221 results match your criteria associated hyperpyrexia


Prediction of Re-positivity for Coronavirus Nucleic Acid Among COVID-19 Patients in the Recovery Phase.

Front Med (Lausanne) 2021 5;8:620727. Epub 2021 May 5.

Department of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China.

Although the pathogenesis and treatment of coronavirus disease 2019 (COVID-19) have been gradually revealed, the risk for re-emergence of coronavirus nucleic acids in recovered patients remains poorly understood. Hence, this study evaluated the risk predictors associated with re-positivity for virus nucleic acid. Between February 1 and March 20, 2020, we retrospectively reviewed the clinical epidemiological data of 129 COVID-19 patients who were treated at Zhongxiang People's Hospital of Hubei Province in China. Read More

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Prevalence of clinical malaria and household characteristics of patients in tribal districts of Pakistan.

PLoS Negl Trop Dis 2021 May 3;15(5):e0009371. Epub 2021 May 3.

Department of Bioscience and Biotechnology, The University of Suwon, Hwaseong City, Gyeonggi-do, Republic of Korea.

Background: Malaria, disproportionately affects poor people more than any other disease of public health concern in developing countries. In resource-constrained environments, monitoring the occurrence of malaria is essential for the success of national malaria control programs. Militancy and military conflicts have been a major challenge in monitoring the incidence and controlling malaria and other emerging infectious diseases. Read More

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Clinical and Radiological Presentations of Various Pulmonary Infections in Hospitalized Diabetes Mellitus Patients: A Prospective, Hospital-Based, Comparative, Case Series Study.

Pulm Med 2021 20;2021:8878746. Epub 2021 Mar 20.

Department of Cardiology, King George's Medical University, Lucknow, Uttar Pradesh 226003, India.

Background: Diabetes mellitus is associated with increased rate of respiratory tract infections. The objective was to compare demographic, clinical, serum biochemical, and typical and atypical radiological profiles among hospitalized diabetics and nondiabetics with lower respiratory tract infection. . Read More

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SARS-CoV-2 associated viral encephalitis with mortality outcome.

Interdiscip Neurosurg 2021 Sep 25;25:101132. Epub 2021 Feb 25.

Department of Neurosurgery, Medical University of South Carolina, Charleston, USA.

Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) appeared in Wuhan, China, in December 2019; apart from common conditions such as cough, fever, and severe respiratory complications, difficulty in breathing, including tachypnea, new studies on neurological manifestations have gained public interest.

Case Report: An 89-year-old man was admitted to the neurocritical care department in a specialized hospital with headache, dizziness, hyperpyrexia, myalgia, rash, and tremors. MRI showed viral encephalitis near to basal ganglia and thalami. Read More

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September 2021

Beneficial effects of dantrolene in the treatment of rhabdomyolysis as a potential late complication associated with COVID-19: a case report.

Eur J Med Res 2021 Feb 8;26(1):18. Epub 2021 Feb 8.

Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashi-Ku, Tokyo, 173-8610, Japan.

Background: Patients with severe COVID-19 have disorders of the respiratory, cardiovascular, coagulation, skeletal muscle, and central nervous systems. These systemic failures may be associated with cytokine release syndrome, characterized by hyperpyrexia, thrombocytopenia, hyperferritinemia, and the elevation of other inflammatory markers. Rhabdomyolysis with high fever is a complication that is rarely found in COVID-19. Read More

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February 2021

Development of Neuroleptic Malignant Syndrome in a Patient with Lewy Body Dementia after Intramuscular Administration of Paliperidone.

Case Rep Neurol Med 2021 13;2021:8879333. Epub 2021 Jan 13.

Department of Neurology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.

Neuroleptic malignant syndrome (NMS) is a potentially fatal diagnosis composed of hyperpyrexia, muscle rigidity, altered mental status, and autonomic instability. This syndrome has significant systemic complications including acute renal failure, rhabdomyolysis, hyperkalemia, and seizure. It is associated with the use of both typical and atypical antipsychotics. Read More

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January 2021

Rift Valley Fever Virus Infection Causes Acute Encephalitis in the Ferret.

mSphere 2020 10 28;5(5). Epub 2020 Oct 28.

University of Pittsburgh, School of Medicine, Department of Pediatrics, Division of Pediatric infectious Disease, Pittsburgh, Pennsylvania, USA

Rift Valley fever virus (RVFV) is a pathogen of both humans and livestock in Africa and the Middle East. Severe human disease is associated with hepatitis and/or encephalitis. Current pathogenesis studies rely on rodents and nonhuman primates, which have advantages and disadvantages. Read More

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October 2020

Intrapartum fetal heart rate between 150 and 160 bpm at or after 40 weeks and labor outcome.

Acta Obstet Gynecol Scand 2021 03 1;100(3):548-554. Epub 2020 Nov 1.

Department of Obstetrics and Gynecology, University of Parma, Parma, Italy.

Introduction: A baseline fetal heart rate between 110 and 160 bpm is considered normal. However, among normal fetuses the average baseline heart rate has been shown to diminish progressively and the 90th centile of the fetal heart rate at 40 weeks of gestation has been consistently found at around 150 bpm. The aim of our study was to assess the labor and neonatal outcome of fetuses at 40 gestational weeks or beyond, whose intrapartum baseline fetal heart rate was between 150 and 160 bpm. Read More

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Toxicoepidemiology and predictors of death in 2,4-dinitrophenol (DNP) toxicity.

Clin Toxicol (Phila) 2021 Jun 6;59(6):515-520. Epub 2020 Oct 6.

Medical Toxicology Center, Newcastle University, Newcastle, UK.

Introduction: 2,4-Dinitrophenol (DNP) is a highly toxic industrial chemical that is sometimes misused to reduce body fat. Toxicity following ingestion of DNP has recently become more common in the United Kingdom. This research was performed to document the frequency of DNP toxicity as reported to poisons centres in the United States (US) and United Kingdom (UK) and to identify the clinical features associated with fatality. Read More

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Dexmedetomidine-Associated Hyperpyrexia in Three Critically Ill Patients With Coronavirus Disease 2019.

Crit Care Explor 2020 Sep 15;2(9):e0213. Epub 2020 Sep 15.

Division of Pulmonary and Critical Care, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Objectives: To present three patients with severe coronavirus disease 2019 infection who developed life-threatening hyperpyrexia while being treated with dexmedetomidine for sedation.

Data Sources: Clinical records.

Study Selection: Case report. Read More

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September 2020

Early clinical predictors for the prognosis of invasive pneumococcal disease.

BMC Infect Dis 2020 Sep 4;20(1):651. Epub 2020 Sep 4.

Pediatric Intensive Care Unit, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.

Background: Risk factors related to mortality due to invasive pneumococcal disease (IPD) have been unveiled previously, but early clinical manifestations of IPD based on prognosis remain uncovered.

Methods: The demographic characteristics, clinical features, serotype, antibiotic susceptibility, and outcomes of 97 hospitalized children with laboratory-confirmed IPD from Suzhou, China, were collected and analyzed retrospectively.

Results: The median age was 0. Read More

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September 2020

Ten years of vaccinovigilance in Italy: an overview of the pharmacovigilance data from 2008 to 2017.

Sci Rep 2020 08 24;10(1):14122. Epub 2020 Aug 24.

Section of Pharmacology, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.

Reporting and analysis of Adverse Events Following Immunization (AEFIs) are the cornerstones of vaccine safety surveillance prompting causality assessment and signal detection. This paper describes the impact of the Italian Pharmacovigilance System of vaccines over a 10-year period (2008-2017). The reporting rate (RR) per all distributed dose was calculated. Read More

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Use of the CytoSorb adsorption device in MDMA intoxication: a first-in-man application and in vitro study.

Intensive Care Med Exp 2020 Jun 15;8(1):21. Epub 2020 Jun 15.

Department of Cardiology and Angiology I, Faculty of Medicine, Heart Center Freiburg University, University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.

Background: 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") abuse is frequent, and overdosing might cause severe and eventually lethal multi-organ failure. To date, there is no causal therapy of MDMA intoxication and removal of MDMA from the circulation might be a reasonable measure to prevent adverse courses after overdosing. We present here first-in-man experience and in vitro data supporting a potential role of an adsorber device in severe MDMA overdosing. Read More

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Acute Flaccid Paralysis as the Initial Manifestation of Japanese Encephalitis: a Case Report.

Jpn J Infect Dis 2020 Sep 30;73(5):381-382. Epub 2020 Apr 30.

The Department of Neurology, West China Hospital, Sichuan University, China.

Japanese encephalitis (JE) is a clinical disease caused by inflammation of the central nervous system. The symptoms of this disease range broadly in severity from mild febrile illness to acute meningomyeloencephalitis. JE has been associated with a variety of neurological abnormalities, such as altered sensorium, seizures, focal neurological deficit, and acute flaccid paralysis (AFP). Read More

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September 2020

Postoperative Tetraplegia to a Child after Cerebellar Pilocytic Astrocytoma Excision at Prone Position: Case Report and Literature Review.

Am J Case Rep 2020 Mar 12;21:e920213. Epub 2020 Mar 12.

Department of Neurosurgery, Agia Sophia, Pediatric Hospital, Athens, Greece.

BACKGROUND Various factors have been implicated in the pathogenesis of infarction after posterior fossa surgery such as venous air embolism, patient's position (seated or prone), hyperflexion of the neck, excessive spinal cord traction, cervical canal stenosis, and systemic arterial hypotension. The main aim of this case report was to elucidate a case in which hydrogen peroxide was implicated in a major and systemic complication after a neurosurgical procedure. CASE REPORT We describe the case of a 5-year-old female patient who was admitted to our hospital because of a cerebellar hemispheric astrocytoma associated with obstructive hydrocephalus and accompanied by 2 syringomyelic cavities in the cervicothoracic portion of the spinal cord. Read More

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Management of cytokine release syndrome related to CAR-T cell therapy.

Front Med 2019 Oct 28;13(5):610-617. Epub 2019 Sep 28.

Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.

Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. Read More

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October 2019

High mobility group box 1 protein released in the course of aseptic necrosis of tissues sensitizes rats to pyrogenic effects of lipopolysaccharide.

J Therm Biol 2019 Aug 4;84:36-44. Epub 2019 Jun 4.

Department of Immunology, Faculty of Biology and Environment Protection, Nicolaus Copernicus University, 1 Lwowska Street, 87-100, Torun, Poland.

It is still an open question as to whether or not aseptic injuries affect the generation of fever due to exogenous pyrogens including bacterial products. Therefore, in the present paper we have investigated the course of endotoxin fever in rats induced with lipopolysaccharide (LPS; given intraperitoneally in a dose of 50 μg/kg) 48 h after subcutaneous administration of turpentine oil (TRP; 0.1 mL per rat) that causes aseptic necrosis of tissues. Read More

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Aplastic anemia associated with Crohn's disease: a tertiary center retrospective study.

Ann Hematol 2019 Sep 29;98(9):2053-2061. Epub 2019 Jun 29.

State key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an, 710032, China.

Aplastic anemia (AA) has been reported to be associated with inflammatory bowel disease (IBD), but mostly with ulcerative colitis (UC). Little is known about the associations between AA and Crohn's disease (CD). We aim to determine the portraits of patients with AA-CD. Read More

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September 2019

Histologic Changes In Recreational Drug Misuse.

Acad Forensic Pathol 2018 Sep 31;8(3):653-691. Epub 2018 Aug 31.

Use of recreational drugs is associated with a number of histologic changes. These may be related to the method of administration or due to systemic effects of the drugs. This paper reviews the histopathological features seen following recreational drug use. Read More

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September 2018

Concomitant severe influenza and cryptococcal infections: A case report and literature review.

Medicine (Baltimore) 2019 May;98(19):e15544

Department of Respiratory and Critical Care Medicine.

Concomitant influenza and cryptococcal infections are rare. Herein, we describe an unusual case of an avian influenza A (H7N9) infection with several severe mixed bacterial infections and systemic super-infection with Cryptococcus neoformans presenting as ventilator-associated pneumonia (VAP) and bloodstream infection in a previously immunocompetent man during hospitalization.A 58-year-old man was admitted to our hospital complaining of hyperpyrexia, dyspnoea, cough, and phlegm with blood. Read More

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When time is of the essence: Managing care in emergency situations in Parkinson's disease.

Parkinsonism Relat Disord 2019 02 18;59:49-56. Epub 2018 Sep 18.

Department of Neurology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore, 560029, Karnataka, India. Electronic address:

A movement disorder emergency is an acute or sub-acutely evolving neurological illness predominated by a primary movement disorder. Although Parkinson's disease (PD) is a chronic, progressive disorder, patients may present with a variety of acute symptoms. Timely diagnosis and management is crucial to reduce mortality and morbidity. Read More

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February 2019

A Clinical Study of Effect of Hyperpyrexia on Otoacoustic Emissions in Children.

Indian J Otolaryngol Head Neck Surg 2018 Sep 26;70(3):438-449. Epub 2018 Apr 26.

Department of ENT, PES Institute of Medical Science and Research, Kuppam, 517 425 India.

Various degrees of sensory neural hearing loss can be seen in the progression of some hereditary periodic fever syndromes. Otoacoustic emission testing can help to establish the inner ear involvement at an early period of a periodic fever with a risk of hearing loss (Abdul Kadir et al. in J Int Adv Otol 9(2. Read More

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September 2018

A comprehensive review of malignant hyperthermia: Preventing further fatalities in orthopedic surgery.

J Orthop 2018 Jun 7;15(2):578-580. Epub 2018 May 7.

The University of Toledo College of Medicine and Life Sciences, Department of Orthopaedic Surgery, 3000 Arlington Avenue, Toledo, OH, 43614-5807, United States.

Most frequently associated with orthopedic surgery, malignant hyperthermia is a rare genetic condition linked to volatile anesthetics and succinylcholine. If not treated quickly with appropriate measures, death may result. To aid in the prevention of further fatalities, this review seeks to educate clinicians and staff on the presentation and treatment of this disease, as well as to provide a comprehensive overview by further addressing prevalence, similar conditions, pathogenesis and other aspects. Read More

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Too Hot to Handle: A Case Report of Extreme Pyrexia After MDMA Ingestion.

Ther Hypothermia Temp Manag 2018 Sep 25;8(3):173-175. Epub 2018 Apr 25.

1 Adult Intensive Care Unit, King's College Hospital NHS Foundation Trust , London, United Kingdom .

Hyperpyrexia is a well-documented adverse effect of 3,4-methylenedioxymethamphetamine (MDMA) and is associated with a poor prognosis. There are currently limited published records of patients surviving a pyrexia of or greater than 43°C after MDMA intake. Rapid cooling and multiorgan support in an intensive care setting may offer patients the best chance of recovery. Read More

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September 2018

Undetectable high-density lipoprotein cholesterol in acute malaria.

J Clin Lipidol 2018 May - Jun;12(3):822-825. Epub 2018 Mar 9.

Guy's, St Thomas' and Lewisham and Greenwich Trust, St. Thomas' Hospital, London, United Kingdom.

We report the case of a 39-year-old West African man in whom high-density lipoprotein cholesterol (HDL-C) was identified as undetectable at <0.08 mmol/L. Total cholesterol in the same sample was 2. Read More

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September 2019

Incidence and risk factors of neurosurgical site infections: results of a prospective multicenter cohort study on 6359 surgeries.

J Neurosurg Sci 2021 Feb 26;65(1):24-32. Epub 2018 Mar 26.

Department of Pediatric Neurosurgery, IRCCS A. Gemelli University Polyclinic Foundation, Rome, Italy.

Background: Neurosurgical surgical site infections (SSI) are life-threatening complications, requiring medical treatment and additional surgeries and remain a substantial cause of morbidity. In order to identify the incidence and the main risk factors for SSI, we developed the Prophylaxis with Antibiotic Protocol for Neurosurgical Site Infections Study (PASSIS), a prospective observational multicenter cohort study for examining a large number of neurosurgical procedures.

Methods: The study PASSIS involved four Italian departments of neurosurgery applying the same antibiotic prophylaxis (ABP) protocol on 6359 consecutive neurosurgical procedures. Read More

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February 2021

Comparison of patients with avian influenza A (H7N9) and influenza A (H1N1) complicated by acute respiratory distress syndrome.

Medicine (Baltimore) 2018 Mar;97(12):e0194

Department of Respiratory Intensive Care Unit.

The aim of this study was to compare the clinical features of patients with avian influenza A (H7N9) and influenza A (H1N1) complicated by acute respiratory distress syndrome (ARDS).The clinical data of 18 cases of H7N9 and 26 cases of H1N1 with ARDS were collected and compared in the respiratory intensive care unit (RICU) of Fuzhou Pulmonary Hospital of Fujian from March 2014 to December 2016.Patients with H7N9 had a higher acute physiology and chronic health evaluation-II score (P < . Read More

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Hyperpyrexia and high fever as a predictor for serious bacterial infection (SBI) in children-a systematic review.

Eur J Pediatr 2018 Mar 31;177(3):337-344. Epub 2018 Jan 31.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

It is not clear if children with high fever are at increased risk for serious bacterial infection (SBI). Our aim was to systematically review if children suffering from high fever are at high risk for SBI. Our data sources were Embase, Medline, and Pubmed; from their inception until the last week of March 2017. Read More

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