1,303,750 results match your criteria association

Maternal exposure to ambient air pollution and congenital heart defects in China.

Environ Int 2021 Apr 7;153:106548. Epub 2021 Apr 7.

Guangdong Provincial Engineering Technology Research Center of Environmental and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Background: Evidence of maternal exposure to ambient air pollution on congenital heart defects (CHD) has been mixed and are still relatively limited in developing countries. We aimed to investigate the association between maternal exposure to air pollution and CHD in China.

Method: This longitudinal, population-based, case-control study consecutively recruited fetuses with CHD and healthy volunteers from 21 cities, Southern China, between January 2006 and December 2016. Read More

View Article and Full-Text PDF

Dipeptidyl peptidase-4 (DPP-4) inhibitor and mortality in coronavirus disease 2019 (COVID-19) - A systematic review, meta-analysis, and meta-regression.

Diabetes Metab Syndr 2021 Apr 1;15(3):777-782. Epub 2021 Apr 1.

Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Padjadjaran, Rumah Sakit Umum Pusat Hasan Sadikin, Bandung, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia. Electronic address:

Background And Aims: This study aims to synthesize evidence on dipeptidyl peptidase-4 (DPP-4) inhibitor and mortality in COVID-19 patients and factors affecting it.

Methods: We performed a systematic literature search from PubMed, Scopus, and Embase databases from inception of databases up until 7 March 2021. Studies that met all of the following criteria were included: 1) observational studies or randomized controlled trials that report COVID-19 patients, 2) reporting DPP-4 inhibitor use, 3) mortality, and 4) mortality based on DPP-4 inhibitor use. Read More

View Article and Full-Text PDF

Adoptees facing adolescence: What accounts for their psychological well-being?

J Adolesc 2021 Apr 7;89:10-17. Epub 2021 Apr 7.

Universidad de Seville, Spain.

Introduction: In accordance with the "resilience paradigm", this study was aimed at exploring the role of the parent-child relationship in supporting internationally adopted adolescents' ability to develop a strong adoptive identity and a feeling of satisfaction with their own life.

Methods: Participants were 105 Italian adopted adolescents (13-17 years) asked to complete a self-report questionnaire.

Results: Results showed that adolescents generally feel fairly comfortable discussing adoption-related issues (especially with their mothers), have a medium-high level of adoptive identity, and appear to be quite satisfied with their life. Read More

View Article and Full-Text PDF

Prospective association between baseline plasma zinc concentration and development of proteinuria in Chinese hypertensive patients.

J Trace Elem Med Biol 2021 Apr 2;66:126755. Epub 2021 Apr 2.

Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510515, China. Electronic address:

Objective: We aimed to evaluate the association between baseline plasma zinc and the development of proteinuria as well as possible effect modifiers in hypertensive patients.

Methods: This is a subset of the China Stroke Primary Prevention Trial (CSPPT) Renal Sub-Study. In the CSPPT, participants were randomized to receive a daily oral dose of 1 tablet containing 10 mg enalapril and 0. Read More

View Article and Full-Text PDF

Intramammary infection caused by Staphylococcus aureus increases IgA antibodies to iron-regulated surface determinant-A, -B, and -H in bovine milk.

Vet Immunol Immunopathol 2021 Mar 31;235:110235. Epub 2021 Mar 31.

Dairy Hygiene Research Division, National Institute of Animal Health, National Agriculture and Food Research Organization, 4 Hitsujigaoka, Toyohira, Sapporo, Hokkaido, 062-0045, Japan. Electronic address:

The aim of this study was to identify virulence factors that have high immunogenicity. An in vivo-expressed Staphylococcus aureus antigen was identified by probing bacteriophage expression libraries of S. aureus with antibodies in bovine mastitis milk. Read More

View Article and Full-Text PDF

Mean Platelet Volume is a Prognostic Marker in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis.

J Stroke Cerebrovasc Dis 2021 Apr 6;30(6):105718. Epub 2021 Apr 6.

Stroke Unit, Department of Neurosciences and Mental Health (Neurology), Hospital Santa Maria; Faculty of Medicine, University of Lisbon, Lisbon, Portugal; Instituto de Medicina Molecular, Lisbon, Portugal.

Background And Objectives: There is conflicting data regarding the association between platelet parameters and prognosis of stroke patients treated with intravenous thrombolysis. We aimed to analyze this association in a cohort of patients treated with rtPA.

Material And Methods: Retrospective, observational study in adult ischemic stroke patients treated with rtPA between January 2015 and February 2017. Read More

View Article and Full-Text PDF

The miRISC component AGO2 has multiple binding sites for Nup358 SUMO-interacting motif.

Biochem Biophys Res Commun 2021 Apr 7;556:45-52. Epub 2021 Apr 7.

National Centre for Cell Science, S.P. Pune University Campus, Pune, India. Electronic address:

Micro-RNA mediated suppression of mRNA translation represents a major regulatory mode of post-transcriptional gene expression. Recently, the nucleoporin Nup358 was shown to interact with AGO protein, a key component of miRNA-induced silencing complex (miRISC), and facilitate the coupling of miRISC with target mRNA. Previous results suggested that SUMO-interacting motifs (SIMs) present on Nup358 mediate interaction with AGO protein. Read More

View Article and Full-Text PDF

Dietary total antioxidant capacity is inversely associated with cardiovascular events and cardiometabolic risk factors: A cross-sectional study.

Nutrition 2021 Feb 19;89:111140. Epub 2021 Feb 19.

Laboratory of Energy Metabolism and Body Composition, Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil. Electronic address:

Objectives: Dietary total antioxidant capacity (dTAC) has been introduced as a useful tool to quantify the antioxidant content of a diet. However, few studies have evaluated the association of dTAC with cardiovascular disease (CVD) occurrence and cardiometabolic risk factors in people with established CVD events. Thus, we aimed to investigate the presence of an association between dTAC values, cardiovascular events, and cardiometabolic risk factors in individuals with previous CVD in a Brazilian multicenter study. Read More

View Article and Full-Text PDF
February 2021

Thrombin generation is associated with ischemic stroke at a young age.

Thromb Res 2021 Mar 29;202:139-144. Epub 2021 Mar 29.

Erasmus MC, University Medical Center Rotterdam, Department of Hematology, the Netherlands. Electronic address:

Introduction: Understanding the underlying mechanisms in ischemic stroke (IS) in young adults remains challenging. Thrombin activates processes that contribute to the development and progression of arterial diseases. We investigated the association between thrombin generation (TG) and a first IS or transient ischemic attack (TIA) in young adults. Read More

View Article and Full-Text PDF

The impact of prenatal stressful life events on adverse birth outcomes: A systematic review and meta-analysis.

J Affect Disord 2021 Mar 31;287:406-416. Epub 2021 Mar 31.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China; Centre for Evidence-Based Practice, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China. Electronic address:

Background: Stressful life events as important stressors have gradually been recognized as the potential etiology that may lead to adverse birth outcomes such as preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA). However, researches on this topic have shown relatively inconsistent results. This systematic review and meta-analysis was performed to synthesize available data on the association between prenatal stressful life events and increased risks of PTB, LBW, and SGA. Read More

View Article and Full-Text PDF

Bidirectional associations between maternal depression, hostile parenting, and early child emotional problems: Findings from the all our families cohort.

J Affect Disord 2021 Mar 26;287:397-404. Epub 2021 Mar 26.

Department of Psychology, University of Calgary, Calgary, Canada; Owerko Centre, Alberta Children's Hospital Research Institute, Calgary, Canada. Electronic address:

Background: An intergenerational association between maternal depression and child emotional problems is well established. However, the underlying processes underpinning this association are still unclear, with relatively little attention paid to potential child-driven effects. This study adds to existing research by examining the bidirectional processes between maternal depression, parenting, and child internalizing symptoms. Read More

View Article and Full-Text PDF

Sustainability and monitoring of the European Code Against Cancer: Recommendations.

Cancer Epidemiol 2021 Apr 7;72:101933. Epub 2021 Apr 7.

Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), 150 cours Albert Thomas, 69372, Lyon CEDEX 08, France.

Introduction: As part of the third European Commission's Joint Action on Cancer (Innovative Partnership for Action Against Cancer, iPAAC), the International Agency for Research on Cancer (IARC) was commissioned to produce a report on recommendations to sustain and monitor future updates of the European Code Against Cancer (ECAC).

Materials And Methods: A co-creational consultation process, including a virtual workshop, was carried out. More than 100 experts in cancer prevention, public health, communication and representatives of European authorities provided input on the scope of future editions of the ECAC, including updating the scientific evidence and its maintenance, and on strategies for its implementation and dissemination across Europe. Read More

View Article and Full-Text PDF

Boron-toxicity induced changes in cell wall components, boron forms, and antioxidant defense system in rice seedlings.

Ecotoxicol Environ Saf 2021 Apr 7;216:112192. Epub 2021 Apr 7.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Root Biology Center, College of Natural Resources and Environment, South China Agricultural University, Guangzhou, 510642 Guangdong, PR China. Electronic address:

Boron (B) is an indispensable micronutrient that ensures the optimal growth and productivity of the plant. However, excessive use of B fertilizers results in B toxicity which is relatively difficult to correct as compared to B deficiency. Moreover, underlying mechanisms of B toxicity induced changes in cell wall components and the association of B forms in the appearance of toxicity symptoms in rice seedlings are lacking. Read More

View Article and Full-Text PDF

Onlay Poly-4-Hydroxybutyrate (P4HB) Mesh for Complex Hernia: Early Clinical and Patient Reported Outcomes.

J Surg Res 2021 Apr 7;264:199-207. Epub 2021 Apr 7.

Division of Plastic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA. Electronic address:

Background: While mesh re-enforcement and advanced surgical techniques are cornerstones of complex ventral hernia repair (CVHR), the risk of complications and recurrence is common. We aim to evaluate the efficacy, safety, and patient reported outcomes (PROs) of patients undergoing CVHR with onlay Poly-4-hydroxybutyrate (P4HB).

Methods: Adult (>18 y old) patients undergoing VHR with P4HB (Phasix) in the onlay plane by a single surgeon from 01/2015 to 05/2020 were reviewed. Read More

View Article and Full-Text PDF

The effects of antibiotics on the efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer differ based on PD-L1 expression.

Eur J Cancer 2021 Apr 7;149:73-81. Epub 2021 Apr 7.

Department of Allergy and Respiratory Medicine, Okayama University Hospital, Japan.

Background: Immune checkpoint inhibitors (ICIs) are essential for treatment of various malignancies, including non-small-cell lung cancer (NSCLC). Recently, several studies have shown that the gut microbiome plays an important role in ICI treatment of solid cancers, and antibiotic (ATB) use had a negative impact on the outcomes of ICI treatment via dysbiosis in the gut. However, whether this is applicable to NSCLC remains unclear. Read More

View Article and Full-Text PDF

Pre and postnatal exposure to mercury and respiratory health in preschool children from the Spanish INMA Birth Cohort Study.

Sci Total Environ 2021 Mar 20;782:146654. Epub 2021 Mar 20.

Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain.

Effects of mercury on maturing immune system have been reported, however the association with respiratory and allergy problems during infancy remains unclear. The aim of this study is to evaluate the association between pre and postnatal mercury exposure and respiratory and allergy problems among preschool children and to examine the role of potential modifying factors. Study subjects were children participant in Spanish Childhood and Environment Project (INMA, 2003-2008). Read More

View Article and Full-Text PDF

Environmental heat-related health symptoms among community in a tropical city.

Sci Total Environ 2021 Mar 30;782:146611. Epub 2021 Mar 30.

Department of Chemical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Due to the changing climate, more frequent and prolonged heatwaves are expected to have a catastrophic consequence on urban human settlement. In tropical cities such as Kuala Lumpur (KL), the quality of the urban environment is made worse by urban heat island (UHI) phenomena due to poor urban planning practices. The prolonged exposure to urban heat is hypothesized to influence human health and well-being, especially in tropical urban areas with high population density. Read More

View Article and Full-Text PDF

Papillary thyroid microcarcinomas that metastasize to lymph nodes.

Am J Otolaryngol 2021 Mar 31;42(5):103023. Epub 2021 Mar 31.

Department of Endocrinology and Metabolism, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey.

Purpose: We aimed to determine clinicopathological features that can predict lymph node metastasis (LNM) in papillary thyroid microcarcinomas (PTMC).

Methods: Medical records of 872 patients with papillary thyroid cancer >1 cm (PTC > 1 cm) and 1184 patients with papillary thyroid microcancer (PTMC) (≤1 cm) were reviewed retrospectively. Demographical, clinical and histopathological features of (PTC > 1 cm) and PTMC were compared. Read More

View Article and Full-Text PDF

Autophagy in the Diabetic Heart: A Potential Pharmacotherapeutic Target in Diabetic Cardiomyopathy.

Ageing Res Rev 2021 Apr 7:101338. Epub 2021 Apr 7.

Department of Biochemistry, Kakatiya Medical College, Warangal, 506007, Telangana, India; Applied Biology, CSIR-Indian Institute of Technology, Uppal Road, Tarnaka, Hyderabad, 50000, Telangana, India. Electronic address:

Association of diabetes with an elevated risk of cardiac failure has been clinically evident. Diabetes potentiates diastolic and systolic cardiac failure following the myocardial infarction that produces the cardiac muscle-specific microvascular complication, clinically termed as diabetic cardiomyopathy. Elevated susceptibility of diabetic cardiomyopathy is primarily caused by the generation of free radicals in the hyperglycemic milieu, compromising the myocardial contractility and normal cardiac functions with increasing redox insult, impaired mitochondria, damaged organelles, apoptosis, and cardiomyocytes fibrosis. Read More

View Article and Full-Text PDF

Associations of Maternal Characteristics and Dietary Factors with Anemia and Iron-Deficiency in Pregnancy.

J Gynecol Obstet Hum Reprod 2021 Apr 7:102137. Epub 2021 Apr 7.

Department of Nutrition and Dietetics, Faculty of Health Sciences, Ankara University, Ankara, Turkey Postal Code: 06290, Phone Number: +90 0312 381 23 50.

Objective: Anemia and iron deficiency during pregnancy influence maternal and fetal health, birth outcomes, and the risk of chronic disease in offspring. This study aimed to examine the association with sociodemographic, maternal factors, supplement use and dietary intakes, and anemia and iron deficiency in pregnancy.

Methods: A cross-sectional study was conducted on 165 pregnant women aged between 19-45 years who were interviewed, and dietary intake was assessed by 24-hours dietary recall, supplement records and food frequency questionnaire. Read More

View Article and Full-Text PDF

Association of HLA mismatch and MTOR inhibitor regimens with malignancy and mortality after kidney transplantation.

Transpl Immunol 2021 Apr 7:101391. Epub 2021 Apr 7.

Department of Pharmacy Practice, College of Pharmacy, University of Rhode Island, Kingston, RI, USA.

Background The association of mammalian target of rapamycin inhibitors (MTORI) with malignancies and mortality in kidney transplant recipients (KTR) with different degrees of human leukocyte antigen mismatch (HLA-mm) at transplant has not been previously studied. Methods Our observational cohort study included 166, 256 adult KTRs in 2000-2018. Immunosuppression in the first post-transplant year were MTORIs in 13,056 (7. Read More

View Article and Full-Text PDF

Serum hs-CRP measured prior transplantation predicts of new-onset diabetes after transplantation in renal transplant recipients.

Transpl Immunol 2021 Apr 7:101392. Epub 2021 Apr 7.

Military Hospital 103, Ha Noi, Viet Nam; Vietnam Military Medical University, Ha Noi, Viet Nam. Electronic address:

Background: To assess the incidence of new-onset diabetes after transplantation (NODAT) for the first year post-transplantation and the predictive value of high-sensitivity C-reactive Protein (hs-CRP) before transplantation for NODAT prediction in kidney transplantation patients.

Material And Methods: A study of 251 consecutive adult end-stage kidney disease patients transplanted kidneys from living donors, follow-up during the first year to find NODAT. We diagnosed NODAT based on blood glucose or HbA1c following to the criteria of the American Diabetes Association. Read More

View Article and Full-Text PDF

Development of a four-gene prognostic model for clear cell renal cell carcinoma based on transcriptome analysis.

Genomics 2021 Apr 7. Epub 2021 Apr 7.

Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China. Electronic address:

This study aimed to develop a prognostic model for clear cell renal cell carcinoma (ccRCC) based on transcriptome analysis. We screened Gene Expression Omnibus (GEO) database and the Cancer Genome Atlas (TCGA) database for gene expression data and clinical characteristics of ccRCC. After differentially expression analysis, we identified 533 key genes of the development of ccRCC. Read More

View Article and Full-Text PDF

A genome-wide association study, supported by a new chromosome-level genome assembly, suggests sox2 as a main driver of the undifferentiatiated ZZ/ZW sex determination of turbot (Scophthalmus maximus).

Genomics 2021 Apr 7. Epub 2021 Apr 7.

Departament of Zoology, Genetics and Physical Anthropology, Faculty of Biology, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. Electronic address:

Background: Understanding sex determination (SD) across taxa is a major challenge for evolutionary biology. The new genomic tools are paving the way to identify genomic features underlying SD in fish, a group frequently showing limited sex chromosome differentiation and high SD evolutionary turnover. Turbot (Scophthalmus maximus) is a commercially important flatfish with an undifferentiated ZW/ZZ SD system and remarkable sexual dimorphism. Read More

View Article and Full-Text PDF

Effect of prenatal phthalate exposure on the association of maternal hormone levels during early pregnancy and reproductive markers in infants at the age of 3 months.

Reprod Toxicol 2021 Apr 7. Epub 2021 Apr 7.

Department of Nursing, Faculty of Social Sciences and Health Care, Constantine the Philosopher University in Nitra, Kraskova 1, 949 74, Nitra, Slovak Republic. Electronic address:

Phthalates belong to the endocrine-disrupting chemicals, altering the hormonal balance in humans during pregnancy with further effects on the reproductive system. This study aimed to investigate the associations between maternal hormone levels during early pregnancy (≤15 week of pregnancy) and reproductive markers in infant boys (n = 37; 61.67%; average age 3. Read More

View Article and Full-Text PDF

Individual variation underlying brain age estimates in typical development.

Neuroimage 2021 Apr 7:118036. Epub 2021 Apr 7.

Developmental Imaging, Murdoch Children's Research Institute; Department of Paediatrics, University of Melbourne.

Typical brain development follows a protracted trajectory throughout childhood and adolescence. Deviations from typical growth trajectories have been implicated in neurodevelopmental and psychiatric disorders. Recently, the use of machine learning algorithms to model age as a function of structural or functional brain properties has been used to examine advanced or delayed brain maturation in healthy and clinical populations. Read More

View Article and Full-Text PDF

Association between VPS13C rs2414739 polymorphism and Parkinson's disease risk: A meta-analysis.

Neurosci Lett 2021 Apr 7:135879. Epub 2021 Apr 7.

Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Objective: We aimed to estimate the role of vacuolar protein sorting 13C (VPS13C) gene single nucleotide polymorphism (SNP) rs2414739 variant in the risk of PD by meta-analysis.

Methods: Five eligible case-control studies including 2796 PD cases and 4138 health controls involved in this meta-analysis. The fixed or random effect model was selected based on the heterogeneity of the included studies which detected by I and Q tests. Read More

View Article and Full-Text PDF

Infographics Are More Effective at Increasing Social Media Attention and Academic Impact in Comparison to Original Research Articles: An Altmetrics-Based Analysis.

Arthroscopy 2021 Apr 7. Epub 2021 Apr 7.

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA.

Purpose: To compare social media attention and citation rates between infographics (visual abstracts) and original research articles.

Methods: All infographics in 2019 from electronic versions of Arthroscopy were matched by topic to articles in the "Original Research" section of the journal in a 4:1 ratio within the same year. The primary outcome was the Altmetric Attention Score (AAS), a cumulative measure of social media attention from various platforms such as Twitter and Facebook. Read More

View Article and Full-Text PDF

Evaluation of Factors Associated with, and Outcomes for Patients with Non-Home Discharge Destinations Following Carotid Endarterectomy.

Ann Vasc Surg 2021 Apr 7. Epub 2021 Apr 7.

Department of Surgery, Pennsylvania State University, College of Medicine, Hershey, PA. Electronic address:

Introduction: Following a carotid endarterectomy (CEA) procedure, patients are discharged to their homes or other locations than home such as an acute care facility or skilled nursing facility based on their functional status and level of medical attention needed. Decision-making for discharge destination following a CEA to home or non-home locations is important due to the differences in survival and post-operative complications. While primary outcomes such as mortality and occurrence of stroke following CEA have been extensively studied, there is a paucity of information characterizing outcomes of discharge destination and the factors associated. Read More

View Article and Full-Text PDF