27 results match your criteria association derailment

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Optimized design to adverse transportation conditions for railway freight system.

Accid Anal Prev 2021 May 16;154:106091. Epub 2021 Mar 16.

China Railway Nanning Group Co. Ltd., Nanning 530000, China. Electronic address:

This study proposed a method for transportation agencies to efficiently and accurately formulate or revise rules for the movement of railway transport while ensuring safety under adverse conditions. Determining such a method in general requires trial-and-error experimentation, which consumes large amounts of time and money. We used the uniform experiment (UE) and generalized linear autoregression (GLAR) to establish our method. Read More

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Derailment within the landscape of psychopathology.

Curr Opin Psychol 2021 Feb 6;41:21-27. Epub 2021 Feb 6.

Department of Human Development, Cornell University, USA.

When perceived changes in course occur, individuals can be left feeling disconnected from who they were in the past. This sensation of being 'off-course' in life is an individual difference we call 'derailment.' In this article, we review derailment's unique contribution to the psychological literature, the role of perceived self and identity change in mental health, and the nuanced association between derailment and depression. Read More

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February 2021

The long and winding road to target protein misfolding in cardiovascular diseases.

Eur J Clin Invest 2021 May 19;51(5):e13504. Epub 2021 Mar 19.

Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.

Background: In the last decades, cardiovascular diseases (CVD) have remained the first leading cause of mortality and morbidity in the world. Although several therapeutic approaches have been introduced in the past, the development of novel treatments remains an important research goal, which is hampered by the lack of understanding of key mechanisms and targets. Emerging evidences in recent years indicate the involvement of misfolded proteins aggregation and the derailment of protein quality control in the pathogenesis of cardiovascular diseases. Read More

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Cancers in Agreement? Exploring the Cross-Talk of Cancer Metabolomic and Transcriptomic Landscapes Using Publicly Available Data.

Cancers (Basel) 2021 Jan 21;13(3). Epub 2021 Jan 21.

Laboratory of Systems and Synthetic Biology, Wageningen University & Research, Stippeneng, 6708 WE Wageningen, The Netherlands.

One of the major hallmarks of cancer is the derailment of a cell's metabolism. The multifaceted nature of cancer and different cancer types is transduced by both its transcriptomic and metabolomic landscapes. In this study, we re-purposed the publicly available transcriptomic and metabolomics data of eight cancer types (breast, lung, gastric, renal, liver, colorectal, prostate, and multiple myeloma) to find and investigate differences and commonalities on a pathway level among different cancer types. Read More

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January 2021

PPM1F controls integrin activity via a conserved phospho-switch.

J Cell Biol 2020 12;219(12)

Lehrstuhl Zellbiologie, Fachbereich Biologie, Universität Konstanz, Konstanz, Germany.

Control of integrin activity is vital during development and tissue homeostasis, while derailment of integrin function contributes to pathophysiological processes. Phosphorylation of a conserved threonine motif (T788/T789) in the integrin β cytoplasmic domain increases integrin activity. Here, we report that T788/T789 functions as a phospho-switch, which determines the association with either talin and kindlin-2, the major integrin activators, or filaminA, an integrin activity suppressor. Read More

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December 2020

Cancer and Alzheimer's disease inverse relationship: an age-associated diverging derailment of shared pathways.

Mol Psychiatry 2021 01 7;26(1):280-295. Epub 2020 May 7.

Department of Drug Sciences, University of Pavia, V.le Taramelli 12/14, 27100, Pavia, Italy.

Several epidemiological studies show an inverse association between cancer and Alzheimer's disease (AD). It is debated whether this association is the consequence of biological mechanisms shared by both these conditions or may be related to the pharmacological treatments carried out on the patients. The latter hypothesis, however, is not sustained by the available evidence. Read More

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January 2021

The unique predictive value of discrete depressive symptoms on derailment.

J Affect Disord 2020 06 1;270:65-68. Epub 2020 Apr 1.

Department of Human Development, Cornell University, Ithaca, NY 14853-4401, United States.

Background: Studies have consistently demonstrated a positive cross-sectional association between depressive symptoms and derailment, or the sense of being "off-course" in life. Still unknown is whether all symptoms of depression similarly relate to derailment. Given that depressive symptoms do not weigh equally in the prediction of other important outcomes, this study aimed to bridge the gap between these novel findings and emerging perspectives focused on the impact of individual depressive symptoms. Read More

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[Newer studies on the strong link between sleep and epilepsy: Epilepsy as an epileptic transformation of sleep plastic functions].

Péter Halász

Ideggyogy Sz 2019 Sep;72(9-10):304-314

Országos Klinikai Idegtudományi Intézet, Budapest.

Aims - Overview of the new data about the strong link of sleep and epilepsy and conjoining cognitive impairment. Methods - Search for relevant references and summary of our own research activity on the topic. Results - Strong interrealtionship exists between epilepsy and plastic brain functions (memory processing and synaptic homeostasis) and the working modes of NREM sleep. Read More

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September 2019

Public Health Senior Deputy's Perceptions of State Health Officials' Success Factors: Professional Characteristics, Personal Attributes, and Signs of Derailment.

J Public Health Manag Pract 2020 Jan/Feb;26(1):16-22

Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, Indiana (Mr Boedigheimer and Drs Yeager and Halverson); de Beaumont Foundation, Bethesda, Maryland (Dr Chapple-McGruder); and Association of State and Territorial Health Officials, Arlington, Virginia (Ms Moffatt).

Context: Senior deputies work closely with state health officials (SHOs) in state public health agencies and are a valuable resource for understanding their roles, responsibilities, and characteristics.

Objective: Examine senior deputies' perceptions of SHO success factors.

Design: Qualitative study including nominal group technique focus groups, a small expert focus group, and interviews. Read More

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February 2021

Preventing Leader Derailment-A Strategic Imperative for Public Health Agencies.

J Public Health Manag Pract 2018 Jul/Aug;24(4):400-403

Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, Indiana (Drs Baker and Halverson and Mr Boedigheimer); University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (Dr Baker); Association of State and Territorial Health Officials, Arlington, Virginia (Ms Moffatt); Center for Creative Leadership, Greensboro, North Carolina (Dr Altman); and de Beaumont Foundation, Bethesda, Maryland (Mr Castrucci).

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November 2019

Vascular robustness: The missing parameter in cardiovascular risk prediction.

Prev Med Rep 2018 Mar 28;9:107-113. Epub 2018 Jan 28.

Clinic of Diagnostic and Interventional Radiology, Saarland University Medical Center, 66421 Homburg, Saar, Germany.

Undetected high risk for premature death of cardiovascular disease (CVD) among individuals with low-to-moderate risk factor scores is an acknowledged obstacle to CVD prevention. The vasculature's functional robustness against risk factor derailment may serve as a novel discriminator of mortality risk under similar risk factor loads. To test this assumption, we hypothesized that the expected inverse robustness-mortality association is verifiable as a significant trend along the age spectrum of risk factor-challenged cohorts. Read More

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Eugene J Mahon

Psychoanal Q 2017 Apr;86(2):409-427

Training and Supervising Analyst at the Center for Psychoanalytic Training and Research, Columbia College of Physicians & Surgeons, and is a member of the New York Freudian Society.

A symptom being studied in the process of analysis can be seen as not unlike the unconscious affect it sprang from. The author presents a case in which a symptom, premature ejaculation, was analogous to the unconscious affect of guilt, which itself seemed to be a premature defensive transformation of a deeper current of anger. Guilt was interpreted as if it were a psychic premature ejaculation, a defensive derailment of anger. Read More

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Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration.

Free Radic Biol Med 2017 07 20;108:668-682. Epub 2017 Apr 20.

Center for Neuroscience and Cell Biology, University of Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Electronic address:

The strict energetic demands of the brain require that nutrient supply and usage be fine-tuned in accordance with the specific temporal and spatial patterns of ever-changing levels of neuronal activity. This is achieved by adjusting local cerebral blood flow (CBF) as a function of activity level - neurovascular coupling - and by changing how energy substrates are metabolized and shuttled amongst astrocytes and neurons - neuroenergetic coupling. Both activity-dependent increase of CBF and O and glucose utilization by active neural cells are inextricably linked, establishing a functional metabolic axis in the brain, the neurovascular-neuroenergetic coupling axis. Read More

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Freight-train derailment rates for railroad safety and risk analysis.

Accid Anal Prev 2017 Jan 24;98:1-9. Epub 2016 Sep 24.

Rail Transportation and Engineering Center (RailTEC), Department of Civil and Environmental Engineering, 1245 Newmark Civil Engineering Lab, MC-250, University of Illinois at Urbana-Champaign, 205 N. Mathews Ave., Urbana, IL 61801. Electronic address:

Derailments are the most common type of train accident in the United States. They cause damage to infrastructure, rolling stock and lading, disrupt service, and have the potential to cause casualties, and harm the environment. Train safety and risk analysis relies on accurate assessment of derailment likelihood. Read More

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January 2017

Inhibited early immunologic response is associated with hypertrophic scarring.

Exp Dermatol 2016 10 3;25(10):797-804. Epub 2016 Aug 3.

Department of Plastic-, Reconstructive- and Hand Surgery, VU Medical Center, Amsterdam, The Netherlands.

This study aimed to examine changes in the inflammatory response in early hypertrophic compared to normal wound healing. The immune system is thought to be involved in hypertrophic scar formation. However, the exact mechanism and time of onset of the derailment remain unknown. Read More

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October 2016

Short-term health effects in the general population following a major train accident with acrylonitrile in Belgium.

Environ Res 2016 07 15;148:256-263. Epub 2016 Apr 15.

Scientific Institute of Public Health, Brussels, Belgium. Electronic address:

Background: Following a train derailment, several tons of acrylonitrile (ACN) exploded, inflamed and part of the ACN ended up in the sewage system of the village of Wetteren. More than 2000 residents living in the close vicinity of the accident and along the sewage system were evacuated. A human biomonitoring study of the adduct N-2-cyanoethylvaline (CEV) was carried out days 14-21 after the accident. Read More

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Neurovascular and neurometabolic derailment in aging and Alzheimer's disease.

Front Aging Neurosci 2015 27;7:103. Epub 2015 May 27.

Center for Neuroscience and Cell Biology, University of Coimbra Coimbra, Portugal ; Faculty of Pharmacy, University of Coimbra Coimbra, Portugal.

The functional and structural integrity of the brain requires local adjustment of blood flow and regulated delivery of metabolic substrates to meet the metabolic demands imposed by neuronal activation. This process-neurovascular coupling-and ensued alterations of glucose and oxygen metabolism-neurometabolic coupling-are accomplished by concerted communication between neural and vascular cells. Evidence suggests that neuronal-derived nitric oxide ((•)NO) is a key player in both phenomena. Read More

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Asthma and chronic obstructive pulmonary disease: common genes, common environments?

Am J Respir Crit Care Med 2011 Jun 4;183(12):1588-94. Epub 2011 Feb 4.

Department of Pulmonology, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands.

Asthma and chronic obstructive pulmonary disease (COPD) show similarities and substantial differences. The Dutch hypothesis stipulated that asthma and COPD have common genetic and environmental risk factors (allergens, infections, smoking), which ultimately lead to clinical disease depending on the timing and type of environmental exposures (Postma and Boezen, Chest 2004;126:96S-104S). Thus, a particular group of shared genetic factors may lead to asthma when combined with specific environmental factors that are met at a certain stage in life, whereas combination with other environmental factors, or similar environmental factors at a different stage in life, will lead toward COPD. Read More

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An analysis of Japan Disaster Medical Assistance Team (J-DMAT) deployments in comparison with those of J-DMAT's counterpart in the United States (US-DMAT).

J Nippon Med Sch 2010 Dec;77(6):318-24

Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Lessons learned from the Great Hanshin-Awaji earthquake of 1995 underscored the necessity of establishing Disaster Medical Assistance Teams (DMATs) in Japan, and in 2005, the Japanese government's Central Disaster Prevention Council revised its Basic Disaster Management Plan to include full deployment of DMATs in disaster areas. Defining a DMAT as a trained, mobile, self-contained medical team that can act in the acute phase of a disaster (48 to 72 hours after its occurrence) to provide medical treatment in the devastated area, the revised plan called for the training of DMAT personnel for rapid deployment to any area of the country hit by a disaster. This paper presents descriptive data on the number and types of missions carried out by Japan DMAT (J-DMAT) in its first 5 years, and clarifies how J-DMAT differs from its counterpart in the United States (US-DMAT). Read More

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December 2010

Merkel cells and permanent disesthesia in the oral mucosa after soft tissue grafts.

J Cell Physiol 2010 Jul;224(1):205-9

Department of Periodontology, University of Turin Dental School, Turin, Italy.

Connective tissue grafts are routinely procedures in the treatment of gingival defects. The clinical success of the gingival tissue graft procedures anyway should ensure not only the aesthetic integration between the tissues but also the physiological activity of the graft in terms of sensitivity and immunity because the skin and the mucosae constitute the first natural aspecific borders against pathogens. The aim of this paper was to investigate nervous net recovery after connective graft procedure, in relation with sensorial alteration in the injured area. Read More

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Hippocampal dysfunction during free word association in male patients with schizophrenia.

Schizophr Res 2008 Apr 19;101(1-3):242-55. Epub 2008 Mar 19.

Department of Psychiatry, RWTH Aachen University, Pauwelsstr. 30, D-52074 Aachen, Germany.

In schizophrenia, speech production deficits in patients with positive formal thought disorder (FTD e.g. loosening of associations and derailment) have been attributed to impairments in the semantic network. Read More

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Increased levels and activity of E2F1 transcription factor in myelodysplastic bone marrow.

Int J Hematol 2004 Aug;80(2):146-54

MDS Center and Section of Myeloid Diseases, Rush University, Chicago, Illinois, USA.

The bone marrow of patients with myelodysplastic syndromes (MDS) shows excessive intramedullary apoptosis, particularly in S-phase cells. In the light of previous reports that showed a link between experimental overexpression of the E2F1 transcription factor and apoptosis in the S phase, we compared the status of E2F1 protein in bone marrow mononuclear cells of MDS patients with that of healthy donors. Nearly 67% of MDS marrow samples showed higher expression of E2F1 transcription factor than in healthy donors. Read More

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Distribution and prognostic significance of cell cycle proteins in squamous carcinoma of the larynx, hypopharynx and adjacent epithelial hyperplastic lesions.

J Laryngol Otol 2003 Apr;117(4):286-93

Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Alterations of cell cycle proteins contribute to the development and biological behaviour of malignant tumours. We evaluated the distribution and prognostic significance of immunohistochemically detected proteins p53, p21, Rb, and cyclin D1 in 101 laryngeal and hypopharyngeal squamous cell carcinomas (SCC) and adjacent epithelial hyperplastic lesions (EHL). Protein expression was correlated with tumour grade and stage. Read More

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The imbalanced brain: from normal behavior to schizophrenia.

S Grossberg

Biol Psychiatry 2000 Jul;48(2):81-98

Department of Cognitive and Neural Systems and Center for Adaptive Systems, Boston University, Boston, Massachusetts 02215, USA.

An outstanding problem in psychiatry concerns how to link discoveries about the pharmacological, neurophysiological, and neuroanatomical substrates of mental disorders to the abnormal behaviors that they control. A related problem concerns how to understand abnormal behaviors on a continuum with normal behaviors. During the past few decades, neural models have been developed of how normal cognitive and emotional processes learn from the environment, focus attention and act upon motivationally important events, and cope with unexpected events. Read More

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Speech performance in mania and schizophrenia: the association of positive and negative thought disorders and reference failures.

P D Harvey J Brault

J Commun Disord 1986 Jun;19(3):161-73

The speech performance of manics (n = 21) and schizophrenics (n = 22) was assessed with both clinical evaluations and an assessment of reference performance. The severity of positive and negative clinical thought disorders was correlated with the frequency of incompetent (unclear and ambiguous) references as measured with a linguistic rating system. It was found that pressure of speech accounted for the majority of the variance in incompetent references in the manic sample, while this relationship was not found for the schizophrenics. Read More

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Schizophrenic thought disorders: comparison between units of symptoms and axial syndrome.

O H Arnold

Psychopathology 1985 ;18(4):230-6

The schizophrenic axial syndrome postulates the presence of thought disorder and/or cryptic neologisms. The theory of symptom units postulates three groups of symptoms within the schizophrenic pattern. Each group arises through a special basic disturbance within the performance of experience close to the biological substrate. Read More

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Goal-directed thinking in schizophrenics' associations.

J Pers Assess 1983 Apr;47(2):161-6

The relationships between associative structure and higher order cognitive processes in schizophrenia were investigated with a continuous word association technique. The chaining hypothesis involves the derailment of organized thought by response-produced stimuli, and the continuity hypothesis postulates a progressive disorganization of connotative meaning. Neither hypothesis was confirmed, as both schizophrenics and nonschizophrenics maintained the set of guiding responses according to the starting stimuli. Read More

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