Free Radic Biol Med 2021 Apr 1;168:55-69. Epub 2021 Apr 1.
Mari State University, Pl. Lenina 1, Yoshkar-Ola, Mari El, 424001, Russia; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, Pushchino, Moscow Region, 142290, Russia; Prokhorov General Physics Institute of the Russian Academy of Sciences, Vavilova 38, Moscow, 119991, Russia.
The paper examines the molecular mechanisms of the cytotoxicity of conjugates of betulinic acid with the penetrating cation F16. The in vitro experiments on rat thymocytes revealed that all the obtained F16-betulinic acid derivatives showed more than 10-fold higher cytotoxicity as compared to betulinic acid and F16. In this case, 0. Read More