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Palliative Surgery Outcomes for Patients with Esophageal Cancer: An NCDB Analysis.

J Surg Res 2021 Jun 19;267:229-234. Epub 2021 Jun 19.

Division of Thoracic and Esophageal Surgery, Department of Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio; Division of Thoracic and Esophageal Surgery, Department of Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio. Electronic address:

Introduction: Many patients with esophageal cancer are not candidates for surgical resection with curative intent, given the advanced stage of disease at presentation. Palliative surgery is one treatment option, but relative survival of palliative surgery has not been described. This study aims to describe the outcomes of palliative surgery in patients with esophageal cancer. Read More

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Audit of empirical antibiotic therapy for sepsis and the impact of early multidisciplinary consultation on patient outcomes.

Int J Antimicrob Agents 2021 Jun 20:106379. Epub 2021 Jun 20.

Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

Objectives: To perform an audit of empirical antibiotic therapy (EAT) of sepsis at the emergency department and to analyse the impact of an antimicrobial stewardship (AMS) programme on process and patient outcomes.

Patients And Methods: A prospective single centre cohort study including patients with SOFA score ≥2 from whom blood cultures were taken, was conducted between February 2019 and April 2020. EAT assessment was done using eight applicable quality indicators for responsible antibiotic use in inpatients (IQIs). Read More

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Short-term Cost Comparison of Systemic Heparin Therapy vs. Catheter Directed Thrombolysis for the Treatment of Massive and Submassive Pulmonary Embolism with Long-Term Chronic Pulmonary Hypertension Cost Model.

S D Med 2021 Feb;74(2):70-74

Sanford Health Vascular Surgery, Sioux Falls, South Dakota.

Introduction: Pulmonary embolism (PE) is a significant disease process that affects an estimated 117 cases per 100,000 person-years. Chronic pulmonary hypertension (CPH) is a long-term complication associated with acute PE which has a significant cost to treat, ranging from $98,000-117,000.

Methods: A retrospective chart review of 341 patients from January 2011 to November 2018 who presented with massive or submassive PE and were treated with either systemic heparin therapy or catheter directed thrombolysis (CDT). Read More

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February 2021

Vitamin D status in children with intestinal failure who have achieved enteral autonomy.

Nutr Clin Pract 2021 Jun 23. Epub 2021 Jun 23.

Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Connecticut Children's Medical Center, Hartford, Connecticut, USA.

Background: Vitamin D deficiency is highly prevalent in children with intestinal failure (IF) who receive parenteral nutrition (PN), but data on vitamin D status after achieving enteral autonomy (EA) are limited. We aimed to evaluate the prevalence of vitamin D deficiency in this population while exploring clinical variables that may be associated with its development.

Methods: A retrospective review was performed on 29 children with IF who had achieved EA. Read More

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Co-Expression of LGR5 and CD133 Cancer Stem Cell Predicts a Poor Prognosis in Patients With Gastric Cancer.

Turk J Gastroenterol 2021 Mar;32(3):261-268

School of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand;Translational Medicine Programs, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand.

Background: The LGR5 and CD133 have been identified as cancer stem cells (CSCs) marker and prognostic marker in several cancers including gastric cancer. The purpose of the present study was to determine the association between co-expression of CSCs marker LGR5 and CD133 in patients with gastric cancer and their clinicopathological outcomes; to analyze the efficacy of co-expression of both markers in evaluating the prognosis of gastric cancer.

Methods: LGR5 and CD133 expression were investigated in a total of 400 patients by using immunohistochemistry. Read More

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Predictors of recruitment and retention in randomised controlled trials of behavioural smoking cessation interventions: a systematic review and meta-regression analysis.

Addiction 2021 Jun 22. Epub 2021 Jun 22.

Health Psychology Group, Institute of Applied Health Sciences, University of Aberdeen.

Aim: To investigate predictors of participant eligibility, recruitment, and retention in behavioural randomised controlled trials (RCTs) for smoking cessation.

Method: Systematic review and pre-specified meta-regression analysis of behavioural RCTs for smoking cessation including adult (≥18 years old) smokers. The pre-specified predictors were identified through a literature review and experts' consultation and included participant, trial and intervention characteristics and recruitment and retention strategies. Read More

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Management of Morgagni's Hernia in the Adult Population: A Systematic Review of the Literature.

World J Surg 2021 Jun 22. Epub 2021 Jun 22.

First Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, 17 Agiou Thoma Str., ZIP Code 11527, AthensAthens, Greece.

Background: Morgagni's hernia (MH) is defined by the protrusion of abdominal viscera through an anterior retrosternal diaphragmatic defect. The objective of this study was to systematically review current literature on MHs in adult population and assess their clinical characteristics and therapeutic approach.

Methods: PubMed and Cochrane bibliographical databases were searched (last search: 15 January 2021) for studies concerning MHs. Read More

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Robotic renal surgery for renal cell carcinoma with inferior vena cava thrombus.

Transl Androl Urol 2021 May;10(5):2195-2198

Fox Chase Cancer Center, Philadelphia, PA, USA.

Surgical management of renal cell carcinoma (RCC) with inferior vena cava (IVC) thrombus is inherently complex, posing challenges for even the most experienced urologists. Until the mid-2000s, nephrectomy with IVC thrombectomy was exclusively performed using variations of the open technique initially described decades earlier, but since then several institutions have reported their robotic experiences. Robotic IVC thrombectomy was initially reported for level I and II thrombi, and more recently in higher-lever III thrombi. Read More

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Geriatric Sinus Surgery: A Review of Demographic Variables, Surgical Success and Complications in Elderly Surgical Patients.

Allergy Rhinol (Providence) 2021 Jan-Dec;12:21526567211010736. Epub 2021 Jun 3.

Department of Otolaryngology-Head and Neck Surgery, Mount Sinai Hospital-New York Eye and Ear Infirmary of Mount Sinai, New York, New York.

Objective: Demonstrate feasibility, safety and outcome metrics of geriatric sinus surgery (GESS).

Study Design: Retrospective review of patients undergoing sinus surgery for indication of chronic rhinosinusitis with and without nasal polyposis.

Setting: Tertiary referral center. Read More

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Identification of an immune checkpoint gene signature that accurately predicts prognosis and immunotherapy response in endometrial carcinoma.

Aging (Albany NY) 2021 Jun 22;13. Epub 2021 Jun 22.

Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China.

In this study, we performed a bioinformatics analysis to identify immune checkpoint genes (ICGs) associated with prognosis and the immunotherapeutic response in endometrial carcinoma (EC) patients. We classified 47 ICGs into high, medium, and low expression groups by performing RNA-sequencing data analysis of EC patient samples from The Cancer Genome Atlas ( = 521) and GSE77688 ( = 88) datasets. Univariate Cox regression analysis showed that seven ICGs ( and ) were associated with prognosis in EC patients. Read More

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Perioperative and Oncologic Outcomes of Single-port Versus Multiport Robot-assisted Radical Prostatectomy: A meta- analysis.

J Endourol 2021 Jun 22. Epub 2021 Jun 22.

Affiliated Hospital of North Sichuan Medical College, 117913, shunqin, Nanchong, China, 637000;

Purpose: Although single-port (SP) robot-assisted radical prostatectomy (SP-RARP) is considered a safe and feasible approach for radical prostatectomy, the comparative performance of the SP robot with earlier models, including da Vinci Xi or Si is elusive. This systematic review summarizes the current evidence on SP-RARP and compares its perioperative, functional, and oncologic outcomes to multiport robot-assisted radical prostatectomy (MP-RARP).

Methods: We performed a systematic search in Pubmed, Embase, Web of Science, Cochrane Library database for RCTs and non-RCTs that compare SP-RARP to MP-RARP. Read More

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Leaf photosynthesis and senescence in heated and droughted field-grown soybean with contrasting seed protein concentration.

Plant Physiol Biochem 2021 Jun 9;166:437-447. Epub 2021 Jun 9.

Unidad de Estudios Agropecuarios (UDEA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto Nacional de Tecnología Agropecuaria (INTA), Córdoba, Camino 60 cuadras km 5.5, 5119, Argentina; CONICET, Argentina. Electronic address:

Soybean plants under heat and drought generate a multiplicity of responses in photosynthesis and senescence, impairing growth, yield, and seed quality. The goal of this study was to analyze and quantify independent and combined effects of heat and drought during seed filling on photosynthesis and senescence, and its subsequent effects on the filling duration in soybean genotypes contrasting on seed protein. Two field experiments were conducted using high and low seed protein genotypes. Read More

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Immunomodulatory effects of lenvatinib plus anti-PD1 in mice and rationale for patient enrichment in hepatocellular carcinoma.

Hepatology 2021 Jun 22. Epub 2021 Jun 22.

Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA.

Background & Aims: Lenvatinib is an effective drug in advanced hepatocellular carcinoma (HCC). Its combination with the anti-PD1 immune checkpoint inhibitor pembrolizumab has generated encouraging results in phase Ib and is currently being tested in phase III trials. Here, we aimed to explore the molecular and immunomodulatory effects of lenvatinib alone or in combination with anti-PD1. Read More

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Influence of Klebsiella pneumoniae and quinolone treatment on prognosis in patients with pancreatic cancer.

Br J Surg 2021 Jun;108(6):709-716

Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Background: An increasing body of evidence suggests that microbiota may promote progression of pancreatic ductal adenocarcinoma (PDAC). It was hypothesized that gammaproteobacteria (such as Klebsiella pneumoniae) influence survival in PDAC, and that quinolone treatment may attenuate this effect.

Methods: This was a retrospective study of patients from the Massachusetts General Hospital (USA) and Ludwig-Maximilians-University (Germany) who underwent preoperative treatment and pancreatoduodenectomy for locally advanced or borderline resectable PDAC between January 2007 and December 2017, and for whom a bile culture was available. Read More

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MCL1 participates in leptin-promoted mitochondrial fusion and contributes to drug resistance in gallbladder cancer.

JCI Insight 2021 Jun 22. Epub 2021 Jun 22.

Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan.

Obesity is a risk factor for gallbladder cancer (GBC) development and correlates with shorter overall survival. Leptin, derived from adipocytes, has been suggested to contribute to the growth of cancer cells. However, the detailed mechanism of leptin in GBC drug resistance remains uninvestigated. Read More

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Sorafenib and hepatocellular carcinoma: is alpha-fetoprotein a biomarker predictive of tumor biology and primary resistance?

Future Oncol 2021 Jun 22. Epub 2021 Jun 22.

Department of Biomedical Sciences & Human Oncology, University of Bari Aldo Moro, Bari, Italy.

Alpha-fetoprotein (AFP) is the only biomarker with proven prognostic value in advanced hepatocellular carcinoma. Preliminary data indicate crosstalk between AFP and VEGF signaling. The authors looked at 69 patients with advanced hepatocellular carcinoma who were previously tested for VEGFR2 expression, had available baseline AFP serum concentrations and were treated with sorafenib within clinical trials. Read More

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Prevalence and predictive factors for posterior vitreous attachment in eyes undergoing epiretinal membrane surgery.

Eye (Lond) 2021 Jun 21. Epub 2021 Jun 21.

Department of Ophthalmology, University Hospital of Nancy, 54500, Vandoeuvre-lès-Nancy, France.

Background: To report the prevalence of posterior vitreous attachment (PVA) in patients with idiopathic epiretinal membrane (iERM) and to determine associated preoperative predictive factors.

Methods: Retrospective observational case series of 408 eyes who underwent surgery for iERM without vitreomacular traction. The status of the posterior hyaloid was assessed intraoperatively. Read More

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FOXM1 is required for small cell lung cancer tumorigenesis and associated with poor clinical prognosis.

Oncogene 2021 Jun 21. Epub 2021 Jun 21.

Institute of Biotechnology, National Tsing Hua University, Hsinchu, 300, Taiwan.

Small cell lung cancer (SCLC) continues to cause poor clinical outcomes due to limited advances in sustained treatments for rapid cancer cell proliferation and progression. The transcriptional factor Forkhead Box M1 (FOXM1) regulates cell proliferation, tumor initiation, and progression in multiple cancer types. However, its biological function and clinical significance in SCLC remain unestablished. Read More

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Polymorphic tandem DNA repeats activate the human telomerase reverse transcriptase gene.

Proc Natl Acad Sci U S A 2021 Jun;118(26)

College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA 99210;

Multiple independent sequence variants of the locus have been associated with telomere length and cancer risks in genome-wide association studies. Here, we identified an intronic variable number tandem repeat, VNTR2-1, as an enhancer-like element, which activated hTERT transcription in a cell in a chromatin-dependent manner. VNTR2-1, consisting of 42-bp repeats with an array of enhancer boxes, cooperated with the proximal promoter in the regulation of hTERT transcription by basic helix-loop-helix transcription factors and maintained hTERT expression during embryonic stem-cell differentiation. Read More

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Trends in survival of older care home residents in England: A 10-year multi-cohort study.

Soc Sci Med 2021 Mar 31:113883. Epub 2021 Mar 31.

Health Economics Group, Norwich Medical School, University of East Anglia, Norwich, UK; Health Organisation, Policy and Economics (HOPE) Research Group, University of Manchester, Manchester, UK.

Increases in longevity combined with a policy emphasis on caring for older people in their own homes could have widened or narrowed the survival gap between care home and community-dwelling resident older people. Knowledge of pre-COVID-19 trends in this gap is needed to assess the longer-term impacts of the pandemic. We provide evidence for England on recent trends in 1, 2 and 3-year mortality amongst care home residents aged 65+ compared with similar community-dwelling residents. Read More

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Risk factors associated with mechanical ventilation, autonomic nervous dysfunction and physical outcome in Vietnamese adults with tetanus.

Trop Med Health 2021 Jun 21;49(1):50. Epub 2021 Jun 21.

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

Background: Tetanus remains common in many low- and middle-income countries, but as critical care services improve, mortality from tetanus is improving. Nevertheless, patients develop severe syndromes associated with autonomic nervous system disturbance (ANSD) and the requirement for mechanical ventilation (MV). Understanding factors associated with worse outcome in such settings is important to direct interventions. Read More

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Targeting WD repeat domain 5 enhances chemosensitivity and inhibits proliferation and programmed death-ligand 1 expression in bladder cancer.

J Exp Clin Cancer Res 2021 Jun 21;40(1):203. Epub 2021 Jun 21.

Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107th Yanjiangxi Road, Guangzhou, China.

Background: Chemotherapy and/or immunotherapy are first-line treatments for advanced muscle-invasive bladder cancer (BCa), but the unsatisfactory objective response rate to these treatments yields poor 5-year patient survival. Discovery of therapeutic targets essential for BCa maintenance is critical to improve therapy response in clinic. This study evaluated the role of targeting WD repeat domain 5 (WDR5) with the small molecule compound OICR-9429 and whether it could be used to treat bladder cancer. Read More

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[Background, Necessity and Methodology of the S3 Guideline "Perioperative Management of Gastrointestinal Tumours (POMGAT)"].

Zentralbl Chir 2021 Jun 21;146(3):241-248. Epub 2021 Jun 21.

Klinik und Poliklinik für Allgemein-, Viszeral-, Thorax- und Gefäßchirurgie, Universitätsklinikum Bonn, Deutschland.

Malignancies are among the most common diseases, especially in old age, and are responsible for 25% of all deaths in Germany. Especially carcinomas of the gastrointestinal tract can be cured in most cases only through extensive surgery with significant morbidity. About 25 years ago, the multimodal, perioperative Fast Track (FT) concept for reducing postoperative complications was introduced and additional elements were added in the following years. Read More

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Detection of circulating immunosuppressive cytokines in malignant pleural mesothelioma patients for prognostic stratification.

Cytokine 2021 Jun 19;146:155622. Epub 2021 Jun 19.

Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy; Medical Oncology 2, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy. Electronic address:

Background: No data on circulating biomarkers for the prognostic stratification of Malignant Pleural Mesothelioma (MPM) patients are available. We prospectively explored the prognostic role of circulating monocyte and cytokine levels and their dynamic change during chemotherapy.

Patients And Methods: MPM patients receiving a first line treatment based on a platinum compound plus pemetrexed were eligible. Read More

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Cytoproliferative activity in colorectal poorly differentiated clusters: Biological significance in tumor setting.

Ann Diagn Pathol 2021 Jun 16;53:151772. Epub 2021 Jun 16.

Department of Medical and Surgical Sciences for Children & Adults, Division of Pathology, University-Hospital of Modena and Reggio Emilia, Modena, Italy.

Background: Poorly differentiated clusters (PDCs) have gained a significant prognostic role in colorectal carcinomas (CRCs) being associated to high risk of lymph node metastasis, shorter survival time and poor prognosis. The knowledge in PDC biology is not completely clear.

Materials And Methods: We assessed Ki-67 LI in 45 CRCs showing ≥10 PDCs. Read More

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Induction within or after 12 hours of ≥ 36 weeks prelabor rupture of membranes: a systematic review and meta-analysis.

Am J Obstet Gynecol MFM 2021 Jun 18:100425. Epub 2021 Jun 18.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

Objective: To evaluate the incidence of chorioamnionitis in women with singleton gestations with ≥36 weeks prelabor rupture of membranes (PROM) induced with oxytocin within or after 12 hours or PROM.

Data Sources: The search was conducted using MEDLINE, Web of Sciences, Scopus, ClinicalTrial.gov, OVID and Cochrane Library as electronic databases from their inception until May 2020. Read More

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Examining patterns of postnatal feeding in relation to Infant's weight during the first year.

Appetite 2021 Jun 18:105473. Epub 2021 Jun 18.

Background: There is mixed evidence regarding specific infant feeding behaviors and later risk for overweight and obesity. We sought to detect underlying patterns in duration of breastfeeding, introduction of solid foods and sweetened beverages, in order to understand the relation to later weight.

Methods: Patterns of postnatal feeding were examined among infants enrolled in the Infant Feeding Practices Study II (N = 3033). Read More

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Tumor invasion in the hyponychium is associated with distant metastasis and poor prognosis in subungual melanoma: A histological landscape of 44 cases.

J Am Acad Dermatol 2021 Jun 18. Epub 2021 Jun 18.

Department of Plastic and Reconstructive Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Subungual melanoma (SUM) has a poor prognosis due to delayed diagnosis. The progression, consensus on surgical treatment, correlation with clinical outcomes remains unclear.

Objective: We aimed to identify the pattern of dermal invasion in different locations of the nail apparatus and its relationship with prognosis. Read More

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Effects of High-Intensity Interval Exercise and Moderate-Intensity Continuous Exercise on Executive Function of Healthy Young Males.

Physiol Behav 2021 Jun 18:113505. Epub 2021 Jun 18.

Department of Health and Physical Education, The Education University of Hong Kong, Hong Kong SAR, China.

Purpose: This study compared the executive function (EF) performance induced by moderate-intensity continuous exercise (MICE) versus high-intensity interval exercise (HIIE), under two exercise modalities (i.e., running vs. Read More

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Blood pressure variability and cognitive dysfunction: A systematic review and meta-analysis of longitudinal cohort studies.

J Clin Hypertens (Greenwich) 2021 Jun 21. Epub 2021 Jun 21.

Department of Medicine, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan.

The variability of blood pressure (BPV) has been suggested as a clinical indicator for cognitive dysfunction, yet the results from clinical studies are variable. This study investigated the relationship between BPV and the risk of cognitive decline or dementia. Bibliographic databases, including PubMed, Scopus, and Embase, were searched systematically for longitudinal cohort studies with BPV measurements and neuropsychological examinations or dementia diagnosis. Read More

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