35,428 results match your criteria associated hscrp

Erectile Dysfunction in Type-2 Diabetes Mellitus Patients: Predictors of Early Detection and Treatment.

Urol Int 2021 May 5:1-7. Epub 2021 May 5.

Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Purpose: To identify risk factors and potential predictors of erectile dysfunction (ED) in type-2 diabetes mellitus (T2DM) patients for early detection and treatment.

Methods: A retrospective cohort was used to assess the clinical data of 105 diabetic patients with ED from May 2019 to April 2020 age-matched to 105 diabetic patients without ED. Potential risk factors that could contribute to ED were compared between the groups. Read More

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Frailty is associated with in-hospital mortality in older hospitalised COVID-19 patients in the Netherlands: the COVID-OLD study.

Age Ageing 2021 May;50(3):631-640

Department of Internal Medicine, Haga Teaching Hospital, The Hague, the Netherlands.

Background: During the first wave of the coronavirus disease 2019 (COVID-19) pandemic, older patients had an increased risk of hospitalisation and death. Reports on the association of frailty with poor outcome have been conflicting.

Objective: The aim of the present study was to investigate the independent association between frailty and in-hospital mortality in older hospitalised COVID-19 patients in the Netherlands. Read More

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Predictive Factors of Chemotherapy Initiation after Biliary Drainage for Advanced Biliary Tract Cancer: A Retrospective Multicenter Study.

J Gastrointestin Liver Dis 2021 May 3. Epub 2021 May 3.

IMAD, Department of Gastroenterology and Digestive Oncology, University Hospital, Nantes, France.

Background And Aims: In unresectable biliary tract cancers, the management of biliary obstruction is often the first step before introduction of chemotherapy. Our aim was to study the predictive factors of chemotherapy initiation after biliary drainage in a series of patients presenting with advanced biliary tract cancer and obstructive jaundice.

Methods: Data of all patients treated for unresectable biliary tract cancer with initial biliary obstruction requiring a drainage in six institutions, from January 2009 to January 2019, were retrospectively collected. Read More

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Bipolar disorder: an association of body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation.

Trends Psychiatry Psychother 2021 May 4. Epub 2021 May 4.

Laboratório de Psiquiatria Molecular, Hospital de Clínicas de Porto Alegre (HCPA). Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Departamento de Psiquiatria e Medicina Legal da Universidade Federal do Rio Grande do Sul, Brazil.

Objective: To investigate body mass index (BMI) associations with white matter fractional anisotropy (FA) and C-reactive protein (CRP) in individuals with bipolar disorder (BD) during euthymia in comparison with a control group of healthy subjects (CTR).

Methods: The sample consisted of 101 individuals (BD n=35 and CTR n=66). Regions of interest (ROI) were defined through machine learning approach. Read More

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Genetically determined elevated C-reactive protein associated with primary colorectal cancer risk: Mendelian randomization with lifestyle interactions.

Am J Cancer Res 2021 15;11(4):1733-1753. Epub 2021 Apr 15.

Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, CA 90095, USA.

Systemic inflammation-related etiologic pathways via inflammatory cytokines in the development of colorectal cancer (CRC) have not been convincingly determined and may be confounded by lifestyle factors or reverse causality. We investigated the genetically predicted C-reactive protein (CRP) phenotype in the potential causal pathway of primary CRC risk in postmenopausal women in a Mendelian randomization (MR) framework. We employed individual-level data of the Women's Health Initiative Database for Genotypes and Phenotypes Study, which consists of 5 genome-wide association (GWA) studies, including 10,142 women, 737 of whom developed primary CRC. Read More

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Serum C-Reactive Protein Is Negatively Associated With Olfactory Identification Ability in Older Adults.

Iperception 2021 Mar-Apr;12(2):20416695211009928. Epub 2021 Apr 14.

Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Stockholm Gerontology Research Center, Stockholm, Sweden.

Importance: Olfactory deficits are common in aging and associated with several conditions linked to inflammation. A few studies suggest that increased concentration of pro-inflammatory biomarkers may be related to olfactory deficits, but these associations are understudied in population-based samples.

Objective: To investigate the association between serum concentrations of C-reactive protein (CRP) and olfactory identification level as well as rate of change in aging. Read More

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Relevance of monitoring transmural disease activity in patients with Crohn's disease: current status and future perspectives.

Therap Adv Gastroenterol 2021 16;14:17562848211006672. Epub 2021 Apr 16.

Department of Gastroenterology, University Teaching Hospital Lueneburg, Bögelstraße 1, Lueneburg 21339, Germany.

Treatment targets of inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD) have evolved over the last decade. Goals of therapy consisting of symptom control and steroid sparing have shifted to control of disease activity with endoscopic remission being an important endpoint. Unfortunately, this requires ileocolonoscopy, an invasive procedure. Read More

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Biomarkers of Potential Harm among Adult Cigarette and Smokeless Tobacco Users in the PATH Study Wave 1 (2013-2014): A Cross-Sectional Analysis.

Cancer Epidemiol Biomarkers Prev 2021 May 4. Epub 2021 May 4.

Center for Tobacco Products, Food and Drug Administration, DHHS.

Background: While smokeless tobacco (ST) is causes oral cancer and is associated with cardiovascular diseases, less is known about how its effects differ from other tobacco use. Biomarkers of potential harm (BOPH) can measure short-term health effects such as inflammation and oxidative stress.

Method: We compared BOPH concentrations (interleukin-6 [IL-6], high-sensitivity C-reactive protein, fibrinogen, soluble intercellular adhesion molecule-1 (sICAM-1), and F2-isoprostane) across 3,460 adults in Wave 1 of the Population Assessment of Tobacco and Health Study (2013-2014) by tobacco use groups: primary ST users (current exclusive ST use among never smokers), secondary ST users (current exclusive ST use among former smokers), exclusive cigarette smokers, dual users of ST and cigarettes, former smokers, and never tobacco users. Read More

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The value of conventional radiographs for diagnosing internal fixation-associated infection.

BMC Musculoskelet Disord 2021 May 4;22(1):411. Epub 2021 May 4.

Department of Traumatology and Orthopedic Surgery, Hospital Universitario 12 de Octubre, Avda Córdoba s/n, 28041, Madrid, Spain.

Background: The aim of the study is to  assess the diagnostic value of preoperative conventional radiographs for diagnosing infection associated with internal fixation devices.

Methods: We prospectively collected data of patients undergoing removal of internal fixation devices for any reason. Infection was diagnosed in case of purulence, sinus tract, positive histopathology and/or positive peri-implant tissue or sonication fluid culture. Read More

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Mild ast elevation as an early sign of COVID-19 severity in a multicenter Madrid cohort.

Rev Esp Enferm Dig 2021 May 5. Epub 2021 May 5.

Liver Unit, Gastroenterology,IDIPHISA,UAM,CIBErehd, Hospital Universitario Puerta de Hierro-Majadahonda.

Introduction: Liver enzyme elevation has been reported for SARS-CoV-2 disease (COVID-19) in heterogeneous cohorts, mainly from China. Comprehensive reports from other countries are needed. We dissect the pattern, evolution and predictive value of such abnormalities in a cohort from Madrid, Spain. Read More

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Lymphopenia and lung complications in patients with coronavirus disease-2019 (COVID-19): A retrospective study based on clinical data.

J Med Virol 2021 May 4. Epub 2021 May 4.

Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Background: A rapid outbreak of novel coronavirus, COVID-19, made it a global pandemic. This study focused on the possible association between lymphopenia and Computed tomography (CT) scan features and COVID-19 patient mortality.

Method: The clinical data of 596 COVID-19 patients were collected from February 2020 to September 2020. Read More

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Cancer is associated with inferior outcome in patients with ischemic stroke.

J Neurol 2021 May 4. Epub 2021 May 4.

Department of Neurology, University Hospital and University of Zurich, CH-8091, Zurich, Switzerland.

Background: Whether patients with stroke and cancer exhibit specific characteristics has remained controversial.

Methods: Medical records of patients with ischemic stroke in 2014 or 2015 registered in the Swiss Stroke Registry of Zurich were retrospectively analyzed and integrated with regional cancer registry data. Associations of clinical and outcome parameters with cancer diagnosed up to 5 years prior to stroke were tested. Read More

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Machine Learning Approaches to Identify Factors Associated with Women's Vasomotor Symptoms Using General Hospital Data.

J Korean Med Sci 2021 May 3;36(17):e122. Epub 2021 May 3.

Department of Obstetrics & Gynecology, Korea University College of Medicine, Seoul, Korea.

Background: To analyze the factors associated with women's vasomotor symptoms (VMS) using machine learning.

Methods: Data on 3,298 women, aged 40-80 years, who attended their general health check-up from January 2010 to December 2012 were obtained from Korea University Anam Hospital in Seoul, Korea. Five machine learning methods were applied and compared for the prediction of VMS, measured by the Menopause Rating Scale. Read More

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SARS-CoV-2 outbreak in immune-mediated inflammatory diseases: the Euro-COVIMID multicentre cross-sectional study.

Lancet Rheumatol 2021 Apr 28. Epub 2021 Apr 28.

Sorbonne Université, Pierre Louis Institute of Epidemiology and Public Health, Inserm UMR 1136, Paris, France.

Background: The COVID-19 pandemic has raised numerous questions among patients with immune-mediated inflammatory diseases regarding potential reciprocal effects of COVID-19 and their underlying disease, and potential effects of immunomodulatory therapy on outcomes related to COVID-19. The seroprevalence of SARS-CoV-2 and factors associated with symptomatic COVID-19 in patients with immune-mediated inflammatory diseases are still unclear. The Euro-COVIMID study aimed to determine the serological and clinical prevalence of COVID-19 among patients with immune-mediated inflammatory diseases, as well as factors associated with COVID-19 occurrence and the impact of the pandemic in its management. Read More

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Insulin resistance and liver histopathology in metabolically unhealthy subjects do not correlate with the hepatic abundance of NLRP3 inflammasome nor circulating IL-1β levels.

BMJ Open Diabetes Res Care 2021 May;9(1)

Department Nutrition, Diabetes and Metabolism, Faculty of Medicine, Pontifical Catholic University of Chile, Santiago, Chile

Introduction: Systemic chronic low-grade inflammation has been linked to insulin resistance (IR) and non-alcoholic steatohepatitis (NASH). NOD-like receptor protein 3 (NLRP3) inflammasome and its final product, interleukin (IL)-1β, exert detrimental effects on insulin sensitivity and promote liver inflammation in murine models. Evidence linking hepatic NLRP3 inflammasome, systemic IR and NASH has been scarcely explored in humans. Read More

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Biomarkers of lipid metabolism in patients with juvenile idiopathic arthritis: relationship with disease subtype and inflammatory activity.

Pediatr Rheumatol Online J 2021 May 3;19(1):66. Epub 2021 May 3.

Department of Pediatrics, Universidade Federal de São Paulo, Rua Borges Lagoa, 802 - Vila Clementino, São Paulo, SP, CEP: 04038-001, Brazil.

Background: To describe the biomarkers of lipid metabolism in children and adolescents with polyarticular and systemic JIA and to relate them to diseases subtypes, diseases activity markers, and nutritional status.

Methods: A cross-sectional study including 62 JIA patients was performed. The following variables were evaluated: disease activity and medications used, body mass index, height for age (z-score), skin folds (bicipital, tricipital, subscapular and suprailiac), food intake based on three 24-h food recalls, lipid profile (total cholesterol (CT), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG) and non-HDL (N-HDLc), glycemia and insulin, erythrocyte sedimentation rate (ESR), ultrasensitive C-reactive protein (us-CRP) and apolipoproteins A-I and B (Apo A-I and Apo B). Read More

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Anemia, Hepcidin, and Vitamin D in Healthy Preterm Infants: A Pilot Study.

Am J Perinatol 2021 May 3. Epub 2021 May 3.

Department of Pediatrics, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective:  The etiology of anemia in premature neonates is multifactorial and may involve anemia of inflammation mediated by hepcidin. Hepcidin expression is suppressed by vitamin D. We aimed to investigate the interrelationship between hepcidin, anemia, and vitamin D status in preterm infants. Read More

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High Mobility Group Box 1 and Interleukin 6 at Intensive Care Unit Admission as Biomarkers in Critically Ill COVID-19 Patients.

Am J Trop Med Hyg 2021 May 3. Epub 2021 May 3.

10School of Medicine, Walailak University, Nakhon Si Thammarat, Thailand.

Exuberant inflammation manifesting as a "cytokine storm" has been suggested as a central feature in the pathogenesis of severe coronavirus disease 2019 (COVID-19). This study investigated two prognostic biomarkers, the high mobility group box 1 (HMGB1) and interleukin-6 (IL-6), in patients with severe COVID-19 at the time of admission in the intensive care unit (ICU). Of 60 ICU patients with COVID-19 enrolled and analyzed in this prospective cohort study, 48 patients (80%) were alive at ICU discharge. Read More

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Glasgow prognostic score for prediction of chemotherapy-triggered acute exacerbation interstitial lung disease in patients with small cell lung cancer.

Thorac Cancer 2021 May 3. Epub 2021 May 3.

Department of Respiratory Medicine, Tokyo Medical University Hospital, Tokyo, Japan.

Background: Predicting the incidence of chemotherapy-triggered acute exacerbation of interstitial lung disease (AE-ILD) in patients with lung cancer is important because AE-ILD confers a poor prognosis. The Glasgow prognostic score (GPS), which is an inflammation-based index composed of serum levels of C-reactive protein and albumin, predicts prognosis in patients with small cell lung cancer (SCLC) without ILD. In this study, we investigated AE-ILD and survival outcome based on the GPS in patients with ILD associated with SCLC who were receiving chemotherapy. Read More

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Gender Minority Stress, Support, and Inflammation in Transgender and Gender-Nonconforming Youth.

Transgend Health 2021 Apr 16;6(2):91-100. Epub 2021 Apr 16.

Department of Pediatrics, Division of Adolescent Medicine, Ann & Robert H. Lurie Children's Hospital, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.

Transgender and gender-nonconforming (TGNC) youth often report higher rates of chronic social stressors such as victimization, discrimination, and rejection. Some of these gender-based stressors may have long-range physical health consequences through inflammation pathways. This study evaluates the feasibility and acceptability of adding biological measures of inflammation to an ongoing prospective clinical study of TGNC youth (ages 9-20 years), initiating affirming medical therapy at a large, urban children's hospital (=56). Read More

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Complex Coronary Instent Chronic Total Occlusion Lesions: Oxidative Stress, Inflammation, and Coronary Stent Lengths.

Oxid Med Cell Longev 2021 15;2021:8815048. Epub 2021 Apr 15.

Department of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian 223002, China.

The oxidative stress and inflammation played the key roles in the development of atherosclerotic coronary plaques. However, the relationships between pro/antioxidant, pro/anti-inflammatory status, and complex coronary instent chronic total occlusion lesions were not clear in the elderly patients with very long stent implantations. We tried to evaluate the roles of pro/antioxidant and pro/anti-inflammatory biomarkers in the diagnosis of complex reocclusion lesions in elderly patients after coronary stenting. Read More

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Interrelation of inflammation and oxidative stress in liver cirrhosis.

Exp Ther Med 2021 Jun 14;21(6):602. Epub 2021 Apr 14.

Department of Biochemistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

Recently, the trend of research has been focused on the role of hematological indicators in assessing the activities of various diseases. The aim of the present study was to determine the usefulness of such hematological indicators for assessment of the relationship between inflammation and oxidative stress in order to provide new predictive tools for a non-invasive investigation of disease outcome for liver cirrhosis patients. A total of 35 subjects with compensated or decompensated liver cirrhosis and 10 age-matched healthy volunteers were included in this study. Read More

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High density lipoprotein cholesterol / C reactive protein ratio in heart failure with preserved ejection fraction.

ESC Heart Fail 2021 May 2. Epub 2021 May 2.

Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.

Aims: The impacts of high density lipoprotein cholesterol (HDL-C) as an anti-inflammatory and C reactive protein (CRP) as inflammatory properties on the pathogenesis of heart failure were reported. At present, the clinical significance of the HDL-C/CRP ratio in heart failure with preserved ejection fraction (HFpEF) patients remains unknown.

Methods And Results: We examined the data on 796 consecutive HFpEF (left ventricular ejection fraction ≥50%) patients hospitalized due to acute decompensated heart failure from the PURSUIT-HFpEF registry, a prospective, multicentre observational study. Read More

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Phase angle association with metabolic profile in adults: A population-based study.

Nutrition 2021 Mar 7;90:111233. Epub 2021 Mar 7.

Universidade Federal de Santa Catarina, Departamento de Nutrição, Santa Catarina, Brasil.

Objective: This study assesses the association of the phase angle (PhA) with the metabolic profile in adults of both sexes.

Methods: This is a cross-sectional, population-based study including 949 adults 20 to 59 y of age living in the Viçosa, Minas Gerais, Brazil - urban zone. The PhA was measured based on electrical bioimpedance analysis. Read More

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Do inflammation and adiposity mediate the association of diet quality with depression and anxiety in young adults?

Clin Nutr 2021 Apr 7;40(5):2800-2808. Epub 2021 Apr 7.

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.

Background & Aims: Diet quality has been inversely associated with depression, but less is known about its association with anxiety and about the mechanisms involved in the association between diet and mental health. This study aimed to assess the associations of diet quality with major depressive disorder (MDD) and generalized anxiety disorder (GAD) in young adults, and to explore whether inflammation, indexed by interleukin-6 (IL-6) and C-reactive protein (CRP), and body mass index (BMI) mediate this association.

Methods: We used data of 3331 participants from the 1993 Pelotas Birth Cohort (Brazil). Read More

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Redefining peripheral inflammation signature in schizophrenia based on the real-world FACE-SZ cohort.

Prog Neuropsychopharmacol Biol Psychiatry 2021 Apr 29:110335. Epub 2021 Apr 29.

Fondation FondaMental, Créteil, France; Université Paris Est Creteil (UPEC), AP-HP, Hôpitaux Universitaires « H. Mondor », DMU IMPACT, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, F-94010 Creteil, France.

Background: Peripheral inflammation is associated with impaired prognosis in schizophrenia (SZ). Highly sensitive C-reactive protein (hs-CRP) is the most used inflammatory biomarker in daily practice. However, no consensual cut-off has been determined to date to discriminate patients with peripheral inflammation from those without. Read More

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Factors associated with reduced infliximab exposure in the treatment of pediatric autoimmune disorders: a cross-sectional prospective convenience sampling study.

Pediatr Rheumatol Online J 2021 May 1;19(1):62. Epub 2021 May 1.

Department of Pediatrics, Duke University Hospital, Durham, NC, USA.

Background: Inadequate systemic exposure to infliximab (IFX) is associated with treatment failure. This work evaluated factors associated with reduced IFX exposure in children with autoimmune disorders requiring IFX therapy.

Methods: In this single-center cross-sectional prospective study IFX trough concentrations and anti-drug antibodies (ADAs) were measured in serum from children diagnosed with inflammatory bowel disease (IBD) (n = 73), juvenile idiopathic arthritis (JIA) (n = 16), or uveitis (n = 8) receiving maintenance IFX infusions at an outpatient infusion clinic in a tertiary academic pediatric hospital. Read More

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Prognostic value of the C-reactive protein to albumin ratio in colorectal cancer: an updated systematic review and meta-analysis.

World J Surg Oncol 2021 May 1;19(1):139. Epub 2021 May 1.

Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, No. 5, Fuxing St., Guishan Dist., Taoyuan, 33305, Taiwan.

Backgrounds: The inflammatory biomarker "C-reactive protein to albumin ratio (CAR)" has been reported to significantly correlate to a variety of human cancers. However, there are conflicting results regarding the prognostic value of CAR in colorectal cancer. Previous studies mainly assessed patients in Eastern countries, so their findings may not be applicable to the Western population. Read More

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IL-6, sTNF-R2, and CRP in the context of sleep, circadian preference, and health in adolescents with eveningness chronotype: Cross-sectional and longitudinal treatment effects.

Psychoneuroendocrinology 2021 Apr 26;129:105241. Epub 2021 Apr 26.

Department of Psychology, University of California, Berkeley, CA, USA. Electronic address:

Background: Inflammation-related processes have emerged as a biological pathway related to adolescent development. This study examined cross-sectional and longitudinal associations of baseline inflammatory markers with sleep, circadian preference, and health at baseline and following treatment.

Methods: Participants included 165 adolescents (58. Read More

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Endocrine and immunomodulatory effects of social isolation and loneliness across adulthood.

Psychoneuroendocrinology 2021 Mar 8;128:105194. Epub 2021 Mar 8.

Department of Psychology, Wayne State University, USA.

Experimental and observational evidence agreed on two interconnected biological mechanisms responsible for the links between social isolation/loneliness and health: alterations in the activity of the hypothalamic-pituitary-adrenal (HPA) axis and compromised functioning of the innate immune system. However, most existing studies did not consider the simultaneous impact of social isolation and loneliness on biological outcomes. Further, they only assessed one biological outcome at a time and did not test any moderation by age, despite empirical and theoretical evidence supporting the plausibility of this hypothesis. Read More

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