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Non-pharmacologic direct cost of a simplified strategy with glecaprevir/pibrentasvir for 8 weeks in naïve non-cirrhotic patients with hepatitis C implemented in clinical practice. The Just SIMPLE Study.

Gastroenterol Hepatol 2021 Jun 12. Epub 2021 Jun 12.

Digestive Diseases, Hospital La Paz, Madrid.

Background And Objective: The emergence of highly tolerable, effective, and shorter duration direct-acting antivirals (DAAs) regimens offers the opportunity to simplify hepatitis C virus management but medical costs are unknown. Thus, we aimed to determine the direct medical costs associated with a combo-simplified strategy (one-step diagnosis and low monitoring) to manage HCV infection within an 8-week glecaprevir/pibrentasvir (GLE/PIB) regimen in clinical practice in Spain.

Patients And Methods: Healthcare resources and clinical data were collected retrospectively from medical charts of 101 eligible patients at 11 hospitals. Read More

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The axial spondyloarthritis clinical phenotype in idiopathic hypoparathyroidism: critical review of concept that muscular hypercontractility can induce enthesopathy lesions.

Clin Exp Rheumatol 2021 Jun 8. Epub 2021 Jun 8.

Family Medicine Resident, Niagara Falls Memorial Medical Center, Niagara Falls, NY, USA.

Idiopathic hypoparathyroidism (iH-PoPT) is a rare condition infrequently associated with axial spondyloarthritis (SpA) which may mimic ankylosing spondylitis (AS). Axial SpA is a unifying clinical term for chronic inflammatory spinal disorders, although biomechanical factors may play a role. The primary objective of this review is to critically describe the iHPoPT/SpA phenotype defined by established criteria and its differentiation from AS. Read More

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Protective role of physical activity patterns prior to COVID-19 confinement with the severity/duration of respiratory pathologies consistent with COVID-19 symptoms in Spanish populations.

Res Sports Med 2021 Jun 15:1-12. Epub 2021 Jun 15.

Department of Didactics of Corporal Expression, University of Jaen, Spain.

The main purpose of the present study was to determine the association of physical activity (PA) patterns prior to COVID-19 confinement with severe respiratory distress consistent with COVID-19 symptoms. Participants were recruited by sending a survey through various social network channels via the snowball method. A voluntary sample of 420 individuals consisting of 199 men and 221 women from the Spanish national territory participated in this study. Read More

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Personality and Cognitive-Emotional Variables in Spanish Children and Adolescents With and Without Cleft Lip and/or Palate.

Cleft Palate Craniofac J 2021 Jul 14;58(7):872-880. Epub 2020 Oct 14.

Department of Medicine and Surgery, Public Health, Psychology and Immunology and Medical Microbiology, Nursing and Dentistry, 16776Rey Juan Carlos University, Alcorcón, Madrid, Spain.

Objectives: To analyze personality (Big Five Model) and cognitive-emotional variables in children and adolescents with a cleft lip/palate (s) in comparison to an equivalent peer sample without an orofacial cleft.

Design: Cross-sectional study with data collected using self-reported questionnaires over 2 years.

Setting: Data were collected during visits to health center dental clinics. Read More

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Mental health impact of the first wave of COVID-19 pandemic on Spanish healthcare workers: A large cross-sectional survey.

Rev Psiquiatr Salud Ment (Engl Ed) 2021 Apr-Jun;14(2):90-105

Center for Public Health Psychiatry, Universitair Psychiatrisch Centrum, KU Leuven, Leuven, Belgium.

Introduction: Healthcare workers are vulnerable to adverse mental health impacts of the COVID-19 pandemic. We assessed prevalence of mental disorders and associated factors during the first wave of the pandemic among healthcare professionals in Spain.

Methods: All workers in 18 healthcare institutions (6 AACC) in Spain were invited to web-based surveys assessing individual characteristics, COVID-19 infection status and exposure, and mental health status (May 5 - September 7, 2020). Read More

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October 2020

Mental health interventions for healthcare workers during the first wave of COVID-19 pandemic in Spain.

Rev Psiquiatr Salud Ment (Engl Ed) 2021 Apr-Jun;14(2):83-89

Valdecilla Biomedical Research Institute (IDIVAL), Santander, Spain; Mental Health Centre, University Hospital "Marqués de Valdecilla", Santander, Spain; Faculty of Health Sciences, Universidad Europea del Atlántico, Santander, Spain.

Objective: In order to reduce distress associated with working with COVID-19 patients, several psychological intervention programmes for healthcare workers have been developed in Spain. We aimed to describe the main characteristics and components of these programmes for healthcare workers treating COVID-19 patients in Spanish hospitals.

Material And Methods: An online survey was designed to evaluate the main characteristics of psychological intervention programmes for healthcare workers during the first wave of COVID-19 pandemic. Read More

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October 2020

Subclinical depression and anxiety impact verbal memory functioning differently in men and women -an fMRI study.

J Psychiatr Res 2021 May 27;140:308-315. Epub 2021 May 27.

Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain; Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.

Background: Depressive symptoms are known to affect memory efficiency in various populations. More specifically, several studies conducted in patients suffering from schizophrenia have indicated that memory efficiency is affected by depressed mood in female patients and by anxiety in male patients. We investigated, using neuroimaging techniques, whether similar gender-specific associations with subclinical depression and anxiety could be observed in a non-clinical sample. Read More

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Aquagenic Keratoma: Treatment Update.

Actas Dermosifiliogr 2021 Jun 11. Epub 2021 Jun 11.

Facultat de Medicina i Ciències de la Salut. UIC-Barcelona, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Barcelona, Spain. Electronic address:

{0>La Queratodermia Acuagénica (QA) es una afectación dermatológica adquirida poco frecuente que se caracteriza por la aparición de edema y pápulas blanquecinas-translúcidas desencadenado por la inmersión o contacto con agua.<}100{>Aquagenic keratoderma is an uncommon acquired dermatosis characterized by edema and whitish-translucent papules triggered by immersion or contact with water.<0} {0>Se han descrito casos asociados a fármacos, hiperhidrosis y a fibrosis quística. Read More

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Immune checkpoint B7-H3 protein expression is associated with poor outcome and androgen receptor status in prostate cancer.

Prostate 2021 Jun 14. Epub 2021 Jun 14.

Biomarkers in Cancer Unit, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.

Background: Novel immune checkpoint-based immunotherapies may benefit specific groups of prostate cancer patients who are resistant to other treatments.

Methods: We analyzed by immunohistochemistry the expression of B7-H3, PD-L1/B7-H1, and androgen receptor (AR) in tissue samples from 120 prostate adenocarcinoma patients treated with radical prostatectomy in Spain, and from 206 prostate adenocarcinoma patients treated with radical prostatectomy in Norway.

Results: B7-H3 expression correlated positively with AR expression and was associated with biochemical recurrence in the Spanish cohort, but PD-L1 expression correlated with neither of them. Read More

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First international workshop of the ATM and cancer risk group (4-5 December 2019).

Fam Cancer 2021 Jun 14. Epub 2021 Jun 14.

Huntsman Cancer Institute, Salt Lake City, USA.

The first International Workshop of the ATM and Cancer Risk group focusing on the role of Ataxia-Telangiectasia Mutated (ATM) gene in cancer was held on December 4 and 5, 2019 at Institut Curie in Paris, France. It was motivated by the fact that germline ATM pathogenic variants have been found to be associated with different cancer types. However, due to the lack of precise age-, sex-, and site-specific risk estimates, no consensus on management guidelines for variant carriers exists, and the clinical utility of ATM variant testing is uncertain. Read More

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Risk factors for a second nonsimultaneous hip fracture in a prospective cohort study.

Arch Orthop Trauma Surg 2021 Jun 14. Epub 2021 Jun 14.

Musculoskeletal Research Unit, IMIM-Parc Salut Mar, CIBERFES, Universitat Autonoma de Barcelona, Doctor Aiguader 88, 20, 08003, Barcelona, Spain.

Introduction: The risk factors for a second nonsimultaneous hip fracture are unclear, and in general, it is empirically assumed that they are similar to those associated with the first hip fracture. We aimed to determine the incidence of a second hip fracture and define the characteristics of the patients sustaining the event in a prospective cohort study in a Spanish population.

Materials And Methods: We conducted a multicentric, prospective cohort study in a representative sample of 45 hospitals from 15 autonomic regions in Spain. Read More

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Metabolite Profiling of Pig Seminal Plasma Identifies Potential Biomarkers for Sperm Resilience to Liquid Preservation.

Front Cell Dev Biol 2021 28;9:669974. Epub 2021 May 28.

Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, Girona, Spain.

Metabolomic approaches allow the study of downstream gene expression events since metabolites are considered as the products of cell signaling pathways. For this reason, many studies in humans have already been conducted to determine the influence of the metabolites present in seminal plasma (SP) on sperm physiology, and to identify putative biomarkers. However, in livestock species, these relationships are yet to be uncovered. Read More

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Autonomous Sensory Meridian Response self-reporters showed higher scores for cognitive reappraisal as an emotion regulation strategy.

PeerJ 2021 26;9:e11474. Epub 2021 May 26.

Escuela de Psicología, Pontificia Universidad Católica de Chile, Santiago, RM, Chile.

Background: Autonomous Sensory Meridian Response (ASMR) describes the experience of a pleasant tingling sensation along the back of the head, accompanied with a feeling of well-being and relaxation, in response to specific audio-visual stimuli, such as whispers, soft sounds, and personal attention. Previous works have assessed individual variations in personality traits associated with ASMR, but no research to date has explored differences in emotion regulation associated with ASMR. This omission occurred even when ASMR, a sensory-emotional experience, has been proposed to be located in a sound sensitivity spectrum as the opposite end of misophonia, a phenomenon associated with difficulties regulating emotions. Read More

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Mental health interventions for healthcare workers during the first wave of COVID-19 pandemic in Spain.

Rev Psiquiatr Salud Ment 2021 Apr-Jun;14(2):83-89. Epub 2021 Feb 4.

Valdecilla Biomedical Research Institute (IDIVAL), Santander, Spain.

Objective: In order to reduce distress associated with working with COVID-19 patients, several psychological intervention programmes for healthcare workers have been developed in Spain. We aimed to describe the main characteristics and components of these programmes for healthcare workers treating COVID-19 patients in Spanish hospitals.

Material And Methods: An online survey was designed to evaluate the main characteristics of psychological intervention programmes for healthcare workers during the first wave of COVID-19 pandemic. Read More

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February 2021

Emotional Reactions and Adaptation to COVID-19 Lockdown (or Confinement) by Spanish Competitive Athletes: Some Lesson for the Future.

Front Psychol 2021 26;12:621606. Epub 2021 May 26.

Department of Social and Developmental Psychology, Faculty of Medicine and Psychology, University of Rome, "La Sapienza", Rome, Italy.

The Coronavirus Covid 19 (SARS-CoV-2) pandemic has produced terrible effects in the world economy and is shaking social and political stability around the world. The world of sport has obviously been severely affected by the pandemic, as authorities progressively canceled all level of competitions, including the 2020 Olympic Games in Tokyo. In Spain, the initial government-lockdown closed the Sports High-performance Centers, and many other sports facilities. Read More

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The Novel KIF1A Missense Variant (R169T) Strongly Reduces Microtubule Stimulated ATPase Activity and Is Associated With NESCAV Syndrome.

Front Neurosci 2021 26;15:618098. Epub 2021 May 26.

Genetics Laboratory, UDIAT-Centre Diagnòstic, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Spain.

KIF1A is a microtubule-dependent motor protein responsible for fast anterograde transport of synaptic vesicle precursors in neurons. Pathogenic variants in have been associated with a wide spectrum of neurological disorders. Here, we report a patient presenting a severe neurodevelopmental disorder carrying a novel missense variant p. Read More

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Cardiovascular Risk Factor Knowledge among Monolingual Hispanics.

J Health Care Poor Underserved 2021 ;32(2):688-699

Hispanics in the United States have worse cardiovascular disease (CVD) risk factor profiles than non-Hispanic Whites. Cardiovascular health literacy is important for health promotion but is not well characterized among monolingual Spanish-speaking Hispanics outside of health care settings. We recruited Hispanic participants (N=235) from a community-based health fair in Denver, Colorado. Read More

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January 2021

Effects of sodium bicarbonate infusion on mortality in medical-surgical ICU patients with metabolic acidosis-A single-center propensity score matched analysis.

Med Intensiva 2021 Jun 10. Epub 2021 Jun 10.

Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Objective: Metabolic acidosis is associated with high mortality. Despite theoretical benefits of sodium-bicarbonate (SB), current evidence remains controversial. We investigated SB-related effects on outcomes in ICU patients with metabolic acidosis. Read More

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Human prion disease surveillance in Spain, 1993-2018: an overview.

Prion 2021 Dec;15(1):94-106

Department of Neurodegeneration, Ageing and Mental Health, National Epidemiology Centre, Carlos III Health Institute, Madrid, Spain.

In Spain, human transmissible spongiform encephalopathies (TSEs) have been undergoing continuous surveillance for over 25 years. In 1995, the system was launched as an EU Concerted Action, with EU surveillance network procedures being incorporated from 2002 onwards. The aim of this report was to describe performance and outcomes of this surveillance system across the period 1993-2018. Read More

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December 2021

An Overview of Cilastatin + Imipenem + Relebactam as a Therapeutic Option for Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia: Evidence to Date.

Expert Opin Pharmacother 2021 Jun 12. Epub 2021 Jun 12.

Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

: Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are prevalent nosocomial infections with a worrisomely increasing prevalence of multidrug-resistant causative organisms, including those with resistance to carbapenems. The addition of relebactam, a β-lactamase inhibitor, to imipenem treatment restores the antimicrobial activity against the most of multidrug-resistant Gram-negative bacteria, including some carrying β-lactamase enzyme-type carbapenemases.: The aim of this article is to summarize the current evidence regarding imipenem/relebactam for the treatment of HAP/VAP. Read More

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The influence of natural vs anthropogenic factors on trace metal(loid) levels in the Mussel Watch programme: Two decades of monitoring in the Spanish Mediterranean sea.

Mar Environ Res 2021 Jun 9;169:105382. Epub 2021 Jun 9.

Instituto Español de Oceanografía (IEO), Centro Oceanográfico de Murcia, C/Varadero, 1, San Pedro del Pinatar, Murcia 30740, Spain.

The spatial distribution and temporal trends of trace metals (i.e. Cd, Cu, Hg, Pb and Zn) and a metalloid (i. Read More

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Early mobilization after total hip or knee arthroplasty: a substudy of the POWER.2 study.

Braz J Anesthesiol 2021 Jun 10. Epub 2021 Jun 10.

Infanta Leonor University Hospital, Department of Anesthesia and Perioperative Medicine, Madrid, Spain; Spanish Perioperative Audit and Research Network (REDGERM), Zaragoza, Spain; Grupo Español de Rehabilitación Multimodal (GERM), Zaragoza, Spain; Río Hortega University Hospital, Department of Anesthesia and Critical Care, Valladolid, Spain.

Background: Early mobilization after surgery is a cornerstone of the Enhanced Recovery After Surgery (ERAS) programs in total hip arthroplasty (THA) or total knee arthroplasty (TKA). Our goal was to determine the time to mobilization after this surgery and the factors associated with early mobilization.

Methods: This was a predefined substudy of the POWER. Read More

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Predicting Potential Prevention Effects on Hospital Burden of Nosocomial Infections: A Multistate Modeling Approach.

Value Health 2021 Jun 13;24(6):830-838. Epub 2021 Apr 13.

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.

Objectives: Hospital-acquired infections (HAIs) place a substantial burden on health systems. Tools are required to quantify the change in this burden as a result of a preventive intervention. We aim to estimate how much a reduction in the rate of hospital-acquired infections translates into a change in hospital mortality and length of stay. Read More

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Fecal microbiota transplant, its usefulness beyond Clostridioides difficile in gastrointestinal diseases.

Gastroenterol Hepatol 2021 Jun 9. Epub 2021 Jun 9.

School of Veterinary Medicine, Faculty of Life Sciences, Universidad Andrés Bello, Chile.

Fecal microbiota transplant (FMT) is currently recommended for recurrent Clostridioides difficile infection. However, it is interesting to acknowledge the potential therapeutic role in other diseases associated with dysbiosis. This review will focus on the current and potential indications of FMT in gastrointestinal diseases, evaluating the available evidence and also exposing the necessary requirements to carry it out. Read More

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Coping strategies in health care providers as second victims: A systematic review.

Int Nurs Rev 2021 Jun 12. Epub 2021 Jun 12.

Fundamental Care and Medical-Surgical Nursing Department, School of Nursing, L'Hospitalet de Llobregat, University of Barcelona, Barcelona, Spain.

Aim: To analyze personal and organizational strategies described in the literature for dealing with the second victim phenomenon among healthcare providers.

Background: The second victim phenomenon involves many associated signs and symptoms, which can be physical, psychological, emotional, or behavioral. Personal and organizational strategies have been developed to deal with this phenomenon. Read More

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Dendritic spines are lost in clusters in Alzheimer's disease.

Sci Rep 2021 Jun 11;11(1):12350. Epub 2021 Jun 11.

Laboratorio Cajal de Circuitos Corticales (CTB), Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Campus Montegancedo S/N, Pozuelo de Alarcon, 28223, Madrid, Spain.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a deterioration of neuronal connectivity. The pathological accumulation of tau in neurons is one of the hallmarks of AD and has been connected to the loss of dendritic spines of pyramidal cells, which are the major targets of cortical excitatory synapses and key elements in memory storage. However, the detailed mechanisms underlying the loss of dendritic spines in individuals with AD are still unclear. Read More

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Multidrug-resistant, gram-negative infections in high-risk haematologic patients: an update on epidemiology, diagnosis and treatment.

Curr Opin Infect Dis 2021 Jun 9. Epub 2021 Jun 9.

Department of Infectious Diseases, Hospital Clinic of Barcelona-IDIBAPS, University of Barcelona, Barcelona, Spain Division of Infectious Diseases, Rambam Healthcare Campus, Haifa, Israel Department of Infectious Diseases, Hospital Universitari de Bellvitge, IDIBELL (Institut d'Investigació Biomèdica de Bellvitge), University of Barcelona, L'Hospitalet de Llobregat Institut Català d'Oncologia (ICO), Hospital Duran i Reynals, IDIBELL, L'Hospitalet de Llobregat, Barcelona REIPI (Spanish Network for Research in Infectious Diseases), Instituto de Salud Carlos III, Madrid, Spain.

Purpose Of Review: Multidrug-resistant Gram-negative bacilli (MDR-GNB) infections are a significant cause of morbidity and mortality in high-risk hematologic patients. Early diagnosis and management of antibiotic treatment in these patients is a challenge for physicians. This review focuses on the latest literature reports that concern the epidemiology, diagnosis and treatment of MDR-GNB infections in this population. Read More

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Semicircular Lipoatrophy: A Case Series With Follow-up of 76 Patients in Madrid and a Proposed Classification.

Actas Dermosifiliogr 2021 Jun 8. Epub 2021 Jun 8.

Servicio de ITS/Dermatología. Sección de Especialidades Médicas, Organismo Autónomo Madrid Salud, Ayuntamiento de Madrid, Madrid, España. Electronic address:

Background And Objective: The clinical presentations of semicircular lipoatrophy (SL) vary, and diagnostic criteria are unclear. Several etiopathogenic factors, including occupational environmental ones, have been suggested. We aimed to describe a cluster of cases of suspected SL that started to appear in May 2008 among employees of the city council of Madrid, Spain. Read More

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Blood Biomarker Landscape in Patients with High-Risk Nonmetastatic Castration-Resistant Prostate Cancer Treated with Apalutamide and Androgen-Deprivation Therapy as They Progress to Metastatic Disease.

Clin Cancer Res 2021 Jun 10. Epub 2021 Jun 10.

Medical Oncology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco.

Purpose: In the placebo-controlled SPARTAN study, apalutamide added to androgen-deprivation therapy (ADT) improved metastasis-free survival, second progression-free survival, and overall survival (OS) in patients with nonmetastatic castration-resistant prostate cancer (nmCRPC). Mechanisms of resistance to apalutamide in nmCRPC require evaluation.

Experimental Design: In a subset of patients from SPARTAN, aberrations were assessed at baseline and end of study treatment (EOST) using targeted next-generation sequencing or quantitative reverse transcription PCR. Read More

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Public Benefit Use and Social Needs in Hospitalized Children With Undocumented Parents.

Pediatrics 2021 Jun 10. Epub 2021 Jun 10.

Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Background And Objectives: Studies supporta recent decline in public benefit enrollment among immigrant families. We aimed to describe health and resource use, barriers to use, and immigration-related fear in families with undocumented parents compared with families without undocumented parents. We also aimed to assess associations with discontinuation of public benefits and fear of deportation. Read More

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