38,586 results match your criteria associated remodeling


SIGNS OF DIASTOLIC DYSFUNCTION ARE GRADED BY SERUM TESTOSTERONE LEVELS IN AGING C57BL/6 MALE MICE.

Mech Ageing Dev 2021 Jun 21:111523. Epub 2021 Jun 21.

Department of Pharmacology, Dalhousie University, Halifax, NS, Canada; Department of Medicine (Geriatric Medicine), Dalhousie University, Halifax, NS, Canada. Electronic address:

We investigated whether maladaptive, age-associated changes in heart structure and function were linked to circulating testosterone levels. Male C57BL/6 mice had a gonadectomy (GDX) or sham surgery at 4 weeks and effects of GDX on the heart were examined with echocardiography. Serum testosterone was measured with ELISA. Read More

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Follicular lymphoma triggers phenotypic and functional remodeling of the human lymphoid stromal cell landscape.

Immunity 2021 Jun 17. Epub 2021 Jun 17.

UMR 1236, Université Rennes, INSERM, Etablissement Français du Sang Bretagne, 35043, Rennes, France; Pôle Biologie, CHU Rennes, 35033 Rennes, France. Electronic address:

Lymphoid stromal cells (LSCs) are essential organizers of immune responses. We analyzed tonsillar tissue by combining flow cytometry, in situ imaging, RNA sequencing, and functional assays, defining three distinct human LSC subsets. The integrin CD49a designated perivascular stromal cells exhibiting features of local committed LSC precursors and segregated cytokine and chemokine-producing fibroblastic reticular cells (FRCs) supporting B and T cell survival. Read More

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Expression of versican mRNA transcript to predict cardiac remodelling after myocardial infarction.

Kardiol Pol 2021 Jun 24. Epub 2021 Jun 24.

1st Chair and Department of Cardiology, Medical University of Warsaw, Warszawa, Poland.

Background: Adverse left-ventricular remodelling (LVR) is defined as an increase in end-diastolic left-ventricular volume by 20% 6 months after acute myocardial infarction (AMI). LVR is associated with cardiac dysfunction, therefore deteriorating the prognosis.

Aims: We aimed to compare the concentrations of messenger RNA transcripts in the peripheral blood of patients with and without LVR at 6 months. Read More

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The Goto Kakizaki rat: Impact of age upon changes in cardiac and renal structure, function.

PLoS One 2021 24;16(6):e0252711. Epub 2021 Jun 24.

St. Michael's Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Canada.

Background: Patients with diabetes are at a high risk for developing cardiac dysfunction in the absence of coronary artery disease or hypertension, a condition known as diabetic cardiomyopathy. Contributing to heart failure is the presence of diabetic kidney disease. The Goto-Kakizaki (GK) rat is a non-obese, non-hypertensive model of type 2 diabetes that, like humans, shares a susceptibility locus on chromosome 10. Read More

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Remodeling of the Fibrillation Pathway of α-Synuclein by Interaction with Antimicrobial Peptide LL-III.

Chemistry 2021 Jun 24. Epub 2021 Jun 24.

TU Dortmund University, Chemistry and Chemical Biology, Otto-Hahn Str. 4a, Physical Chemistry I, 44227, Dortmund, GERMANY.

Liquid-liquid phase separation (LLPS) has emerged as a key mechanism for intracellular organization, and many recent studies have provided important insights into the role of LLPS in cell biology. There is also evidence that LLPS is associated with a variety of medical conditions, including neurodegenerative disorders. Pathological aggregation of α-synuclein, which is causally linked to Parkinson's disease, can proceed via droplet condensation, which then gradually transitions to the amyloid state. Read More

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Functional genomics of GPR126 in airway smooth muscle and bronchial epithelial cells.

FASEB J 2021 Jul;35(7):e21300

Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, Biodiscovery Institute, University of Nottingham, Nottingham, UK.

GPR126 is an adhesion G protein-coupled receptor which lies on chromosome 6q24. Genetic variants in this region are reproducibly associated with lung function and COPD in genome wide association studies (GWAS). The aims of this study were to define the role of GPR126 in the human lung and in pulmonary disease and identify possible casual variants. Read More

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Detrimental effects of elevated transpulmonary gradient on outcomes following restrictive mitral annuloplasty in patients with pre-existing pulmonary hypertension.

J Thorac Dis 2021 May;13(5):2746-2757

Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Background: This study retrospectively examined the association between elevated trans-pulmonary gradient (TPG), which reflects pre-capillary contribution to pulmonary hypertension (PH), and postoperative pulmonary hemodynamics and outcomes following restrictive mitral annuloplasty (RMA) in patients with pre-existing PH.

Methods: Pre- and postoperative (1 month) cardiac catheterization was performed in 64 patients with severely impaired left ventricular function (i.e. Read More

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Poly adenosine diphosphate-ribosylation, a promising target for colorectal cancer treatment.

World J Gastrointest Oncol 2021 Jun;13(6):574-588

Research and Development, Metimedi Pharmaceuticals, Incheon 22006, South Korea.

The development of colorectal cancer (CRC) can result from changes in a variety of cellular systems within the tumor microenvironment. Particularly, it is primarily associated with genomic instability that is the gradual accumulation of genetic and epigenetic changes consisting of a characteristic set of mutations crucial for pathways in CRC progression. Based on this background, the potential to focus on poly [adenosine diphosphate (ADP)-ribose] polymerase (PARP)-1 and poly-ADP ribosylation (PARylation) as the main causes of malignant formation of CRC may be considered. Read More

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Presence of Left Atrial Fibrosis May Contribute to Aberrant Hemodynamics and Increased Risk of Stroke in Atrial Fibrillation Patients.

Front Physiol 2021 7;12:657452. Epub 2021 Jun 7.

Alliance for Cardiovascular Diagnostic and Treatment Innovation, Johns Hopkins University, Baltimore, MD, United States.

Atrial fibrillation (AF) patients are at high risk of stroke, with the left atrial appendage (LAA) found to be the most common site of clot formation. Presence of left atrial (LA) fibrosis has also been associated with higher stroke risk. However, the mechanisms for increased stroke risk in patients with atrial fibrotic remodeling are poorly understood. Read More

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MUC1-C activates the PBAF chromatin remodeling complex in integrating redox balance with progression of human prostate cancer stem cells.

Oncogene 2021 Jun 23. Epub 2021 Jun 23.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

The polybromo-associated PBAF (SWI/SNF) chromatin remodeling complex, which includes PBRM1, ARID2, and BRD7, regulates cell differentiation and genomic integrity. MUC1-C is an oncogenic protein that drives lineage plasticity in prostate cancer (PC) progression. The present work demonstrates that MUC1-C induces PBRM1, ARID2, and BRD7 expression by the previously unrecognized E2F1-mediated activation of their respective promoters. Read More

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Gene expression profiles during tissue remodeling following bladder outlet obstruction.

Sci Rep 2021 Jun 23;11(1):13171. Epub 2021 Jun 23.

Department of Urology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto-City, Kyoto, 602-8566, Japan.

Bladder outlet obstruction (BOO) often results in lower urinary tract symptoms (LUTSs) and negatively affects quality of life. Here, we evaluated gene expression patterns in the urinary bladder during tissue remodeling due to BOO. We divided BOO model rats into two groups according to the degree of hypertrophy of smooth muscle in the bladder. Read More

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Surfing the clinical trials of mesenchymal stem cell therapy in ischemic cardiomyopathy.

Stem Cell Res Ther 2021 Jun 23;12(1):361. Epub 2021 Jun 23.

Department of Cardiology, Institute CARDIOMET, University Hospital of Toulouse, Toulouse, France.

While existing remedies failed to fully address the consequences of heart failure, stem cell therapy has been introduced as a promising approach. The present review is a comprehensive appraisal of the impacts of using mesenchymal stem cells (MSCs) in clinical trials mainly conducted on ischemic cardiomyopathy. The benefits of MSC therapy for dysfunctional myocardium are likely attributed to numerous secreted paracrine factors and immunomodulatory effects. Read More

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Craniosynostosis - A Review for Providers.

S D Med 2021 Feb;74(2):83-88

Sanford Children's Specialty Clinic, Sanford Medical Center, Sioux Falls, South Dakota.

Craniosynostosis is premature fusion of one or more sutures of the cranial vault. Craniosynostosis may occur as an isolated condition or can be syndromic involving multiple body systems. The specific suture affected results in different types of craniosynostosis, each with a characteristic head shape. Read More

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February 2021

Atorvastatin Attenuates Vascular Remodeling in Mice with Metabolic Syndrome.

Arq Bras Cardiol 2021 Jun 18. Epub 2021 Jun 18.

Universidade Federal de Jataí - Unidade Acadêmica de Ciências da Saúde, Jataí, GO - Brasil.

Background: Metabolic syndrome is characterized by an array of comorbidities. During this syndrome, structural changes are observed in the cardiovascular system, especially vascular remodeling. One of the predisposing causes for these changes is chronic inflammation resulting from changes in the structure and composition of perivascular adipose tissue. Read More

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Salivary molecules of bone remodeling and tissue repair after head and neck radiotherapy.

Braz Oral Res 2021 16;35:e079. Epub 2021 Jun 16.

Universidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Oral Surgery and Pathology, Belo Horizonte, MG, Brazil.

Head and neck radiotherapy causes quantitative and qualitative changes in saliva. The objective of this case-control study was to evaluate the salivary biomarkers associated with bone remodeling and tissue repair in patients submitted to radiotherapy for head and neck cancer treatment, compared with non-irradiated individuals. Total unstimulated saliva was collected for ELISA assay analysis of receptor activator for nuclear factor κ B (RANK) and its ligand (RANK-L), osteoprotegerin, matrix metalloproteinase-9/ tissue inhibitor of metalloproteinase-2, vascular endothelial growth factor, and epidermal growth factor. Read More

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CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents.

PLoS One 2021 23;16(6):e0251079. Epub 2021 Jun 23.

Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Platinum sensitivity is an important prognostic factor in patients with ovarian cancer. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a core member of the nucleosome remodeling and deacetylase complex, which functions as a chromatin remodeler. Emerging evidence indicates that CHD4 could be a potential therapeutic target for cancer therapy. Read More

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Bro1 stimulates Vps4 to promote intralumenal vesicle formation during multivesicular body biogenesis.

J Cell Biol 2021 Aug 23;220(8). Epub 2021 Jun 23.

Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN.

Endosomal sorting complexes required for transport (ESCRT-0, -I, -II, -III) execute cargo sorting and intralumenal vesicle (ILV) formation during conversion of endosomes to multivesicular bodies (MVBs). The AAA-ATPase Vps4 regulates the ESCRT-III polymer to facilitate membrane remodeling and ILV scission during MVB biogenesis. Here, we show that the conserved V domain of ESCRT-associated protein Bro1 (the yeast homologue of mammalian proteins ALIX and HD-PTP) directly stimulates Vps4. Read More

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Low body mass is associated with reduced left ventricular mass in Chinese elderly with severe COPD.

Sci Rep 2021 Jun 22;11(1):13074. Epub 2021 Jun 22.

Division of Cardiology, Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.

There is limited information on the association of body mass index (BMI) with left ventricular (LV) remodeling corresponding to severity of reduced lung function in patients with chronic obstructive pulmonary disease (COPD). Therefore, we investigated whether BMI is associated with cardiac atrial and ventricular dimensions according to severity of lung functional impairment in Chinese COPD elderly. A total of 563 hospitalized COPD patients with lung function impairment and 184 patients with non-COPD (aged 65-92 years) were collected retrospectively in a cross-sectional study in a university affiliated tertiary hospital in China. Read More

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Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Down Regulation of sGC and Contributes to Exercise-Induced Pulmonary Hypertension in HFpEF.

Circulation 2021 Jun 23. Epub 2021 Jun 23.

Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA; Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Many patients with heart failure with preserved ejection fraction (HFpEF) have metabolic syndrome and develop exercise-induced pulmonary hypertension (EIPH). Increases in pulmonary vascular resistance in patients with HFpEF portend a poor prognosis; this phenotype is referred to as combined pre-and post-capillary PH (CpcPH). Therapeutic trials for EIPH and CpcPH have been disappointing, suggesting the need for strategies that target upstream mechanisms of disease. Read More

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Clinical Significance of Global Wasted Work in patients with Heart Failure receiving Cardiac Resynchronization Therapy.

J Am Soc Echocardiogr 2021 Jun 19. Epub 2021 Jun 19.

Université Lille Nord de France, GCS-Groupement des Hôpitaux de l'Institut Catholique de Lille, Laboratoire d'échocardiographie, service de cardiologie Nord, Centre des Valvulopathies, Faculté de Médecine et de Maïeutique, Université Catholique de Lille, Lille, France; Centre Hospitalier Universitaire d'Amiens, Amiens, France. Electronic address:

Background: The relationship between myocardial work assessment using pressure-strain loops by echocardiography prior to cardiac resynchronization therapy (CRT) and response to CRT has been recently revealed. Among myocardial work parameters, the impact of left ventricular (LV) myocardial global wasted work (GWW) on response to CRT and outcome following CRT has been seldom studied. Hence, we evaluated here the relationship between preprocedural GWW and outcome in a large prospective cohort of patients with heart failure and reduced ejection fraction (HFrEF) receiving CRT. Read More

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HS alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome.

Int J Cardiol 2021 Jun 19. Epub 2021 Jun 19.

Department of Pharmacy, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441000, Hubei, China. Electronic address:

Background: Vascular remodeling and inflammation are involved in aortic aneurysm (AA) and aortic dissection (AD) . TGF-β1 signaling is involved in tissue fibrosis, extracellular matrix remodeling and inflammation, which are linked with AA and AD. The inhibition of NLRP3 inflammasome suppresses AA and AD. Read More

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Extracellular matrix protein laminin β1 regulates pain sensitivity and anxiodepression-like behaviors in mice.

J Clin Invest 2021 Jun 22. Epub 2021 Jun 22.

Department of Neurobiology, Fourth Military Medical University, Xi'an, China.

Patients with neuropathic pain often experience comorbid psychiatric disorders. Cellular plasticity in the anterior cingulate cortex (ACC) is assumed as a critical interface for pain perception and emotion. However, substantial efforts thus far are focused on intracellular mechanisms of plasticity rather than extracellular alterations that might trigger and facilitate intracellular changes. Read More

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[Evaluation of aqueous cytokine levels in eyes with Fuchs endothelial corneal dystrophy and bullous keratopathy].

Vestn Oftalmol 2021 ;137(3):13-18

Research Institute of Eye Diseases, Moscow, Russia.

Purpose: To evaluate cytokine levels in the aqueous humor (AH) of patients with Fuchs endothelial corneal dystrophy (FECD) and bullous keratopathy (BK).

Material And Methods: The study included 74 patients (74 eyes). The first group consisted of 31 patients (72. Read More

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Yes-associated protein regulates the hepatoprotective effect of vitamin D receptor activation through promoting adaptive bile duct remodeling in cholestatic mice.

J Pathol 2021 Jun 22. Epub 2021 Jun 22.

Department of Cell Biology, School of Medicine, Taizhou University, Taizhou, PR China.

Mounting clinical evidence has revealed that vitamin D receptor (VDR) is associated with cholestatic liver injury, although the functions of VDR in this condition remain largely unexplored. Here, we investigated the effects of VDR activation on bile duct ligation (BDL) mice, and the underlying mechanisms were further investigated. A low-calcemic VDR agonist, paricalcitol (PAL, 200 ng/kg), was intraperitoneally injected into BDL mice every other day for 5 days or 28 days. Read More

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Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells.

Elife 2021 Jun 22;10. Epub 2021 Jun 22.

Naomi Berrie Diabetes Cente, Columbia University, New York, United States.

Background: Marrow adipose tissue (MAT) has been shown to be vital for regulating metabolism and maintaining skeletal homeostasis in the bone marrow (BM) niche. As a reflection of BM remodeling, MAT is highly responsive to nutrient fluctuations, hormonal changes, and metabolic disturbances such as obesity and diabetes mellitus. Expansion of MAT has also been strongly associated with bone loss in mice and humans. Read More

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The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation.

J Am Heart Assoc 2021 Jun 22:e019904. Epub 2021 Jun 22.

Cardiovascular Research Center School of Medicine University of Virginia Charlottesville VA.

Background A hallmark of heart failure is cardiac fibrosis, which results from the injury-induced differentiation response of resident fibroblasts to myofibroblasts that deposit extracellular matrix. During myofibroblast differentiation, fibroblasts progress through polarization stages of early proinflammation, intermediate proliferation, and late maturation, but the regulators of this progression are poorly understood. Planar cell polarity receptors, receptor tyrosine kinase-like orphan receptor 1 and 2 (Ror1/2), can function to promote cell differentiation and transformation. Read More

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Early inhibition of subchondral bone remodeling slows load-induced post-traumatic osteoarthritis development in mice.

J Bone Miner Res 2021 Jun 22. Epub 2021 Jun 22.

Cornell University, Ithaca, New York.

Post-traumatic osteoarthritis (PTOA) is associated with abnormal and increased subchondral bone remodeling. Inhibiting altered remodeling immediately following joint damage can slow PTOA progression. Clinically, however, inhibiting remodeling when significant joint damage is already present has minimal effects in slowing further disease progression. Read More

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Cardiac Tissue Factor Regulates Inflammation, Hypertrophy and Heart Failure in Mouse Model of .

Diabetes 2021 Jun 21. Epub 2021 Jun 21.

Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore.

Diabetes patients have an increased risk of heart failure (HF). Diabetes is highly prevalent in HF with preserved ejection fraction (HFpEF), which is on the rise worldwide. The role of diabetes in HF is less established and available treatments of HF are not effective in HFpEF patients. Read More

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Activities of matrix metalloproteinase-2 and -9 in amniotic fluid at parturition in mares with normal and high-risk pregnancy.

Theriogenology 2021 Jun 16;172:116-122. Epub 2021 Jun 16.

Department of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano dell'Emilia, Bologna, Italy; Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano dell'Emilia, Bologna, Italy.

The matrix metalloproteinases (MMPs) are a family of enzymes involved in extracellular matrix remodeling. MMPs are secreted in a latent form and activated by local and infiltrating cells. MMP-2 and -9 are the most studied in reproduction and have been detected in bovine, ovine, equine and human placenta. Read More

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The Long Road to Understanding RNAPII Transcription Initiation and Related Syndromes.

Annu Rev Biochem 2021 Jun;90:193-219

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, Université de Strasbourg, 67404 Illkirch CEDEX, Commune Urbaine de Strasbourg, France; email:

In eukaryotes, transcription of protein-coding genes requires the assembly at core promoters of a large preinitiation machinery containing RNA polymerase II (RNAPII) and general transcription factors (GTFs). Transcription is potentiated by regulatory elements called enhancers, which are recognized by specific DNA-binding transcription factors that recruit cofactors and convey, following chromatin remodeling, the activating cues to the preinitiation complex. This review summarizes nearly five decades of work on transcription initiation by describing the sequential recruitment of diverse molecular players including the GTFs, the Mediator complex, and DNA repair factors that support RNAPII to enable RNA synthesis. Read More

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