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Combined healthy lifestyle and depressive symptoms: a meta-analysis of observational studies.

J Affect Disord 2021 Apr 26;289:144-150. Epub 2021 Apr 26.

Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan. Electronic address:

Background: To systematically summarize the association between combined lifestyle (at least three factors, including but not limited to smoking, drinking, physical activity, body mass index, diet) and depressive symptoms by a meta-analysis in general populations.

Methods: Multiple electronic databases were searched for observational studies investigating combined lifestyle factors and depressive symptoms published before September 2020. Pooled risk estimates were calculated using random-effects models. Read More

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Cerebrospinal fluid dynamics correlate with neurogenic claudication in lumbar spinal stenosis.

PLoS One 2021 12;16(5):e0250742. Epub 2021 May 12.

Department of Brain and Cognitive Engineering, Korea University, Seoul, South Korea.

Neurogenic claudication is a typical manifestation of lumbar spinal stenosis (LSS). However, its pathophysiology is still unclear. The severity of clinical symptoms has been shown not to correlate with the degree of structural stenosis. Read More

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Circulating adiponectin mediates the association between omentin gene polymorphism and cardiometabolic health in Asian Indians.

PLoS One 2021 12;16(5):e0238555. Epub 2021 May 12.

Department of Molecular Genetics, Madras Diabetes Research Foundation, Chennai, India.

Background: Plasma omentin levels have been shown to be associated with circulating adiponectin concentrations and cardiometabolic disease-related outcomes. In this study, we aim to examine the association of omentin gene polymorphism with serum adiponectin levels and cardiometabolic health status using a genetic approach, and investigate whether these associations are modified by lifestyle factors.

Methods: The study included 945 normal glucose tolerant and 941 unrelated individuals with type 2 diabetes randomly selected from the Chennai Urban Rural Epidemiology Study (CURES), in southern India. Read More

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Association between Healthy Eating Index-2015 and physical frailty among the United States elderly adults: the National Health and Nutrition Examination Survey (NHANES) 2011-2014.

Aging Clin Exp Res 2021 May 12. Epub 2021 May 12.

School of Public Health, Xi'an Jiaotong University, 76 West Yanta Road, Xi'an, 710061, China.

Background: Diet plays an important role in the development of age-related chronic diseases. However, the association between diet quality assessed by Healthy Eating Index (HEI)-2015, the latest version of HEI, and physical frailty among the general United States (US) elderly adults remains unclear.

Aims: The present study aims to explore the association between HEI-2015 and physical frailty in elderly adults using data from National Health and Nutrition Examination Survey (NHANES) 2011-2014. Read More

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Vital signs of the systemic inflammatory response syndrome in adult patients with acute infections presenting in out-of-hours primary care: A cross-sectional study.

Eur J Gen Pract 2021 Dec;27(1):83-89

Scientific Centre for Quality of Healthcare (IQ healthcare), Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

Background: Signs of the systemic inflammatory response syndrome (SIRS) - fever (or hypothermia), tachycardia and tachypnoea - are used in the hospital setting to identify patients with possible sepsis.

Objectives: To determine how frequently abnormalities in the vital signs of SIRS are present in adult out-of-hours (OOH) primary care patients with suspected infections and assess the association with acute hospital referral.

Methods: We conducted a cross-sectional study at the OOH GP cooperative in Nijmegen, the Netherlands, between August and October 2015. Read More

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December 2021

The Hepcidin and 25-OH-Vitamin D Levels in Obese Children as a Potential Mediator of the Iron Status.

Clin Lab 2021 May;67(5)

Background: Obesity is associated with the risk factors such as iron and vitamin D deficiencies. Increased risk of iron deficiency generally correlates with the high levels of serum hepcidin in obese children. Vitamin D deficiency was also linked to an increase in serum hepcidin levels. Read More

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Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans.

EMBO J 2021 May 12:e106864. Epub 2021 May 12.

Center for Reproductive Medicine, Cheeloo College of Medicine, Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China.

Current understanding holds that Klinefelter syndrome (KS) is not inherited, but arises randomly during meiosis. Whether there is any genetic basis for the origin of KS is unknown. Here, guided by our identification of some USP26 variations apparently associated with KS, we found that knockout of Usp26 in male mice resulted in the production of 41, XXY offspring. Read More

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The association between carotenoids and subjects with overweight or obesity: a systematic review and meta-analysis.

Food Funct 2021 May 12. Epub 2021 May 12.

Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, 130021, P. R. China.

Background: Excess body weight, including overweight and obesity, is one of the major factors influencing human health, and plays an important role in the global burden of disease. Carotenoids serve as precursors of vitamin A-related retinoids, and are considered to have potential effects on many diseases. However, the influence of carotenoids on people with excess body weight is unclear. Read More

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Excellent Outcome in Living Donor Liver Transplantation Treating Acute on Chronic Liver Failure patients.

Liver Transpl 2021 May 12. Epub 2021 May 12.

Liver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Introduction: Acute-on-chronic liver failure (ACLF) is a fatal condition and liver transplantation is a vital option for these patients. However, the result of living donor liver transplantation (LDLT) for ACLF is not well investigated. This study aimed to investigate the outcomes of LDLT in patients with ACLF as compared to patients without ACLF. Read More

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Likelihood of meeting physical activity guidelines in rural and urban adults: cross-sectional analysis of the Canadian Community Health Survey.

Can J Public Health 2021 May 12. Epub 2021 May 12.

University of Northern British Columbia, Prince George, Canada.

Objectives: The goal of this study was to compare the odds of meeting physical activity (PA) guidelines among adults living in rural and urban areas of Canada.

Methods: Data from the 2017 cycle of the Canadian Community Health Survey were analyzed using binomial logistic regression with a sample of 47,266 adults representing a survey-weighted total of 25,669,018. The odds of meeting PA guidelines were determined based on self-reported moderate-to-vigorous PA (<150 min per week or ≥150 min per week). Read More

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Association between sleep disturbance and low back and pelvic pain in 4-month postpartum women: A cross-sectional study.

Eur Spine J 2021 May 11. Epub 2021 May 11.

Department of Public Health, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma-ku, Kobe, Japan.

Purpose: Persistent low back and pelvic pain (LBPP) is a postpartum-specific health problem. Sleep disturbances' association with persistent LBPP is not yet clear. We aimed to examine the cross-sectional association between sleep disturbance and persistent LBPP at 4 months postpartum. Read More

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Adipotropic effects of heavy metals and their potential role in obesity.

Fac Rev 2021 26;10:32. Epub 2021 Mar 26.

IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Epidemiological studies demonstrated an association between heavy metal exposure and the incidence of obesity and metabolic syndrome. However, the particular effects of metal toxicity on adipose tissue functioning are unclear. Therefore, recent findings of direct influence of heavy metals (mercury, cadmium, and lead) and metalloid (arsenic) on adipose tissue physiology are discussed while considering existing gaps and contradictions. Read More

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Association between measures of adiposity and blood pressure levels in adult Cameroonians.

Health Sci Rep 2021 Jun 3;4(2):e259. Epub 2021 May 3.

Non-Communicable Diseases Research Unit Medical Research Council Cape Town South Africa.

Introduction: Several anthropometric measurements are variably recommended to assess adiposity in routine practice, with less agreement on their comparative performance. We assessed and compared the relationship of seven anthropometric measures of adiposity-waist circumference (WC), waist-to-height ratio (WHtR), Body Mass Index (BMI), Ponderal Index (PI), Conicity Index (C index), A Body Shape Index (ABSI), and Body Roundness Index (BRI)-with blood pressure (BP) levels and prevalent hypertension in adult Cameroonians.

Methods: Data were collected as Cameroon's contribution to the global May Measurement Month 2017(MMM17) survey. Read More

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Association between transient appetite loss and vitamin B1 deficiency in elderly patients with suspected deficiency.

J Gen Fam Med 2021 May 17;22(3):128-133. Epub 2020 Nov 17.

Internal Medicine Unnan City Hospital Unnan Japan.

Background: There is scarce evidence associating vitamin B1 levels and appetite loss duration in elderly patients with suspected B1 deficiency. We aimed to investigate this association in elderly hospitalized patients with suspected vitamin B1 deficiency in rural Japan.

Methods: This cross-sectional study evaluated 309 elderly patients (aged ≥ 65 years) admitted to one rural Hospital between April 2017 and March 2019. Read More

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Association between body mass index and blood pressure levels across socio-demographic groups and geographical settings: analysis of pooled data in Peru.

PeerJ 2021 21;9:e11307. Epub 2021 Apr 21.

CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.

Background: Understanding the relationship between BMI and blood pressure requires assessing whether this association is similar or differs across population groups. This study aimed to assess the association between body mass index (BMI) and blood pressure levels, and how these associations vary between socioeconomic groups and geographical settings.

Methods: Data from the National Demographic Health Survey of Peru from 2014 to 2019 was analyzed considering the complex survey design. Read More

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Illness Expectations Assessment in People with Asthma: A Tool for Explicit and Implicit Beliefs.

J Asthma Allergy 2021 3;14:449-455. Epub 2021 May 3.

Pneumological Rehabilitation, IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.

Background: Illness expectations are cognitive schemas, both explicit and implicit, describing how symptoms are expected to be in the future. They can be particularly relevant to disease in a mind/body framework. Asthma is a condition in which the psychological aspects can highly influence the body, but no study has directly explored these specific expectations, and no dedicated assessment tools are available. Read More

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Dental Caries, Body Mass Index, and Socioeconomic Status among Preschoolers in Private Preschools and Anganwadi Centers in Bengaluru City: A Comparative Study.

Int J Clin Pediatr Dent 2020 Nov-Dec;13(6):630-634

Department of Public Health Dentistry, RajaRajeswari Dental College and Hospital, Bengaluru, Karnataka, India.

Aim: Preschool is the time when deleterious oral habits, caries pattern, and risk factor are established and is the time to intervene and establish healthy trends which can have a lifelong influence. Individuals living in various socioeconomic conditions have an assortment of hazard factors that impact oral well-being. This work was conducted to study the prevalence of dental caries, body mass index (BMI), and socioeconomic status (SES) among preschoolers in private preschools and Anganwadi centers within Bengaluru. Read More

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Pathological analysis of batch safety testing of veterinary vaccines using small laboratory animals.

J Toxicol Pathol 2021 Apr 25;34(2):137-146. Epub 2021 Feb 25.

National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan.

Batch safety tests (BSTs) of veterinary vaccines are conducted using small laboratory animals to assure the safety of vaccines according to several criteria, including clinical signs and change in body weight. Although the latter is used as an evaluation index in BSTs, there have been no reports on the internal changes that affect body weight during the test period. Therefore, we analyzed BST via pathological examination of the tested animals. Read More

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Gastroenterology practice in the COVID-19 era: Ghana Association for the Study of Liver and Digestive Diseases (GASLIDD) position statement.

Ghana Med J 2020 Dec;54(4 Suppl):104-106

Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

The COVID-19 pandemic has impacted healthcare negatively across the globe. The practice of gastroenterology has been affected especially gastrointestinal (GI) endoscopy which is considered high risk for transmission of the virus. As a community of practitioners there is the need to share information and make evidence-based statements to guide GI practice in Ghana. Read More

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December 2020

Does the built environment have independent obesogenic power? Urban form and trajectories of weight gain.

Int J Obes (Lond) 2021 May 11. Epub 2021 May 11.

Center for Public Health Nutrition, 305 Raitt Hall, #353410, University of Washington, Seattle, WA, USA.

Objective: To determine whether selected features of the built environment can predict weight gain in a large longitudinal cohort of adults.

Methods: Weight trajectories over a 5-year period were obtained from electronic health records for 115,260 insured patients aged 18-64 years in the Kaiser Permanente Washington health care system. Home addresses were geocoded using ArcGIS. Read More

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Comparison of the triglyceride glucose index and blood leukocyte indices as predictors of metabolic syndrome in healthy Chinese population.

Sci Rep 2021 May 11;11(1):10036. Epub 2021 May 11.

Health Management Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.

Triglyceride glucose (TyG) index and inflammatory markers are reported to have a positive association with metabolic syndrome (MetS). However, no previous study has assessed the value of TyG index and inflammatory markers as predictors of metabolic syndrome in the same study. This study looks at the comparison of the triglyceride index and blood leukocyte indices as predictors of metabolic syndrome in the Chinese population. Read More

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Adjustment for body mass index changes inverse associations of HDL-cholesterol with blood pressure and hypertension to positive associations.

J Hum Hypertens 2021 May 11. Epub 2021 May 11.

School of Science, Psychology and Sport, Federation University Australia, Ballarat, VIC, Australia.

The associations between high-density lipoprotein cholesterol (HDL-C) and blood pressure (BP) or hypertension are inconsistent in previous studies. This study aimed to assess these associations in a large cohort of Chinese adults and across different age groups. This cross-sectional association study included 22,081 Chinese adults. Read More

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Comparison of anthropometric and body composition indices in the identification of metabolic risk factors.

Sci Rep 2021 May 11;11(1):9931. Epub 2021 May 11.

Future Medicine Division, Korea Institute of Oriental Medicine, Deajeon, 305-811, Republic of Korea.

Whether anthropometric or body composition indices are better indicators of metabolic risk remains unclear. The objectives of this study were to compare the association of metabolic risk factors with anthropometric and body composition indices and to identify the better indicators for risk factors in a large-scale Korean population. In this cross-sectional study, the associations of body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) as anthropometric indices and trunk fat mass (TFM), percent trunk fat mass (%TFM), whole-body total fat mass (WBTFM), and percent whole-body total fat mass (%WBTFM) as body composition indices with metabolic risk factors were compared by complex-samples multiple logistic regression models based on complex-sample survey data. Read More

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Age and gender differences in objective sleep properties using large-scale body acceleration data in a Japanese population.

Sci Rep 2021 May 11;11(1):9970. Epub 2021 May 11.

Graduate School of Education, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Using large-scale objective sleep data derived from body acceleration signals of 68,604 Japanese residents ranging from adolescents to the elderly (10-89 years old), we found significant age- and gender-related differences in sleep properties (timing, duration, and quality) in real-life settings. Time-in-bed and total sleep time (TST) showed a U-shaped association with age, indicating their decrease in adulthood following their increase in the elderly. There was a remarkable shift in sleep phase toward earlier bedtime and earlier wake time with increasing age (> 20 years), together with worsening of sleep quality, which is estimated by sleep efficiency (SE) and wake time after sleep onset. Read More

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Sex and body mass index dependent associations between serum 25-hydroxyvitamin D and pulse pressure in middle-aged and older US adults.

Sci Rep 2021 May 11;11(1):9989. Epub 2021 May 11.

Department of Preventive Medicine, Gachon University College of Medicine, 155 Gaetbeol-ro, Yeonsu-gu, Incheon, 21999, Republic of Korea.

High pulse pressure (PP) is a valid indicator of arterial stiffness. Many studies have reported that vitamin D concentration is inversely associated with vascular stiffening. This association may differ depending on sex and body mass index (BMI). Read More

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Adolescents with and without head and neck burns: comparison of long-term outcomes in the burn model system national database.

Burns 2021 Apr 20. Epub 2021 Apr 20.

Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Charlestown, MA, United States. Electronic address:

Introduction: Facial burns account for persistent differences in psychosocial functioning in adult burn survivors. Although adolescent burn survivors experience myriad chronic sequelae, little is known about the effect of facial injuries. This study examines differences in long-term outcomes with and without head and neck involvement. Read More

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Breastfeeding history and the risk of overweight and obesity in middle-aged women.

BMC Womens Health 2021 May 11;21(1):196. Epub 2021 May 11.

Institute of Health Sciences, Medical College, Jan Kochanowski University, Kielce, Poland.

Background: The increased metabolic activity required to sustain breastfeeding and its associated milk production helps to reduce maternal fat stores accumulated during pregnancy. This study aims to assess the association between breastfeeding duration and fatness indices in middle-aged women.

Methods: The analysis was carried out in a group of 7500 parous 55. Read More

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Associations between Inhaled Corticosteroid in the First 6 Years of Life and Obesity Related Traits.

Am J Respir Crit Care Med 2021 May 11. Epub 2021 May 11.

University of Copenhagen, 4321, COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, Kobenhavn, Denmark;

Rationale Infants and young children might be particularly susceptible to the potential clinical side effects of inhaled corticosteroids (ICS) on body mass index (BMI), adiposity rebound and body composition, but this has rarely been studied in long-term studies in this age-group. Objective To determine the association between ICS exposure in the first 6 years of life on BMI, adiposity rebound, body composition and blood lipid levels. Methods Children from the two Copenhagen Prospective Studies on Asthma in Childhood mother-child cohorts were included. Read More

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A scoping review of the methodology used in studies of genetic influences on the development of keloid or hypertrophic scarring in adults and children after acute wounding.

Adv Wound Care (New Rochelle) 2021 May 11. Epub 2021 May 11.

Children's Burn Research Centre, University Hospital Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom of Great Britain and Northern Ireland.

Significance: Keloid and hypertrophic scarring are common following acute wounds. However, the variability in scarring outcomes between individuals and in particular, the association between genetic factors and scarring, is not well understood. This scoping review aims to summarise the methodology used in studies of genetic influences on the development of keloid or hypertrophic scarring in adults and children after acute wounding. Read More

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Association Between Penile Color Doppler Ultrasonography and Cardiorespiratory Fitness in Patients With Vascular Erectile Dysfunction.

Sex Med 2021 May 8;9(3):100347. Epub 2021 May 8.

Sports and Exercise Medicine Division, Department of Medicine, University of Padova, Padova, Italy.

Introduction: Vascular erectile dysfunction (ED) is a burdensome condition, associated with increased cardiovascular risk. Peak systolic velocity (PSV) represents the maximum pulse velocity in the cavernous artery measured by a penile color doppler ultrasonography (PCDU) during a pharmacologically induced erection and is considered a reliable parameter for the diagnosis of vascular ED. However, the cut-off value of standard PSV (30 cm/s) provides high sensitivity only in the diagnosis of advanced arteriogenic disease. Read More

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