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Prevalence of liver injury in 445 patients with Corona Virus Disease-19-Single-centre experience from southern India.

Indian J Gastroenterol 2021 May 15. Epub 2021 May 15.

Department of Gastroenterology and Hepatology, MIOT International, 4/112, Mount Poonamalle High Road, Sathya Nagar, Manapakkam, Chennai, 600 089, India.

Background: Abnormal liver function tests (LFT) are common in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vary from 15% to 53%. There are scanty data  from India on the prevalence of liver injury in corona virus disease 2019 (COVID-19) patients.

Methods: We did this retrospective study in a tertiary care hospital, Chennai, India. Read More

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The natural course of COVID-19 patients without clinical intervention.

J Med Virol 2021 May 15. Epub 2021 May 15.

Department of Infectious Diseases, the First Affiliated Hospital, Nanchang University, 330006, Nanchang, China.

Objective: The natural course of COVID-19 patients without clinical intervention has not yet been documented.

Methods: One hundred and fifty-eight patients from two hospitals were enrolled to identify the indicators of severe COVID-19 and observe the natural course of COVID-19 patients without clinical intervention.

Results: The total computed tomography (CT) score, a quantitative score based on assessment of the number, quadrant, and area of the lesions in CT, tended to perform better than assessment based only on the number or area of the lesions (p = 0. Read More

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Modulatory effects of carvacrol against cadmium-induced hepatotoxicity and nephrotoxicity by molecular targeting regulation.

Life Sci 2021 May 11;277:119610. Epub 2021 May 11.

Erzurum Veterinary Control Institute, 25070 Erzurum, Turkey.

Aim: Cadmium (Cd) is a toxic heavy metal that causes severe toxic effects on different tissues including liver and kidney. Therefore the research for alternatives to reduce the damage caused by Cd has substantial importance. This study was performed to examine the possible modulatory effects of carvacrol (CRV) against Cd-induced hepatorenal toxicities and the possible mechanisms underlying these effects. Read More

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Effect of Butylated Hydroxy Toluene and Vitamin E on the Cryosurvivability of Buck Semen.

Cryo Letters 2020 Mar-Apr;41(2):68-74

Department of Animal Reproduction, Gynaecology and Obstetrics, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, India.

Background: The quality of frozen semen can be improved by supplementing Tris extender with antioxidant to prevent oxidation and maintain sperm motility.

Objective: To study the effects of adding combinations of suitable concentrations of butylated hydroxy toluene (BHT) and Vitamin E in Tris extender on the quality of frozen goat semen.

Materials And Methods: A total of 40 ejaculates collected from five Beetal bucks were used to study the effect on the quality of frozen semen of supplementing Tris extender with 200 µM BHT, 2 mM Vitamin E and 200 µM BHT + 2 mM Vitamin E. Read More

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Lycopene alleviates hepatic ischemia reperfusion injury via the Nrf2/HO-1 pathway mediated NLRP3 inflammasome inhibition in Kupffer cells.

Ann Transl Med 2021 Apr;9(8):631

School of Medicine, Southeast University, Nanjing, China.

Background: Lycopene is a naturally occurring carotenoid found in many fruits and vegetables, which has antioxidant effects. Although lycopene's protective effect has been observed on ischemia reperfusion (IR) injury in different organs, the effect of lycopene on Kupffer cells (KCs) has not been clearly elucidated in IR-induced acute hepatic inflammatory injury.

Methods: Mice were administered with either olive oil (10 mL/kg body weight) as the control or lycopene (20 mg/kg body weight) by gavage for 2 weeks before undergoing hepatic IR injury. Read More

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CHI3L1 alleviate acute liver injury by inhibiting Th1 cells differentiation through STAT3 signaling pathway.

Ann Transl Med 2021 Apr;9(7):529

Liver Transplantation Center, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.

Background: Acute liver injury (ALI) is a severe liver disease. Chitinase 3-like-1 (CHI3L1), a protein belonging to the glycosyl hydrolase family 18, is involved in many diseases, such as inflammatory diseases, bacterial infections, and various malignant tumors; however, the function of CHI3L1 in ALI remains unclear. The objective of this study was to evaluate the protective functions of CHI3L1 against thioacetamide (TAA)-induced ALI in mice and explore its potential mechanisms. Read More

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SS-31 Protects Liver from Ischemia-Reperfusion Injury via Modulating Macrophage Polarization.

Oxid Med Cell Longev 2021 13;2021:6662156. Epub 2021 Apr 13.

Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.

Ischemia-reperfusion injury (IRI) is a common complication in liver surgeries. It is a focus to discover effective treatments to reduce ischemia-reperfusion injury. Previous studies show that oxidative stress and inflammation response contribute to the liver damage during IRI. Read More

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Effects of sildenafil citrate on pancreatic and lung complications in an experimental L-arginine-induced acute pancreatitis model.

Prz Gastroenterol 2021 26;16(1):29-35. Epub 2021 Mar 26.

Department of Pathology, School of Medicine, Firat University, Elazig, Turkey.

Aim: In this study, we aimed to investigate the effects of sildenafil citrate on acute pancreatitis and pulmonary complications of the disease.

Material And Methods: In this study, we used 21 male Wistar-Albino rats weighing between 185 and 230 g. The rats were divided into 3 groups. Read More

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Boldenone Undecylenate-Mediated Hepatorenal Impairment by Oxidative Damage and Dysregulation of Heat Shock Protein 90 and Androgen Receptors Expressions: Vitamin C Preventive Role.

Front Pharmacol 2021 27;12:651497. Epub 2021 Apr 27.

Department of Biochemistry, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

Boldenone Undecylenate (BLD) is a synthetic derivative of testosterone and a widely used anabolic androgenic steroid. The health risk of BLD use as a pharmaceutical or dietary supplement is still underestimated and under-reported. Vitamin C (VC) has been recognized as an antioxidant with prominent hepatorenal protective effects. Read More

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Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity.

Sci Rep 2021 May 13;11(1):10308. Epub 2021 May 13.

Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, St. Joseph Medical Center, Steward Health, 1315 St Joseph Parkway, Houston, TX, 77002, USA.

Prognostic markers are needed to understand the disease course and severity in patients with Covid-19. There is evidence that Covid-19 causes gastrointestinal symptoms and abnormalities in liver enzymes. We aimed to determine if hepatobiliary laboratory data could predict disease severity in patients with Covid-19. Read More

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A model based on routine liver tests can reliably exclude intrahepatic cholestasis of pregnancy.

Eur J Intern Med 2021 May 10. Epub 2021 May 10.

Faculty of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, POB 12000, Jerusalem 91120, Israel. Electronic address:

Objectives: Serum bile acid (BA) levels testing is used for the diagnosis of intrahepatic cholestasis of pregnancy (ICP). We aimed to determine the performance of routine liver tests in the evaluation of ICP.

Methods: A retrospective cohort study conducted at a university hospital, including all pregnant women who underwent serum BA levels testing due to suspected ICP during 2007-2019. Read More

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[Interaction of IL-6 gene with tumor necrosis factor-α and white blood cell in metabolic syndrome].

Wei Sheng Yan Jiu 2021 Mar;50(2):261-273

School of Public Health, Ningxia Medical University, Yinchuan 750004, China.

Objective: To investigate the associations between the polymorphisms and interaction of the interleukin 6(IL-6) genes at-634 C/G, -174 G/C, -1363 G/T loci, as well as the interactions between the three loci and tumor necrosis factor(TNF-α), and peripheral blood leukocytes(white blood cell, WBC) with metabolic syndrome(MS).

Methods: Using the case-control research method, according to the inclusion and exclusion criteria, from March 2015 to March 2016 from the General Hospital of Ningxia Medical University and Wuzhong City People's Hospital, 376 unrelated cases and 408 control groups were selected. We conducted questionnaire surveys(including general conditions, disease and medication history, family history, etc. Read More

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The Protective Effect of Boric Acid on Cholestatic Rats Liver Ischemia Reperfusion Injury.

Turk J Med Sci 2021 May 14. Epub 2021 May 14.

Background/aim: To evaluate the potential protective effects of Boric Acid (BA) in experimental cholestatic liver ischemia reperfusion (IR) injury model.

Materials And Methods: The study included 24 female rats which were divided into 3 groups each containing 8 rats. The control group (Group 1) only received laparotomy. Read More

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3-Acetyldeoxynivalenol induces cell death through endoplasmic reticulum stress in mouse liver.

Environ Pollut 2021 Apr 27;286:117238. Epub 2021 Apr 27.

State Key Laboratory of Animal Nutrition, Department of Animal Nutrition and Feed Science, China Agricultural University, Beijing, 100193, China; Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, 100193, China.

Ingestion of food or cereal products contaminated by deoxynivalenol (DON) and related derivatives poses a threat to the health of humans and animals. However, the toxicity and underlying mechanisms of 3-acetyldeoxynivalenol (3-Ac-DON), an acetylated form of deoxynivalenol, have not been fully elucidated. In the present study, we showed that 3-Ac-DON caused significant oxidative damage, as shown by elevated aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactic dehydrogenase (LDH) in serum, increased lipid peroxidation products, such as hydrogen peroxide (HO) and malondialdehyde (MDA), decreased activities of antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD). Read More

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Blood concentration of levetiracetam after bolus administration in patients with status epilepticus.

Seizure 2021 Apr 25;89:41-44. Epub 2021 Apr 25.

Department of Emergency and Critical Care Medicine, Nippon Medical School, Tama-Nagayama Hospital, 1-7-1 Nagayama, Tama City, Tokyo 2068512, Japan.

Purpose: We aimed to evaluate the blood concentration of levetiracetam (LEV), as a second-line drug, in patients with status epilepticus (SE) in an emergency clinical setting.

Methods: We prospectively evaluated 20 consecutive patients with SE admitted to our department between July 2017 and July 2019. LEV (2500 mg) was administered via bolus infusion after diazepam infusion, followed by 500 mg every 12 h for 48 h and then 500 mg orally. Read More

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Effect of dihydromyricetin on hepatic encephalopathy associated with acute hepatic failure in mice.

Pharm Biol 2021 Dec;59(1):557-564

Department of Gastroenterology, Lanzhou University Second Hospital, Lanzhou, People's Republic of China.

Context: Hepatic encephalopathy (HE) is a complex neuropsychiatric disease caused by liver failure. Dihydromyricetin (DMY) is a traditional medicine used to treat liver injury.

Objective: To investigate the effects of dihydromyricetin (DMY) on hepatic encephalopathy associated with acute hepatic failure mice models established by thioacetamide (TAA) exposure. Read More

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December 2021

[Metabolic mechanism of Prunella vulgaris in treatment of ethanol-induced oxidative stress in rats based on metabonomics].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1813-1821

Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine Changsha 410208, China.

Prunella vulgaris(PV) is an edible and traditional medicinal herb which has a wide range application in fighting inflammation and oxidative stress, and protecting liver. Now it has been used to treat various types of liver diseases and has significant clinical efficacy. This study aims to investigate the effects of PV on ethanol-induced oxidative stress injury in rats and its metabolic mechanism. Read More

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[Study on anti-hyperlipidemia effect of Linderae Radix via regulating reverse cholesterol transport].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1795-1802

College of Pharmaceutical Sciences, Zhejiang Chinese Medical University Hangzhou 310053, China.

This article aims to investigate the ameliorative effect of Linderae Radix ethanol extract on hyperlipidemia rats induced by high-fat diet and to explore its possible mechanism from the perspective of reverse cholesterol transport(RCT). SD rats were divided into normal group, model group, atorvastatin group, Linderae Radix ethanol extract(LREE) of high, medium, low dose groups. Except for the normal group, the other groups were fed with a high-fat diet to establish hyperlipidemia rat models; the normal group and the model group were given pure water, while each administration group was given corresponding drugs by gavage once a day for five weeks. Read More

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Dexmedetomidine Protects Against Septic Liver Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT1 Signaling Pathway.

Front Pharmacol 2021 26;12:658677. Epub 2021 Apr 26.

Department of Intensive Care Unit, Children's Hospital of Chongqing Medical University, Chongqing, China.

Liver injury is one of the serious complications of sepsis. Previous studies suggested that dexmedetomidine (DEX) could alleviate cecal ligation and puncture (CLP)-induced liver injury. However, it is unclear whether the protective effect of DEX on sepsis-induced liver injury is related to autophagy. Read More

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Health-related quality of life in patients with autoimmune hepatitis.

Qual Life Res 2021 May 12. Epub 2021 May 12.

Metabolic Liver Research Program, I. Department of Medicine, University Medical Centre Mainz, Mainz, Germany.

Background: Autoimmune hepatitis (AIH) is a rare chronic liver disease. Impaired health-related quality of life (HRQL) contributes to the overall disease burden. At current, only limited data related to the impact of treatment response on HRQL are available. Read More

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The Relationship between Serum Uric Acid Level and Liver Function in Patients with Hepatitis B in China.

Clin Lab 2021 May;67(5)

Background: To explore the correlation between serum uric acid (UA) level and liver function indexes in patients with hepatitis B, so as to provide guidance for the prediction and treatment of liver function damage in patients with hepatitis B.

Methods: Four hundred and eighty-five patients with hepatitis B were selected as the case group and 312 patients without hepatitis B matched in the same period as the control group. The difference of blood UA level in each group was analyzed, and the correlation between UA and ALT, AST and CREA in each group was analyzed. Read More

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Protective effects of fucoidan against ethanol-induced liver injury through maintaining mitochondrial function and mitophagy balance in rats.

Food Funct 2021 May;12(9):3842-3854

The Institute of Human Nutrition, Qingdao University, Ning Xia Road 308, Qingdao 266071, China.

For alcoholic liver disease (ALD), mitophagy has been reported as a promising therapeutic strategy to alleviate the hepatic lesion elicited by ethanol. This study was conducted to investigate the regulatory effects of fucoidan on mitophagy induced by chronic ethanol administration in rats. Here, 20 male rats in each group were treated with fucoidan (150 and 300 mg per kg body weight) by gavage once daily. Read More

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Comparative evaluation of cardioprotective activity of and juice against isoprenaline-induced cardiotoxicity in rats.

J Complement Integr Med 2021 May 12. Epub 2021 May 12.

Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India.

Objectives: Comparative evaluation of cardioprotective activity of and juice against isoprenaline induced cardiotoxicity in rats.

Methods: Rats (125-150 g) were orally administered (GA) and (FA) apple juice (3 mL/day, per oral) for 13 days. Myocardial injury was inducted on 14th and 15th day by the administration of Isoprenaline (85 mg/kg/day, subcutaneous). Read More

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Influence of leaf extract on doxorubicin-induced toxicity and inhibition of carbonyl reductase mediated metabolism.

J Complement Integr Med 2021 May 10. Epub 2021 May 10.

Department of Biochemistry, Faculty of Science, Ekiti State University, Ado-Ekiti, Nigeria.

Objectives: Doxorubicin (DOX) is a commonly used chemotherapeutic drug. However, its non-target organ toxicities pose a serious problem. This study is to assess the protective role of leaf extract (CVE) against DOX-induced toxicities in rats. Read More

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Protective Effects of Silymarin Against D-Gal/LPS-Induced Organ Damage and Inflammation in Mice.

Drug Des Devel Ther 2021 4;15:1903-1914. Epub 2021 May 4.

Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing, 400067, People's Republic of China.

Aim: Silymarin contains various flavonoids and exhibits antioxidative, anti-inflammatory, and anticancer effects, in addition to other pharmacological properties. This study explored the alleviating effect of silymarin on multiple-organ damage induced by D-galactose/lipopolysaccharide in Kunming mice.

Methods: Kunming mice were injected intraperitoneally with D-galactose (30 mg/kg·BW)/LPS (3 μg/kg·BW) and then treated using silymarin with different doses (75 mg/kg·bw and 150 mg/kg·bw) via intragastric administration. Read More

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Effects of astaxanthin in animal models of obesity-associated diseases: a systematic review and meta-analysis.

Free Radic Biol Med 2021 May 8. Epub 2021 May 8.

Centre for Obesity Research and Education (CORE), School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, UK. Electronic address:

Background And Aim: Obesity is a major risk factor for several diseases, including metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). The use of natural products, such as astaxanthin (ASX), a potent antioxidant compound produced by the freshwater green microalga Haematococcus pluvialis, has gained particular interest to reduce oxidative stress and inflammation, and to improve redox status, often associated with obesity. A systematic review and meta-analysis was performed to comprehensively examine the effects of ASX in animal models of diet induced obesity-associated diseases in order to inform the design of future human clinical studies for ASX use as supplement or nutraceutical. Read More

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Astragaloside alleviates alcoholic fatty liver disease by suppressing oxidative stress.

Kaohsiung J Med Sci 2021 May 11. Epub 2021 May 11.

Department of Preclinical Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China.

Alcoholic fatty liver disease (AFLD) is the most common liver disease and can progress to fatal liver cirrhosis and carcinoma, affecting millions of patients worldwide. The functions of astragaloside on the cardiovascular system have been elucidated. However, its role in AFLD is unclear. Read More

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The protective potential of alpha lipoic acid on amiodarone-induced pulmonary fibrosis and hepatic injury in rats.

Mol Cell Biochem 2021 May 10. Epub 2021 May 10.

Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.

Amiodarone (AMD) is a widely used antiarrhythmic drug prescribed to treat cardiac tachyarrhythmias; however, AMD has been reported to provoke pulmonary fibrosis (PF) and hepatotoxicity. This study aimed to investigate the influence of alpha lipoic acid (ALA) on AMD-induced PF and hepatotoxicity in male Wistar rats. AMD administration resulted in elevated lung contents of hydroxyproline (Hyp), malondialdehyde (MDA), and increased serum levels of transforming growth factor beta-1 (TGF-β1), interferon-γ (IFN-γ), alanine amino transaminase (ALT), aspartate amino transaminase (AST), total cholesterol (TC), and glucose. Read More

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CRP is a superior and prognostically significant inflammation biomarker for hepatocellular cancer patients treated by liver transplantation.

Clin Pract (Lond) 2021 ;18(2):1626-1632

Department of Surgery, Liver Transplantation Institute, Inonu University, Turkey.

Background: Inflammation and its markers are considered prognostically important for many cancers, including Hepatocellular Carcinoma (HCC). However, it is not really clear which markers are the best.

Aims: To assess in a cohort of prospectively-evaluated HCC patients who were treated with liver transplant and whose survival was known, multiple commonly used inflammatory markers in relation to survival and to both clinical and tumor aggressiveness parameters. Read More

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January 2021

Dietary supplementation with melatonin: influence on growth performance, oxidative stress status, and amelioration of silver nanoparticles-induced toxicity in Nile tilapia (Oreochromis niloticus).

Trop Anim Health Prod 2021 May 10;53(2):314. Epub 2021 May 10.

Department of Fisheries, Faculty of Natural Resources and Environment, Ferdowsi University of Mashhad, P.B, Mashhad, 91773-1363, Iran.

Excessive use of silver nanoparticles (AgNPs) due to antibacterial properties can raise concerns about their release into environment and potential toxicity in aquatic organisms. Melatonin has several physiological functions especially antioxidant potential against oxidative stress. The current study was conducted to investigate the potential effects of two doses of dietary melatonin on growth performance, plasma biochemistry, and liver enzyme activity in Nile tilapia (Oreochromis niloticus) juveniles. Read More

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