16,992 results match your criteria asymptomatic individuals

Patterns of pharmaceuticals use during the first wave of COVID-19 pandemic in Athens, Greece as revealed by wastewater-based epidemiology.

Sci Total Environ 2021 Jul 21;798:149014. Epub 2021 Jul 21.

Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece. Electronic address:

Since 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), impaired public health with considerable morbidity and mortality due to the lack of vaccines and effective treatment. The severe disease mainly harmed adults with predisposing medical comorbidities (such as heart disease, hypertension, chronic lung disease), while it can occur in healthy individuals that may be asymptomatic. Wastewater-based Epidemiology (WBE), a non-invasive, objective, chemical tool was used to monitor and estimate the changes in drug's consumption and prescription patterns under normal conditions (2019) and under COVID-19 pandemic conditions (2020). Read More

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The potential of SARS-CoV-2 antigen-detection tests in the screening of asymptomatic persons.

Clin Microbiol Infect 2021 Jul 26. Epub 2021 Jul 26.

Center of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany; German Center of Infection Research, Site Heidelberg, Heidelberg, Germany. Electronic address:

Objectives: To assess the performance of antigen-based rapid diagnostic tests (Ag-RDTs) for SARS CoV-2 when implemented for large-scale universal screening of asymptomatic individuals.

Methods: This study is a pragmatic implementation study for universal Ag-RDT-based screening at a tertiary care hospital in Germany where patients presenting for elective procedures and selected personnel without symptoms suggestive of SARS-CoV-2 were screened with an Ag-RDT since October 2020. Test performance was calculated on an individual-patient level. Read More

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A seroprevalence survey of anti-SARS-CoV-2 antibodies among individuals 18 years of age or older living in a vulnerable region of the city of São Paulo, Brazil.

PLoS One 2021 29;16(7):e0255412. Epub 2021 Jul 29.

Diretoria de Atenção Primária e Rede Assistencial, Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brasil.

A second wave of COVID-19 has demonstrated how challenging it will be to achieve sustained control of the disease, even with vaccination underway in many countries. Therefore, it remains relevant to keep improving our understanding of the distribution of COVID-19, especially of asymptomatic individuals, among different populations, and particularly in vulnerable regions. Hence, this population-based serosurvey had the objective of estimating the prevalence of individuals 18 years of age or older infected by SARS-CoV-2, and the proportion of asymptomatic individuals, among a vulnerable population living in an urban setting. Read More

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Comparison of immunogenicity and reactogenicity of inactivated SARS-CoV-2 vaccine (CoronaVac) in previously SARS-CoV-2 infected and uninfected health care workers.

Hum Vaccin Immunother 2021 Jul 29:1-5. Epub 2021 Jul 29.

Memorial Ataşehir Hospital, Clinic of Pediatrics, İstanbul, Turkey.

The effects of inactivated SARS-CoV-2 vaccine (CoronaVac) on previously naturally infected individuals are unknown. This study compared immunogenicity and reactogenicity of CoronaVac in once naturally infected health-care workers (HCWs) and uninfected HCWs. All HCWs were immunized with two doses of CoronaVac (600 U/0. Read More

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When intuition falters: repeated testing accuracy during an epidemic.

Eur J Epidemiol 2021 Jul 28. Epub 2021 Jul 28.

Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Widespread, repeated testing using rapid antigen tests to proactively detect asymptomatic SARS-CoV-2 infections has been a promising yet controversial topic during the COVID-19 pandemic. Concerns have been raised over whether currently authorized lateral flow tests are sufficiently sensitive and specific to detect enough infections to impact transmission whilst minimizing unnecessary isolation of false positives. These concerns have often been illustrated using simple, textbook calculations of positivity rates and positive predictive value assuming fixed values for sensitivity, specificity and prevalence. Read More

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Diagnostic and Prognostic Significance of miR-675-3p in Patients With Atherosclerosis.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211024754

Department of Neurosurgery, Binzhou Medical University Hospital, Binzhou, Shandong, People's Republic of China.

In recent years, a rising number of studies have confirmed that microRNA (miRNA) plays a prominent role in the early diagnosis and prognostic value assessment of cardiovascular diseases. The current study was conducted to examine the expression of miR-675-3p in atherosclerosis (AS) patients and to evaluate its clinical diagnosis and prognostic value. 110 AS patients and 70 healthy controls were included in the study. Read More

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IgE and IgG4 Repertoire in Asymptomatic HDM-Sensitized and HDM-Induced Allergic Rhinitis Patients.

Int Arch Allergy Immunol 2021 Jul 28:1-12. Epub 2021 Jul 28.

Department of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China.

Introduction: Asymptomatic sensitization is defined as the presence of positive skin prick test (SPT) and/or positive serum allergen-specific IgE in the absence of clinical allergic symptoms. Currently, there is no convincing explanation why some people with positive allergen tests do not show symptoms. We aimed to investigate the house dust mite (HDM)-specific IgE and IgG4 repertoire in asymptomatic HDM-sensitized subjects and HDM-induced allergic rhinitis (AR) patients. Read More

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Metabolomics analysis for diagnosis and biomarker discovery of transthyretin amyloidosis.

Amyloid 2021 Jul 28:1-9. Epub 2021 Jul 28.

Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

Untargeted metabolomics is a well-established technique and a powerful tool to find potential plasma biomarkers for early diagnosing hereditary transthyretin amyloidosis. Hereditary transthyretin amyloidosis (ATTRv) is a disabling and fatal disease with different clinical features such as polyneuropathy, cardiomyopathy, different gastrointestinal symptoms and renal failure. Plasma specimens collected from 27 patients with ATTRv (ATTRV30M), 26 asymptomatic V30M carriers and 26 control individuals were subjected to gas chromatography (GC)- and liquid chromatography (LC)-mass spectrometry (MS)-based metabolomics analysis. Read More

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High-Throughput Multiplex SARS-CoV-2 IgG Microsphere Immunoassay for Dried Blood Spots: A Public Health Strategy for Enhanced Serosurvey Capacity.

Microbiol Spectr 2021 Jul 28:e0013421. Epub 2021 Jul 28.

Wadsworth Center, New York State Department of Healthgrid.238491.5, Albany, New York, USA.

Early in the pandemic when diagnostic testing was not widely available, serosurveys played an important role in estimating the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different populations. Dried blood spots (DBS), which can be collected in nonclinical settings, provide a minimally invasive alternative to serum for serosurveys. We developed a Luminex-based SARS-CoV-2 microsphere immunoassay (MIA) for DBS that detects IgG antibodies to nucleocapsid (N) and spike subunit 1 (S1) antigens. Read More

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Health Care Workers and Patients as Trojan Horses: a COVID19 ward outbreak.

Infect Prev Pract 2020 Sep 4;2(3):100073. Epub 2020 Jul 4.

Public Health Wales Microbiology Department, 8 Eaton Cres, Sketty, Swansea, SA2 8QA, UK.

Background: Transmission in healthcare settings can result in significant infections in healthcare workers and patients. Understanding infection dynamics has important implications for methods employed in hospitals to prevent nosocomial transmission events.

Methods: In this case series report we describe a cluster of COVID-19 (Coronavirus disease 2019) in a tertiary care university hospital, in the early phases of the epidemic, after hospital visiting had been stopped and when the UK lockdown was in place. Read More

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September 2020

What we learned in the past year in managing our COVID-19 patients in intensive care units?

World J Crit Care Med 2021 Jul 9;10(4):81-101. Epub 2021 Jul 9.

Department of Medicine, Texas A&M University, Corpus Christi, TX 78404, United States.

Coronavirus disease 2019 is a pandemic, was first recognized at Wuhan province, China in December 2019. The disease spread quickly across the globe, spreading stealthily from human to human through both symptomatic and asymptomatic individuals. A multisystem disease which appears to primarily spread bio aerosols, it has exhibited a wide clinical spectrum involving multiple organ systems with the respiratory system pathology being the prime cause of morbidity and mortality. Read More

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Diagnostic accuracy of rapid antigen tests in asymptomatic and presymptomatic close contacts of individuals with confirmed SARS-CoV-2 infection: cross sectional study.

BMJ 2021 Jul 27;374:n1676. Epub 2021 Jul 27.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

Objective: To assess the diagnostic test accuracy of two rapid antigen tests in asymptomatic and presymptomatic close contacts of people with SARS-CoV-2 infection on day 5 after exposure.

Design: Prospective cross sectional study.

Setting: Four public health service covid-19 test sites in the Netherlands. Read More

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Pooled SARS-CoV-2 antigen tests in asymptomatic children and their caregivers: Screening for SARS-CoV-2 in a pediatric emergency department.

Am J Infect Control 2021 Jul 24. Epub 2021 Jul 24.

Department of Gastroenterology, Hepatology, Pneumology and Infectious diseases, Katharinenhospital, Klinikum Stuttgart, Kriegsbergstraße 60, 70174 Stuttgart, Germany; Department of Hospital Hygiene, Klinikum Stuttgart, Kriegsbergstraße 60, 70174 Stuttgart Germany; Department I of Internal Medicine, Division of Infectious Diseases, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. Electronic address:

Background: Universal admission screening for SARS-CoV-2 in children and their caregivers (CG) is critical to prevent hospital outbreaks. We evaluated pooled SARS-CoV-2 antigen tests (AG) to identify infectious individuals while waiting for PCR test results.

Methods: This single-center study was performed from November 5, 2020 to March 1, 2021. Read More

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Rapid antigen detection alone may not be sufficient for early diagnosis and/or mass screening of COVID-19.

J Med Virol 2021 Jul 27. Epub 2021 Jul 27.

Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.

Currently, COVID-19 pandemic is still severe, and the major challenge in the fight against this pandemic is how to early find pre-symptomatic and asymptomatic individuals and to eliminate silent transmission. Rapid antigen detection alone may not be sufficient for early diagnosis and/or mass screening of COVID-19, and direct probe-based RT-LAMP assay or other nucleic acid amplification (NAA)-based POCT strategies should be recommended to use alone or together with rapid antigen test in mass screening or community-based testing of SARS-CoV-2 This article is protected by copyright. All rights reserved. Read More

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Cohort profile: A Prospective Household cohort study of Influenza, Respiratory syncytial virus and other respiratory pathogens community burden and Transmission dynamics in South Africa, 2016-2018.

Influenza Other Respir Viruses 2021 Jul 23. Epub 2021 Jul 23.

Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Purpose: The PHIRST study (Prospective Household cohort study of Influenza, Respiratory Syncytial virus, and other respiratory pathogens community burden and Transmission dynamics in South Africa) aimed to estimate the community burden of influenza and respiratory syncytial virus (RSV) including the incidence of infection, symptomatic fraction, and to assess household transmission.

Participants: We enrolled 1684 individuals in 327 randomly selected households in a rural and an urban site over three consecutive influenza and two RSV seasons. A new cohort of households was enrolled each year. Read More

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The use of echocardiography in type 1 diabetes.

Rev Port Cardiol 2021 Jul 19. Epub 2021 Jul 19.

Universidade Federal de Santa Catarina, Florianópolis, PR, Brasil.

Introduction: Type 1 diabetes (T1D) is a chronic disease with peak incidence in adolescence; it has a major impact on morbidity and mortality, especially cardiovascular. Diabetic cardiomyopathy is characterized by structural and functional lesions in the absence of other diseases and is involved in the progression to heart failure. Echocardiography has led to the identification of early cardiac lesions, despite controversial results in the literature in patients with T1D. Read More

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Ligaments of the scapho-trapezial-trapezoidal joint: MR anatomy in asymptomatic and symptomatic individuals.

Skeletal Radiol 2021 Jul 26. Epub 2021 Jul 26.

Radiology, Balgrist University Hospital, Forchstrasse 340, 8008, Zurich, Switzerland.

Purpose: To evaluate the MRI anatomy of the scapho-trapezial-trapezoidal (STT) ligament complex in asymptomatic and symptomatic individuals.

Material And Methods: In this retrospective study, STT ligament complex of 42 (male 69%, median age 37.5 years) asymptomatic (n = 25) and symptomatic (n = 17) (defined as pain described over the STT joint) individuals was examined using a high-resolution 3D proton density-weighted isovoxel sequence (MR arthrogram) with multiplanar reconstructions. Read More

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Breast health screening: a UK-wide questionnaire.

BMJ Nutr Prev Health 2021 4;4(1):206-212. Epub 2021 May 4.

Department of Chemistry and Biosciences, University of Bradford, Bradford, UK.

Background: Currently, there is an unmet clinical need in identifying and screening women at high risk of breast cancer, where tumours are often aggressive and treatment intervention is too late to prevent metastasis, recurrence and mortality. This has been brought into sharp focus by the SARS-CoV-2 global pandemic, constantly changing hospital policies and surgical guidelines in reducing access to established screening and treatment regimens. Nipple aspirate fluid (NAF), is thought to provide a unique window into the biological processes occurring within the breast, particularly in the context of a developing neoplasm. Read More

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Acute Hyponatremia After a Religious Fast.

AACE Clin Case Rep 2021 Jul-Aug;7(4):236-238. Epub 2021 Mar 4.

Columbia University Irving Medical Center, Department of Medicine, Division of Nephrology, New York, New York.

Objective: Our objective is to describe how polydipsia and intake of nonsteroidal anti-inflammatory drugs (NSAIDs) after fasting while breastfeeding may result in acute symptomatic hyponatremia.

Case Report: We present the case of a 24-year-old woman at 4 weeks postpartum who engaged in a 20-hour fast from both eating and drinking, during which she continued to breastfeed her newborn child. After ending her fast, she noted decreased milk supply. Read More

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Olfactory and Gustatory Dysfunctions in Patients With Laboratory-Confirmed COVID-19 Infection: A Change in the Trend.

Indian J Otolaryngol Head Neck Surg 2021 Jul 18:1-7. Epub 2021 Jul 18.

Department of Otorhinolaryngology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, 110029 India.

To study the presence of olfactory and gustatory dysfunctions in patients with laboratory-confirmed COVID-19 infection in our set up. Longitudinal study, 1st March 2020-15th August 2020, at a tertiary care hospital. RT PCR positive for SARSCoV-2 patients, above 18 years age included. Read More

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A Field-Based Study of the Magnitude of Risk Factors and Health Habits in Young Volunteers in the Community.

Cureus 2021 Jun 22;13(6):e15821. Epub 2021 Jun 22.

Cardiology, King Saud Bin Abdulaziz University for Health Sciences, College of Medicine-Western Region, Ministry of National Guard Health Affairs, Jeddah, SAU.

Objective A field study is more informative in terms of epidemiological data than a hospital-based study. Undiagnosed risk factors may be discovered in an asymptomatic group. This study aimed to estimate if the community was well informed about the risk factors for coronary artery disease and if that affected the prevalence and the anthropometric among those who participated in the study. Read More

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Long-term dynamics of transmission in Japan, 2005-2019.

PeerJ 2021 12;9:e11769. Epub 2021 Jul 12.

Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.

continues to evolve, adjusting its pathogenesis and transmissibility. In the present study, we systematically collected datasets on outbreaks in Japan from 2005 to 2019 and analyzed time-dependent changes in the asymptomatic ratio, the probability of virus detection, and the probability of infection given exposure. Reports of 1,728 outbreaks were published, and feces from all involved individuals, including those with asymptomatic infection, were tested for virus in 434 outbreaks. Read More

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Genetic basis and hematologic manifestations of sitosterolemia in a group of Turkish patients.

J Clin Lipidol 2021 Jul 10. Epub 2021 Jul 10.

Department of Food Engineering, Ankara University, Faculty of Engineering, Ankara, Turkey.

Background: Sitosterolemia is a rare lipid disorder caused by mutations in adenosine triphosphate-binding cassette genes (ABCG) 5 and 8.

Objective: To evaluate the phenotypic/genotypic features of sitosterolemia in a group of Turkish patients.

Methods: Seven probands with unexplained hematologic abnormalities and their 13 relatives were enrolled. Read More

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Idiopathic guttate hypomelanosis: Presentation and Management.

J Cosmet Laser Ther 2021 Jul 25:1-8. Epub 2021 Jul 25.

Private Practitioner, Ahmedabad, India.

Idiopathic guttate hypomelanosis (IGH) is a benign, typically asymptomatic, acquired leukoderma characteristically affecting mature individuals. Although the etiopathogenesis is unclear, chronic sun exposure and senile degeneration are important triggers. Researchers have been engaged in a continuous effort to unveil the gray areas encompassing different aspects of IGH pathogenesis. Read More

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Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study.

Lancet Neurol 2021 Aug;20(8):615-626

Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Background: Due to trisomy of chromosome 21 and the resultant extra copy of the amyloid precursor protein gene, nearly all adults with Down syndrome develop Alzheimer's disease pathology by the age of 40 years and are at high risk for dementia given their increased life expectancy compared with adults with Down syndrome in the past. We aimed to compare CSF biomarker patterns in Down syndrome with those of carriers of autosomal dominant Alzheimer's disease mutations to enhance our understanding of disease mechanisms in these two genetic groups at high risk for Alzheimer's disease.

Methods: We did a cross-sectional study using data from adults enrolled in the Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study, a multisite longitudinal study of Alzheimer's disease in Down syndrome, as well as a cohort of carriers of autosomal dominant Alzheimer's disease mutations and non-carrier sibling controls enrolled in the Dominantly Inherited Alzheimer Network (DIAN) study. Read More

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Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study.

Lancet Neurol 2021 Aug;20(8):605-614

Sant Pau Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Madrid, Spain; Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain; Horizon 21 Consortium, Paris, France. Electronic address:

Background: Adults with Down syndrome are at an ultra-high risk of Alzheimer's disease, but diagnosis of Alzheimer's disease in this population is challenging. We aimed to validate the clinical utility of plasma neurofilament light chain (NfL) for the diagnosis of symptomatic Alzheimer's disease in Down syndrome, assess its prognostic value, and establish longitudinal changes in adults with Down syndrome.

Methods: We did a multicentre cohort study, including adults with Down syndrome (≥18 years), recruited from six hospitals and university medical centres in France, Germany, Spain, the UK, and the USA, who had been assessed, followed up, and provided at least two plasma samples. Read More

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Higher viral load drives infrequent SARS-CoV-2 transmission between asymptomatic residence hall roommates.

J Infect Dis 2021 Jul 24. Epub 2021 Jul 24.

BioFrontiers Institute.

Background: The COVID-19 pandemic spread to over 200 countries in less than six months. To understand COVID spread, determining transmission rate and defining factors that increase transmission risk are essential. Most cases are asymptomatic, but they have viral loads indistinguishable from symptomatic people and do transmit SARS-CoV-2 virus. Read More

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Prospective analytical performance evaluation of the QuickNavi™-COVID19 Ag for asymptomatic individuals.

J Infect Chemother 2021 Jul 9. Epub 2021 Jul 9.

Division of Infectious Diseases, Department of Medicine, Tsukuba Medical Center Hospital, 1-3-1 Amakubo Tsukuba, Ibaraki, 305-8558, Japan; Department of Infectious Diseases, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. Electronic address:

Introduction: Antigen testing may help screen for and detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in asymptomatic individuals. However, limited data regarding the diagnostic performance of antigen tests for this group are available.

Methods: We used clinical samples to prospectively evaluate the analytical and clinical performance of the antigen test QuickNavi™-COVID19 Ag. Read More

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Generation and characterization of three human induced pluripotent stem cell lines (EURACi007-A, EURACi008-A, EURACi009-A) from three different individuals of the same family with arrhythmogenic cardiomyopathy (ACM) carrying the plakophillin2 p.N346Lfs*12 mutation.

Stem Cell Res 2021 Jul 15;55:102466. Epub 2021 Jul 15.

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy. Electronic address:

Arrhythmogenic Cardiomyopathy (ACM) is a genetically based cardiomyopathy associated with ventricular arrhythmias and fibro-fatty substitution of cardiac tissue. It is characterized by incomplete penetrance. We generated human iPSCs by episomal reprogramming of blood cells from three members of the same family: the proband, affected by ACM and carrying the heterozygous plakophillin2 p. Read More

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