501,698 results match your criteria associated lower


Post-diagnostic reliance on plant-compared with animal-based foods and all-cause mortality in omnivorous long-term colorectal cancer survivors.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Institute of Epidemiology, University Hospital Schleswig-Holstein, University of Kiel, Kiel, Germany.

Background: Plant-rich diets are associated with lower cardiometabolic risks and longer survival in the general population, but their association with mortality in cancer survivors is still unclear.

Objectives: We aimed to examine the associations of 3 postdiagnostic plant-based diet indices with all-cause mortality in omnivorous long-term colorectal cancer (CRC) survivors.

Methods: Diet was assessed with FFQs at a median of 6 years after diagnosis in 1404 CRC survivors (56% male; median age, 69 years) in a Northern German prospective cohort study. Read More

View Article and Full-Text PDF

Association of food insecurity with dietary intakes and nutritional biomarkers among US children, National Health and Nutrition Examination Survey (NHANES) 2011-2016.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Department of Nutrition Science, Purdue University, West Lafayette, IN, USA.

Background: Food insecurity is associated with poorer nutrient intakes from food sources and lower dietary supplement use. However, its association with total usual nutrient intakes, inclusive of dietary supplements, and biomarkers of nutritional status among US children remains unknown.

Objective: The objective was to assess total usual nutrient intakes, Healthy Eating Index-2015 (HEI-2015) scores, and nutritional biomarkers by food security status, sex, and age among US children. Read More

View Article and Full-Text PDF

Metabolic risk factors, genetic predisposition, and risk of severe liver disease in Chinese: a prospective study of 0.5 million people.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.

Background: Metabolic risk factors have been shown to be associated with severe liver disease (SLD) in Chinese populations. However, there is limited evidence on the combined impact of these factors, or the genetic variants associated with SLD.

Objectives: We examined the associations of combined metabolic risk factors with risks of SLD, both overall and by genetic predisposition to SLD. Read More

View Article and Full-Text PDF

Association of obesity-related inflammatory pathways with lung function and exercise capacity.

Respir Med 2021 Apr 30;183:106434. Epub 2021 Apr 30.

From the Cardiovascular Research Center, Division of Massachusetts General Hospital, Boston, MA, USA; Cardiology Division of Massachusetts General Hospital, Boston, MA, USA. Electronic address:

Background: Obesity has multifactorial effects on lung function and exercise capacity. The contributions of obesity-related inflammatory pathways to alterations in lung function remain unclear.

Research Question: To examine the association of obesity-related inflammatory pathways with pulmonary function, exercise capacity, and pulmonary-specific contributors to exercise intolerance. Read More

View Article and Full-Text PDF

Longitudinal changes in HRV across pregnancy and postpartum: Effect of negative partner relationship qualities.

Psychoneuroendocrinology 2021 Apr 21;129:105216. Epub 2021 Apr 21.

Department of Psychiatry & Behavioral Health and the Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

During pregnancy, there are significant physiological changes to support a healthy fetus. Parasympathetic activity normatively decreases across pregnancy, and psychological stress can promote even further decreased heart rate variability (HRV). This study evaluated (1) changes in vagally-mediated HRV from pregnancy to postpartum, (2) changes in vagally-mediated HRV from pregnancy to postpartum based on negative partner relationship qualities, and (3) changes in depressive symptoms from pregnancy to postpartum based on negative partner relationship qualities. Read More

View Article and Full-Text PDF

Shorter outpatient wait-times for buprenorphine are associated with linkage to care post-hospital discharge.

Drug Alcohol Depend 2021 Apr 20;224:108703. Epub 2021 Apr 20.

Department of Medicine, Boston University School of Medicine, 801 Massachusetts Ave, Boston, MA, 02118, USA.

Background: Inpatient addiction consult services (ACS) lower barriers to accessing medications for opioid use disorder (MOUD), however not every patient recommended for MOUD links to outpatient care. We hypothesized that fewer days between discharge date and outpatient appointment date was associated with improved linkage to buprenorphine treatment among patients evaluated by an ACS.

Methods: We extracted appointment and demographic data from electronic medical records and conducted retrospective chart review of adults diagnosed with opioid use disorder (OUD) evaluated by an ACS in Boston, MA between July 2015 and August 2017. Read More

View Article and Full-Text PDF

The association between treatment and systemic inflammation in acromegaly.

Growth Horm IGF Res 2021 Apr 30;57-58:101391. Epub 2021 Apr 30.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

Objective: Acromegaly is characterized by an excess of growth hormone (GH) and insulin like growth-factor 1 (IGF1), and it is strongly associated with cardiovascular diseases (CVD). Both acute and long-lasting pro-inflammatory effects have been attributed to IGF1. Previous results suggest the presence of systemic inflammation in treated patients. Read More

View Article and Full-Text PDF

Cognitive network hyperactivation and motor cortex decline correlate with ALS prognosis.

Neurobiol Aging 2021 Mar 10;104:57-70. Epub 2021 Mar 10.

Academic Unit of Neurology, Trinity College Dublin, the University of Dublin, Dublin 2, Ireland.

We aimed to quantitatively characterize progressive brain network disruption in Amyotrophic Lateral Sclerosis (ALS) during cognition using the mismatch negativity (MMN), an electrophysiological index of attention switching. We measured the MMN using 128-channel EEG longitudinally (2-5 timepoints) in 60 ALS patients and cross-sectionally in 62 healthy controls. Using dipole fitting and linearly constrained minimum variance beamforming we investigated cortical source activity changes over time. Read More

View Article and Full-Text PDF

COVID-19 Related Symptoms of Anxiety, Depression, and PTSD among US Adults.

Psychiatry Res 2021 Apr 24;301:113959. Epub 2021 Apr 24.

Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, NY, USA. Electronic address:

During the COVID-19 pandemic, social distancing measures often result in individual isolation, which can lead to adverse mental outcomes. We collected online questionnaires from 3,952 US adults to examine the impact of "shelter-in-place" guidelines on mental health, and to explore potential disparities and modifiable factors. Self-reported anxiety, depression, and PTSD symptoms were associated with more restrictive quarantine. Read More

View Article and Full-Text PDF

The "celebrity canary in the coal mine for the coronavirus": An examination of a theoretical model of celebrity illness disclosure effects.

Soc Sci Med 2021 Apr 28;279:113963. Epub 2021 Apr 28.

Murrow College of Communication, 208 Goertzen Hall, PO BOX 642530, Pullman, WA, 99164, USA. Electronic address:

Rationale: On March 11, 2020, actor Tom Hanks announced via social media that he had been diagnosed with COVID-19. Previous research has found celebrity illness disclosures to influence behavior, but during the uncertainty of a pandemic, the effects of such a disclosure were unclear.

Objective: To test the proposed Celebrity Illness Disclosure Effects (CIDE) model, demonstrating how an illness disclosure, communicated through mediated and interpersonal channels, may shape willingness to engage in prevention behaviors. Read More

View Article and Full-Text PDF

Risk factors for dementia development, frailty, and mortality in older adults with epilepsy - A population-based analysis.

Epilepsy Behav 2021 May 5;120:108006. Epub 2021 May 5.

Department of Medicine, University of Calgary, North Tower, 1403-29 St NW, Calgary, AB T2N 2T9, Canada; Department of Community Health Sciences, University of Calgary, 3D10 - 3280 Hospital Drive NW, Calgary, AB T2N 4Z6, Canada; Hotchkiss Brain Institute, University of Calgary, 1A10 - 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada; Alberta Health Services, Foothills Medical Centre, 1403-29 St. NW, Calgary, Alberta T2N 2T9, Canada; O'Brien Institute for Public Health, University of Calgary, 3rd Floor TRW Building, 3280 Hospital Drive NW, Calgary, AB T2N 4Z6, Canada. Electronic address:

Objective: Although the prevalence of comorbid epilepsy and dementia is expected to increase, the impact is not well understood. Our objectives were to examine risk factors associated with incident dementia and the impact of frailty and dementia on mortality in older adults with epilepsy.

Methods: The CALIBER scientific platform was used. Read More

View Article and Full-Text PDF

Differential risks of changes in seizure frequency with transitions between hormonal and non-hormonal contraception in women with epilepsy: A prospective cohort study.

Epilepsy Behav 2021 May 5;120:108011. Epub 2021 May 5.

Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, MA, United States.

This prospective, observational, cohort study of 101 women with epilepsy (WWE) assesses the seizure safety of systemic hormonal contraception (HC) versus non-HC (NHC). It reports risks of changes in seizure frequency associated with transition from NHC to HC relative to HC to NHC for (1) proportions of WWE with ≥50% increase and decrease in seizure frequency, (2) changes in seizure frequency, (3) changes in seizure severity, and 4) changes in AED regimen during the study. In comparing NHC to HC versus HC to NHC, NHC to HC had greater risk of ≥50% increase in seizure frequency: RR = 1. Read More

View Article and Full-Text PDF

Encephalocele-Associated Drug Resistant Epilepsy of Adult-Onset: Diagnosis, Management, and Outcomes.

World Neurosurg 2021 May 5. Epub 2021 May 5.

Epileptogenic encephaloceles, most frequently located in the temporal lobe, are a known lesional cause of focal epilepsy. Data are limited regarding diagnosis, management, and outcomes of patients with epilepsy in the setting of an encephalocele, as the literature is mostly comprised of case reports, case series, and retrospective studies. We conducted a broad literature review for manuscripts related to encephaloceles and epilepsy regardless of level of evidence. Read More

View Article and Full-Text PDF

Cross-sectional association of meal skipping with lipid profiles and blood glucose in Chinese adults.

Nutrition 2021 Mar 17;90:111245. Epub 2021 Mar 17.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Beijing, China. Electronic address:

Objectives: There is an increasing trend of skipping meals, especially breakfast and dinner, in China. Previous studies on the association of meal skipping with lipid profiles and blood glucose have yielded inconsistent results.

Methods: A national representative survey of 47 841 adults (age ≥ 45 y) was conducted in China. Read More

View Article and Full-Text PDF

Adipocyte Inducible 6-phosphofructo-2-kinase Suppresses Adipose Tissue Inflammation and Promotes Macrophage Anti-inflammatory Activation.

J Nutr Biochem 2021 May 5:108764. Epub 2021 May 5.

Department of Nutrition, Texas A&M University, College Station, TX, USA. Electronic address:

Obesity-associated inflammation in white adipose tissue (WAT) is a causal factor of systemic insulin resistance. To better understand how adipocytes regulate WAT inflammation, the present study generated chimeric mice in which inducible 6-phosphofructo-2-kinase (iPfk2) was low, normal, or high in WAT while the expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (Pfkfb3) was normal in hematopoietic cells, and analyzed changes in high-fat diet (HFD)-induced WAT inflammation and systemic insulin resistance in the mice. Indicated by proinflammatory signaling and cytokine expression, the severity of HFD-induced WAT inflammation in WT → Pfkfb3 mice, whose Pfkfb3 was disrupted in WAT adipocytes but not hematopoietic cells, was comparable with that in WT → WT mice, whose Pfkfb3 was normal in all cells. Read More

View Article and Full-Text PDF

Congenital eyelid imbrication syndrome with microphthalmia: a case report.

J AAPOS 2021 May 5. Epub 2021 May 5.

Department of Pediatric Ophthalmology and Strabismus, Sankara Nethralaya, Chennai, Tamil Nadu, India.

In congenital eyelid imbrication syndrome, a rare condition, the upper eyelids override the lower lids. It has been described in the literature either as an isolated entity or associated with floppy eyelid syndrome. We report the case of a 2-month-old with congenital eyelid imbrication syndrome associated with complex microphthalmos in the same eye and persistent fetal vasculature in the other eye, with no other systemic abnormality. Read More

View Article and Full-Text PDF

Outcomes of Posterior Labral Repair with or without Concomitant High-Grade Glenohumeral Chondral Pathology: a retrospective cohort with minimum 2-year follow-up.

J Shoulder Elbow Surg 2021 May 5. Epub 2021 May 5.

Carolinas Medical Center, Atrium Musculoskeletal Institute, 1025 Morehead Medical Dr., Suite #300, Charlotte, NC, 28204, USA. Electronic address:

Background: The purpose of this study was to compare outcomes of patients who underwent posterior labral repair with and without concomitant glenohumeral chondral pathology.

Methods: A retrospective review was performed on patients ≥ 18 years of age who underwent primary posterior labral repair over 5 years. Charts were reviewed to determine the presence and location of high-grade (Outerbridge Grade III/IV) pathology. Read More

View Article and Full-Text PDF

Ozone therapy versus surgery for lumbar disc herniation: a randomized double-blind controlled trial.

Complement Ther Med 2021 May 5:102724. Epub 2021 May 5.

Research Network on Health Services in Chronic Diseases (REDISSEC), Madrid, Spain; Canary Islands Health Research Institute Foundation (FIISC), Tenerife, Spain; Evaluation Unit of the Canary Islands Health Service (SESCS), Tenerife, Spain.

Objectives: Surgery is the treatment of choice for symptomatic disc herniation after conservative management. Several studies have suggested the potential utility of intradiscal ozone infiltration in this pathology. The aim of this trial was to compare intradiscal ozone infiltration vs. Read More

View Article and Full-Text PDF

Morphological and transcriptomic alterations in neonatal lamb testes following developmental exposure to low-level environmental chemical mixture.

Environ Toxicol Pharmacol 2021 May 5:103670. Epub 2021 May 5.

School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK. Electronic address:

Exposure to anthropogenic environmental chemical mixtures could be contributing to the decline in male reproductive health. This study used the biosolid treated pasture (BTP) sheep model to assess the effects of exposure to low-dose chemical mixtures. Maternal BTP exposure was associated with lower plasma testosterone concentrations, a greater proportion of Sertoli cell-only seminiferous tubules, and fewer gonocytes in the testes of neonatal offspring. Read More

View Article and Full-Text PDF

Establishing the Minimal Clinically Important Difference and Patient-Acceptable Symptomatic State after Arthroscopic Meniscal Repair and Associated Variables for Achievement.

Arthroscopy 2021 May 5. Epub 2021 May 5.

Rush University Medical Center Department of Orthopedic Surgery, Chicago, IL, USA. Electronic address:

Purpose: The purpose of this study is to establish the minimal clinically important difference (MCID) and patient-acceptable symptomatic state (PASS) after arthroscopic meniscal repair and identify the factors associated with achieving these outcomes.

Methods: This is a retrospective study with prospectively collected data. Patient-reported outcome measures (PROMs) were collected from April 2017 to March 2020. Read More

View Article and Full-Text PDF

An increased posterior slope of the medial and lateral meniscus posterior horn is associated with anterior cruciate ligament injuries.

Arthroscopy 2021 May 5. Epub 2021 May 5.

Department of Anatomy, School of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa; Department of Anatomy and Cellular Biology, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates.

Purpose: The purpose of this study was to measure slope of both the medial and lateral posterior horn of the meniscus, and its contribution to the overall resulting posterior tibial slope (bone and meniscus combined slope) in ACL-intact (ACLI) and ACL-deficient (ACLD) knees.

Methods: MR images of patients with intact menisci aged between 16-60 years were included. Posterior tibial bone slope (PTS) and meniscus slope (MS) were measured at 25%, 50%, and 75% from the medial and lateral borders of the tibial plateau. Read More

View Article and Full-Text PDF

Comparison of clinical efficacy of neoadjuvant chemoradiotherapy between lower and higher radiation dose for carcinoma of the esophagus and gastroesophageal junction: a systematic review.

Int J Radiat Oncol Biol Phys 2021 May 5. Epub 2021 May 5.

Department of Radio-Chemotherapy, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou City, Jiangsu Province, China. Electronic address:

Background: Neoadjuvant concurrent chemoradiotherapy (nCRT) plus surgery has been a standard treatment for locoregionally advanced esophageal cancer and carcinoma of the gastroesophageal junction (EC/GEJ), but an optimal preoperative radiation dose is still unclear.

Purpose: We performed this systematic review to explore the treatment efficacy and toxicity of different radiation dose levels and find an optimal dose-fractionation strategy in EC/GEJ patients receiving nCRT.

Methods: Embase and Ovid Medline were searched for articles involving operable squamous and adenocarcinoma of the esophagus and GEJ receiving nCRT up to a dose of 50. Read More

View Article and Full-Text PDF

Sar1b mutant mice recapitulate gastrointestinal abnormalities associated with chylomicron retention disease.

J Lipid Res 2021 May 5:100085. Epub 2021 May 5.

Research Center, CHU Ste-Justine; Departments of Pharmacology & Physiology,; Nutrition. Electronic address:

Chylomicron retention disease (CRD) is an autosomal recessive disorder associated with biallelic Sar1b mutations leading to defects in intracellular chylomicron (CM) trafficking and secretion. To date, a direct cause-effect relationship between CRD and Sar1b mutation has not been established, but genetically modified animal models provide an opportunity to elucidate unrecognized aspects of these mutations. To examine the physiological role and molecular mechanisms of Sar1b function, we generated mice expressing either a targeted deletion or mutation of human Sar1b using the CRISPR/Cas9 system. Read More

View Article and Full-Text PDF

Comparison of First Nations and non-First Nations children's profiles with bronchiectasis over two five-year periods from the Northern Territory, Australia.

Chest 2021 May 5. Epub 2021 May 5.

Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia; Australian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, QLD, Australia; Department of Respiratory and Sleep Medicine, Queensland Children's Hospital, Brisbane, QLD, Australia.

Background: Although the burden of bronchiectasis is globally recognised, there is limited paediatric data particularly on trends over the years. There is also no published data on whether vitamin D deficiency/insufficiency and human T-cell lymphotropic virus type 1 (HTLV-1) infection, both found to relate with severe bronchiectasis in First Nations adults, is also important in children with bronchiectasis.

Research Question: Among children with bronchiectasis, has (a) the clinical and bronchoalveolar lavage (BAL) profiles changed between two 5-year periods (period-1=2007-11, period-2=2012-16); and (b) is vitamin D deficiency/insufficiency and/or HTLV-1 infection associated with radiological severity of bronchiectasis?

Study Design And Methods: We analysed the data from children with bronchiectasis prospectively enrolled at Royal Darwin Hospital, Australia at their first diagnosis i. Read More

View Article and Full-Text PDF

Pediatric Asthma Incidence Rates in the United States from 1980-2017.

J Allergy Clin Immunol 2021 May 5. Epub 2021 May 5.

Background: Few studies have examined longitudinal asthma incidence rates from a public health surveillance perspective.

Objective: Calculate descriptive asthma incidence rates in children over time considering demographics and parental asthma history.

Methods: Data from nine US birth cohorts were pooled into one population covering 1980-2017. Read More

View Article and Full-Text PDF

One-and-one-half Ventricle Repair: Role for Restricting Antegrade Pulmonary Blood Flow.

Ann Thorac Surg 2021 May 5. Epub 2021 May 5.

Harvard Medical School, Boston, MA; Department of Cardiovascular Surgery, Boston Children's Hospital, Boston, MA. Electronic address:

Background: In patients with hypoplastic sub-pulmonary ventricles, the one-and-one-half ventricle (1.5V) repair is an alternative to the Fontan. However, 1. Read More

View Article and Full-Text PDF

One year survival worse for lung retransplants relative to primary lung transplants.

Ann Thorac Surg 2021 May 5. Epub 2021 May 5.

Division of Cardiothoracic Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri.

Background: Outcomes after lung re-transplantation (LRT) remain inferior compared to primary lung transplantation (PLT). We examined the impact of center volume on one-year survival after LRT.

Methods: Using the UNOS database, we abstracted patients undergoing PLT and LRT between January 2006 and December 2017, excluding combined heart-lung transplants and multiple re-transplants. Read More

View Article and Full-Text PDF

Burnout, Professional Fulfillment, Intention to Leave, and Sleep-Related Impairment Among Faculty Radiologists in the United States: An Epidemiologic Study.

J Am Coll Radiol 2021 May 5. Epub 2021 May 5.

Department of Urology, Georgetown University School of Medicine, Washington, DC.

Objective: To examine the prevalence of burnout in faculty radiologists in the United States and to explore the relationship between burnout and professional fulfillment (PF), intention to leave (ITL), and sleep-related impairment by gender.

Methods: This cross-sectional study was conducted through a voluntary anonymous, electronic survey of radiologists at 11 academic medical institutions participating in the Physician Wellness Academic Consortium between January 2017 and September 2018. Faculty radiologists who completed the survey were included in the study. Read More

View Article and Full-Text PDF

Factors Associated With Potentially Inappropriate Transfer to the Emergency Department Among Nursing Home Residents.

J Am Med Dir Assoc 2021 May 5. Epub 2021 May 5.

Gérontopôle, Toulouse University Hospital, Toulouse, France; INSERM, UMR 1027, Toulouse, France.

Objectives: To determine the factors associated with the potentially inappropriate transfer of nursing home (NH) residents to emergency departments (EDs) and to compare hospitalization costs before and after transfer of individuals addressed inappropriately vs those addressed appropriately.

Design: Multicenter, observational, case-control study.

Setting And Participants: 17 hospitals in France, 1037 NH residents. Read More

View Article and Full-Text PDF

Loss of Cxcr4 in Endometriosis Reduces Proliferation and Lesion Number while Increasing Intraepithelial Lymphocyte Infiltration.

Am J Pathol 2021 May 5. Epub 2021 May 5.

Department of Obstetrics, Gynecology, & Reproductive Medicine, Yale School of Medicine, New Haven, CT, USA.

Hyperactivation of the CXCL12-CXCR4 axis occurs in endometriosis; the therapeutic potential of treatments aimed at global inhibition of the axis was recently demonstrated. As CXCR4 is predominantly expressed on epithelial cells in the uterus, our aim was to explore the effects of targeted disruption of CXCR4 in endometriosis lesions. Uteri derived from adult female mice homozygous for a floxed allele of CXCR4 and co-expressing Cre recombinase under control of progesterone receptor were sutured onto the peritoneum of cycling GFP+ host mice. Read More

View Article and Full-Text PDF