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The Association of Delayed Care With Depression Among US Middle-Aged and Older Adults During the COVID-19 Pandemic: Cross-sectional Analysis.

Yan Luo

JMIR Aging 2021 Jul 31. Epub 2021 Jul 31.

The University of Alabama, 2106 Forest Lake Dr., Tuscaloosa, US.

Background: During the Coronavirus Disease 2019 (COVID-19) pandemic, the depression level among US adults has significantly increased. Age disparity in depression during the pandemic was also reported in recent studies. Delay or avoidance of medical care is one of the collateral damages caused by the COVID-19 pandemic and it can lead to increased morbidity and mortality. Read More

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Evaluation of Epidural Analgesia Use During Labor and Infection in Full-term Neonates Delivered Vaginally.

JAMA Netw Open 2021 Sep 1;4(9):e2123757. Epub 2021 Sep 1.

Department of Anesthesia, the International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Importance: Quantification of potential consequences associated with the use of epidural analgesia during labor could help to improve the safety and quality of labor and delivery care for parturient women.

Objective: To evaluate the association between epidural analgesia use during labor and neonatal infection in a large cohort of parturient women.

Design, Setting, And Participants: This propensity score-matched cohort study was conducted at a university-affiliated hospital in Shanghai, China. Read More

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September 2021

Association of Timing and Duration of Prenatal Analgesic Opioid Exposure With Attention-Deficit/Hyperactivity Disorder in Children.

JAMA Netw Open 2021 Sep 1;4(9):e2124324. Epub 2021 Sep 1.

PharmacoEpidemiology and Drug Safety Research Group, Department of Pharmacy, PharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.

Importance: Prior studies have reported that the use of illicit opioids during pregnancy is associated with increased risk of attention-deficit/hyperactivity disorder (ADHD) in offspring; however, evidence regarding the association of analgesic opioids is limited.

Objective: To examine the association of timing and duration of prenatal analgesic opioid exposure with ADHD in children.

Design, Setting, And Participants: This cohort study uses data from the Norwegian Mother, Father and Child Cohort study (1999-2008), a nationwide birth cohort study linked to national health registries, with a mean (SD) follow-up of 10. Read More

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September 2021

Comparative Effectiveness and Functional Outcome of C2 Dome-like Expansive Versus C2 Expansive Open-door Laminoplasty for Upper Cervical Ossification of the Posterior Longitudinal Ligament: A Retrospective Cohort Study.

Spine (Phila Pa 1976) 2021 Sep 14. Epub 2021 Sep 14.

Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou City, Zhejiang Province, PR China Orthopedics Research Institute of Zhejiang University, Hangzhou City, Zhejiang Province, PR China Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P.R. China.

Study Design: Retrospective Cohort Study.

Objectives: This study compared the function and radiographical outcomes of the patients who underwent C2 dome-like expansive laminoplasty to those C2 expansive open-door laminoplasty for the treatment of OPLL with C2 involved.

Summary Of Background Data: There are few comparative studies of these two surgical methods. Read More

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September 2021

Gastrointestinal manifestations of coronavirus disease 2019.

Curr Opin Infect Dis 2021 Oct;34(5):471-476

Liver Center, Division of Abdominal Transplantation, Michael E DeBakey Department of General Surgery.

Purpose Of Review: The ubiquitous expression of angiotensin-converting enzyme-2 receptors and its significance as the origin of viral entry have assisted in comprehending the pathophysiology of extrapulmonary manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this review, we focus on the clinical significance of gastrointestinal manifestations.

Recent Findings: The global pandemic, a result of the widespread implications of SARS-CoV-2, remains a significant burden to current healthcare systems. Read More

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October 2021

Physical therapists should play a greater role in managing patients with opioid use and opioid misuse.

Subst Abus 2021 Sep 15:1-6. Epub 2021 Sep 15.

Program for Addiction Research, Clinical Care, Knowledge and Advocacy (PARCKA), Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.

The U.S. opioid crisis necessitates that health care providers of all types work collaboratively to manage patients taking prescription opioid medications and manage those who may be misusing prescription opioids. Read More

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September 2021

Methylome-wide association study of early life stressors and adult mental health.

Hum Mol Genet 2021 Sep 15. Epub 2021 Sep 15.

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

The environment and events that we are exposed to in utero, during birth and in early childhood influence our future physical and mental health. The underlying mechanisms that lead to these outcomes are unclear, but long-term changes in epigenetic marks, such as DNA methylation, could act as a mediating factor or biomarker. DNA methylation data was assayed at 713522 CpG sites from 9537 participants of the Generation Scotland: Scottish Family Health Study, a family-based cohort with extensive genetic, medical, family history and lifestyle information. Read More

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September 2021

Reviewing pharmacogenetics to advance precision medicine for opioids.

Biomed Pharmacother 2021 Sep 12;142:112060. Epub 2021 Sep 12.

Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Institute of Medical Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Centre for Addiction and Mental Health, Toronto, ON, Canada. Electronic address:

Background: Adequate opioid prescribing is critical for therapeutic success of pain management. Despite the widespread use of opioids, optimized opioid therapy remains unresolved with risk of accidental lethal overdosing. With the emergence of accumulating evidence linking genetic variation to opioid response, pharmacogenetic based treatment recommendations have been proposed. Read More

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September 2021

[Effectiveness of three-dimensional printing artificial vertebral body and interbody fusion Cage in anterior cervical surgery].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Sep;35(9):1147-1154

Department of Orthopedics, Third Hospital of Shanxi Medical University (Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), Taiyuan Shanxi, 030032, P.R.China.

Objective: To evaluate the effectiveness of three-dimensional (3D) printing artificial vertebral body and interbody fusion Cage in anterior cervical disectomy and fusion (ACCF) combined with anterior cervical corpectomy and fusion (ACDF).

Methods: The clinical data of 29 patients with multilevel cervical spondylotic myelopathy who underwent ACCF combined with ACDF between May 2018 and December 2019 were retrospectively analyzed. Among them, 13 patients were treated with 3D printing artificial vertebral body and 3D printing Cage as 3D printing group and 16 patients with ordinary titanium mesh Cage (TMC) and Cage as TMC group. Read More

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September 2021

[Clinical significance of different imaging manifestations of osteonecrosis of femoral head in the peri-collapse stage].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Sep;35(9):1105-1110

Guangdong Academy of Traditional Chinese Medicine Orthopedics and Traumatology, Guangzhou Guangdong, 510378, P.R.China.

Objective: To explore the different imaging manifestations of osteonecrosis of the femoral head (ONFH) and their correlation with the occurrence of pain during the peri-collapse period.

Methods: The 372 patients (624 hips) with ONFH in the peri-collapse stage who were admitted between December 2016 and October 2019 and met the selection criteria were selected as the research objects. Among them, there were 270 males and 102 females, with an average age of 35. Read More

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September 2021

Heart Failure Association of the European Society of Cardiology position paper on the management of left ventricular assist device-supported patients for the non-left ventricular assist device specialist healthcare provider: Part 2: at the emergency department.

ESC Heart Fail 2021 Sep 14. Epub 2021 Sep 14.

Ziekenhuis Oost-Limburg, Genk, Belgium.

The improvement in left ventricular assist device (LVAD) technology and scarcity of donor hearts have increased dramatically the population of the LVAD-supported patients and the probability of those patients to present to the emergency department with expected and non-expected device-related and patient-device interaction complications. The ageing of the LVAD-supported patients, mainly those supported with the 'destination therapy' indication, increases the risk for those patients to suffer from other co-morbidities common in the older population. In this second part of the trilogy on the management of LVAD-supported patients for the non-LVAD specialist healthcare provider, definitions and structured approach to the LVAD-supported patient presenting to the emergency department with bleeding, neurological event, pump thrombosis, chest pain, syncope, and other events are presented. Read More

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September 2021

The association of prothrombin complex concentrates with postoperative outcomes in cardiac surgery: an observational substudy of the FIBRES randomized controlled trial.

Can J Anaesth 2021 Sep 14. Epub 2021 Sep 14.

Department of Anesthesia and Pain Management, Toronto General Hospital - University Health Network, Sinai Health System, Women's College Hospital,, University of Toronto, 200 Elizabeth Street, 3EN-464, Toronto, ON, M5G 2C4, Canada.

Purpose: The mainstay of therapy for coagulation factor deficiency in cardiac surgical patients is frozen plasma (FP); however, prothrombin complex concentrates (PCCs) may offer logistical and safety advantages. As there is limited comparative evidence, we conducted this study to explore the association of comparable PCC or FP doses with transfusion and outcomes.

Methods: This was a post hoc analysis of a multicentre randomized trial comparing fibrinogen concentrate with cryoprecipitate (FIBRES trial) in bleeding cardiac surgical patients. Read More

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September 2021

The relation between sleep quality, sleep quantity, and gastrointestinal problems among colorectal cancer survivors: result from the PROFILES registry.

Support Care Cancer 2021 Sep 14. Epub 2021 Sep 14.

Department of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands.

Purpose: Common residual symptoms among survivors of colorectal cancer (CRC) are sleep difficulties and gastrointestinal symptoms. Among patients with various gastrointestinal (inflammatory) diseases, sleep quality has been related to gastrointestinal symptoms. For CRC survivors, this relation is unclear; therefore, we examined the association between sleep quality and quantity with gastrointestinal symptoms among CRC survivors. Read More

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September 2021

Medium- to long-term clinical and functional outcomes of isolated and combined subscapularis tears repaired arthroscopically.

Arch Med Sci 2021 28;17(5):1351-1364. Epub 2020 Jul 28.

Orthopaedic and Traumatology Clinic, Department of Surgery, Oncology and Gastroenterology DiSCOG, University of Padua, Padova, Italy.

Introduction: The purpose of this study was twofold. First, the efficacy of arthroscopic repair in patients with full thickness, isolated subscapularis tendon tears (I-STTs) or combined subscapularis tendon tears (C-STTs) involving the rotator cuff tendons was evaluated. Second, the outcomes between these two groups were compared. Read More

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Factors associating with disability of non-specific low back pain in different subgroups: A hierarchical linear regression analysis.

Sci Rep 2021 Sep 14;11(1):18278. Epub 2021 Sep 14.

Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.

This study aimed to explore factors associating with disability, which means physical impairment affecting a person's mobility, capacity, stamina, or agility, of non-specific low back pain (NSLBP) of the acute and non-acute groups. Two hundred thirty-five patients with NSLBP of less than 8 weeks' duration as acute groups (n = 124) and more than 8 weeks' duration as non-acute group (n = 111) were recruited. It was collected data on pain intensity, disability and psychosocial factors, including pain catastrophising, fear of movement and pain self-efficacy. Read More

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September 2021

Opioid and healthcare service use in medical cannabis patients with chronic pain: a prospective study.

BMJ Support Palliat Care 2021 Sep 14. Epub 2021 Sep 14.

Rambam Health Care Campus, Haifa, Israel.

Background: Various jurisdictions have legalised medical cannabis (MC) for use in chronic pain treatment. The objective of this study was to determine if the use of MC is related to a reduction in the use of prescription opioids and other prescription medications and healthcare services.

Methods: A retrospective cohort study was conducted using the medical files of 68 Israeli patients with chronic pain using MC. Read More

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September 2021

Chronic Pain in Schoolchildren and its Association With Psychological Wellbeing Before and During the COVID-19 Pandemic.

J Adolesc Health 2021 Sep 11. Epub 2021 Sep 11.

German Paediatric Pain Centre, Children's and Adolescents' Hospital, Datteln, Germany; Department of Children's Pain Therapy and Paediatric Palliative Care, Faculty of Health, School of Medicine, Witten/Herdecke University, Witten, Germany; PedScience Research Institute, Datteln, Germany.

Purpose: The current longitudinal observational study aimed to explore how chronic pain among schoolchildren changed before and during the COVID-19 pandemic, and how changes in chronic pain were related to changes in psychological wellbeing and COVID-19-related experiences.

Methods: Data were collected from N = 777 German schoolchildren (aged 9-17 years) at two assessments before and one assessment during the COVID-19 pandemic lockdown. Participants self-reported chronic pain experience, anxiety, depression, and quality of life across all assessments; and COVID-19-related experiences at the last assessment. Read More

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September 2021

The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual "window of treatment success" in RA patients.

Arthritis Res Ther 2021 Sep 14;23(1):239. Epub 2021 Sep 14.

Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Charite Campus Mitte, Rheumatologisches Forschungslabor - AG Skriner, Chariteplatz 1 (intern Virchowweg 11, 5.OG, R011), 10117, Berlin, Germany.

Background: There is a need for biomarker to identify patients "at risk" for rheumatoid arthritis (risk-RA) and to better predict the therapeutic response and in this study we tested the hypothesis that novel native and citrullinated heterogeneous nuclear ribonucleoprotein (hnRNP)-DL autoantibodies could be possible biomarkers.

Methods: Using protein macroarray and ELISA, epitope recognition against hnRNP-DL was analysed in sera from different developed RA disease and diagnosed SLE patients. Toll-like receptor (TLR) 7/9 and myeloid differentiation primary response gene 88 (MyD88)-dependency were studied in sera from murine disease models. Read More

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September 2021

Opioid agonist treatment and patient outcomes during the COVID-19 pandemic in south east Sydney, Australia.

Drug Alcohol Rev 2021 Sep 14. Epub 2021 Sep 14.

Drug and Alcohol Services, South Eastern Sydney Local Health District, Sydney, Australia.

Introduction: In early 2020, many services modified their delivery of opioid treatment in response to the COVID-19 pandemic, to limit viral spread and maintain treatment continuity. We describe the changes to treatment and preliminary analysis of the association with patients' substance use and well-being.

Methods: A pre-post comparison of treatment conditions and patient self-reported outcomes using data extracted from electronic medical records in the 5 months before (December 2019-April 2020) and after (May 2020-September 2020) changes were implemented in three public treatment services in South Eastern Sydney Local Health District. Read More

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September 2021

Is adiposity associated with back and lower limb pain? A systematic review.

PLoS One 2021 14;16(9):e0256720. Epub 2021 Sep 14.

Department Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Background: Back and lower limb pain have a major impact on physical function and quality of life. While obesity is a modifiable risk factor for musculoskeletal pain, the role of adiposity is less clear. This systematic review aimed to examine the relationship between both adiposity and its distribution and back and lower limb pain. Read More

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September 2021

Incidental finding of hereditary multiple osteochondroma causing ischiofemoral impingement.

BMJ Case Rep 2021 Sep 13;14(9). Epub 2021 Sep 13.

Orthopaedics, Dubai Hospital, Dubai, UAE.

Ischiofemoral impingement (IFI) has been described in the medical literature as a cause of hip pain. IFI occurs due to an abnormal contact or reduced space between the lesser trochanter and the lateral border of the ischium and is an often unrecognised cause of pain and snapping in the hip. Association of multiple exostoses and a skeletal dysplasia characterised by an abnormal modelling of bone metaphysis and osseous deformities is highly characteristic of this disease. Read More

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September 2021

Does Patient Body Mass Index Affect the Outcome of Multimodal Rehabilitation in Chronic Mechanical Low Back Pain?

Spine (Phila Pa 1976) 2021 Oct;46(19):1336-1343

Centre for Public Health, Tata Institute of Social Sciences, Mumbai, Maharashtra, India.

Study Design: Retrospective.

Objective: The aim of this study was to investigate the effect of body mass index (BMI) on pain and disability in patients with chronic mechanical low back pain (LBP) treated with multimodal rehabilitation.

Summary Of Background Data: Despite being a well-known risk factor for developing LBP, there is minimal data on the effect of BMI on pain and disability in patients with chronic mechanical low back pain (LBP) treated with multimodal rehabilitation. Read More

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October 2021

Association Between Intraoperative Arterial Hypotension and Postoperative Delirium After Noncardiac Surgery: A Retrospective Multicenter Cohort Study.

Anesth Analg 2021 Sep 13. Epub 2021 Sep 13.

Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, New York, New York.

Background: It is unclear whether intraoperative arterial hypotension is associated with postoperative delirium. We hypothesized that intraoperative hypotension within a range frequently observed in clinical practice is associated with increased odds of delirium after surgery.

Methods: Adult noncardiac surgical patients undergoing general anesthesia at 2 academic medical centers between 2005 and 2017 were included in this retrospective cohort study. Read More

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September 2021

Prognostic value of signs and symptoms in heart failure patients using remote telemonitoring.

J Telemed Telecare 2021 Sep 13:1357633X211039404. Epub 2021 Sep 13.

Department of Cardiology, 199236Maastricht University Medical Centre, the Netherlands.

Introduction: Heart failure is a serious burden on health care systems due to frequent hospital admissions. Early recognition of outpatients at risk for clinical deterioration could prevent hospitalization. Still, the role of signs and symptoms in monitoring heart failure patients is not clear. Read More

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September 2021

Do neuroticism and conscientiousness interact with health conditions in predicting 4-year changes in self-rated health among Swedish older adults?

Psychol Aging 2021 Sep;36(6):730-743

German Centre of Gerontology.

Health conditions such as higher disease burden, pain, or lower functional health are associated with poorer self-rated health (SRH) in older age. Poorer SRH, in turn, is a predictor of morbidity and mortality. Personality traits are associated with SRH as well, but little is known about the interaction of personality and health conditions. Read More

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September 2021

The Role of NF-κB/NLRP3 Inflammasome Signaling Pathway in Attenuating Pyroptosis by Melatonin Upon Spinal Nerve Ligation Models.

Neurochem Res 2021 Sep 13. Epub 2021 Sep 13.

Department of Gynecology and Obstetrics, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, Shandong Province, China.

Accumulated evidence has demonstrated causative links between neuropathic pain (NP) and immune-mediated inflammatory disorders. However, the role of inflammasome-induced pyroptosis in NP remains elusive. Melatonin possesses a well-documented analgesic action in various pain models. Read More

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September 2021

Pruritus, Pain, and Depression Associated with the Most Common Skin Diseases: Data from the French Study "Objectifs Peau".

Dermatology 2021 Sep 7:1-6. Epub 2021 Sep 7.

Société Française de Dermatologie (SFD), Paris, France.

Background: The prevalence and impact of pruritus, pain, and other sensory symptoms in skin diseases are poorly known.

Objective: To assess the frequency of these symptoms with dermatoses and their association with depression using data from the "Objectifs Peau" survey.

Methods: A representative sample of 20,012 French individuals was created using the usual quota method. Read More

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September 2021

Association between Discontinuing Chronic Opioid Therapy and Newly Diagnosed Substance Use Disorders, Accidents, Self-Inflicted Injuries and Drug Overdoses within the Prescribers' Health Care System: A Retrospective Cohort Study.

Addiction 2021 Sep 13. Epub 2021 Sep 13.

Division of Pharmaceutical Evaluation and Policy, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR.

Background And Aim: Prescribers are commonly confronted with discontinuing opioid therapy among patients prescribed chronic opioid therapy (COT). This study aimed to measure the association between discontinuing COT and diagnoses of substance use disorders (SUDs) and opioid-related adverse outcomes (AOs).

Design: Retrospective cohort study SETTING: U. Read More

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September 2021

Physical activity levels, lifestyle behaviour and musculoskeletal health profiles among seated video gamers during COVID-19.

BMJ Open Sport Exerc Med 2021 7;7(3):e001194. Epub 2021 Sep 7.

Biomedical Engineering and Healthcare Technology (BEAHT) Research Centre, Faculty of Health Sciences, University of Johannesburg, Johannesburg, Gauteng, South Africa.

Objectives: The aim of this research study was to determine the physical activity levels of non-active video gamers, and to determine how much other time was spent with sedentary behaviours, both in recreational and occupational domains.

Methods: The study used the International Physical Activity Questionnaire, and investigated physical activity levels and health data of seated gamers. Typical weekly gaming habits, self-reported musculoskeletal pain and physical activity levels experienced by participants while gaming was also obtained. Read More

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September 2021

Work-Related Musculoskeletal Disorders Among Hospital Midwives in Chenzhou, Hunan Province, China and Associations with Job Stress and Working Conditions.

Risk Manag Healthc Policy 2021 3;14:3675-3686. Epub 2021 Sep 3.

Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People's Republic of China.

Background: Midwives have a high risk of work-related musculoskeletal disorders (WMSDs), which are the leading cause of pain and disability. However, the association between job stress and WMSDs among midwives has not been studied. The aim of this project was to specifically describe relationships between the job stress and WMSDs among a sample of hospital midwives in Chenzhou, Hunan Province, China. Read More

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September 2021