10,520 results match your criteria associated pol

European registry of type A aortic dissection (ERTAAD) - rationale, design and definition criteria.

J Cardiothorac Surg 2021 Jun 10;16(1):171. Epub 2021 Jun 10.

Leipzig Heart center, Leipzig, Germany.

Background: Acute Stanford type A aortic dissection (TAAD) is a life-threatening condition. Surgery is usually performed as a salvage procedure and is associated with significant postoperative early mortality and morbidity. Understanding the patient's conditions and treatment strategies which are associated with these adverse events is essential for an appropriate management of acute TAAD. Read More

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HIV-1 Gag recruits oligomeric Vpr via two binding sites in p6, but both mature p6 and Vpr are rapidly lost upon target cell entry.

J Virol 2021 Jun 9:JVI0055421. Epub 2021 Jun 9.

Retroviral Replication Laboratory, The Francis Crick Institute, London, NW1 1AT, United Kingdom.

The p12 region of MLV Gag and the p6 region of HIV-1 Gag contain late-domains required for virus budding. Additionally, the accessory protein Vpr is recruited into HIV particles via p6. Mature p12 is essential for early viral replication events, but the role of mature p6 in early replication is unknown. Read More

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The influence of preincubation time of prepared sperm before IVF on fertilization, embryo developmental competence and the reproductive outcomes.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Department of Obstetrics and Gynecology, The First Medical Center of PLA General Hospital, Medical School of Chinese PLA, Beijing, China.

Objectives: It has been provided that if incubation time of prepared sperm can affect sperm motility and DNA fragment, but little is known about the influence of sperm preincubation time (SI) on the sperm's fertilizing ability, subsequent embryonic development and pregnancy outcomes in in vitro fertilization (IVF). The aim of this study was to explore the association of SI with fertilization rate, embryo development and clinical outcomes in IVF, further, to find an optimal preincubation time for prepared sperm before insemination in IVF.

Material And Methods: This retrospective cohort study included a total of 1453 infertile couples undergoing IVF in our center performed from January 2016 to January 2019. Read More

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Perinatal and neonatal outcome in patients with preeclampsia.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

International Centre for Cancer Vaccine Science Cancer Immunology Group, University of Gdansk, Poland.

Objectives: Preeclampsia (PE) affects 2-5% of pregnant women. Hypertensive disorders of pregnancy are associated with adverse maternal and perinatal outcomes.

Material And Methods: This study included 88 women showing gestational hypertension (GH) or PE symptoms, and their newborns. Read More

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Serum S100B Protein Concentrations in SGA/FGR newborns.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Department of Neonatology, Children Clinical Hospital, Medical University of Warsaw, Poland.

Objectives: Fetal growth restriction is associated with chronic fetal hypoxia, poor perinatal outcome and increased perinatal mortality. There are no reliable methods to detect cell damage in the central nervous system (CNS) in these patients. The findings of increased an acidic calcium-binding protein (S100B) concentration in biological fluids of infants after brain injury have supported the use of S100B as a biochemical marker of CNS damage. Read More

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Impact of clinicopathological variables on laparoscopic hysterectomy complications, a tertiary center experience.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Objectives: To analyze intraoperative and postoperative complications according to Clavian-Dindo Classification (CDC) and evaluate the influence of clinicopathological features on the feasibility and safety of total laparoscopic hysterectomy (TLH) in patients that underwent surgery in a tertiary center.

Material And Methods: We retrospectively reviewed the database of 469 patients that underwent surgery for patients who underwent extra facial TLH from 2013 to 2020.

Results: A total of 86 (18. Read More

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Role of tumor location on high-grade serous ovarian cancer prognosis.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Istanbul Medeniyet University.

Objectives: Ovarian cancer is associated with the highest mortality of gynecologic cancers. Epidemiological and genetic factors of ovarian cancer development are clearly defined but prognostic factors have not been adequately identified. Right and left ovarian cancers seem to act different behaviors at high-grade serous ovarian cancer (HGSOC) prognosis. Read More

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The assessment of cognitive and behavioural disturbances in vascular cognitive impairment (VCI) - recommendations of an expert working group.

Neurol Neurochir Pol 2021 Jun 7. Epub 2021 Jun 7.

Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

With newer research-based classification systems, the term Vascular Cognitive Impairment (VCI) is now preferred to vascular dementia. VCI is an umbrella term that includes all forms of cognitive deficits ranging from mild cognitive impairment of vascular origin (VaMCI) to vascular dementia (VaD). The new VCI construct takes into account the fact that in addition to single strategic infarcts, multiple infarcts, and leukoaraiosis, there are other mechanisms of cerebrovascular disease such as chronic hypoperfusion that might account for the pattern of cognitive deficits associated with vascular dementia. Read More

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Percutaneous ultrasound-guided plugged liver biopsy - a single-centre experience.

Pol J Radiol 2021 26;86:e239-e245. Epub 2021 Apr 26.

Gleneagle Global Hospital, India.

Background: Liver biopsy is a widely used, safe diagnostic tool utilised by clinicians for the histopathological assessment of the liver. Our study aims to report our experience in patients who underwent ultrasound-guided plugged percutaneous liver biopsy in a tertiary care hospital in India.

Material And Methods: The Institutional Ethical Review Board approved this retrospective study, and informed consent was obtained from all the patients. Read More

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Toxic Anterior Segment Syndrome After an Uncomplicated Vitrectomy With Epiretinal Membrane Peeling.

Piotr Kanclerz

Cureus 2021 Apr 13;13(4):e14464. Epub 2021 Apr 13.

Ophthalmology, Hygeia Clinic, Gdansk, POL.

Infectious endophthalmitis is the most devastating complication of eye surgery and is associated with severe inflammation of ocular tissues. This study aimed to present a similar condition, a case of toxic anterior segment syndrome (TASS) after an uncomplicated vitrectomy. A 69-year-old woman presented with epiretinal membrane and underwent 25-gauge pars plana vitrectomy with membrane peeling in her left eye. Read More

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Ononin induces cell apoptosis and reduces inflammation in rheumatoid arthritis fibroblast-like synoviocytes by alleviating MAPK and NF-κB signaling pathways.

Acta Biochim Pol 2021 Jun;68(2):239-245

Department of Joint Surgery, The Fifth Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong Province, 510900, China.

As a kind of chronic inflammatory diseases, Rheumatoid arthritis (RA) has a low cure rate and easy recurrence. It has widely reported that abnormal activation of mitogen-activated protein kinase (MAPK) and nuclear factor kappa-B (NF-κB) signaling pathways are associated with the development of RA inflammation. Blocking the inflammatory signaling pathways of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) can delay the development of RA. Read More

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CX-5461 Enhances the Efficacy of APR-246 via Induction of DNA Damage and Replication Stress in Triple-Negative Breast Cancer.

Int J Mol Sci 2021 May 28;22(11). Epub 2021 May 28.

QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD 4006, Australia.

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer lacking targeted therapy. Here, we evaluated the anti-cancer activity of APR-246, a P53 activator, and CX-5461, a RNA polymerase I inhibitor, in the treatment of TNBC cells. We tested the efficacy of individual and combination therapy of CX-5461 and APR-246 in vitro, using a panel of breast cancer cell lines. Read More

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The Ribosomal Gene Loci-The Power behind the Throne.

Genes (Basel) 2021 May 18;12(5). Epub 2021 May 18.

ACRF Department of Cancer Biology and Therapeutics, John Curtin School of Medical Research, Australian National University, Acton 2601, Australia.

Nucleoli form around actively transcribed ribosomal RNA (rRNA) genes (rDNA), and the morphology and location of nucleolus-associated genomic domains (NADs) are linked to the RNA Polymerase I (Pol I) transcription status. The number of rDNA repeats (and the proportion of actively transcribed rRNA genes) is variable between cell types, individuals and disease state. Substantial changes in nucleolar morphology and size accompanied by concomitant changes in the Pol I transcription rate have long been documented during normal cell cycle progression, development and malignant transformation. Read More

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JC Virus Seroprevalence and JCVAb Index in Polish Multiple Sclerosis Patients Treated with Immunomodulating or Immunosuppressive Therapies.

J Clin Med 2021 May 6;10(9). Epub 2021 May 6.

Department of Neurology, Medical University of Lublin, 20-090 Lublin, Poland.

The use of a highly-effective treatment for multiple sclerosis (MS) is associated with a severe risk of developing complications, such as progressive multifocal leukoencephalopathy (PML) caused by the John Cunningham virus (JCV). The aim of this study was to evaluate the correlation between anti-JCV Ab seroprevalence, anti-JCV AI, demographic and clinical factors as well as the type of therapy used in the Polish MS population. This is a multicentre, prospective and cross-sectional study involving 1405 MS patients. Read More

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Molecular Diagnosis of Koala Retrovirus (KoRV) in South Australian Koalas ().

Animals (Basel) 2021 May 20;11(5). Epub 2021 May 20.

School of Animal and Veterinary Sciences, University of Adelaide, Roseworthy 5371, Australia.

Koala retrovirus, a recent discovery in Australian koalas, is endogenised in 100% of northern koalas but has lower prevalence in southern populations, with lower proviral and viral loads, and an undetermined level of endogenisation. KoRV has been associated with lymphoid neoplasia, e.g. Read More

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Is cytisine contraindicated in smoking patients with coronary artery disease after percutaneous coronary intervention?

Kardiol Pol 2021 Jun 1. Epub 2021 Jun 1.

Department of Cardiology, Centre of Postgraduate Medical Education, Warszawa, Poland.

Background: Cytisine is contraindicated and its effects have not been evaluated in patients with coronary artery disease (CAD).

Aim: The safety, feasibility and short-term efficacy of cytisine for smoking cessation were evaluated in active smokers with CAD after percutaneous coronary interventions (PCI).

Methods: Patients with stable CAD and acute coronary syndromes (ACS), who smoked at least 10 cigarettes per day, were included 30 days post PCI and offered cytisine therapy. Read More

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ARS2/SRRT: at the nexus of RNA polymerase II transcription, transcript maturation and quality control.

Biochem Soc Trans 2021 Jun 1. Epub 2021 Jun 1.

Aarhus University, Aarhus, Denmark.

ARS2/SRRT is an essential eukaryotic protein that has emerged as a critical factor in the sorting of functional from non-functional RNA polymerase II (Pol II) transcripts. Through its interaction with the Cap Binding Complex (CBC), it associates with the cap of newly made RNAs and acts as a hub for competitive exchanges of protein factors that ultimately determine the fate of the associated RNA. The central position of the protein within the nuclear gene expression machinery likely explains why its depletion causes a broad range of phenotypes, yet an exact function of the protein remains elusive. Read More

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Lymphocytic gastritis and celiac disease.

Pol J Pathol 2021 ;72(1):87-88

Gastroenterology Unit. Department of Life, Health and Environmental Sciences. University of L'Aquila, L'Aquila, Italy.

We read with great interest the review article "Lymphocytic gastritis" by Puderecki et al., which was recently published in your journal [1]. The article describes the features of lymphocytic gastritis (LG), a rare form of gastritis with unclear pathogenesis. Read More

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Morphological features of non-parenchymal liver cells of full-term stillbirths from HIV-mono-infected mothers.

Pol J Pathol 2021 ;72(1):57-63

Human Anatomy Department, Medical School, V.N. Karazin Kharkiv National University, Kharkiv, Ukraine.

Fifty-one liver tissue biopsies of full-term stillbirths from HIV-mono-infected mothers were investigated. All morphometric indices of non-parenchymal liver cells were calculated using the Avtandilov microscopic morphometric grid, which consisted of 100 equidistant points. It was inserted into the microscope ocular tube with a total × 200 microscope magnification. Read More

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Activation of the P38-MSK1 axis in colorectal adenocarcinoma determines a good prognostic outcome.

Pol J Pathol 2021 ;72(1):39-47

Assistant professor of Pathology, Faculty of Medicine, Minia University, Minia, Egypt.

Colorectal cancer (CRC) is the third most common cancer worldwide and is associated with a high level of mortality and morbidity. In this study we evaluate expression of p-p38 and p-MSK1 in CRC and determine whether there is an association between expression of these markers and any clinicopathologic parameters that could be of prognostic value. Expression of p-p38, p-MSK1 and ki-67 were examined by immunohistochemistry in 135 archival CRC cases and the findings were correlated with the patient clinicopathological data. Read More

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Prognostic and clinicopathological implications of expression of Beclin-1 and hypoxia-inducible factor 1α in serous ovarian carcinoma: an immunohistochemical study.

Pol J Pathol 2021 ;72(1):23-38

Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Serous ovarian carcinoma (SOC) is an ovarian cancer with a high fatality rate. Therefore, a lot of researchers have tried to identify novel prognostic biomarkers which might improve the patient prognosis. The aims of the study were to detect the tissue protein expression of Beclin-1 in addition to HIF-1α in SOC patients, to evaluate the relationship between their expression, the clinicopathological parameters, patients' prognosis, and the relation to chemotherapy resistance in SOC. Read More

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The diagnostic utility of INSM1 and GATA3 in discriminating problematic medullary thyroid carcinoma, thyroid and parathyroid lesions.

Pol J Pathol 2021 ;72(1):11-22

Department of Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Discriminating thyroid and parathyroid lesions may sometimes pose a diagnostic difficulty. Medullary thyroid carcinomas (MTCs) display various cytologic and architectural features that resemble other thyroid and even rarely some parathyroid neoplasms. Moreover, some MTCs may have negative serum calcitonin, rendering them difficult to diagnose. Read More

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Cardiac dysfunction associated with consumptive hypothyroidism in a case of hepatic hemangioma: case report.

Endokrynol Pol 2021 May 31. Epub 2021 May 31.

Department of Pediatric, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,China, 109 West Xueyuan Road, Wenzhou, Zhejiang 325027, P.R. China, 325027 Zhejiang, China.

Background: Infantile hepatic hemangiomas (IHHs) are the most common liver tumor in infancy. And they have proved to lead to cardiac insufficiency and consumptive hypothyroidism.

Case Presentation: A two-month-old girl had two purple skin lesions. Read More

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Serum zonulin levels in type 2 diabetes patients with diabetic kidney disease.

Endokrynol Pol 2021 May 31. Epub 2021 May 31.

Department of Medical Biochemistry, Faculty of Medicine, Suleyman Demirel University, 32260 Isparta, Turkey.

Introduction: Recent data has shown that diabetic kidney disease is associated with abnormal gut microbiota composition. Zonulin is a physiological tight junction modulator and an intestinal permeability marker. In this study we aimed to investigate serum levels of zonulin and interleukin 6 (IL-6) in patients with type 2 diabetes mellitus and different levels of albuminuria. Read More

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Battery for deep brain stimulation depletion in Parkinson's Disease and dystonia patients - a systematic review.

Neurol Neurochir Pol 2021 May 31. Epub 2021 May 31.

Neurology&Stroke Dpt., St. Adalbert Hospital, Gdańsk, Poland.

Introduction: Deep brain stimulation (DBS) therapy for Parkinson's Disease (PD) and dystonia is associated with the possibility of both minor and major complications. One possible side effect is the depletion of implantable pulse generator (IPG) battery and the associated sudden recurrence of PD or dystonia symptoms, which can be potentially life-threatening. Delayed or postponed outpatient visits due to COVID -19 may be a risk factor of battery end-of-life consequences. Read More

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Regulation of RNA Polymerase II Transcription Initiation and Elongation by Transcription Factor TFII-I.

Front Mol Biosci 2021 13;8:681550. Epub 2021 May 13.

Department of Biochemistry and Molecular Biology, College of Medicine, UF Health Cancer Center, Genetics Institute, Powell Gene Therapy Center, University of Florida, Gainesville, FL, United States.

Transcription by RNA polymerase II (Pol II) is regulated by different processes, including alterations in chromatin structure, interactions between distal regulatory elements and promoters, formation of transcription domains enriched for Pol II and co-regulators, and mechanisms involved in the initiation, elongation, and termination steps of transcription. Transcription factor TFII-I, originally identified as an initiator (INR)-binding protein, contains multiple protein-protein interaction domains and plays diverse roles in the regulation of transcription. Genome-wide analysis revealed that TFII-I associates with expressed as well as repressed genes. Read More

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The impact of donor pancreas extraction time on graft survival and postoperative complications in pancreas transplant recipients.

Pancreatology 2021 May 9. Epub 2021 May 9.

Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Background: Simultaneous pancreas kidney transplantation (SPK) is the best therapeutic option for patients with diabetes mellitus type 1 and end-stage renal disease. Recently, donor organ extraction time has been shown to affect kidney and liver graft survival. This study aimed to assess the effect of pancreas donor extraction time on graft survival and postoperative complications. Read More

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Movement disorders associated with chromosomal aberrations diagnosed in adult patients.

Neurol Neurochir Pol 2021 May 26. Epub 2021 May 26.

Department of Neurology, Faculty of Health Science, Medical University of Warsaw, Kondratowicza 8, 03-242 Warsaw, Poland.

Introduction: Chromosomal aberrations are rare but important causes of various movement disorders. In cases of movement disorders associated with dysmorphic features, multiorgan involvement and/or intellectual disability, the identification of causative chromosomal aberrations should be considered.

Aim Of The Study: The purpose of this article was to summarise clinical findings in six patients with dystonia and two with parkinsonism and identified chromosomal aberrations in a single-centre prospective study. Read More

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Cardiovascular dysautonomia and cognition in Parkinson's Disease - a possible relationship.

Neurol Neurochir Pol 2021 May 26. Epub 2021 May 26.

Department of Neurological Psychiatric Nursing, Medical University of Gdansk, Poland, ul. M. Skłodowskiej-Curie 3a, 80-210 Gdańsk, Poland.

Dementia in advanced Parkinson's Disease (PD) is a fatal milestone resulting in reduced life expectancy and nursing home placement. Cognitive impairment and cardiovascular dysautonomia are common and debilitating non-motor symptoms that frequently coexist in PD since the early stages and progress in subsequent years. In particular, blood pressure (BP) abnormalities, including orthostatic hypotension (OH), supine hypertension (SH) and the loss of nocturnal BP fall (non-dipping) in PD have been associated with cognitive deterioration. Read More

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Frailty and Kidney Transplantation: A Systematic Review and Meta-analysis.

Transplant Direct 2021 Jun 18;7(6):e701. Epub 2021 May 18.

Division of Transplantation Surgery, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Frailty is a multidimensional condition and is the result of the body's age-associated decline in physical, cognitive, physiological, and immune reserves. The aim of this systematic review is to assess the quality of evidence of the included studies, determine the prevalence of frailty among kidney transplant candidates, and evaluate the relationship between frailty and associated patient characteristics and outcomes after kidney transplantation.

Methods: A systematic search was performed for relevant literature on frailty and kidney transplantation. Read More

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