634,818 results match your criteria associated survival


Single-cell Polyfunctional Proteomics of CD4 Cells from Patients with AML Predicts Responses to Anti-PD-1-based therapy.

Blood Adv 2021 Sep 23. Epub 2021 Sep 23.

MD Anderson Cancer Center, Houston, Texas, United States.

Acute myeloid leukemia (AML) remains a difficult disease to treat disease. In a phase 2 clinical trial in patients with relapsed/refractory AML, combining the hypomethylating agent, azacitidine, with the PD-1 checkpoint inhibitor, nivolumab, demonstrated encouraging response rates (33%), median event-free and overall survival, compared with a historical cohort of contemporary patients treated with azacitidine-based therapies, with an acceptable safety profile. Biomarkers of response are yet to be determined. Read More

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September 2021

Clinical impact of NPM1-mutant molecular persistence after chemotherapy for acute myeloid leukemia.

Blood Adv 2021 Sep 23. Epub 2021 Sep 23.

Alfred Hospital and Monash University, Melbourne, Australia.

Monitoring of NPM1 mutant (mut) measurable residual disease (MRD) in acute myeloid leukemia (AML) has an established role in patients treated with intensive chemotherapy. The European LeukemiaNet has defined molecular persistence at low copy number (MP-LCN) as MRD transcript level <1-2% with <1-log change between any 2 positive samples collected after the end of treatment (EOT). As the clinical impact of MP-LCN is unknown, we sought to characterize outcomes in patients with persistent NPM1mut MRD after EOT and identify factors associated with disease progression. Read More

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September 2021

Clinicopathological and Prognostic Features of 67 Cases with Pulmonary Sarcomatoid Carcinoma: An 18-Year Single-Centre Experience.

Oncol Res Treat 2021 Sep 23:1-10. Epub 2021 Sep 23.

Department of Medical Oncology, Istanbul University Institute of Oncology, Istanbul, Turkey.

Introduction: Pulmonary sarcomatoid carcinoma (PSC) is a very rare subtype of non-small-cell lung cancer (NSCLC). It is frequently diagnosed in the advanced stage and is resistant to conventional chemotherapeutics. Due to the unique nature and rarity, we evaluated the epidemiological, clinicopathological, and survival data of PSC patients treated at our centre. Read More

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September 2021

High CTSL2 expression predicts poor prognosis in patients with lung adenocarcinoma.

Aging (Albany NY) 2021 Sep 23;13(undefined). Epub 2021 Sep 23.

Department of Intensive Care Unit, The First Hospital of Jilin University, Changchun 130021, China.

Cathepsin like 2 (CTSL2) is a lysosomal cysteine protease, and may be associated with tumor metastasis. However, CTSL2 has not been reported as a biomarker in lung adenocarcinoma (LUAD). In this study, bioinformatics analysis using data from The Cancer Genome Atlas was performed. Read More

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September 2021

Impact of Nonadherence to NCCN Adjuvant Radiotherapy Initiation Guidelines in Head and Neck Squamous Cell Carcinoma in an Underserved Urban Population.

J Natl Compr Canc Netw 2021 Sep 22:1-7. Epub 2021 Sep 22.

6Department of Otorhinolaryngology-Head and Neck Surgery, Montefiore Medical Center, Bronx, New York.

Background: Nonadherence to NCCN Guidelines during time from surgery to postoperative radiotherapy (S-PORT) can alter survival outcomes in head and neck squamous cell carcinomna (HNSCC). There is a need to validate this impact in an underserved urban population and to understand risk factors and reasons for delay. We sought to investigate the impact of delayed PORT with outcomes of overall survival (OS) in HNSCC, to analyze predictive factors of delayed PORT, and to identify reasons for delay. Read More

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September 2021

Nanomaterial-based aptasensors as an efficient substitute for cardiovascular disease diagnosis: Future of smart biosensors.

Biosens Bioelectron 2021 Sep 7;193:113617. Epub 2021 Sep 7.

National Agri-Food Biotechnology Institute (NABI), S.A.S. Nagar, Punjab, 140306, India. Electronic address:

As a major cause of deaths in developed countries, cardiovascular disease (CVD) has been a big burden for human health systems. Its early and rapid detection is crucial to efficiently apply appropriate on time therapy and to ultimately reduce the associated mortality rate. Aptamers, known as single-stranded DNA/RNA or oligonucleotides containing receptors and/or catalytic properties, have been widely employed in biodetection platforms due to their beneficial properties. Read More

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September 2021

Construction of a prognostic signature in Ewing's sarcoma: Based on metabolism-related genes.

Transl Oncol 2021 Sep 20;14(12):101225. Epub 2021 Sep 20.

Department of Orthopaedics, the First Hospital of Jilin University, Street Xinmin 71, Changchun, China. Electronic address:

Objective: By combining the expression profiles of metabolism-related genes (MRGS) with clinical information, the expression quantities of MRGS and the influence on development and prognosis were systematically analyzed, so as to provide a theoretical basis for the clinical study on the prognosis of Ewing's sarcoma.

Methods: MRGs expression profiles of 64 patients with Ewing's sarcoma were obtained from GEO dataset. Univariate Cox regression analysis was used to identify metabolization-related differentially expressed genes (DEGs) related with prognosis in Ewing's sarcoma patients. Read More

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September 2021

Candida spp. co-infection in COVID-19 patients with severe pneumonia: Prevalence study and associated risk factors.

Respir Med 2021 Sep 17;188:106619. Epub 2021 Sep 17.

Laboratório de Biofísica de Fungos, Instituto de Biofísica Carlos Chagas Filho, Universidad Federal Do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address:

Background: Invasive fungal infections (IFI) are increasing in prevalence in recent years. In the last few months, the rise of COVID-19 patients has generated a new escalation in patients presenting opportunistic mycoses, mainly by Aspergillus. Candida infections are not being reported yet. Read More

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September 2021

Synergistic cytotoxicity of dual PI3K/mTOR and FLT3 inhibition in FLT3-ITD AML cells.

Adv Biol Regul 2021 Sep 17;82:100830. Epub 2021 Sep 17.

Cellular Signaling Unit, Section of Human Morphology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, 41125, Italy. Electronic address:

Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy, characterized by a heterogeneous genetic landscape and complex clonal evolution, with poor outcomes. Mutation at the internal tandem duplication of FLT3 (FLT3-ITD) is one of the most common somatic alterations in AML, associated with high relapse rates and poor survival due to the constitutive activation of the FLT3 receptor tyrosine kinase and its downstream effectors, such as PI3K signaling. Thus, aberrantly activated FLT3-kinase is regarded as an attractive target for therapy for this AML subtype, and a number of small molecule inhibitors of this kinase have been identified, some of which are approved for clinical practice. Read More

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September 2021

PPBP as a marker of diabetic nephropathy podocyte injury via Bioinformatics Analysis.

Biochem Biophys Res Commun 2021 Aug 30;577:165-172. Epub 2021 Aug 30.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China; Department of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address:

Diabetic nephropathy (DN) is a type of kidney injuries associated with diabetes mellitus and the prevalence of DN has increased dramatically. However, DN still pose problems in therapy, and prognosis. Identifying new DN biomarkers would be helpful in reducing morbidity and mortality from DN and developing novel preventive approaches. Read More

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Copy number alteration of the interferon gene cluster in cancer: Individual patient data meta-analysis prospects to personalized immunotherapy.

Neoplasia 2021 Sep 20;23(10):1059-1068. Epub 2021 Sep 20.

Department of Biosciences and Nutrition, Neo, Karolinska Institute, Huddinge, Sweden. Electronic address:

Interferon (IFN) therapy has been the standard of care for a variety of cancers for decades due to the pleiotropic actions of IFNs against malignancies. However, little is known about the role of copy number alteration (CNA) of the IFN gene cluster, located at the 9p21.3, in cancer. Read More

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September 2021

Poorly differentiated neuroendocrine carcinomas of the gastrointestinal tract: A single-institute study of 43 cases.

Pathol Res Pract 2021 Sep 11;226:153614. Epub 2021 Sep 11.

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA. Electronic address:

Objectives: To characterize the clinicopathologic and immunohistochemical features of poorly differentiated neuroendocrine carcinomas (NEC) in the gastrointestinal tract.

Design: A total of 43 cases were identified and reassessed based on modern classification.

Results: The cohort (27M, 16F; median age: 66 years) included 16 (37%) large cell NEC, 12 (28%) small cell NEC, 5 (12%) NEC not otherwise specified, and 10 (23%) mixed adenoneuroendocrine carcinomas. Read More

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September 2021

Individual patient data meta-analysis of neoadjuvant chemotherapy followed by surgery versus upfront surgery for carcinoma of the oesophagus or the gastro-oesophageal junction.

Eur J Cancer 2021 Sep 20;157:278-290. Epub 2021 Sep 20.

Oncostat U1018, Inserm, Université Paris-Saclay, Équipe Labellisée Ligue Contre le Cancer, Villejuif, France; Bureau de Biostatistiques et Epidémiologie, Gustave Roussy Cancer Campus, Villejuif, France.

Introduction: Which neoadjuvant treatment for locally advanced thoracic oesophagus (TE) or gastro-oesophageal junction carcinoma is best remains an open question. Randomised controlled trials variously accrued patients with adenocarcinoma and squamous cell carcinoma, making strong conclusions hard to obtain. The primary objective of this individual participant data meta-analysis was to investigate the effect of neoadjuvant chemotherapy on overall survival (OS). Read More

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September 2021

Interleukin-36α inhibits colorectal cancer metastasis by enhancing the infiltration and activity of CD8 T lymphocytes.

Int Immunopharmacol 2021 Sep 20;100:108152. Epub 2021 Sep 20.

School of Life Sciences, Zhengzhou University, Zhengzhou 450000, China; International Joint Laboratory for Protein and Peptide Drugs of Henan Province, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

Colorectal cancer is one of the deadliest cancers, and the discovery of new diagnostic biomarkers and therapeutic targets is vital. Interleukin-36α (IL-36α) is a proinflammatory factor that can initiate the inflammatory response and promote the systemic T helper-1 (Th1) immune response. In this study, we investigated the immunological role of IL-36α in CRC. Read More

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September 2021

Comparison of the clinical features in open and closed format intensive care units: A systematic review and meta-analysis.

Anaesth Crit Care Pain Med 2021 Sep 20:100950. Epub 2021 Sep 20.

Biotechnology Research Centre, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Applied biomedical Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Importance: The difference in clinical outcomes between closed and open designs of intensive care units (ICUs) is still an open question.

Objective: We conducted a systematic review and meta-analysis to compare total mortality, hospital and ICU length of stay (LOS) and mortality as primary outcomes, and severity of illness based on physiological variables, organ failure assessment, age, duration of mechanical ventilation and ventilator-associated pneumonia frequency as secondary outcomes in closed and open ICUs.

Evidence Review: Medline, PubMed, Scopus, Web of Science, Cochrane database, Iran-doc and Elm-net according to the MeSH terms were searched from 1988 to October 2019. Read More

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September 2021

Cachexia is Prevalent in Patients with Hepatocellular Carcinoma and Associated with Worse Prognosis.

Clin Gastroenterol Hepatol 2021 Sep 20. Epub 2021 Sep 20.

Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern, Dallas TX; Harold C. Simmons Comprehensive Cancer Center, UT Southwestern, Dallas TX.

Background: Cancer cachexia is a wasting syndrome associated with functional impairment and reduced survival that impacts up to 50% of patients with gastrointestinal cancers. However, data are limited on the prevalence and clinical significance of cachexia in patients with hepatocellular carcinoma (HCC).

Methods: We performed a retrospective cohort study of patients diagnosed with HCC at two U. Read More

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September 2021

Survival outcomes in emergency medical services witnessed traumatic out-of-hospital cardiac arrest after the introduction of a trauma-based resuscitation protocol.

Resuscitation 2021 Sep 20. Epub 2021 Sep 20.

Department of Paramedicine, Monash University, Frankston, Victoria, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; Centre for Research and Evaluation, Ambulance Victoria, Blackburn North, Victoria, Australia.

Aim: In this study, we examine the impact of a trauma-based resuscitation protocol on survival outcomes following emergency medical services (EMS) witnessed traumatic out-of-hospital cardiac arrest (OHCA).

Methods: We included EMS-witnessed OHCAs arising from trauma and occurring between 2008 and 2019. In December 2016, a new resuscitation protocol for traumatic OHCA was introduced prioritising the treatment of potentially reversible causes before conventional cardiopulmonary resuscitation. Read More

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September 2021

Comparison of Contemporary and Historical Outcomes of Elective and Ruptured Open Abdominal Aortic Aneurysm Repair.

J Vasc Surg 2021 Sep 21. Epub 2021 Sep 21.

The George Washington University Department of Surgery, Washington, District of Columbia.

Introduction: Recently, open AAA repair (OSR) has become less common and is often reserved for more complex aortic anatomy. Despite improvement in patient management, reduced surgical volume raises concern for potentially worsened outcomes in the contemporary era (2014-2019) compared to an earlier era where open repair was more widely practiced (2005-2010). This study compares the 30-day outcomes of open AAA repair between these two eras. Read More

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September 2021

MiR-BART2-3p targets Unc-51-like kinase 1 and inhibits cell autophagy and migration in Epstein-Barr virus-associated gastric cancer.

Virus Res 2021 Sep 20:198567. Epub 2021 Sep 20.

Department of Pathogeny Biology, Basic Medicine College, Qingdao University, Qingdao, 266071, China. Electronic address:

ULK1 (Unc-51-like kinase 1) is an evolutionarily conserved serine/threonine kinase that plays a central role in the regulation of autophagy. ULK1 is associated with prognosis for metastasis and survival in several tumors. However, its relationship with Epstein-Barr virus (EBV) has not been studied. Read More

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September 2021

Endoscopic vacuum therapy for the management of upper GI leaks and perforations: a multicenter retrospective study of factors associated with treatment failure (with video).

Gastrointest Endosc 2021 Sep 21. Epub 2021 Sep 21.

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. Electronic address:

Background And Aims: The optimal management of upper gastrointestinal (UGI) leaks and perforations remains controversial. Endoscopic vacuum therapy (EVT) is a new alternative endoscopic treatment that has recently shown a high rate of successful closure of UGI leaks and perforations. However, only few reports have been made on the factors that affect clinical success rates. Read More

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September 2021

30-Year Trends in Graft Survival After Heart Transplant: Modeled Analyses of a Transplant Registry.

Ann Thorac Surg 2021 Sep 21. Epub 2021 Sep 21.

Rutgers Robert Wood Johnson Medical School, Department of Medicine, 125 Paterson St, New Brunswick, NJ; Robert Wood Johnson University Hospital, 1 Robert Wood Johnson Place, New Brunswick, NJ; Institute for Health, Health Care Policy and Aging Research, 112 Paterson St, New Brunswick, NJ. Electronic address:

Background: Heart failure is an epidemic in the United States, and transplantation remains the most definitive therapy. We describe multi-decade trends in post-transplant graft survival, adjusted for concurrent changes in the population, over the 30 years antecedent to the most recent heart allocation policy change.

Methods: Scientific Registry of Transplant Recipients data were used to identify all primary adult heart recipients 1989 through 2017. Read More

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September 2021

A case report and statewide surveillance of "weak meat" condition of Alaska weathervane scallops, Patinopecten caurinus, linked to a recently identified pathogenic parasite, Merocystis kathae (Apicomplexa: Aggregatidae).

J Invertebr Pathol 2021 Sep 20:107668. Epub 2021 Sep 20.

Alaska Department of Fish and Game, Commercial Fisheries Division, Twin Lakes Fish, Pathology Laboratory, 3333 Glacier Highway, Juneau, Alaska 99811 USA. Electronic address:

Weathervane scallop, Patinopecten caurinus, the largest scallop species in the world, is distributed from northern California, U.S.A. Read More

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September 2021

Non-alcoholic fatty liver disease and risk of fatal and non-fatal cardiovascular events: an updated systematic review and meta-analysis.

Lancet Gastroenterol Hepatol 2021 Sep 20. Epub 2021 Sep 20.

Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy. Electronic address:

Background: Studies have reported a significant association between non-alcoholic fatty liver disease (NAFLD) and increased incidence of cardiovascular disease (CVD). However, the magnitude of the risk and whether this risk changes with the severity of NAFLD remains uncertain. We performed a meta-analysis of observational studies to quantify the magnitude of the association between NAFLD and risk of incident CVD events. Read More

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September 2021

CircRNA circ_0001821 predicts an unfavorable prognosis and promotes the proliferation of multiple myeloma.

Hematology 2021 Dec;26(1):716-723

Department of Hematology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, People's Republic of China.

Background: A previous study reported circ_0001821 serves as a new diagnostic biomarker in lung and gastric cancer. However, whether circ_0001821 associates with the development of multiple myeloma is still unclear.

Objective: To investigate the clinical significance and biological function of circ_0001821 in human multiple myeloma. Read More

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December 2021

P300/CBP-associated factor (PCAF)-mediated acetylation of Fascin at lysine 471 inhibits its actin-bundling activity and tumor metastasis in esophageal cancer.

Cancer Commun (Lond) 2021 Sep 23. Epub 2021 Sep 23.

The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, Guangdong, 515041, P. R. China.

Background: Fascin is crucial for cancer cell filopodium formation and tumor metastasis, and is functionally regulated by post-translational modifications. However, whether and how Fascin is regulated by acetylation remains unclear. This study explored the regulation of Fascin acetylation and its corresponding roles in filopodium formation and tumor metastasis. Read More

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September 2021

Chemotherapy, Target Therapy and Immunotherapy: Which Drugs Can Be Safely Used in The Solid Organ Transplant Recipients?

Transpl Int 2021 Sep 23. Epub 2021 Sep 23.

Renal Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA.

In solid organ transplant recipients, cancer is associated with worse prognosis than in the general population. Among the causes of increased cancer-associated mortality, are the limitations in selecting the optimal anticancer regimen in solid organ transplant recipients, because of the associated risks of graft toxicity and rejection, drug-to-drug interactions, reduced kidney or liver function, and patient frailty and comorbid conditions. The advent of immunotherapy has generated further challenges, mainly because checkpoint inhibitors increase the risk of rejection, which may have life-threatening consequences in recipients of life-saving organs. Read More

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September 2021

Diastolic function grading by American Society of Echocardiography guidelines and prediction of heart failure readmission and all-cause mortality in a community-based cohort.

Echocardiography 2021 Sep 23. Epub 2021 Sep 23.

Department of Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.

Background: Diastolic function (DF) guidelines have been simplified but lack extensive outcome data. Using a rural university heart failure (HF) database, we assessed whether DF grading could predict HF, HF readmission, and all-cause mortality (ACM).

Methods: In this single-center retrospective study that included 613 patients in sinus rhythm hospitalized for HF (HF with preserved-254 patients, with mid-range-216 patients, and reduced ejection fraction-143 patients), we recorded demographics, Doppler-echo, Framingham HF score, laboratories, HF readmission, and ACM with follow-up to 2167 days. Read More

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September 2021

Elucidation of ER stress and UPR pathway in sialic acid-deficient cells: Pathological relevance to GNEM.

J Cell Biochem 2021 Sep 23. Epub 2021 Sep 23.

School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.

Accumulation of misfolded proteins in endoplasmic reticulum (ER) generates a stress condition in the cell. The cell combats ER stress by activating unfolded protein response (UPR) and ERAD (ER stress-associated degradation) pathway. Failure to restore favorable folding environment results in cell dysfunction and apoptosis. Read More

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September 2021

Letter to the Editor: Postdiagnosis aspirin use associated with decreased biliary tract cancer?

Hepatology 2021 Sep 23. Epub 2021 Sep 23.

Department of Allergy, Immunology, and Rheumatology, Chung Shan Medical University Hospital, Taichung City, Taiwan.

We read with great interest the article by Liao et al. revealing postdiagnosis aspirin was associated with improved biliary tract cancer (BTC)-specific mortality of various subtypes. We agree the author collected data from the national, multicenter Cancer Registration Database and conducted a great cohort study. Read More

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September 2021