994,927 results match your criteria associated risk

Newborns at risk of Covid-19 - lessons from the last year.

J Perinat Med 2021 Jun 11. Epub 2021 Jun 11.

Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

After more than 1 year of the SARS-CoV-2 pandemic, a great deal of knowledge on how this virus affects pregnant women, the fetus and the newborn has accumulated. The gap between different guidelines how to handle newborn infants during this pandemic has been minimized, and the American Academy of Pediatrics (AAP)'s recommendations are now more in accordance with those of the World Health Organization (WHO). In this article we summarize present knowledge regarding transmission from mother to the fetus/newborn. Read More

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Cancer-Associated Splanchnic Vein Thrombosis.

Semin Thromb Hemost 2021 Jun 11. Epub 2021 Jun 11.

Department of Medicine and Surgery, University of Insubria, Varese, Italy.

Splanchnic vein thrombosis (SVT), which includes portal, mesenteric, and splenic vein thrombosis and the Budd-Chiari syndrome, is an infrequent manifestation of venous thromboembolism (VTE). Like typical site VTE, SVT is also frequently associated with cancer, particularly intra-abdominal solid malignancies and myeloproliferative neoplasms (MPNs). The clinical presentation of SVT is nonspecific. Read More

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Experiencing Bullying Is Associated With Firearm Access, Weapon Carriage, Depression, Marijuana Use, and Justice Involvement in Adolescents.

Pediatr Emerg Care 2021 Jun 11. Epub 2021 Jun 11.

From the Department of Emergency Medicine, Children's National Hospital, Washington, DC.

Objectives: The aims of this study were to assess whether bullying experience among youths is associated with firearm access and to evaluate assault perpetration risk factors between bullied and nonbullied adolescents.

Methods: This was a secondary analysis of a cross-sectional survey designed to measure self-reported social determinants of health and behavioral health risks among adolescents (13-21 years) in a pediatric emergency department between July 2017 and August 2019. Participants were included in this subanalysis if they responded to a survey item that assessed bullying. Read More

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Corneal Allograft Rejection Associated With Herpes Zoster Recombinant Adjuvanted Vaccine.

Alice Matoba

Cornea 2021 Jun 9. Epub 2021 Jun 9.

Department of Ophthalmology, Baylor College of Medicine, Houston, TX.

Purpose: The purpose of this article is to report 3 cases of corneal allograft rejection that occurred in temporal proximity to administration of the zoster subunit vaccine (RZV).

Methods: Three cases of corneal transplant rejection that developed after RZV administration were identified. Clinical history, including existence of other risk factors, timing of rejection, corticosteroid therapy at the time of onset of rejection, and course were reviewed. Read More

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Late morbidity and mortality following revascularization surgery for moyamoya disease in the pediatric population.

J Neurosurg Pediatr 2021 Jun 11:1-6. Epub 2021 Jun 11.

Objective: There are limited reports on long-term morbidity in pediatric patients who have undergone surgical revascularization for moyamoya disease (MMD). Here, the authors report long-term morbidity and mortality in a population of pediatric patients who underwent pial synangiosis for MMD from 1988 through 2016.

Methods: A single-center retrospective review of the hospital and personal operative databases of the senior authors was carried out to identify all patients who were treated for MMD at Boston Children's Hospital between 1988 and 2016, and who experienced any episode of late morbidity or mortality, which the authors defined as an event resulting in significant neurological deficit or death occurring more than 1 year after revascularization surgery. Read More

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Pathways linking census tract typologies with subjective neighborhood disorder and depressive symptoms in the Black Women's Experiences Living with Lupus (BeWELL) Study.

Health Place 2021 Jun 8;70:102587. Epub 2021 Jun 8.

Department of Global Community Health and Behavioral Sciences, Tulane University School of Public Health and Tropical Medicine, 1440 Canal St, New Orleans, LA, 70112, USA.

Depression is a common comorbidity among Black women with systemic lupus erythematosus (SLE), an understudied autoimmune disease characterized by major racial and gender inequities. Research is needed that examines how area-level factors influence risk of depression in this population. Latent profile analysis revealed four neighborhood typologies among metropolitan Atlanta, Georgia census tracts that participants (n=438) in the Black Women's Experiences Living with Lupus (BeWELL) Study were living in: Integrated/High-SES, Moderately Segregated/Mid-SES, Highly Segregated/Mid-SES, and Highly Segregated/Low-SES. Read More

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Interaction of CP levels in maternal and nursery diets, and its effect on performance, protein digestibility, and serum urea levels in piglets.

Animal 2021 Jun 8;15(7):100266. Epub 2021 Jun 8.

Flanders Research Institute for Agriculture, Fisheries and Food (ILVO), 9090 Melle, Belgium; Department of Nutrition, Genetics and Ethology, Ghent University, Merelbeke, Belgium. Electronic address:

Reduced protein levels in nursery diets have been associated with a lower risk of postweaning diarrhea, but the interaction with CP levels in maternal diet on the performance of the offspring remains unclear. The objective of this study was to determine the effect of protein content in sow gestation and piglet nursery diets on the performance of the piglets until slaughter. This was studied in a 2 × 2 factorial trial (35 sows, 209 piglets), with higher or lower (H or L) dietary CP in sow diets (168 vs 122 g CP/kg) during late gestation. Read More

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Long-read nanopore sequencing enables accurate confirmation of a recurrent PMS2 insertion-deletion variant located in a region of complex genomic architecture.

Cancer Genet 2021 May 28;256-257:122-126. Epub 2021 May 28.

Leeds Institute of Medical Research, University of Leeds, St. James's University Hospital, Leeds LS9 7TF, United Kingdom; The Clinical Genetics Department, Chapel Allerton Hospital, Leeds LS7 4SA, United Kingdom.

Targeted next generation sequencing (NGS) is the predominant methodology for the molecular genetic diagnosis of inherited conditions. In many laboratories, NGS-identified variants are routinely validated using a different method, to minimize the risk of a false-positive diagnosis. This can be particularly important when pathogenic variants are located in complex genomic regions. Read More

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Providing universal access to modern contraceptive methods: An extended cost-effectiveness analysis of meeting the demand for modern contraception in Ethiopia.

Soc Sci Med 2021 May 25;281:114076. Epub 2021 May 25.

Bergen Centre for Ethics and Priority Setting, Institute of Global Public Health and Primary Care, University of Bergen, Årstadveien 21, 5009, Bergen, Norway; Harvard T.H. Chan School of Public Health, Harvard University, 677 Huntington Ave, Boston, MA, 02115, United States. Electronic address:

Despite recent advances in access to and use of modern contraception in Ethiopia, further improvement is needed, particularly among poorer women. This extended cost-effectiveness analysis investigated the health outcomes, their distribution, and financial risk protection associated with meeting the demand for modern contraception for all Ethiopian women. We developed five Markov models with wealth quintile-specific input data to investigate the effects of meeting this demand and followed a hypothetical cohort of 1,252,000 women through their reproductive lives from ages 15-49 years. Read More

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Composite psychosocial risk based on the fear avoidance model in patients undergoing anterior cruciate ligament reconstruction: Cluster-based analysis.

Phys Ther Sport 2021 Jun 2;50:217-225. Epub 2021 Jun 2.

Department of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA; Center for Musculoskeletal Research, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Physical Medicine and Rehabilitation, Osher Center for Integrative Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

Objectives: To examine associations between preoperative fear-avoidance model (FAM) risk subgroup status and patient expectation of surgical success with postoperative outcomes at 6 and 12 months after anterior cruciate ligament reconstruction (ACLR).

Design: Cohort study.

Setting: Academic medical center. Read More

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A higher percentage of leukemic blasts with vacuoles predicts unfavorable outcomes in patients with acute myeloid leukemia.

Leuk Res 2021 Jun 6;109:106638. Epub 2021 Jun 6.

Department of Hematology, Zhengzhou University People's Hospital and Henan Provincial People's Hospital, Henan, People's Republic of China. Electronic address:

Cytoplasmic vacuoles, which are a morphological feature of dysplasia, can be observed under a microscope at initial diagnosis. Recently, this typical morphological feature has been found to be associated with impaired survival. To investigate the clinical significance of the grading of blasts with vacuoles in acute myeloid leukemia (AML), we retrospectively studied 152 patients newly diagnosed with non-M3 AML. Read More

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Adjuvant endocrine therapy for premenopausal women with breast cancer: Patient adherence and physician prescribing practices in Mexico.

Breast 2021 Jun 1;59:8-15. Epub 2021 Jun 1.

Departamento de Tumores Mamarios e Investigacion, Instituto Nacional de Cancerologia, San Fernando 22, Belisario Dominguez Secc 16, Tlalpan, Mexico City, 14080, Mexico.

Background: In resource-constrained settings, data regarding breast cancer patients' adherence to endocrine therapy (ET) and physicians' prescribing practices is limited. This study aims to decrease this knowledge gap in a real-world clinical practice.

Methods: Premenopausal women with stage 0-III hormone-sensitive breast cancer and receiving adjuvant ET during the past 1-5 years were identified in three Mexican referral centers. Read More

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Serum Inhibin-A and PAPP-A2 in the prediction of pre-eclampsia during the first and second trimesters in high-risk women.

Pregnancy Hypertens 2021 Jun 2;25:116-122. Epub 2021 Jun 2.

Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland; Department of Obstetrics and Gynecology, Tampere University Hospital and Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland.

Objectives: Maternal serum inhibin-A, pregnancy associated plasma protein-A (PAPP-A) and PAPP-A2 together with placental growth factor (PlGF), maternal risk factors and uterine artery pulsatility index (UtA PI) were analysed to study their ability to predict pre-eclampsia (PE).

Study Design: Serial serum samples for the nested case-control study were collected prospectively at 12-14, 18-20 and 26-28 weeks of gestation from 11 women who later developed early-onset PE (EO PE, diagnosis < 34 + 0 weeks of gestation), 34 women who developed late-onset PE (LO PE, diagnosis ≥ 34 + 0 weeks) and 89 controls.

Main Outcome Measures: Gestational age -adjusted multiples of the median (MoM) values were calculated for biomarker concentrations. Read More

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Evaluation of the Cepheid Xpert SA Nasal Complete for direct detection of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus in nasal swabs from pediatric patients.

Diagn Microbiol Infect Dis 2021 May 4;101(1):115417. Epub 2021 May 4.

Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital; Department of Pathology, The Ohio State University, Columbus, OH; Department of Pediatrics, The Ohio State University, Columbus, OH. Electronic address:

Nasal carriers of Staphylococcus aureus (SA) are at increased risk for health-care associated infections with this organism. Timely detection of SA and Methicillin-resistant SA (MRSA) and subsequent decolonization are important components of infection control. While performance of nucleic acid amplification-based tests for detection of SA/MRSA in adults has been well-described, limited data are available in children. Read More

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Association of short-term fine particulate matter exposure with pulmonary function in populations at intermediate to high-risk of cardiovascular disease: A panel study in three Chinese cities.

Ecotoxicol Environ Saf 2021 Jun 8;220:112397. Epub 2021 Jun 8.

Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences, Beijing 100037, China. Electronic address:

Background: Decline in pulmonary function contributes to increasing cardiovascular disease (CVD) risk. Although adverse effects of short-term exposure to fine particulate matter (PM) on pulmonary function have been recognized in healthy people or patients with respiratory disease, these results were not well illustrated among people with elevated CVD risk.

Materials And Methods: A panel study was conducted in three Chinese cities with three repeated visits among populations at intermediate to high-risk of CVD, defined as treated hypertension patients or those with blood pressure ≥ 130/80 mmHg, who met any of the three conditions including abdominal obesity, dyslipidemia, and diabetes mellitus. Read More

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Association of BPA exposure during pregnancy with risk of preterm birth and changes in gestational age: A meta-analysis and systematic review.

Ecotoxicol Environ Saf 2021 Jun 8;220:112400. Epub 2021 Jun 8.

Chinese Academy of Medical Science Research Unit (2019RU014), NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing 100022, China.

The associations of bisphenol A exposure during pregnancy with risk of preterm birth (PTB) and changes in gestational age have remained controversial. To conduct the meta-analysis, the relevant studies were searched through PubMed, OVID, and Web of Science from inception through June ‎17, ‎2020. Data were independently extracted and analyzed using odds ratio (OR) or regression coefficient (β) and their 95% confidence intervals (CIs). Read More

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The promotions on radical formation and micropollutant degradation by the synergies between ozone and chemical reagents (synergistic ozonation): A review.

J Hazard Mater 2021 Jun 8;418:126327. Epub 2021 Jun 8.

Key Laboratory of Microorganism Application and Risk Control of Shenzhen, Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental Safety, Institute of Environment and Ecology, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China. Electronic address:

The combination of ozone (O) and chemical reagents (such as HO) shows synergies on the radical formation and micropollutant degradation. The promoting performance was associated with various parameters including chemical reagents, micropollutants, solution pH, and the water matrix. In this review, we summarized existing knowledge on radical formation pathways, radical yields, and radical oxidation for different synergistic ozonation processes in various water matrices (such as groundwater, surface water, and wastewater). Read More

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An adaptive text message intervention to promote well-being and health behavior adherence for patients with cardiovascular disease: intervention design and preliminary results.

J Acad Consult Liaison Psychiatry 2021 Jun 8. Epub 2021 Jun 8.

Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:

Background: Most individuals with heart disease struggle to adhere to cardiovascular health behaviors, despite their known health benefits. Text message interventions (TMIs) are a promising treatment modality for health behavior promotion, but existing TMIs typically deliver a fixed set of messages and do not target well-being constructs associated with adherence and cardiovascular health.

Methods: A four-week TMI, which delivers daily messages to promote well-being and adherence to health behaviors and dynamically adapts based on participant feedback to deliver increasingly customized messages, was developed by the study team. Read More

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Clin Gastroenterol Hepatol 2021 Jun 8. Epub 2021 Jun 8.

Backgrounds And Aims: Inpatient endoscopy delay (IED) negatively impacts the delivery of high-quality care. We aimed to identify factors associated with IED and evaluate its effect on hospital length-of-stay (LOS) and re-admission.

Methods: Retrospective analysis of all inpatient endoscopies performed between November 2017 to November 2019 at a tertiary care center. Read More

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Heterogeneity in prenatal substance use screening despite universal screening recommendations: findings from PRAMS, 2016-2018.

Am J Obstet Gynecol MFM 2021 Jun 8:100419. Epub 2021 Jun 8.

Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.

Background: The American College of Obstetricians and Gynecologists recommends universal screening for tobacco, alcohol, and drug use as a part of routine prenatal care. However, little is known about the prevalence of prenatal substance use screening or factors that may contribute to differential rates of screening during prenatal care.

Objectives: To describe the prevalence of prenatal substance use screening by substance, year, state, and state-level prenatal substance use policies, and to examine individual-level factors associated with receipt of screening. Read More

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Age-related amyloidosis outside the brain: A state-of-the-art review.

Ageing Res Rev 2021 Jun 8:101388. Epub 2021 Jun 8.

Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Electronic address:

Inside and outside the brain, accumulation of amyloid fibrils plays key roles in the pathogenesis of fatal age-related diseases such as Alzheimer's and Parkinson's diseases and wild-type transthyretin amyloidosis. Although the incidence of all amyloidoses increases with age, for some types of amyloidosis aging is known as the main direct risk factor, and these types are typically diseases of elderly people. More than 10 different precursor proteins are known to cause age-associated amyloidosis; these proteins include amyloid β protein, α-synuclein, transthyretin, islet amyloid polypeptide, atrial natriuretic factor, and the newly discovered epidermal growth factor-containing fibulin-like extracellular matrix protein 1. Read More

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Metformin and primary bone cancer risk in Taiwanese patients with type 2 diabetes mellitus.

Chin-Hsiao Tseng

Bone 2021 Jun 8:116037. Epub 2021 Jun 8.

Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan; Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Division of Environmental Health and Occupational Medicine of the National Health Research Institutes, Zhunan, Taiwan. Electronic address:

Background: The effect of metformin on primary bone cancer risk has not been researched. This retrospective cohort study investigated the risk of primary bone cancer between metformin initiators and non-metformin initiators in patients with type 2 diabetes mellitus.

Methods: A total of 673,532 patients with newly diagnosed type 2 diabetes mellitus and had been prescribed antidiabetic drugs for 2 or more times during 1999-2009 were enrolled from Taiwan's National Health Insurance. Read More

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The seroprevalence of SARS-CoV-2 antibodies among health care workers before the Era of vaccination: A systematic review and meta-analysis.

Clin Microbiol Infect 2021 Jun 8. Epub 2021 Jun 8.

Koç University İş Bank Research Center for Infectious Diseases (KUISCID), Istanbul, Turkey; Koç University, School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey. Electronic address:

Background: The prevalence of SARS-CoV-2 infection among HCWs provide information to for the spread of COVID-19 within health care facilities, and to detect the risk groups.

Objective: We aimed to describe the rate of SARS-CoV-2 seroprevalence and its determinants among health care workers.

Data Sources: We used Web of Science, Scopus, MEDLINE, EBSCOhost and Cochrane Library. Read More

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How representative is a point-of-care randomized trial? Clinical outcomes of patients excluded from a point-of-care randomized controlled trial evaluating antibiotic duration for Gram-negative bacteremia: a multicenter prospective observational cohort study.

Clin Microbiol Infect 2021 Jun 8. Epub 2021 Jun 8.

Division of Infectious Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland; Center for Clinical Research, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.

Objectives: Patients included in randomized controlled trials (RCT) are poorly representative of the general population. We compared outcomes of patients excluded from the PIRATE trial, a point-of-care RCT evaluating antibiotic durations for Gram-negative bacteremia, to those of enrolled patients.

Methods: A prospective observational cohort study, "EPCO" (Excluded Patients' Clinical Outcomes) included patients excluded from the PIRATE trial. Read More

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The Effects of At-Birth Adoption on Atypical Behavior and Anxiety: A Nonhuman Primate Model.

J Am Acad Child Adolesc Psychiatry 2021 Jun 8. Epub 2021 Jun 8.

Objective: Adopted children tend to show an increased risk for a variety of psychopathological outcomes, even when adoption occurs at birth, which some suggest is a result of non-random assignment of adoptees and parents. This study utilizes a nonhuman primate model, in which adoptions were randomly assigned, to investigate the behavioral and physiological outcomes associated with at-birth adoption.

Method: Immediately following birth, rhesus monkey infants were randomly assigned to be reared by either their biological mother (n=113) or by an unrelated, lactating, adoptive mother (n=34). Read More

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T2 heterogeneity as an in vivo marker of microstructural integrity in medial temporal lobe subfields in ageing and mild cognitive impairment.

Neuroimage 2021 Jun 8:118214. Epub 2021 Jun 8.

Bristol Medical School, University of Bristol, Bristol, UK; Clinical Neurosciences, North Bristol NHS Trust, Bristol, UK.

A better understanding of early brain changes that precede loss of independence in diseases like Alzheimer's disease (AD) is critical for development of disease-modifying therapies. Quantitative MRI, such as T2 relaxometry, can identify microstructural changes relevant to early stages of pathology. Recent evidence suggests heterogeneity of T2 may be a more informative MRI measure of early pathology than absolute T2. Read More

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Sestrin2 suppression aggravates oxidative stress and apoptosis in endothelial cells subjected to pharmacologically induced endoplasmic reticulum stress.

Eur J Pharmacol 2021 Jun 8:174247. Epub 2021 Jun 8.

Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar; Biomedical and Pharmaceutical Research Unit (BPRU), QU Health, Qatar University, P.O. Box 2713, Doha, Qatar; Office of Vice President for Research and Graduate Studies, Qatar University, P.O. Box 2713, Doha, Qatar. Electronic address:

Endoplasmic reticulum (ER) stress is an inflammatory response that contributes to endothelial dysfunction, a hallmark of cardiovascular diseases, in close interplay with oxidative stress. Recently, Sestrin2 (SESN2) emerged as a novel stress-inducible protein protecting cells from oxidative stress. We investigated here, for the first time, the impact of SESN2 suppression on oxidative stress and cell survival in human endothelial cells subjected to pharmacologically (thapsigargin)-induced ER stress and studied the underlying cellular pathways. Read More

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Prenatal Antidepressant Use and the Implication of Hypertensive Disorders during Pregnancy.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

School of Pharmacy, College of Pharmacy, Taipei Medical University. Electronic address:

Background: Evidence regarding prenatal antidepressant use and the development of hypertensive disorders during pregnancy is inconsistent. Previous studies have reported that antidepressant use during pregnancy increases the risk of gestational hypertension and preeclampsia, but the results of these studies are potentially confounded by important methodologic limitations. Furthermore, it remains unknown whether a higher cumulative dose of antidepressant increases the risk of hypertensive disorders of pregnancy. Read More

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Differences in coronavirus disease 2019 screening, diagnosis, and hospitalization rates among U.S. pregnant women with and without a substance use disorder.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

Department of Obstetrics, Gynecology & Reproductive Sciences Magee-Womens Research Institute University of Pittsburgh Pittsburgh, Pennsylvania.

Objective: Pregnant women are at increased risk for severe morbidity and mortality due to respiratory infections like SARS-CoV-2 (COVID-19) during pregnancy. Those with substance use disorders (SUD) may be especially vulnerable due to high rates of smoked tobacco, cannabis and methamphetamine use which adversely affect pulmonary function. However, little is known about differential effects of COVID-19 on pregnant women with and without SUD. Read More

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Phosphodiesterase-5 inhibitors in Pregnancy: Systematic review and meta-analysis of maternal and perinatal safety and clinical outcomes.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

Mater Research Institute - University of Queensland, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, Queensland 4101, Australia; Faculty of Medicine, University of Medicine, Whitty Building, Annerley Road, South Brisbane, Queensland 4101, Australia; NHMRC Stillbirth Centre For Research Excellence, Mater Research Institute, South Brisbane, Queensland 4101, Australia. Electronic address:

Objective: Phosphodiesterase-5 inhibitors have recently been used for the treatment of severe early onset pre-eclampsia and fetal growth restriction. There are however concerns that they may increase the risk of neonatal morbidity and mortality. The aim of this systematic review was to assess the safety profile and clinical outcomes of phosphodiesterase-5 inhibitors use in pregnancy. Read More

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