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Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: Overlapping Mechanisms.

Semin Liver Dis 2021 May 15. Epub 2021 May 15.

Department of Clinical Medicine, University of Copenhagen, Denmark.

Nonalcoholic fatty liver disease (NAFLD) denotes a condition with excess fat in the liver. The prevalence of NAFLD is increasing, averaging > 25% of the Western population. In 25% of the patients, NAFLD progresses to its more severe form: nonalcoholic steatohepatitis and >25% of these progress to cirrhosis following activation of inflammatory and fibrotic processes. Read More

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Differences in kinetic metabolomics in Eisenia fetida under single and dual exposure of imidacloprid and dinotefuran at environmentally relevant concentrations.

J Hazard Mater 2021 May 8;417:126001. Epub 2021 May 8.

Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China. Electronic address:

Metabolomic responses of earthworms to neonicotinoids are important for understanding their molecular-level toxicity and assessing their ecological risks, but little is known until now. We investigated impact of imidacloprid (IMI, 52.6 ng/g) and dinotefuran (DIN, 52. Read More

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Impaired global efficiency in boys with conduct disorder and high callous unemotional traits.

J Psychiatr Res 2021 Apr 29;138:560-568. Epub 2021 Apr 29.

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center on Psychiatry and Psychology, Changsha, China; Medical Psychological Institute of Central South University, Changsha, China; National Clinical Research Center for Mental Disorders, Changsha, China. Electronic address:

Callous unemotional (CU) traits differentiate subtypes of conduct disorder (CD). It has been suggested that CU traits may be related to topographical irregularities that hinder information integration. To date, there is limited evidence of whether CU traits may be associated with abnormal brain topology. Read More

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Sodium fluoride causes oxidative damage to silkworm (Bombyx mori) testis by affecting the oxidative phosphorylation pathway.

Ecotoxicol Environ Saf 2021 May 11;218:112229. Epub 2021 May 11.

School of Biotechnology, Southwest University, Chongqing, China. Electronic address:

Bombyx mori was used to study the molecular mechanism of fluoride induced reproductive toxicity. In our previous study, we confirmed the physiological and biochemical effects of NaF on reproductive toxicity, and we found that the molecular mechanism of NaF induced reproductive damage may be associated with the oxidative phosphorylation pathway. To further study the function of NaF exposure on the oxidative phosphorylation pathway in the testis in Bombyx mori, and the relationship between oxidative phosphorylation and oxidative stress, we measured the changes in the main ROS (O and HO) in the testis, the activity of the main electron transport chain complex enzymes in the oxidative phosphorylation pathway and the transcription levels of the corresponding genes; we additionally performed pathological observations of the silkworm testis after exposure to 200 mg/L NaF solution for different times. Read More

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Associations between malignancy and cardiovascular complications following emergency laparotomy - A retrospective cohort study.

Surg Oncol 2021 May 5;38:101591. Epub 2021 May 5.

Center for Surgical Science, Department of Surgery, Zealand University Hospital, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark.

Background: Systemic inflammation in patients with malignant disease has been associated with increased risk of cardiovascular events. The pro-inflammatory perturbations following surgical trauma may further promote adverse perioperative cardiovascular events and increase the risk of patients with cancer undergoing major surgery. Our objective was to estimate the association between malignant disease and postoperative cardiovascular complications. Read More

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Cr (VI) induces abnormalities in glucose and lipid metabolism through ROS/Nrf2 signaling.

Ecotoxicol Environ Saf 2021 May 12;219:112320. Epub 2021 May 12.

Department of Environmental Hygiene, School of Public Health, Weifang Medical College, Weifang, China. Electronic address:

The hexavalent form of chromium, Cr (VI), has been associated with various diseases in humans. In this study, we examined the mechanisms underlying the effect of Cr (VI) on glucose and lipid metabolism in vivo and in vitro. We found that Cr (VI) induced abnormal liver function, increased fasting blood glucose (FBG), as well as glucose and insulin intolerance in mice. Read More

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Seizures and status epilepticus may be risk factor for cardiac arrhythmia or cardiac arrest across multiple time frames.

Epilepsy Behav 2021 May 12;120:107998. Epub 2021 May 12.

Department of Neurology, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY 10029, USA.

Objective: To determine if Emergency Department (ED) or inpatient encounters for epilepsy or status epilepticus are associated with increased odds of cardiac arrhythmia or cardiac arrest over successively longer time frames.

Methods: The State Inpatient and ED Databases (from New York, Florida, and California) are statewide datasets containing data on 97% of hospitalizations and ED encounters from these states. In this retrospective, case-crossover study, we used International Classification of Diseases, Ninth Revision, Clinical Modification codes to identify index cardiac arrhythmia encounters. Read More

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Sleep and physical activity from before conception to the end of pregnancy in healthy women: a longitudinal actigraphy study.

Sleep Med 2021 Apr 28;83:89-98. Epub 2021 Apr 28.

Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.

Background: Sleep and physical activity changes are common in pregnancy, but longitudinal data starting before conception are scarce. Our aim was to determine the changes of the daily total sleep time (TST) and physical activity duration (PAD) from before conception to end of pregnancies in respect of pregestational maternal factors.

Methods: This longitudinal observational study formed part of the CONIMPREG research project and recruited healthy women planning to become pregnant. Read More

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Sleep architectural dysfunction and undiagnosed obstructive sleep apnea after chronic ischemic stroke.

Sleep Med 2021 Apr 15;83:45-53. Epub 2021 Apr 15.

The Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia; University of Melbourne, Melbourne, VIC, Australia.

Objective/background: Sleep-wake dysfunction is bidirectionally associated with the incidence and evolution of acute stroke. It remains unclear whether sleep disturbances are transient post-stroke or are potentially enduring sequelae in chronic stroke. Here, we characterize sleep architectural dysfunction, sleep-respiratory parameters, and hemispheric sleep in ischemic stroke patients in the chronic recovery phase compared to healthy controls. Read More

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Chronic sleep restriction triggers inadequate napping habits in adolescents: a population-based study.

Sleep Med 2021 Apr 19;83:115-122. Epub 2021 Apr 19.

Human Chronobiology Laboratory, Department of Physiology, Biological Sciences Sector, Federal University of Paraná, Curitiba, Paraná, Brazil. Electronic address:

Background: The prevalence of chronic sleep restriction during adolescence is a major public health issue. Napping has been adopted to alleviate sleep pressure complaints. However, it also has the potential to amplify sleep restriction due to a vicious cycle triggered by delayed sleep times. Read More

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Population-based study on the association between autoimmune disease and lymphoma: National Health Insurance Service-National Sample Cohort 2002-2015 in Korea.

J Autoimmun 2021 May 12;121:102647. Epub 2021 May 12.

Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, South Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea. Electronic address:

Background: We aimed to evaluate the association between autoimmune disease (AID) and lymphoma incidence in the Korean population. We also aimed to compare the overall survival (OS) in patients with AID-associated lymphoma (AAL) with that in patients with lymphoma without AID.

Material And Methods: We used National Sample Cohort 2002-2015 provided by National Health Insurance Service. Read More

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Immobilization of cadmium and lead using phosphorus-rich animal-derived and iron-modified plant-derived biochars under dynamic redox conditions in a paddy soil.

Environ Int 2021 May 12;156:106628. Epub 2021 May 12.

University of Wuppertal, School of Architecture and Civil Engineering, Institute of Foundation Engineering, Water- and Waste-Management, Laboratory of Soil- and Groundwater-Management, Pauluskirchstraße 7, 42285 Wuppertal, Germany; University of Sejong, Department of Environment, Energy and Geoinformatics, Guangjin-Gu, Seoul 05006, Republic of Korea. Electronic address:

Functionalized biochar has gained extensive interests as a sustainable amendment for an effective remediation of paddy soils contaminated with heavy metals (HMs). We examined the efficiency of pig carcass-derived biochar (P-rich biochar, total P = 8.3%) and pristine (raw biochar, total Fe = 0. Read More

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Ergonomic arm support prototype device for smartphone users reduces neck and shoulder musculoskeletal loading and fatigue.

Appl Ergon 2021 May 12;95:103458. Epub 2021 May 12.

University of South Australia: Allied Health and Human Performance, iCAHE (International Centre for Allied Health Evidence), Adelaide, Australia.

Smartphone use is a risk factor for both neck and shoulder musculoskeletal disorders. The objective of this study was to evaluate an ergonomic arm support prototype device, which may help improve posture while using a smartphone, by determining its effect on muscle activity, muscle fatigue, and neck and shoulder discomfort. Twenty-four healthy young adult smartphone users performed 20 min of smartphone game playing under two different conditions, smartphone use with support prototype device (i. Read More

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Relationships between patterns of technology-based weight-related self-monitoring and eating disorder behaviors among first year university students.

Eat Behav 2021 May 8;42:101520. Epub 2021 May 8.

Department of Nutritional Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, United States of America.

Objective: To identify patterns of technology-based weight-related self-monitoring (WRSM) and assess associations between identified patterns and eating disorder behaviors among first year university students.

Methods: First year university students (n = 647) completed a web-based survey to assess their use of technology-based WRSM and eating disorder behaviors. The cross-sectional data were analyzed using gender-stratified latent class analysis to identify patterns of WRSM, followed by logistic regression to calculate the predicted probability of eating disorder behaviors for each pattern of WRSM. Read More

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Resynchronizing the first eligible estrus in dairy cattle after a prior insemination and fertility of the prior insemination after gonadotropin-releasing hormone and progesterone treatments.

Theriogenology 2021 Apr 30;170:54-66. Epub 2021 Apr 30.

Department of Animal Sciences and Industry, Kansas State University, Manhattan, 66506-0201, United States.

The hypothesis of this study tested whether application of designed treatments to synchronize estrus in nonpregnant previously inseminated lactating dairy cows increased the proportion of nonpregnant cows in estrus before early pregnancy diagnosis on Day 32 after the previous insemination (Day 0) and increase fertility of the pretreatment insemination. A progesterone insert (CIDR) and GnRH were applied to cows after insemination to resynchronize the returning estrus of cows that failed to conceive on Day 0. The combination of GnRH (Day 14) and a CIDR insert (d 17 through 24) in experiment 1 (n = 347 cows) did not increase (P = 0. Read More

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Clinical utility of next generation sequencing to detect IGH/IL3 rearrangements [t(5;14)(q31.1;q32.1)] in B-lymphoblastic leukemia/lymphoma.

Ann Diagn Pathol 2021 May 10;53:151761. Epub 2021 May 10.

Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States of America. Electronic address:

The t(5;14)(q31.1;q32.1) associated with B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is a rare, recurrent genetic abnormality recognized as a distinct entity by the 2017 World Health Organization (WHO) classification. Read More

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Extrinsic foot muscle forces and joint contact forces in flexible flatfoot adult with foot orthosis: A parametric study of tibialis posterior muscle weakness.

Gait Posture 2021 May 10;88:54-59. Epub 2021 May 10.

Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region; The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China. Electronic address:

Background: The posterior tibialis tendon dysfunction (PTTD) is typically associated with progressive flatfoot deformity, which could be alleviated with foot orthosis. However, the evaluation of tibialis posterior (TP) weakness on lower limb mechanics of flatfoot adults with foot orthoses is scarce and requires further investigation.

Research Question: This study aimed to examine the effects of TP weakness on lower limb mechanics in flatfoot adults with foot orthosis through gait analysis and musculoskeletal modelling. Read More

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Tropical cyclone effects on water and sediment chemistry and the microbial community in estuarine ecosystems.

Environ Pollut 2021 May 5;286:117228. Epub 2021 May 5.

Department of Civil and Environmental Engineering, Princeton University, Princeton, NJ, 08544, USA. Electronic address:

Frequent and intense storm disturbances can have widespread and strong effects on the nitrogen and iron cycles and their associated microbial communities in estuary systems. A three-year investigation was conducted in the Pearl River and Zhanjiang estuaries in Guangdong Province, China through repeated sampling at three timepoints, defined as pre-storm (<1 month before storm), post-storm (<1 month after storm), and non-storm (6-8 months after storm). Increased nutrient concentrations (total organic carbon, nitrate, nitrite, ammonium, and sulfate) in both the sediment and water column were observed immediately after storm. Read More

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Relapse protection following early CMV reactivation after HSCT is limited to HLA-C KIR ligand homozygous recipients.

Transplant Cell Ther 2021 May 12. Epub 2021 May 12.

Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, Austria; Medical Faculty, Johannes Kepler University, Linz, Austria.

Background: While the risk for non-relapse mortality (NRM) associated with early cytomegalovirus (CMV) reactivation (CMVR) after allogeneic hematopoietic stem cell transplantation (HSCT) is well established, debate is ongoing on whether CMVR may reduce the risk of primary disease relapse.

Objective: Relapse protection following early CMV reactivation after HSCT in the context of the HLA-C KIR ligands of the recipients.

Study Design: In this retrospective, bi-centric study, 406 matched-related or unrelated transplants for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) were stratified by HLA-C KIRL groups (homozygous versus heterozygous) and were separately analyzed for the impact of early CMVR on the cumulative incidence of relapse, non-relapse mortality (NRM), acute and chronic graft-versus-host-disease (GVHD), using landmark and multi-state analyses. Read More

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Pre-transplant red blood cell and platelet transfusion burden in de novo myelodysplastic syndrome undergoing allogeneic transplantation: Pre-transplant red blood cell and platelet transfusion burden in de novo MDS after allogeneic transplantation.

Transplant Cell Ther 2021 May 12. Epub 2021 May 12.

Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan; Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: Most patients of myelodysplastic syndrome (MDS) require red blood cell (RBC) and/or platelet transfusion during their disease courses, which could cause an increased risk of iron overload and alloimmunization. However, it remains less clear whether pre-transplant RBC or platelet transfusion burden affects transplant outcomes in patients with MDS.

Objective: The objective was to examine the significance of pre-transplant RBC and platelet transfusion burden on transplant outcomes after allogeneic HCT for adults with de novo MDS. Read More

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Factors Associated with Postpartum Readmission for Hypertensive Disorders of Pregnancy.

Am J Obstet Gynecol MFM 2021 May 12:100397. Epub 2021 May 12.

The Permanente Medical Group, Kaiser Permanente Santa Clara Medical Center, Department of Obstetrics and Gynecology, Division of Obstetric Hospitalists, Santa Clara, CA.

Background: Postpartum readmission (PPR) has negative implications for patients and health systems. Prior studies suggest that up to 5% of women with hypertensive disorders of pregnancy (HDP) experience PPR. Studies examining factors associated with PPR for hypertension have had small sample sizes and conflicting results. Read More

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Total IgE variability is associated with future asthma exacerbations: a one-year prospective cohort study.

J Allergy Clin Immunol Pract 2021 May 12. Epub 2021 May 12.

Airway Physiology and Imaging Group and the Woolcock Emphysema Centre, The Woolcock Institute of Medical Research, Sydney, NSW, Australia; Discipline of Medical Sciences, School of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia.

Background: Few prospective studies have investigated the relationship between IgE variability and risk of asthma exacerbations (AEs).

Objective: To explore the relationship between IgE variability and AEs.

Methods: Recruited patients with stable asthma underwent two serum total IgE tests within a month (at screening [baseline IgE] and one-month) to obtain coefficient of variation (CV) of base-10 log-transformed IgE. Read More

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Sleep disturbance in school-aged children with atopic dermatitis: prevalence and severity in a cross-sectional sample.

J Allergy Clin Immunol Pract 2021 May 12. Epub 2021 May 12.

Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611.

Rationale: Atopic dermatitis(AD) causes sleep disturbance, yet the epidemiology is not known.

Objective: Estimate the US prevalence of sleep disturbance and its impact on psychological and neurocognitive function.

Methods: Cross-sectional survey of 180 parent-child dyads with AD, using stratified sampling based on disease severity(POEM,Patient Oriented Eczema Measure,mild(n=30)/moderate(n=75)/severe (n=75)), age, and race (White/Black or African American/Other). Read More

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Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy.

J Hepatol 2021 May 12. Epub 2021 May 12.

Section of Digestive Diseases, Department of internal Medicine, Yale School of Medicine, New Haven, CT 06520, U.S.A.. Electronic address:

Background And Aims: COVID-19 is associated with liver injury and elevated IL-6. We hypothesized that IL-6 trans-signaling in liver sinusoidal endothelial cells (LSECs) leads to endotheliopathy (a proinflammatory and procoagulant state) and liver injury in COVID-19.

Methods: Coagulopathy, endotheliopathy, and ALT were retrospectively analyzed in a subset (n=68), followed by a larger cohort(n=3,780) of COVID-19 patients. Read More

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Dynamic changes of HCV genomes under selective pressure from DAAs therapy in relapsed patients.

Virus Res 2021 May 12:198453. Epub 2021 May 12.

Department of Infectious Disease Center, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China. Electronic address:

Currently, direct-acting antiviral drugs (DAAs) are widely used as therapeutic methods for hepatitis C virus (HCV)-positive patients, however, patients may experience treatment failure, and the dynamic changes of HCV genomes in these patients are unknown. In this study, three real-world DAAs cohorts were enrolled to observe clinical efficacy. In addition, serum samples from treatment failure patients at baseline and relapse were used to analyze changes of the HCV genomes at near full-length genome level, including resistance-associated variants (RAVs), viral quasispecies diversity and selection analysis. Read More

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CTRP3 promotes TNF-α-induced apoptosis and barrier dysfunction in salivary epithelial cells.

Cell Signal 2021 May 12:110042. Epub 2021 May 12.

Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China. Electronic address:

Background: C1q/tumour necrosis factor-related protein 3 (CTRP3) plays important roles in metabolism and inflammatory responses in various cells and tissues. However, the expression and function of CTRP3 in salivary glands have not been explored.

Methods: The expression and distribution of CTRP3 were detected by western blot, polymerase chain reaction, immunohistochemical and immunofluorescence staining. Read More

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Microaeration improves the removal/biotransformation of organic micropollutants in anaerobic wastewater treatment systems.

Environ Res 2021 May 12:111313. Epub 2021 May 12.

Department of Hydraulic and Environmental Engineering, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address:

This work assessed the effect of increasing microaeration flow rates (1-6 mL·min at 28 °C and 1 atm, equivalent to 0.025-0.152 L O·L feed) on the removal/biotransformation of seven organic micropollutants (OMPs) (three hormones, one xenoestrogen, and three pharmaceuticals), at 200 μg·L each, in a lab-scale upflow anaerobic sludge blanket reactor operated at a hydraulic retention time (HRT) of 7. Read More

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National Trends in the Cost Burden of Pediatric Gunshot Wounds Across the United States.

J Pediatr 2021 May 12. Epub 2021 May 12.

Cardiovascular Outcomes Research Laboratories (CORELAB), Division of Cardiac Surgery, David Geffen School of Medicine, University of California, Los Angeles. Electronic address:

Objective: To characterize hospitalization costs attributable to gun-related injuries in children across the US.

Study Design: The 2005-2017 National Inpatient Sample (NIS) was used to identify all pediatric admissions for gunshot wounds (GSW). Patients were stratified by ICD-procedural codes for trauma-related operations. Read More

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Impact of Parental Illness and Injury on Pediatric Disorders of Gut-Brain Interaction.

J Pediatr 2021 May 12. Epub 2021 May 12.

Department of Pediatrics. Uniformed Services University of the Health Sciences. Bethesda, MD.

Objective: To evaluate the relationship between parental injury and illness and disorders of gut brain interaction (DGBI) in children.

Study Design: A self-controlled case series using data from the Military Health System Data Repository compared ICD-9 identified DGBI related outpatient visits and prescriptions in 442,651 children ages 3-16 years in the two-years before and the two-years after the injury and/or illness of their military parent. Negative binomial regression was used to compare visit rates for constipation, fecal incontinence, abdominal pain, irritable bowel syndrome, and a composite of these before and after parental injury and/or illness. Read More

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