1,032 results match your criteria associated sjs

HLA-B*15:11 status and carbamazepine-induced severe cutaneous adverse drug reactions in HLA-B*15:02 negative Chinese.

Int J Dermatol 2021 Sep 22. Epub 2021 Sep 22.

Division of Transplantation and Immunogenetics, Department of Pathology, Queen Mary Hospital, Hong Kong, Hong Kong.

Background: HLA-B*15:11 is associated with carbamazepine (CBZ)-induced severe cutaneous adverse drug reactions (SCARs) in Japanese and some Asian populations, but such data remains relatively limited in Chinese. Routine HLA-B*15:02 screening is mandatory before CBZ commencement, however, SCARs related to CBZ were still observed in non-HLA*B-15:02 carriers.

Objective: We aimed to find out the prevalence of HLA-B*15:11 in Chinese patients and its associations with CBZ-induced SCARs. Read More

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September 2021

Evaluation of microglia in a rodent model of Parkinson's disease primed with L-DOPA after sub-anesthetic ketamine treatment.

Neurosci Lett 2021 Sep 15:136251. Epub 2021 Sep 15.

University of Arizona, College of Nursing, 1305 N. Martin Ave, P.O. Box 210203, Tucson, AZ 85721, USA. Electronic address:

Parkinson's disease (PD) is a neurodegenerative disease caused by the death of dopaminergic neurons in the substantia nigra pars compacta (SNpc), characterized by motor dysfunction. While PD symptoms are well treated with L-DOPA, continuous use can cause L-DOPA-induced dyskinesia (LID). We have previously demonstrated that sub-anesthetic ketamine attenuated LID development in rodents, measured by abnormal involuntary movements (AIMs), and reduced the density of maladaptive striatal dendritic mushroom spines. Read More

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September 2021

Antirheumatic Drug Intake Influence on Occurrence of COVID-19 Infection in Ambulatory Patients with Immune-Mediated Inflammatory Diseases: A Cohort Study.

Rheumatol Ther 2021 Sep 16. Epub 2021 Sep 16.

Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.

Introduction: We aimed to study the prevalence of a history of COVID-19 infection among patients suffering from systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren's syndrome (SjS) or psoriatic arthritis (PsA), and the potential influence of long-term hydroxychloroquine (HCQ) intake.

Methods: We performed an observational monocentric cohort study at the Adolphe de Rothschild Foundation Hospital ophthalmology division (Paris, France). Electronic medical records (EMR) data were searched for keywords associated with SLE, RA, SjS, or PsA. Read More

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September 2021

Toxic epidermal necrosis associated with phenobarbitone: a case report and brief review of the literatures.

Allergy Asthma Clin Immunol 2021 Sep 8;17(1):88. Epub 2021 Sep 8.

Department of Dermatovenereology, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Toxic epidermal necrolysis (TEN)/Stevens-Johnson syndrome (SJS) is the spectrum of severe, acute, mucocutaneous, T-cell mediated delayed type IV hypersensitivity reaction and universally related to different drugs. Phenobarbitone is known to cause hypersensitivity reactions with benign pattern; ranging from a mild to moderate rashes but not life-threatening reactions such as TEN/SJS.

Case Report: We report a 14-year-old asthmatic male patient admitted to a local hospital for an acute exacerbation of asthma, after he presented with shortness of breath, cough, and fever. Read More

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September 2021

Managing respiratory complications in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

Int J Dermatol 2021 Sep 8. Epub 2021 Sep 8.

Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore, Singapore.

In the recently published guidelines by the Society of Dermatology Hospitalists on the management of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), a brief section was included on airway management. These recommendations provide an easy reference on how to manage respiratory complications of the disease. Understanding the evidence that underlies these recommendations would offer physicians greater clarity on the considerations behind every decision and treatment offered. Read More

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September 2021

Association between the HLA-B*1502 gene and mild maculopapular exanthema induced by antiepileptic drugs in Northwest China.

BMC Neurol 2021 Sep 6;21(1):340. Epub 2021 Sep 6.

Department of Neurology, First Affiliated Hospital of Xinjiang Medical University, 830000, Urumqi, Xinjiang Province, China.

Background: The relationship between the HLA-B*1502 gene and maculopapular exanthema (MPE) induced by antiepileptic drugs (AEDs) has not yet been elucidated. In this study, we investigated the association between AED-induced MPE (AED-MPE) and the HLA-B*1502 gene in patients in Northwest China.

Methods: We enrolled 165 subjects including nine patients with AED-MPE and 156 AED-tolerant patients as controls. Read More

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September 2021

Decreasing complications of pectoralis major muscle flap reconstruction with two modalities of negative pressure wound therapy.

Scand J Surg 2021 Sep 5:14574969211043330. Epub 2021 Sep 5.

Department of Plastic Surgery, Kainuu Central Hospital, Kajaani, Finland.

Background And Objective: Deep sternal wound infection is a feared complication of open-heart surgery. Negative pressure wound therapy has gained an important role in the treatment of deep sternal wound infection. Incisional negative pressure wound therapy has been introduced as a method to prevent wound complications after sternotomy, and lately, after flap reconstructions in the treatment of deep sternal wound infection. Read More

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September 2021

Pembrolizumab associated Stevens-Johnson syndrome with porokeratosis in a patient in the setting of primary hepatocellular carcinoma.

Australas J Dermatol 2021 Aug 31. Epub 2021 Aug 31.

Department of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Pembrolizumab is a humanised therapeutic antibody against the PD-1 receptor. It has been used in various advanced cancer immunotherapies. Here, we report an extremely rare case of a 32-year-old man who developed Stevens-Johnson syndrome (SJS) with porokeratosis simultaneously during pembrolizumab treatment for primary hepatocellular carcinoma (T3N1M1). Read More

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Non-IgE-Mediated Drug Hypersensitivity Reactions.

Curr Allergy Asthma Rep 2021 08 31;21(7):41. Epub 2021 Aug 31.

Division of Allergy and Immunology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.

Purpose Of Review: Non-IgE-mediated drug reactions have traditionally been poorly defined and studied, though they are the most common form of hypersensitivity. Their presentations are highly variable and can range in severity from mild, cutaneous-only reactions to severe systemic disease.

Recent Findings: The most notable advance in non-IgE-mediated hypersensitivity reactions is in diagnostics. Read More

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Association of , and Phenytoin-Induced Cutaneous Adverse Drug Reactions in the South Indian Tamil Population.

J Pers Med 2021 Jul 28;11(8). Epub 2021 Jul 28.

Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, Hat Yai 90110, Thailand.

Phenytoin (PHT) is one of the most commonly reported aromatic anti-epileptic drugs (AEDs) to cause cutaneous adverse reactions (CADRs), particularly severe cutaneous adverse reactions (SCARs). Although human leukocyte antigen is associated with PHT-induced Steven Johnson syndrome/toxic epidermal necrosis (SJS/TEN) in East Asians, the association is much weaker than it is reported for carbamazepine (CBZ). In this study, we investigated the association of pharmacogenetic variants of the HLA B gene and with PHT-CADRs in South Indian epileptic patients. Read More

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Assessment of Treatment Approaches and Outcomes in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Insights From a Pan-European Multicenter Study.

JAMA Dermatol 2021 Aug 25. Epub 2021 Aug 25.

ToxiTEN group, European Reference Network for Rare Skin Diseases, Paris, France.

Importance: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe drug reactions associated with a high rate of mortality and morbidity. There is no consensus on the treatment strategy.

Objective: To explore treatment approaches across Europe and outcomes associated with the SJS/TEN disease course, as well as risk factors and culprit drugs. Read More

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Severe and life-threatening COVID-19-related mucocutaneous eruptions: A systematic review.

Int J Clin Pract 2021 Aug 19:e14720. Epub 2021 Aug 19.

Department of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences (IUMS), Tehran, Iran.

Objectives: Earlier diagnosis and the best management of virus-related, drug-related or mixed severe potentially life-threatening mucocutaneous reactions of COVID-19 patients are of great concern. These patients, especially hospitalized cases, are usually in a complicated situation (due to multi-organ failures), which makes their management more challenging. In such consultant cases, achieving by the definite beneficial management strategies that therapeutically address all concurrent comorbidities are really hard to reach or even frequently impossible. Read More

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Stevens-Johnson syndrome/toxic epidermal necrolysis in patients treated with immune checkpoint inhibitors: A safety analysis of clinical trials and FDA pharmacovigilance database.

EClinicalMedicine 2021 Jul 10;37:100951. Epub 2021 Jun 10.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, PR China.

Background: The association between immune checkpoint inhibitors (ICIs) and Stevens-Johnsons syndrome (SJS) /toxic epidermal necrolysis (TEN) is unclear. We assessed the risk of SJS and TEN related to ICIs, via a systematic analysis of SJS/TEN cases reported in clinical trials and the FDA Adverse Event Reporting System (FAERS).

Methods: We explored ICIs related SJS/TEN events in randomized control trials available in ClinicalTrials. Read More

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Stevens-Johnson syndrome post second dose of Pfizer COVID-19 vaccine: a case report.

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Oct 19;132(4):e139-e142. Epub 2021 Jul 19.

Assistant Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tanta University, Tanta, Egypt; Associate Professor of Oral and Maxillofacial Surgery, College of Dentistry, Taibah University, Al Medinah, Kingdom of Saudi Arabia.

Coronavirus disease 2019 (COVID-19) began in December 2019 and has affected millions of people all over the world. Respiratory illness in the form of severe pneumonia, in addition to multiorgan failure and death, is the clinical spectrum of COVID-19. Although there are no specific therapeutic agents for COVID-19 infection, the COVID-19 vaccine reduces morbidity and mortality associated with COVID-19 infection and is generally well tolerated. Read More

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October 2021

Prognostic significance of matrix metalloproteinase 9 in COMET operated chronic ocular Stevens-Johnson syndrome.

Br J Ophthalmol 2021 Aug 6. Epub 2021 Aug 6.

Vision Eye Institute, Melbourne, Victoria, Australia.

Purpose: Molecular pathogenesis underlying persistent ocular surface inflammation in chronic Stevens-Johnson syndrome (SJS) still remains largely unexplored. The present study investigates the expression of matrix metalloproteinase 2 (MMP2), MMP3, MMP9, MMP11 and TIMP1 (tissue inhibittor of matrix metalloproteinase 1) in pannus tissues of chronic ocular SJS undergoing cultivated oral mucosal epithelial transplantation (COMET) and their prognostic relevance.

Methods: In this prospective study, 45 eyes with chronic SJS underwent COMET for visual and anatomical rehabilitation. Read More

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Genetic variants associated with severe cutaneous adverse drug reactions induced by carbamazepine.

Br J Clin Pharmacol 2021 Aug 4. Epub 2021 Aug 4.

Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Aims: Carbamazepine (CBZ) is one of the most common causative drugs of severe cutaneous adverse drug reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reactions with eosinophilia and systemic symptoms. Although genetic polymorphisms of the human leucocyte antigens (HLA) are well recognized key elements for the susceptibility to CBZ-induced SCARs, some evidence suggest that polymorphisms of microsomal epoxide hydrolase 1 (EPHX1) may also contribute to the risk of these SCARs. This study investigated the association between the HLA and EPHX1 polymorphisms on CBZ-induced SCARs in large sample sizes and well-defined SCARs patients. Read More

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Genetics of Severe Cutaneous Adverse Reactions.

Front Med (Lausanne) 2021 15;8:652091. Epub 2021 Jul 15.

Department of Dermatology, Xiamen Chang Gung Allergology Consortium, Xiamen Chang Gung Hospital, Xiamen, China.

Severe cutaneous adverse reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS) are T cells-mediated life-threatening immune reactions, most commonly induced by drug. The last decade has seen significant progress in SCARs research. Recent studies have unveiled the pathogenesis of SCARs involved in susceptible genes, including human leukocyte antigens (HLA) and drugs-T cell receptor (TCR) interaction that may trigger T cell activation with downstream immune signaling of cytokines/chemokines and specific cytotoxic proteins releases. Read More

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The potential role of HLA typing to risk stratify melanoma patients on immunotherapy with associated SJS: pitfalls and opportunities.

Int J Dermatol 2021 Jul 24. Epub 2021 Jul 24.

Department of Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.

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Different cerebral functional segregation in Sjogren's syndrome with or without systemic lupus erythematosus revealed by amplitude of low-frequency fluctuation.

Acta Radiol 2021 Jul 20:2841851211032441. Epub 2021 Jul 20.

Department of Radiology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, PR China.

Background: Sjögren's syndrome (SjS) associated with systemic lupus erythematosus (SjS-SLE) was considered a standalone but often-overlooked entity.

Purpose: To assess altered spontaneous brain activity in SjS-SLE and SjS using amplitude of low-frequency fluctuation (ALFF).

Material And Methods: Sixteen patients with SjS-SLE, 17 patients with SjS, and 17 matched controls underwent neuropsychological tests and subsequent resting-state functional magnetic resonance imaging (fMRI) examinations. Read More

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Severe cutaneous adverse reactions in Asians: Trends observed in culprit anti-seizure medicines using VigiBase®.

Seizure 2021 Oct 13;91:332-338. Epub 2021 Jul 13.

Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.

Purpose: Diverse ethnic genetic populations display variability in the risk regarding anti-seizure medicine (ASM)-induced severe cutaneous adverse reactions (SCARs). However, clinical and epidemiological data on ASM-induced SCARs in Asians is limited.

Methods: We conducted a retrospective, post-market study until April 30, 2020 using VigiBase® for demographic characteristics, causative ASMs, complications and mortality. Read More

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October 2021

Adverse cardiac mechanics and incident coronary heart disease in the Cardiovascular Health Study.

Heart 2021 Jul 13. Epub 2021 Jul 13.

Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

Objectives: Speckle-tracking echocardiography enables detection of abnormalities in cardiac mechanics with higher sensitivity than conventional measures of left ventricular (LV) dysfunction and may provide insight into the pathogenesis of coronary heart disease (CHD). We investigated the relationship of LV longitudinal strain, LV early diastolic strain rate (SR) and left atrial (LA) reservoir strain with long-term CHD incidence in community-dwelling older adults.

Methods: The association of all three strain measures with incidence of non-fatal and fatal CHD (primary outcome of revascularisation, non-fatal and fatal myocardial infarction) was examined in the population-based Cardiovascular Health Study using multivariable Cox proportional hazards models. Read More

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Corona virus disease 2019-associated Stevens-Johnson syndrome: a case report.

BMC Ophthalmol 2021 Jul 12;21(1):274. Epub 2021 Jul 12.

Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: To report Stevens-Johnson syndrome (SJS) in a patient with acute pneumonia secondary to SARS-CoV-2 infection.

Case Presentation: A 45-years-old woman with a diagnosis of acute pneumonia secondary to SARS-CoV-2 infection who had received azithromycin and naproxen. Three days after starting the medication, she appeared ill and developed ocular discomfort, photophobia, dysuria, and macular rashes on the trunk and the extremities. Read More

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Anti-Ro52 antibody is highly prevalent and a marker of better prognosis in patients with ovarian cancer.

Clin Chim Acta 2021 Oct 8;521:199-205. Epub 2021 Jul 8.

Department of Medical Oncology, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background And Aims: Anti-Ro52 antibody (Ab) reactivity is highly prevalent in autoimmune rheumatic diseases (ARDs), mainly Sjögren's syndrome (SjS) and systemic lupus erythematosus (SLE), but also in other inflammatory disorders. Thorough assessment of the prevalence, clinical significance and epitope specificity of Ro52-autoAbs in cancerous diseases is still lacking.

Material And Methods: Anti-Ro52 Ab reactivity was tested in a large cohort of 490 patients with various malignant diseases. Read More

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October 2021

Clinical Aspects of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis With Severe Ocular Complications in Brazil.

Front Med (Lausanne) 2021 18;8:649369. Epub 2021 Jun 18.

Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute and potentially fatal inflammatory vesiculobullous reactions that affect the skin and mucous membranes, and which are most often triggered by particular medications and infections. In Brazil, the drugs most frequently associated with TEN and SJS include cold medicine such as dipyrone and NSAIDs, followed by carbamazepine, phenobarbital, penicillin, and allopurinol. Genetic variations have been found to increase the risk of SJS/TEN in response to triggering factors such as medications. Read More

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Corticosteroid Pulse Therapy for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Patients with Acute Ocular Involvement.

Am J Ophthalmol 2021 Jun 29. Epub 2021 Jun 29.

From the Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan. Electronic address:

Purpose: To investigate the long-term effects of corticosteroid pulse therapy (CPT) for the treatment of acute-stage Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) patients with severe ocular involvement.

Design: Retrospective, comparative case series.

Methods: In this study, we retrospectively reviewed the medical records of 116 SJS/TEN patients who developed the disease between 2002 and 2018. Read More

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HLA-B*58:01 screening to prevent allopurinol-induced severe cutaneous adverse reactions in Chinese patients with chronic kidney disease.

Arch Dermatol Res 2021 Jul 2. Epub 2021 Jul 2.

Division of Dermatology, Department of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Human leukocyte antigen (HLA)-B*58:01 allele is a significant risk factor for allopurinol-induced severe cutaneous adverse reactions (SCARs) which is potentially fatal. In some studies, chronic kidney disease (CKD) was also implicated to compound the risk of SCARs. We aim to investigate if pre-treatment HLA-B*58:01 screening can prevent allopurinol-induced SCARs in Chinese patients with CKD and its cost-effectiveness. Read More

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Chemokines in Severe Cutaneous Adverse Reactions (SCARs).

Biomolecules 2021 06 6;11(6). Epub 2021 Jun 6.

Department of Dermatology, Nara Medical University School of Medicine, 840 Shijo, Kashihara, Nara 634-8522, Japan.

Although the incidence of severe cutaneous adverse reactions (SCARs) to medications is very low, SCARs can result in disability or even death if they are not diagnosed and treated properly. As the rapid recognition of SCARs is essential, it is necessary to develop diagnostic markers for them that can also be used to assess severity and predict outcomes in the early phase. In addition, it is important to identify novel therapeutic targets for SCARs. Read More

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Neutrophils initiate and exacerbate Stevens-Johnson syndrome and toxic epidermal necrolysis.

Sci Transl Med 2021 06;13(600)

Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening mucocutaneous adverse drug reactions characterized by massive epidermal detachment. Cytotoxic T cells and associated effector molecules are known to drive SJS/TEN pathophysiology, but the contribution of innate immune responses is not well understood. We describe a mechanism by which neutrophils triggered inflammation during early phases of SJS/TEN. Read More

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Spectrum of cutaneous adverse reactions to aromatic antiepileptic drugs and human leukocyte antigen genotypes in Thai patients and meta-analysis.

Pharmacogenomics J 2021 Jun 26. Epub 2021 Jun 26.

Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Aromatic antiepileptic drugs (AEDs)-induced cutaneous adverse drug reactions (cADRs) add up to the limited use of the AEDs in the treatment and prevention of seizures. Human leukocyte antigen-B (HLA-B) alleles have been linked to AEDs-induced cADRs. We investigated the association between cADRs (including Stevens-Johnson syndrome; SJS/toxic epidermal necrolysis; TEN, drug reaction with eosinophilia and systemic symptoms; DRESS, and Maculopapular eruption; MPE) caused by AEDs (phenytoin, carbamazepine, lamotrigine, phenobarbital and oxcarbazepine) and HLA-B alleles in Thai population. Read More

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Capecitabine induced Steven-Johnson syndrome: A rare case report.

J Oncol Pharm Pract 2021 Jun 24:10781552211027945. Epub 2021 Jun 24.

Department of Oncology, Lourdes Hospital, Kochi, India.

Introduction: Steven-Johnson syndrome (SJS) is a serious mucocutaneous reaction, characterized by fever, influenza-like symptoms and followed by dermatological manifestations. Capecitabine is an oral fluoropyrimidine carbamate analogue of 5-Fluorouracil (5-FU). It is widely accepted for many malignancies because of its better safety profile and tolerability. Read More

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