected subcutaneous (SC) alone versus local anesthetic injected both SC and deep in patients undergoing open appendecectomy operations. Sixty patients ASA class I-II undergoing open appendecectomy for presumed acute appendicitis will be randomly assigned into three groups. After routine monitoring, anesthesia induction was performed with propofol, fentanyl and, cis-atracurium; later, maintenance was continued with isoflurane. Read More

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The incidence of perioperative hypersensitivity reactions: a single-center, prospective, cohort study.

Anesth Analg 2015 Jul;121(1):117-23

From the Departments of *Allergy and †Anaesthesiology, Clínica Universidad de Navarra, Pamplona, Spain.

Background: The incidence of perioperative hypersensitivity reactions, which can be life-threatening, ranges from 1 in 20,000 to 1 in 1361. These reactions are usually classified as IgE or non-IgE mediated. The aim of this study was to determine the incidence of allergic reactions during general anesthesia in our hospital, to establish the incidence of the allergic reactions for each drug used, to assess the frequency of IgE-mediated reactions in even mild reactions, and to compare the degree of agreement between anesthesiologist suspicion and allergy diagnosis. Read More

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Comparison between general anesthesia and spinal anesthesia in attenuation of stress response in laparoscopic cholecystectomy: A randomized prospective trial.

Saudi J Anaesth 2015 Apr-Jun;9(2):184-8

Department of Anesthesiology, N.R.S. Medical College, Kolkata, West Bengal, India.

Background: Laparoscopy though minimally invasive produces significant hemodynamic surge and neuroendocrine stress response. Though general anesthesia (GA) is the conventional technique, now-a-days, regional anesthesia has been accepted for laparoscopic diagnostic procedures, and its use is also being extended to laparoscopic surgeries.

Objective: The aim was to compare the hemodynamic surge and neuroendocrine stress response during laparoscopic cholecystectomy (LC) under GA and spinal anesthesia (SA) in American Society of Anesthesiologists (ASA) PS 1 patients. Read More

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[General anesthesia for ambulatory surgery : Clinical pharmacological considerations on the practical approach].

Anaesthesist 2014 Nov;63(11):865-70, 872-4

Klinik für Anästhesiologie und Intensivmedizin, RTH Christoph 8, Klinikum Lünen - St.-Marien-Hospital, 44534, Lünen, Deutschland,

Due to modern surgical and anesthesia techniques, many patients undergoing small or even medium surgical procedures will recover within minutes and can then be discharged after a few hours of monitoring. Aside from an optimized surgical technique, a precise and differentiated anesthesia concept is needed to guarantee rapid recovery and home readiness. Nowadays, remifentanil-propofol represents the standard regime in ambulatory anesthesia. Read More

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November 2014

Distal tracheoesophageal fistula in pediatric patient - an anesthetic challenge.

Paediatr Anaesth 2014 Aug;24(8):886-8

Department of Anesthesiology and Intensive Care, All India Institute of Medical Sciences, New Delhi, India.

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Cisatracurium pretreatment with tourniquet reduces propofol injection pain: a double-blind randomized controlled trial.

J Int Med Res 2014 Apr 26;42(2):360-7. Epub 2014 Feb 26.

Department of Anaesthesia and Pain Medicine, Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea.

Objectives: To investigate the efficacy of pretreatment with cisatracurium for prevention of pain associated with propofol injection, and compare its efficacy with that of lidocaine.

Methods: Patients undergoing general anaesthesia were randomized to receive normal saline (control group), lidocaine (0.5 mg/kg), 0. Read More

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[Anaphylaxis by atracurium. One case report].

Rev Alerg Mex 2013 Apr-Jun;60(2):78-81

Departamento de Alergias, Centro Regional de Alergias e InmunologÌa ClÌnica, Hospital Universitario Dr JosÈ E Gonz·lez, Monterrey, Nuevo LeÛn, MÈxico.

Background: The incidence of severe intraoperative anesthetic reactions varies among countries from 1:10,000 to 1:13 000 patients submitted to surgery.

Case Report: A 13 year old male, with family history of atopy, who underwent 5 surgeries for hydrocephalus, using general anesthesia. He was on lamotrigine for seizures. Read More

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Effects of peribulbar anesthesia (sub-Tenon injection of a local anesthetic) on akinesia of extraocular muscles, mydriasis, and intraoperative and postoperative analgesia in dogs undergoing phacoemulsification.

Am J Vet Res 2013 Aug;74(8):1126-32

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea.

Objective: To evaluate the effects of peribulbar anesthesia (sub-Tenon injection of lidocaine hydrochloride) on akinesia of extraocular muscles, mydriasis, and intraoperative and postoperative analgesia in dogs undergoing phacoemulsification.

Animals: 14 Beagles with ophthalmically normal eyes.

Procedures: A blinded randomized controlled trial was performed. Read More

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Comparison of systemic atracurium, retrobulbar lidocaine, and sub-Tenon's lidocaine injections in akinesia and mydriasis in dogs.

Vet Ophthalmol 2013 Nov 24;16(6):440-5. Epub 2013 Jan 24.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea.

Objective: To compare the effect of sub-Tenon's lidocaine injections (ST) on akinesia and mydriasis to those of systemic atracurium (AT) and retrobulbar lidocaine injections in dogs.

Animal Studied: Ten healthy beagle dogs without apparent ocular disease.

Procedures: Three treatments were performed on 10 beagle dogs with a minimum 7-day washout period: intravenous injection of AT (0. Read More

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November 2013

Accuracy of preparation of i.v. medication syringes for anesthesiology.

Am J Health Syst Pharm 2013 Jan;70(2):137-42

Pharmacy Cytotoxic Unit, Pharmacy, Geneva University Hospitals, Geneva, Switzerland.

Purpose: The results of a study of the accuracy of i.v. medication preparation by anesthesiologists are presented. Read More

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January 2013

Influence of anesthesia on the results of intraoperative diagnostic electromyostimulation in patients with anorectal malformation.

J Pediatr Surg 2011 Nov;46(11):2135-9

Department of Anesthesiology, 2nd Faculty of Medicine, Charles University and Motol Hospital, 150 06 Prague, Czech Republic.

Background And Purpose: Stimulation electromyography (sEMG) is useful in identifying the sphincter muscle (M) in patients with anorectal malformations (ARMs). This study evaluates the effect of anesthetic agents and M relaxants on sEMG findings.

Materials And Methods: Seventeen infants (10 boys and 7 girls) with a mean age of 6. Read More

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November 2011

Comparing the effect of using atracourium and cis-atracourium as adjuvant agents to the local anesthetic substance on peribulbar-induced akinesia.

Acta Med Iran 2011 ;49(8):509-12

Department of Anesthesiology, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Peribulbar anesthesia is widely applied in cataract surgeries. The aim of this study was comparing the effect of using Atracourium, cis-Atracourium, and placebo as adjuvant agents to the local anesthetic substance on peribulbar-induced akinesia in cataract surgeries. The study was double-blind randomized clinical trial, among the patients candidate for the cataract surgery who were hospitalized in ocular surgery ward in Farabi Hospital between 2006 and 2007. Read More

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A single injection of botulinum toxin decreases the margin of safety of neurotransmission at local and distant sites.

Anesth Analg 2012 Jan 14;114(1):102-9. Epub 2011 Oct 14.

Department of Anesthesia & Critical Care, Massachusetts General Hospital, Boston, USA.

Background: We tested the hypothesis that a single injection of botulinum toxin not only has local, but also distant effects on muscle function, biochemistry, and pharmacodynamics of atracurium.

Methods: Botulinum toxin (2.5 U) was injected into the tibialis muscle of anesthetized rats (n = 26). Read More

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January 2012

Intravenous regional anesthesia: a review of common local anesthetic options and the use of opioids and muscle relaxants as adjuncts.

Local Reg Anesth 2011 25;4:57-76. Epub 2011 Nov 25.

Department of Anesthesia, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.

Purpose: To provide a review of local anesthetic (LA) agents and adjuncts, opioids and muscle relaxants, and their intraoperative effects and postoperative outcomes in intravenous regional anesthesia (IVRA).

Source: A search for prospective, double-blind, randomized controlled trials evaluating LA agents, opioids and muscle relaxants as adjuvants for IVRA, was conducted (MEDLINE(®), Embase). Intraoperative benefits (onset/recovery of sensory and motor block, intraoperative analgesia, tourniquet pain), postoperative benefits (pain score, analgesic consumption, time to first analgesia), and side effects were recorded. Read More

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October 2012

Effect of an intravenous infusion of lidocaine on cisatracurium-induced neuromuscular block duration: a randomized-controlled trial.

Acta Anaesthesiol Scand 2010 Nov 14;54(10):1192-6. Epub 2010 Sep 14.

Department of Anaesthesia and Intensive Care Medicine, CHU of Liège, University of Liège, Belgium.

Background: Intravenous lidocaine can be used intraoperatively for its analgesic and antihyperalgesic properties but local anaesthetics may also prolong the duration of action of neuromuscular blocking agents. We hypothesized that intravenous lidocaine would prolong the time to recovery of neuromuscular function after cisatracurium.

Methods: Forty-two patients were enrolled in this randomized, double-blind, placebo-controlled study. Read More

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November 2010

The effect of addition of low dose atracurium to local anesthetic in retrobulbar block for cataract surgery.

Middle East J Anaesthesiol 2010 Feb;20(4):535-8

Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Addition of some neuromuscular blockers to local anesthetics proved to be effective in improving the quality of anesthesia in different regional techniques. This study was carried out to determine whether the addition of low-dose atracurium to a local anesthetic has any effect on the onset and duration of akinesia in retrobulbar block.

Patients And Methods: This study was conducted on sixty-four unpremedicated, ASA I or 11 patients scheduled for cataract surgery under local anesthesia. Read More

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February 2010

The effect of local anesthetics on the inhibition of adult muscle-type nicotinic acetylcholine receptors by nondepolarizing muscle relaxants.

Eur J Pharmacol 2010 Mar 4;630(1-3):29-33. Epub 2010 Jan 4.

Department of Anesthesiology, First People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

The primary action of local anesthetics is to inhibit voltage-gated Na(+) channels. However, local anesthetics also have an inhibitory effect on muscle-type nicotinic acetylcholine receptors. Because local anesthetics could increase the neuromuscular blockade produced by nondepolarizing muscle relaxants, we investigated the interaction of local anesthetics with nondepolarizing muscle relaxants at adult muscle-type nicotinic acetylcholine receptors. Read More

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[Analgesic and sedative effects of multimodal analgesia in stage of emergence after general anesthesia for cleft lip and/or palate prosthesis].

Zhonghua Yi Xue Za Zhi 2009 Apr;89(13):906-8

Department of Anesthesiology, Second Affiliated Hospital, Wenzhou Medical College, Wenzhou 325027, China.

Objective: To investigate the effects of multimodal analgesia on analgesia and sedation during emergence of general anesthesia for cleft lip and/or palate surgery pediatric patients.

Methods: Fifty-four pediatric patients with ASA I and II cleft lip and/or palate, aged 2-7, undergoing prosthesis were randomly allocated into 2 groups: control group (Group C, n=28) inhaling nitrous oxide/oxygen (50%:50%) and sevoflurane(5%) for general anesthesia, and multimodal group (Group M, n=26), injected intravenously with fentanyl and atracurium in addition to inhalation of nitrous oxide/oxygen (50%:50%) and sevoflurane (5%). Ventilation was controlled with PCV modal to maintain end-tidal CO2 to 35-45 mmHg. Read More

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