3 results match your criteria association isw1p

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Methylation of H3 lysine 4 at euchromatin promotes Sir3p association with heterochromatin.

J Biol Chem 2004 Nov 27;279(46):47506-12. Epub 2004 Jul 27.

Wellcome Trust/Cancer Research United Kingdom Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QR, United Kingdom.

Set1p methylates lysine 4 of histone H3 and can activate transcription by recruiting the chromatin-remodeling factor Isw1p. In addition, Lys-4-methylated H3 is required for maintenance of silencing at the telomeres, rDNA, and HML locus in Saccharomyces cerevisiae. The molecular mechanism underlying the role of Set1p in silencing is not known. Read More

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November 2004

Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin.

Mol Cell 2003 Nov;12(5):1325-32

Wellcome Trust/Cancer Research UK Institute and Department of Pathology, Tennis Court Road, Cambridge CB2 1QR, United Kingdom.

Set1p methylates lysine 4 (K4) of histone H3 and regulates the expression of many genes in yeast. Here we use a biochemical approach to identify a protein, Isw1p, which recognizes chromatin preferentially when it is di- and trimethylated at K4 H3. We show that on certain actively transcribed genes, the Isw1p chromatin remodeling ATPase requires K4 H3 methylation to associate with chromatin in vivo. Read More

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November 2003
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