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Anticipating the impact of COVID19 and comorbidities on the South African healthcare system by agent-based simulations.

Sci Rep 2021 Apr 12;11(1):7901. Epub 2021 Apr 12.

Next Generation Mobility Group, Department of Dynamics of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17, 37077, Göttingen, Germany.

Tuberculosis (TB) is the 10th leading cause of death worldwide, and since 2007 it has been the main cause of death from a single infectious agent, ranking above HIV/AIDS. The current COVID-19 is a pandemic which caused many deaths around the world. The danger is not only a coinfection as observed for TB and HIV for a long time, but that both TB and SARS-CoV-2 affect the respiratory organs and thus potentiate their effect or accelerate the critical course. Read More

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Transepithelial versus epithelium-off corneal crosslinking for progressive keratoconus.

Cochrane Database Syst Rev 2021 03 23;3:CD013512. Epub 2021 Mar 23.

Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Background: Keratoconus is the most common corneal dystrophy. It can cause loss of uncorrected and best-corrected visual acuity through ectasia (thinning) of the central or paracentral cornea, irregular corneal scarring, or corneal perforation. Disease onset usually occurs in the second to fourth decade of life, periods of peak educational attainment or career development. Read More

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Reimagining Bias: Making Strange With Disclosure.

J Contin Educ Health Prof 2021 Mar 16. Epub 2021 Mar 16.

Ms. Paton: Education Research Coordinator Continuing Professional Development, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada, PhD Candidate, Department of Leadership, Higher and Adult Education, Ontario Institute for Studies in Education, University of Toronto, Toronto, Ontario, Canada, and Fellow, Centre for Ambulatory Care Education, Women's College Hospital, Toronto, Ontario, Canada. Dr. Soleas: Director, Continuing Professional Development, Professional Development & Educational Scholarship, Faculty of Health Sciences, Queen's University, Kingston, Canada. Dr. Hodges: Executive Vice President Education & Chief Medical Officer, University Health Network, Toronto, Ontario, Canada, Professor, Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, Senior Fellow, Massey College, University of Toronto, Toronto, Ontario, Canada, and Senior Strategy Advisor, The AMS Phoenix Project, Toronto, Canada.

Abstract: Academic presentations in health professions continuing professional development (CPD) often begin with a declaration of real or potential conflicts utilizing a three-slide template or a similar standardized display. These declarations are required in some constituencies. The three-slide template and similar protocols exist to assure learners that the content that follows has been screened, is notionally bias free, and without financial or other influence that might negatively affect health provider behavior. Read More

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An Acute Stress Scale for Health Care Professionals Caring for Patients With COVID-19: Validation Study.

JMIR Form Res 2021 03 9;5(3):e27107. Epub 2021 Mar 9.

Be+ Against COVID, Alicante, Spain.

Background: The COVID-19 pandemic has affected the response capacity of the health care workforce, and health care professionals have been experiencing acute stress reactions since the beginning of the pandemic. In Spain, the first wave was particularly severe among the population and health care professionals, many of whom were infected. These professionals required initial psychological supports that were gradual and in line with their conditions. Read More

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Current status of emergency treatment of chemical eye burns in workplaces.

Int J Ophthalmol 2021 18;14(2):306-309. Epub 2021 Feb 18.

Faculty of Health Department of Human Medicine, Occupational Medicine and Corporate Health Management, Witten/Herdecke University, Alfred-Herrhausen-Strabe 50, Witten 58448, Germany.

Chemical eye burns present an avoidable, but frequent, occupational injury with potentially detrimental consequences for the quality of life and occupational rehabilitation of the injured. A periodical review of guidelines is required to assure the optimal emergency management. We reviewed the literature with emphasis on current German guidelines, primarily MEDLINE. Read More

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February 2021

Identification of drug resistance mutations among Mycobacterium bovis lineages in the Americas.

PLoS Negl Trop Dis 2021 Feb 16;15(2):e0009145. Epub 2021 Feb 16.

Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Estado de México, México.

Identifying the Mycobacterium tuberculosis resistance mutation patterns is of the utmost importance to assure proper patient's management and devising of control programs aimed to limit spread of disease. Zoonotic Mycobacterium bovis infection still represents a threat to human health, particularly in dairy production regions. Routinary, molecular characterization of M. Read More

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February 2021

Low specificity of point-of-care circulating cathodic antigen (POCCCA) diagnostic test in a non-endemic area for schistosomiasis mansoni in Brazil.

Acta Trop 2021 May 13;217:105863. Epub 2021 Feb 13.

Oswaldo Cruz Institute, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, RJ, Brazil. Electronic address:

A point-of-care test for detecting schistosome circulating cathodic antigen in urine (POCCCA) has been proposed for mapping infection and defining prevalence thresholds for mass drug administration (MDA). However, there is increasing evidence that POCCCA may yield false-positive results, which requires rigorous specificity evaluation in non-endemic areas. POCCCA was applied in an area known to be free from infection and devoid of any condition for schistosomiasis transmission as part of a multicentre study to evaluate the performance of POCCCA in Brazil's low or potentially endemic settings. Read More

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Guidelines for the orthopedic surgeon in the era of COVID-19.

Orthop Rev (Pavia) 2020 Dec 28;12(4):8833. Epub 2021 Jan 28.

Department of General and Special Surgery, Faculty of Medicine, The Hashemite University, Zarqa.

Amid the current pandemic of coronavirus disease 2019 (COVID-19), orthopaedic surgery was one of the fewer specialties that remained active managing emergent and urgent orthopaedic and trauma cases. On the other hand, with the continued spread of this pandemic and its associated socioeconomic confinement and unpredictability of the pandemic curve; many health care facilities were forced into halting all elective and non-urgent activities including orthopaedic specialties. This in part was to help in reallocation of required resources and focusing on the proper management of COVID-19 patients, and to prevent the transmission of infection among health care workers and patients. Read More

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December 2020

The interrelationship between confidence and correctness in a multiple-choice assessment: pointing out misconceptions and assuring valuable questions.

BDJ Open 2021 Feb 12;7(1):10. Epub 2021 Feb 12.

USASK-University of Saskatchewan, College of Dentistry, Saskatoon, SK, Canada.

Introduction: The aim of this study was to better understand the interfaces of being correct or incorrect and confident or unconfident; aiming to point out misconceptions and assure valuable questions.

Methods: This cross-sectional study was conducted using a convenience sample of second-year dental students (n = 29) attending a preclinical endodontics course. Students answered 20 multiple-choice questions ("basic" or "moderate" level) on endodontics, all of which were followed by one confidence question (scale). Read More

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February 2021

Industrial Control under Non-Ideal Measurements: Data-Based Signal Processing as an Alternative to Controller Retuning.

Sensors (Basel) 2021 Feb 10;21(4). Epub 2021 Feb 10.

Wireless Information Networking (WIN) Group, Escola d'Enginyeria, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.

Industrial environments are characterised by the non-lineal and highly complex processes they perform. Different control strategies are considered to assure that these processes are correctly performed. Nevertheless, these strategies are sensible to noise-corrupted and delayed measurements. Read More

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February 2021

Optimal Initial Positioning of Chest Tubes to Prevent Retained Hemothorax Using a Novel Steerable Chest Tube With Extendable Infusion Cannula.

Mil Med 2021 01;186(Suppl 1):324-330

Sim*Vivo, LLC, Naples, FL 34110, USA.

Introduction: With blunt and penetrating trauma to the chest, warfighters and civilians frequently suffer from punctured lung (pneumothorax) and/or bleeding into the pleural space (hemothorax). Optimal management of this condition requires the rapid placement of a chest tube to evacuate as much of the blood and air as possible. Incomplete drainage of blood leading to retained hemothorax may be the result of the final tube tip position not being in contact with the blood collections. Read More

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January 2021

How to Quantitatively Balance a Total Knee? A Surgical Algorithm to Assure Balance and Control Alignment.

Sensors (Basel) 2021 Jan 20;21(3). Epub 2021 Jan 20.

Department of Structure and Repair, Ghent University, 9000 Ghent, Belgium.

To achieve a balanced total knee, various surgical corrections can be performed, while intra-operative sensors and surgical navigation provide quantitative, patient-specific feedback. To understand the impact of these corrections, this paper evaluates the quantitative impact of both soft tissue releases and bone recuts on knee balance and overall limb alignment. This was achieved by statistically analyzing the alignment and load readings before and after each surgical correction performed on 479 consecutive primary total knees. Read More

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January 2021

Intraoperative ultrasonography-guided surgery: An effective modality for breast conservation after neo-adjuvant chemotherapy.

Breast J 2020 09 30;26(9):1680-1687. Epub 2020 Jul 30.

Department of General Surgery, School of Medicine, Marmara University, Istanbul, Turkey.

Margin status is one of the significant prognostic factors for recurrence in breast-conserving surgery (BCS). The issue that merits consideration for oncologic safety and cost-effectiveness about the modalities to assure clear margins at initial surgical intervention remains controversial after neo-adjuvant chemotherapy (NAC). The presented study aimed to assess the impact of intraoperative ultrasound (IOUS)-guided surgery on accurate localization of tumor site, adequacy of excision with clear margins, and healthy tissue sacrifice in BCS after NAC. Read More

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September 2020

Generation and manipulation of human iPSC-derived platelets.

Cell Mol Life Sci 2021 Apr 13;78(7):3385-3401. Epub 2021 Jan 13.

Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

The discovery of iPSCs has led to the ex vivo production of differentiated cells for regenerative medicine. In the case of transfusion products, the derivation of platelets from iPSCs is expected to complement our current blood-donor supplied transfusion system through donor-independent production with complete pathogen-free assurance. This derivation can also overcome alloimmune platelet transfusion refractoriness by resulting in autologous, HLA-homologous or HLA-deficient products. Read More

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High-precision multiclass cell classification by supervised machine learning on lectin microarray data.

Regen Ther 2020 Dec 16;15:195-201. Epub 2020 Oct 16.

Department of Reproductive Biology, National Center for Child Health and Development, Tokyo, 157-8535, Japan.

Introduction: Establishment of a cell classification platform for evaluation and selection of human pluripotent stem cells (hPSCs) is of great importance to assure the efficacy and safety of cell-based therapy. In our previous work, we introduced a discriminant function that evaluates pluripotency from the cells' glycome. However, it is not yet suitable for general use. Read More

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December 2020

[The Mexican Association of Spine Surgery Guideline for the decision making to perform a spine surgery during the COVID-19 pandemic].

Acta Ortop Mex 2020 May-Jun;34(3):167-175

Asociación Mexicana de Cirujanos de Columna (AMCICO). México.

The COVID-19 pandemic has changed in a significant way the lifestyle in the world and in Mexico. Medicine is not an exception, therefore, modifications in how the assessment and treatment of our patients is done, is mandatory to assure the safeness of the patient, the medical team, the hospital staff, the medical facility, and the community. In this paper, the Mexican Association of Spine Surgery (AMCICO) make recommendations based in the information available at the moment, to help decide when and how to perform a spine surgery in the coronavirus pandemic. Read More

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January 2021

Expanded Carrier Screening and the Complexity of Implementation.

Obstet Gynecol 2021 02;137(2):345-350

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, California.

Advances in genetic technology have allowed for the development of multiplex panels that can test for hundreds of genetic disorders at the same time; these large panels are referred to as expanded carrier screening. This process can screen couples for far more conditions than the gene-by-gene approach used with traditional carrier screening; however, although expanded carrier screening has been promoted as an efficient means of detecting many more disorders, the complexities of genetic sequencing raise substantial challenges and concerns. In our practice, we have seen a number of complex cases in which only attention to detail on the part of thorough genetic counselors allowed identification of misclassified variants that could have resulted in significant patient harm. Read More

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February 2021

Pedigree analysis of 220 almond genotypes reveals two world mainstream breeding lines based on only three different cultivars.

Hortic Res 2021 Jan 1;8(1):11. Epub 2021 Jan 1.

Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Mas Bové, Ctra. Reus-El Morell Km 3,8, 43120, Constantí, Tarragona, Spain.

Loss of genetic variability is an increasing challenge in tree breeding programs due to the repeated use of a reduced number of founder genotypes. However, in almond, little is known about the genetic variability in current breeding stocks, although several cases of inbreeding depression have been reported. To gain insights into the genetic structure in modern breeding programs worldwide, marker-verified pedigree data of 220 almond cultivars and breeding selections were analyzed. Read More

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January 2021

Tissue and species identification in minced meat and meat products from Italian commercial markets by DNA microarray and histological approach.

Vet Ital 2020 07 14;56(2):77-85. Epub 2020 Jul 14.

Università degli Studi di Torino.

Adequate testing and adulterant detection of food products are required to assure its safety and avoid fraudulent activities. Adulteration/substitution of costlier meat with a cheaper or inferior meat is one of the most common fraudulence in meat industry. Aim of this study was to check the correct labelling of meat and ready to cook bovine meat products, combining the DNA microarray approach to identify the animal species with the histological examination, to check the composition and safety of meat. Read More

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Lethal (2) giant discs (Lgd)/CC2D1 is required for the full activity of the ESCRT machinery.

BMC Biol 2020 12 22;18(1):200. Epub 2020 Dec 22.

Institute of Genetics, Heinrich-Heine-Universitaet Duesseldorf, Universitaetsstr. 1, 40225, Duesseldorf, Germany.

Background: A major task of the endosomal sorting complex required for transport (ESCRT) machinery is the pinching off of cargo-loaded intraluminal vesicles (ILVs) into the lumen of maturing endosomes (MEs), which is essential for the complete degradation of transmembrane proteins in the lysosome. The ESCRT machinery is also required for the termination of signalling through activated signalling receptors, as it separates their intracellular domains from the cytosol. At the heart of the machinery lies the ESCRT-III complex, which is required for an increasing number of processes where membrane regions are abscised away from the cytosol. Read More

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December 2020

The MRD disk: automated minimal residual disease monitoring by highly sensitive centrifugal microfluidic multiplex qPCR.

Lab Chip 2021 02;21(3):558-570

Hahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany. and Laboratory for MEMS Applications, IMTEK - Department of Microsystems Engineering, University of Freiburg, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.

We present a proof-of-principle study on automated, highly sensitive and multiplexed qPCR quantification by centrifugal microfluidics. The MRD disk can be used for standardisation of repetitive, longitudinal assays with high requirements on reproducibility and sensitivity, such as cancer monitoring. In contrast to high-throughput qPCR automation by bulky and expensive robotic workstations we employ a small centrifugal microfluidic instrument, addressing the need of low- to mid-throughput applications. Read More

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February 2021

Use of GlideScope in Patients Undergoing NIM Thyroidectomy.

Ear Nose Throat J 2020 Dec 14:145561320974829. Epub 2020 Dec 14.

21693University of Mississippi Medical Center, Jackson, MS, USA.

Objectives: Thyroidectomy and parathyroidectomy using the nerve integrity monitor (NIM) require proper placement of the endotracheal tube with electrodes aligned correctly within the larynx. The purpose of this study is to determine the percentage of patients who require positional adjustments of the endotracheal tube prior to beginning surgery and to understand the value of using the GlideScope to assure proper NIM tube placement within the larynx.

Methods: This prospective study examines operative data from 297 patients who underwent NIM thyroidectomy and parathyroidectomy. Read More

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December 2020

Factors for peripherally inserted central catheters care delay in cancer patients during the COVID-19 pandemic.

Ann Palliat Med 2020 Nov;9(6):3818-3829

Department of Thoracic Oncology, the Cancer Center of the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.

Background: Coronavirus disease 2019 (COVID-19) has rapidly evolved into a global pandemic. The public health systems have consequently been placed under tremendous pressure. Peripherally inserted central catheters (PICCs) are widely used in patients with cancers. Read More

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November 2020

Three-dimensional CBCT based evaluation of the inferior part of the maxillary sinus: Retrospective Study.

Sci Rep 2020 12 3;10(1):21012. Epub 2020 Dec 3.

Department of Oral Anatomy, Dental College Dankook Institute For Future Science and Emerging Convergence, Dan-Kook University, Cheonan, 330-714, South Korea.

The maxillary sinus is the largest of the four paranasal sinuses in humans, and its close proximity to the teeth means that caution is required during dental treatment. In particular, implant surgeries involving the maxillary posterior teeth should include evaluating the inferior part of the maxillary sinus. The purpose of this study is to evaluate the differences by comparing the inferior part of the maxillary sinus based on the nasal cavity floor (NCF) between patients (male 30, female 30) genders through the use of the three-dimensional (3-D) program that can facilitate 3-D visualizations. Read More

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December 2020

Framework and Strategies to Eliminate Disparities in Colorectal Cancer Screening Outcomes.

Annu Rev Med 2021 01 18;72:383-398. Epub 2020 Nov 18.

Section of Gastroenterology, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA.

Preventable differences in colorectal cancer (CRC) mortality across racial/ethnic, economic, geographic, and other groups can be eliminated by assuring equitable access and quality across the care continuum, but few interventions have been demonstrated to do so. Multicomponent strategies designed with a health equity framework may be effective. A health equity framework takes into account social determinants of health, multilevel influences (policy, community, delivery, and individual levels), screening processes, and community engagement. Read More

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January 2021

A Comprehensive Dependability Model for QoM-Aware Industrial WSN When Performing Visual Area Coverage in Occluded Scenarios.

Sensors (Basel) 2020 Nov 16;20(22). Epub 2020 Nov 16.

INEGI/INESC-TEC-Faculty of Engineering, University of Porto (FEUP), 4200-465 Porto, Portugal.

In critical industrial monitoring and control applications, dependability evaluation will be usually required. For wireless sensor networks deployed in industrial plants, dependability evaluation can provide valuable information, enabling proper preventive or contingency measures to assure their correct and safe operation. However, when employing sensor nodes equipped with cameras, visual coverage failures may have a deep impact on the perceived quality of industrial applications, besides the already expected impacts of hardware and connectivity failures. Read More

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November 2020

Improving Effectiveness of Phototherapy in an Academic Center: A Quality Improvement Project.

Glob Pediatr Health 2020 29;7:2333794X20969275. Epub 2020 Oct 29.

Hennepin Healthcare, Minneapolis, MN, USA.

Neonatal hyperbilirubinemia is a common cause of delayed discharge and readmissions in our institution. As previously published, the irradiance our phototherapy (PT) units provided was below the irradiance recommended by the AAP for intensive phototherapy (>30 µW/cm/nm). We measured irradiance delivered by our PT units (Drager 4000) using a standardized footprint grid. Read More

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October 2020

Providing Culturally Competent Care for COVID-19 Intensive Care Unit Delirium: A Case Report and Review.

Cureus 2020 Oct 9;12(10):e10867. Epub 2020 Oct 9.

Medical Education, Lake Erie College of Osteopathic Medicine, Erie, USA.

Coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization in March 2020. Caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, its high transmissibility required infected individuals to be placed in negative pressure isolation rooms when admitted to intensive care units (ICU). Studies have shown that limited social support can increase the risk of developing delirium during ICU stays. Read More

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October 2020