229,906 results match your criteria associated inflammatory

Home-based exercise training influences gut bacterial levels in multiple sclerosis.

Complement Ther Clin Pract 2021 Jul 30;45:101463. Epub 2021 Jul 30.

Department of Physical Education and Sport Sciences, Tarbiat Modares University, Tehran, Iran.

Background: Multiple sclerosis is associated with gut microbiome alterations. The current study aimed to investigate the effect of home-based exercise on gut bacteria in people with multiple sclerosis (MS). We also examined the association of exercise-induced gut bacterial modulation with circulating levels of inflammatory and anti-inflammatory cytokines. Read More

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Environmental enteric dysfunction induces regulatory T cells that inhibit local CD4+ T cell responses and impair oral vaccine efficacy.

Immunity 2021 Jul 29. Epub 2021 Jul 29.

R.K. Mellon Institute for Pediatric Research, Pediatrics Department, Infectious Disease Section, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224 USA; Program in Microbiology and Immunology, Department of Immunology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, USA. Electronic address:

Environmental enteric dysfunction (EED) is a gastrointestinal inflammatory disease caused by malnutrition and chronic infection. EED is associated with stunting in children and reduced efficacy of oral vaccines. To study the mechanisms of oral vaccine failure during EED, we developed a microbiota- and diet-dependent mouse EED model. Read More

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Dietary Inflammatory Index in Relation to Psoriasis Risk, Cardiovascular Risk Factors and Clinical Outcomes; A Result from Case-Control Study in Psoriasis Patients.

Appl Physiol Nutr Metab 2021 Aug 4. Epub 2021 Aug 4.

Thapar Institute of Engineering & Technology, Department of Biotechnology, Delhi , India;

Psoriasis is an inflammatory skin disease. Despite the understanding of the disease pathogenesis, the link between diet-induced inflammation and the risk of psoriasis remains underexplored. Therefore, we have examined the capability of literature-derived Energy-adjusted Dietary Inflammatory Index (E-DII) as a predictive tool for inflammation, incidence, and severity of psoriasis (as indexed by The Psoriasis Area Severity Index (PASI)). Read More

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Direct and Indirect Anticancer Activity of Plant-Derived Alkaloid Conophylline.

Crit Rev Oncog 2021 ;26(2):67-72

Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.

K-Ras is one of the most important oncogenes in human oncogenesis. K-Ras transfection of normal rat fibroblasts induces phenotypic change from flat to round morphology. Then, we screened compounds inducing flat morphology in K-Ras transformed fibroblasts from microbial culture filtrates and plant extracts. Read More

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January 2021

Prospective analysis over time of semen parameters in spinal cord-injured patients: results of a pilot study.

Andrology 2021 Aug 4. Epub 2021 Aug 4.

Neuro-Uro-Andrology Raymond Poincare academic hospital, AP-HP, 104 bvd Raymond Poincare, Garches, 92380, France.

Background: Spinal cord injury (SCI) often results in erectile dysfunction and anejaculation along with impaired semen parameters. Fertility is a major concern in SCI adult males and some fear that the delay post-SCI may negatively affect sperm quality.

Objectives: We aimed to i) assess semen parameters over time in SCI patients according to age at SCI, time post-SCI, and the SCI level and completeness and ii) measure markers in semen for inflammation (MSI) and marker of oxidative stress (MOS) to investigate their impact on sperm parameters. Read More

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Swimming exercise decreases depression-like behaviour and inflammatory cytokines in a mouse model of type 2 diabetes.

Exp Physiol 2021 Aug 4. Epub 2021 Aug 4.

Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.

New Findings: What is the central question of this study? Can swimming exercise decrease depression-like behaviour and inflammation in type 2 diabetic mice? What is the main finding and its importance? This study demonstrates that swimming exercise decreased depression-like behaviour by reducing inflammation in type 2 diabetic mice. This study suggests that swimming exercise might be useful for the treatment of depression-related disorders in patients with type 2 diabetes.

Abstract: Clinical and experimental studies have shown that type 2 diabetes is associated with depression-related disorders. Read More

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A case-control study on the association between periodontitis and coronavirus disease (COVID-19).

J Periodontol 2021 Aug 4. Epub 2021 Aug 4.

Department of Dentistry, Oral Health Institute, Hamad Medical Corporation.

Background: Coronavirus disease (COVID-19) and periodontitis share common characteristics, such as an exaggerated inflammatory response. As periodontal diseases were shown to be associated with respiratory diseases, such as pneumonia, it is quite possible that a relationship may exist between periodontitis and COVID-19. Hence, the aim of the present study was to determine whether periodontitis and poor oral hygiene are associated with COVID-19. Read More

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Clinical features, laboratory and radiological findings of patients with acute inflammatory myelopathy following COVID-19 infection: a narrative review.

Am J Phys Med Rehabil 2021 Aug 3. Epub 2021 Aug 3.

Department of Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, Bhubaneswar, India.

Abstract: The objective of this review is to analyze the existing data on acute inflammatory myelopathies (AIM) associated with COVID-19 infection, which were reported globally in 2020. PubMed, CENTRAL, MEDLINE, and online publication databases were searched. Thirty-three AIM cases (among them, seven cases had associated brain lesions) associated with COVID-19 infection were reported. Read More

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The Effect of Vitamin B12 on Synaptic Plasticity of Hippocampus in Alzheimer's disease model rats.

Int J Neurosci 2021 Aug 4:1-8. Epub 2021 Aug 4.

Neuroscience Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Hippocampus cells, responsible for learning and memory, are disturbed in Alzheimer's disease (AD), resulting in production of several inflammatory markers, such as neurexin 1 -neuroligin, cyclooxygenase-2 (COX-2), and caspase-3 proteins, used in measurement of AD's severity and development. Vitamin B, which plays a role in brain functioning, has anti-inflammatory properties and its impairment is associated with apoptosis in Alzheimer's disease. This study aimed to investigate the effect of vitamin B on restoration of Synaptic Plasticity on scopolamine-induced AD in rats. Read More

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Vitamin D deficiency as a predictor of severity in patients with COVID-19 infection.

Sci Prog 2021 Jul-Sep;104(3):368504211036854

Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Background: As an immune modulator, vitamin D has been implicated in the coronavirus disease 2019 (COVID-19) severity. This study aimed to investigate the association between vitamin D levels and the severity of COVID-19 infection.

Methods: A cross-sectional study, which included 124 patients diagnosed with COVID-19 and were selected from Ain Shams University Hospitals and assigned to two groups; mild and severe COVID-19. Read More

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The Link Between Positive and Negative Parenting Behaviors and Child Inflammation: A Systematic Review.

Child Psychiatry Hum Dev 2021 Aug 4. Epub 2021 Aug 4.

Department of Psychology, University of Oregon, 1451 Onyx Street, Eugene, OR, 97403, USA.

Children's inflammation may be an important link between parenting behaviors and health outcomes. The aims of this systematic review were to: (1) describe associations between parenting behaviors and child inflammatory markers, and (2) evaluate the relevance of existing literature to the review question. Database searches identified 19 studies that included a measure of positive or negative parenting behaviors and a marker of child inflammation, 53% of which measured parental responsiveness/warmth. Read More

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ELTD1-deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.

Neuro Oncol 2021 Aug 4. Epub 2021 Aug 4.

Department of Immunology, Genetics and Pathology, The Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, 75185 Uppsala, Sweden.

Background: Tumor vessels in glioma are molecularly and functionally abnormal, contributing to treatment resistance. Proteins differentially expressed in glioma vessels can change vessel phenotype and be targeted for therapy. ELTD1 (Adgrl4) is an orphan member of the adhesion G-protein-coupled receptor family upregulated in glioma vessels, and has been suggested as a potential therapeutic target. Read More

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Characterization of Skeletal Phenotype and Associated Mechanisms With Chronic Intestinal Inflammation in the Winnie Mouse Model of Spontaneous Chronic Colitis.

Inflamm Bowel Dis 2021 Aug 4. Epub 2021 Aug 4.

Department of Medicine-Western Health, The University of Melbourne, Melbourne, VIC, Australia.

Background: Osteoporosis is a common extraintestinal manifestation of inflammatory bowel disease (IBD). However, studies have been scarce, mainly because of the lack of an appropriate animal model of colitis-associated bone loss. In this study, we aimed to decipher skeletal manifestations in the Winnie mouse model of spontaneous chronic colitis, which carries a MUC2 gene mutation and closely replicates ulcerative colitis. Read More

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Germline Alterations in Patients With IBD-associated Colorectal Cancer.

Inflamm Bowel Dis 2021 Aug 4. Epub 2021 Aug 4.

Division of Gastroenterology, Fondazione IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.

Background: Patients with inflammatory bowel diseases (IBD), both ulcerative colitis (UC) and Crohn's disease (CD), are at risk of developing a colorectal cancer (CRC). No information is available on the contribution of patients' genetic background to CRC occurrence. This study investigates germline alterations in patients with IBD-associated CRC. Read More

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Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury.

Am J Respir Crit Care Med 2021 Aug 4. Epub 2021 Aug 4.

University of Pennsylvania, 6572, Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, Philadelphia, Pennsylvania, United States.

Rationale: Primary graft dysfunction (PGD) is a severe form of acute lung injury, leading to increased early morbidity and mortality after lung transplantation. Obesity is a major health problem, and recipient obesity is one of the most significant risk factors for developing PGD.

Objectives: We hypothesized that T-regulatory (Treg) cells are able to dampen early ischemia/reperfusion events and thereby decrease risk of PGD, whereas that action is impaired in obese recipients. Read More

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Eur J Sport Sci 2021 Aug 4:1-33. Epub 2021 Aug 4.

Neuromuscular Research Laboratory/Warrior Human Performance Research Center. Department of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA, USA.

Adaptation to military operational stress is a complex physiological response that calls upon the sympathetic nervous system (SNS), hypothalamic pituitary adrenal (HPA) axis and immune system, to create a delicate balance between anabolism and catabolism and meet the demands of an ever-changing environment. As such, resilience, the ability to withstand and overcome the negative impact of stress on military performance, is likely grounded in an appropriate biological adaptation to encountered stressors. Neuroendocrine [i. Read More

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Murine Norovirus infection results in anti-inflammatory response downstream of amino acid depletion in macrophages.

J Virol 2021 Aug 4:JVI0113421. Epub 2021 Aug 4.

Faculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom.

Murine norovirus (MNV) infection results in a late translation shut-off, that is proposed to contribute to the attenuated and delayed innate immune response observed both and Recently, we further demonstrated the activation of the eIF2α kinase GCN2 during MNV infection, which has been previously linked to immunomodulation and resistance to inflammatory signalling during metabolic stress. While viral infection is usually associated with activation of dsRNA binding pattern recognition receptor PKR, we hypothesised that the establishment of a metabolic stress in infected cells is a proviral event, exploited by MNV to promote replication through weakening the activation of the innate immune response. In this study, we used multi-omics approaches to characterise cellular responses during MNV replication. Read More

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[Multisystem inflammatory syndrome associated with COVID-19: Not just a pediatric disease].

Ned Tijdschr Geneeskd 2021 Jul 29;165. Epub 2021 Jul 29.

Haga Ziekenhuis, Den Haag: Afd. Kindergeneeskunde (locatie Juliana Kinderziekenhuis).

Background: Since the start of the COVID-19 pandemic, a hyperinflammatory syndrome has appeared which develops weeks after a SARS-CoV-2 infection. This multisystem inflammatory syndrome has been described mainly in children (MIS-C), but lately has also been found in adults (MIS-A).

Case Description: We present a case of a woman with MIS-A. Read More

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Is cyclooxygenase-1 involved in neuroinflammation?

J Neurosci Res 2021 Aug 4. Epub 2021 Aug 4.

Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Purpose: Reactive microglia are an important hallmark of neuroinflammation. Reactive microglia release various inflammatory mediators, such as cytokines, chemokines, and prostaglandins, which are produced by enzymes like cyclooxygenases (COX). The inducible COX-2 subtype has been associated with inflammation, whereas the constitutively expressed COX-1 subtype is generally considered as a housekeeping enzyme. Read More

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L-ergothioneine and its combination with metformin attenuates renal dysfunction in type-2 diabetic rat model by activating Nrf2 antioxidant pathway.

Biomed Pharmacother 2021 Jul 30;141:111921. Epub 2021 Jul 30.

Department of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban X54001, South Africa.

L-ergothioneine (L-egt) is a bioactive compound recently approved by the food and drug administration as a supplement. L-egt exerts potent cyto-protective, antioxidant and anti-inflammatory properties in tissues exposed to injury, while metformin is a first-line prescription in type-2 diabetes. Therefore, the present study investigated the protective effect of L-egt alone, or combined with metformin, on renal damage in a type-2 diabetic (T2D) rat model. Read More

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Screening of biomarkers for prediction of multisite artery disease in patients with recent myocardial infarction.

Scand J Clin Lab Invest 2021 Aug 4:1-8. Epub 2021 Aug 4.

Department of Medical Sciences, Clinical Chemistry, Uppsala, Sweden.

A few studies have examined biomarkers in patients with myocardial infarction (MI) and peripheral artery disease (PAD), i.e. multisite artery disease (MSAD). Read More

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Periconceptional nonsteroidal anti-inflammatory drug use, folic acid intake, and the risk of spina bifida.

Birth Defects Res 2021 Aug 3. Epub 2021 Aug 3.

Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.

Background: Use of nonsteroidal anti-inflammatory drugs (NSAIDs) during pregnancy may increase risk for neural tube defects (NTDs), including spina bifida. Folic acid intake can prevent NTDs, but it is not known whether it modifies any risks associated with NSAID use.

Objectives: To assess the impact of periconceptional NSAID use on the risk of spina bifida overall and stratified by folic acid intake. Read More

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Multiple sclerosis immunomodulatory therapies tested for effectiveness in COVID-19.

Neurol Neurochir Pol 2021 Aug 4. Epub 2021 Aug 4.

Department of Neurology in Zabrze, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.

Introduction: The global pandemic of COVID-19 began in Wuhan, China in December 2019. Research into effective therapies has been conducted worldwide. Currently, there is no antiviral treatment and many patients develop a severe course of the disease, including severe respiratory failure. Read More

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Novel role of long non-coding RNAs in autoimmune cutaneous disease.

J Cell Commun Signal 2021 Aug 3. Epub 2021 Aug 3.

Division Dermatology, McGill University Health Centre, 1650 Cedar Ave, Montreal, QC, H3G 1A4, Canada.

Systemic autoimmune rheumatic diseases (SARDs) are a heterogeneous group of chronic multisystem inflammatory disorders that are thought to have a complex pathophysiology, which is not yet fully understood. Recently, the role of non-coding RNAs, including long non-coding RNA (lncRNA), has been of particular interest in the pathogenesis of SARDs. We aimed to summarize the potential roles of lncRNA in SARDs affecting the skin including, systemic sclerosis (SSc), dermatomyositis (DM) and cutaneous lupus erythematosus (CLE). Read More

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Current Surgical Management of Inflammatory Breast Cancer.

Ann Surg Oncol 2021 Aug 3. Epub 2021 Aug 3.

Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Inflammatory breast cancer (IBC) is a rare and aggressive breast cancer characterized by erythema and edema of at least one-third of the breast. The diagnosis remains a clinical one. Standard of care involves trimodality therapy with anthracycline-based neoadjuvant chemotherapy and human epidermal growth factor receptor 2 (HER2)-directed therapy if HER2 positive, followed by modified radical mastectomy and post-mastectomy radiation therapy to the chest wall in addition to regional nodal basins including supraclavicular and internal mammary nodes. Read More

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Initial-onset acute uveitis associated with Vogt-Koyanagi-Harada disease presenting with unilateral exudative retinal detachment despite bilateral choroidal involvement.

Int Ophthalmol 2021 Aug 3. Epub 2021 Aug 3.

Department of Ophthalmology, College of Medicine, King Saud University Medical City, Old Airport Road, P.O. Box 245, Riyadh, 11411, Saudi Arabia.

Purpose: To investigate the frequency of initial-onset acute uveitis associated with Vogt-Koyanagi-Harada (VKH) disease presenting with unilateral exudative retinal detachment.

Methods: A retrospective case series.

Results: During the period between January 1998 and December 2020, we identified 135 patients with initial-onset acute uveitis associated with VKH disease. Read More

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The effects of genotype on inflammatory response in hippocampal progenitor cells: A computational approach.

Brain Behav Immun Health 2021 Aug;15:100286

Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Cell culture models are valuable tools to study biological mechanisms underlying health and disease in a controlled environment. Although their genotype influences their phenotype, subtle genetic variations in cell lines are rarely characterised and taken into account for in vitro studies. To investigate how the genetic makeup of a cell line might affect the cellular response to inflammation, we characterised the single nucleotide variants (SNPs) relevant to inflammation-related genes in an established hippocampal progenitor cell line (HPC0A07/03C) that is frequently used as an in vitro model for hippocampal neurogenesis (HN). Read More

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Complement Inhibition and COVID-19: The Story so Far.

Immunotargets Ther 2021 26;10:273-284. Epub 2021 Jul 26.

Department of Intensive Care, Hôpital Raymond Poincaré (APHP), Garches, 92380, France.

Acute respiratory distress syndrome (ARDS) is the most severe complication of COVID-19, a disease caused by severe acute respiratory syndrome coronavirus (SARS CoV) 2. The mechanisms underlying the progression from asymptomatic disease to pneumonia and ARDS are complex and by far unelucidated. As for bacterial sepsis, the release of damage associated molecular patterns and pathogen associated molecular patterns triggers activation of the complement cascade. Read More

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Takotsubo Cardiomyopathy as a Manifestation of Dysautonomia in Guillain-Barré Syndrome: A Case Series and Review of the Literature.

Cureus 2021 Jun 30;13(6):e16069. Epub 2021 Jun 30.

Neurology, University of Miami, Miami, USA.

Guillain-Barré syndrome (GBS) is an inflammatory polyneuropathy that classically presents with low back pain, sensory paresthesias, and rapidly progressive weakness. Patients with GBS can develop dysautonomia, and Takotsubo cardiomyopathy (TCM) is a rare potential manifestation of this dysautonomia. This association has been reported only 12 times in the literature so far, which we review here. Read More

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