J Biol Chem 2004 Nov 27;279(46):47506-12. Epub 2004 Jul 27.
Wellcome Trust/Cancer Research United Kingdom Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QR, United Kingdom.
Set1p methylates lysine 4 of histone H3 and can activate transcription by recruiting the chromatin-remodeling factor Isw1p. In addition, Lys-4-methylated H3 is required for maintenance of silencing at the telomeres, rDNA, and HML locus in Saccharomyces cerevisiae. The molecular mechanism underlying the role of Set1p in silencing is not known. Read More