777,251 results match your criteria associated higher


Pain and mortality among older adults in Korea.

Epidemiol Health 2021 Sep 7:e2021058. Epub 2021 Sep 7.

Graduated School of Public Health, Seoul National University, Seoul, Korea.

Objectives: With the rising elderly population subject to chronic disease, pain becomes crucial to understand and design an appropriate approach to it. While pain is a noted mortality risk factor, limited studies exists due to various causes of pain and subjectivity of pain expression. This study aims to examine the relationship between pain and mortality, controlling for other disease and socio-cultural factors. Read More

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September 2021

Association of regional-level perceived stress and depression with health related quality-of-life of Korean adults: a multilevel analysis of 2017 Korea Community Health Survey data.

Epidemiol Health 2021 Sep 8:e2021062. Epub 2021 Sep 8.

Department of Preventive Medicine, Chungnam National University College of Medicine, Daejeon, Korea.

Objectives: We examined the association of individual and regional-level perceived stress and depression with health related quality-of-life (HRQOL) of Korean adults.

Methods: We used data from the 2017 Korean Community Health Survey (KCHS), which included 216,713 adults living within 254 municipal districts. As individual-level independent variables, perceived stress (higher vs. Read More

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September 2021

Association between body temperature and leukocyte telomere length in middle-aged and older adults.

Epidemiol Health 2021 Sep 8:e2021063. Epub 2021 Sep 8.

Department of Foods and Nutrition, College of Natural Sciences, Kookmin University, 02707 Seoul, Republic of Korea.

Objectives: Data on the association between body temperature (BT) and leukocyte telomere length (LTL), which has been widely used as a biomarker of cellular senescence in recent epidemiological studies, are limited. Aims: The present study aimed to explore the association between a normal BT range (35.0 to 37. Read More

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September 2021

Social competence, leisure time activities, and smoking trajectories among adolescent boys: Data from The Korean Children & Youth Panel Survey.

Epidemiol Health 2021 Sep 9:e2021066. Epub 2021 Sep 9.

Division of Cancer Prevention & Early Detection, National Cancer Control Institute, National Cancer Center, Goyang, Korea.

Objectives: To identify trajectories and potential predictors of tobacco use patterns among adolescents in Korea and to develop appropriate strategies for the implementation of primary prevention of tobacco use.

Methods: Tobacco trajectory and associated predictors were analyzed for 1,169 children from sixth (age 11) to tenth (age 15) grades in The Korean Children & Youth Panel Survey from 2012 to 2016.

Results: The three trajectory of smoking experience was identified: non-smokers (T1; 82. Read More

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September 2021

Clinical analysis of uterine intravenous leiomyomatosis: A retrospective study of 260 cases.

J Obstet Gynaecol Res 2021 Sep 15. Epub 2021 Sep 15.

Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

Methods: We collected the clinical data of 260 patients admitted to the hospital from April 2003 to September 2019 with pathologically confirmed intravenous leiomyomatosis (IVL) and followed up with these patients regularly. Univariate and multivariate logistic regression analyses were carried out on the relevant recurrence factors.

Results: A total of 166 patients were regularly followed up, the median follow-up time was 36 (range 2-168) months, 14 (5. Read More

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September 2021

Patients with Severe Lactic Acidosis in the Intensive Care Unit: A Retrospective Study of Contributing Factors and Impact of Renal Replacement Therapy.

Blood Purif 2021 Sep 15:1-7. Epub 2021 Sep 15.

Department of Nephrology, Ghent University Hospital, Ghent, Belgium.

Introduction: Hyperlactatemia is a regular condition in the intensive care unit, which is often associated with adverse outcomes. Control of the triggering condition is the most effective treatment of hyperlactatemia, but since this is mostly not readily possible, extracorporeal renal replacement therapy (RRT) is often tried as a last resort. The present study aims to evaluate the factors that may contribute to the decision whether to start RRT or not and the potential impact of the start of RRT on the outcome in patients with severe lactic acidosis (SLA) (lactate ≥5 mmol/L). Read More

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September 2021

Anti-Vibrio dibutyl phthalate from marine-derived Streptomyces sp. S073.

Res Vet Sci 2021 Sep 8;140:198-202. Epub 2021 Sep 8.

Department of Ecology, Institute of Hydrobiology, School of Life Science and Technology, Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes, Engineering Research Center of Tropical and Subtropical Aquatic Ecological Engineering, Ministry of Education, Jinan University, Guangzhou 510632, PR China. Electronic address:

Marine Streptomyces S073 was previously shown to have strong anti-Vibrio activity, and its antibacterial mechanism was proposed to be associated with siderophore-mediated iron competition and other antagonistic agents. In this study, anti-Vibrio compounds produced by S073 were isolated by bioassay-guided fractionation using column chromatography and HPLC, and the target compound in the most active fraction was identified as dibutyl phthalate (DBP) by various spectroscopic analyses, including EI-MS, H NMR and C NMR. The DBP-producing capacity of S073 was 2. Read More

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September 2021

Applying interpretable deep learning models to identify chronic cough patients using EHR data.

Comput Methods Programs Biomed 2021 Sep 4;210:106395. Epub 2021 Sep 4.

Indiana University School of Medicine, 340W 10th St #6200, Indianapolis, IN 46202, United States; Regenstrief Institute, 1101W 10th Street, Indianapolis, IN, 46202, United States. Electronic address:

Background And Objective: Chronic cough (CC) affects approximately 10% of adults. Many disease states are associated with chronic cough, such as asthma, upper airway cough syndrome, bronchitis, and gastroesophageal reflux disease. The lack of an ICD code specific for chronic cough makes it challenging to identify such patients from electronic health records (EHRs). Read More

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September 2021

AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke.

Cell Rep 2021 Sep;36(11):109693

Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; LEAP, Japan Agency for Medical Research and Development, Tokyo 113-0033, Japan; Laboratoire d'ImmunoRhumatologie Moléculaire, Plateforme GENOMAX, Institut National de la Santé et de la Recherche Médicale UMR_S 1109, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg, Laboratory of Excellence TRANSPLANTEX, Université de Strasbourg, Strasbourg, France. Electronic address:

The sterile inflammation caused by damage-associated molecular patterns (DAMPs) worsens the prognosis following primary injury such as ischemic stroke. However, there are no effective treatments to regulate DAMPs. Here, we report that AIM (or CD5L) protein reduces sterile inflammation by attenuating DAMPs and that AIM administration ameliorates the deleterious effects of ischemic stroke. Read More

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September 2021

Hydrokinetic pancreatic function and insulin secretion are moduled by Cl uniporter Slc26a9 in mice.

Acta Physiol (Oxf) 2021 Sep 15:e13729. Epub 2021 Sep 15.

Dept. of Gastroenterology, Hannover Medical School, Hannover, Germany.

Aim: Slc26a9 is a member of the Slc26 multifunctional anion transporter family. Polymorphisms in Slc26a9 are associated with an increased incidence of meconium ileus and diabetes in cystic fibrosis patients. We investigated the expression of Slc26a9 in the murine pancreatic ducts, islets and parenchyma, and elucidated its role in pancreatic ductal electrolyte and fluid secretion and endocrine function. Read More

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September 2021

Genome- and transcriptome-wide association studies reveal the genetic basis and the breeding history of seed glucosinolate content in Brassica napus.

Plant Biotechnol J 2021 Sep 15. Epub 2021 Sep 15.

National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.

A high content of seed glucosinolates (GSLs) and their degradation products impose anti-nutritional effects on livestock; therefore, persistent efforts are made to reduce the seed GSL content to increase the commercial value of rapeseed meal. Here, we dissected the genetic structure of SGC by genome-wide association studies (GWAS) combined with transcriptome-wide association studies (TWAS). Fifteen reliable QTLs were identified to be associated with the reduced SGC in modern B. Read More

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September 2021

Single base editing of rs12603332 on Chromosome 17q21 with a Cytosine Base Editor regulates ORMDL3 and ATF6α expression.

Allergy 2021 Sep 15. Epub 2021 Sep 15.

Department of Medicine, University of California San Diego, La Jolla, California, USA.

Background: Genetic association studies have demonstrated that the SNP rs12603332 located on chromosome 17q21 is highly associated with the risk of the development of asthma.

Methods: To determine whether SNP rs1260332 is functional in regulating levels of ORMDL3 expression we used a Cytosine Base Editor (CBE) plasmid DNA or a CBE mRNA to edit the rs12603332 C risk allele to the T non-risk allele in a human lymphocyte cell line (i.e. Read More

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September 2021

IL-1 Mediates Microbiome-Induced Inflamm-Ageing of Hematopoietic Stem Cells in Mice.

Blood 2021 Sep 15. Epub 2021 Sep 15.

University Hospital Zurich and University of Zurich, Zurich, Switzerland.

Ageing is associated with impaired hematopoietic and immune function. This is caused in part by decreased hematopoietic stem cell (HSC) population fitness and an increased myeloid differentiation bias. The reasons for this aging-associated HSC impairment are incompletely understood. Read More

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September 2021

Adiponectin, leptin and resistin and the risk of dementia.

J Gerontol A Biol Sci Med Sci 2021 Sep 15. Epub 2021 Sep 15.

Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Adipokines are hormones secreted by adipose tissue with roles in energy homeostasis and regulation of metabolism. Their dysregulation is suggested to contribute to the increased risk of dementia seen with midlife obesity, but longitudinal studies investigating this are scarce. We determined the association between plasma levels of adiponectin, leptin and resistin with the risk of dementia. Read More

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September 2021

Health Care Costs and Resource Utilization Among Patients With Crohn's Disease With and Without Perianal Fistula.

Inflamm Bowel Dis 2021 Sep 15. Epub 2021 Sep 15.

Vanderbilt University Medical Center, Nashville, TN, USA.

Background: Perianal fistula (PAF), a complication of Crohn's disease (CD), is associated with substantial economic costs and poor prognosis. We determined prevalence of PAF CD in the United States and compared costs and health care resource utilization (HRU) of PAF CD patients with matched non-PAF CD patients.

Methods: This was a retrospective cohort study of claims data from the IBM MarketScan Commercial Database from October 1, 2015, to September 30, 2018. Read More

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September 2021

Characterization of HLH-Like Manifestations as a CRS Variant in Patients Receiving CD22 CAR T-Cells.

Blood 2021 Sep 15. Epub 2021 Sep 15.

National Institute of Health, Bethesda, Maryland, United States.

CAR T-cell toxicities resembling hemophagocytic lymphohistiocytosis (HLH) occur in a subset of patients with cytokine release syndrome (CRS). As a variant of conventional CRS, a comprehensive characterization of CAR T-cell associated HLH (carHLH) and investigations into associated risk factors are lacking. In the context of 59 patients infused with CD22 CAR T-cells where a substantial proportion developed carHLH, we comprehensively describe the manifestations and timing of carHLH as a CRS variant and explore factors associated with this clinical profile. Read More

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September 2021

Plasminogen activator inhibitor-1and Adiponectin are associated with metabolic syndrome components.

Am J Hypertens 2021 Sep 15. Epub 2021 Sep 15.

Departmento de Endocrinología, Escuela de Medicina, Pontificia Universidad Católica de Chile. Avda Libertador Bernardo O´Higgins, Santiago Centro, Santiago, Chile.

Background: We aimed to study the associations of adipocytokines, endothelial damage markers, and hs-CRP with metabolic syndrome (MetS) components.

Methods: This cross-sectional study included 202 subjects categorized into MetS and No-MetS according to Harmonizing ATP III.

Results: Subjects with MetS showed higher levels of pro-inflammatory molecules but significantly lower adiponectin levels than subjects with No-MetS. Read More

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September 2021

Stromal marker fibroblast activation protein drives outcome in T1 non-muscle invasive bladder cancer.

PLoS One 2021 15;16(9):e0257195. Epub 2021 Sep 15.

Department of Urology, University Hospitals Leuven, Leuven, Belgium.

Fibroblast activation protein-α (FAP) is a transmembrane peptidase and a surrogate marker for cancer-associated fibroblasts (CAFs). FAP has been linked to worse prognosis and therapy resistance in several cancers. We hypothesised that FAP might have a prognostic 3biomarker potential to stratify patients with high-grade (HG) T1 non-muscle-invasive bladder cancer (NMIBC). Read More

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September 2021

Acceptance of COVID-19 vaccine in Pakistan among health care workers.

PLoS One 2021 15;16(9):e0257237. Epub 2021 Sep 15.

Department of Hematology, Foundation University Medical College, Islamabad, Pakistan.

Objective: Acceptance of the COVID-19 vaccine will impart a pivotal role in eradicating the virus. In Pakistan, health care workers (HCWs) are the first group to receive vaccination. This survey aimed at the level of acceptance to the COVID-19 vaccine and predictors of non-acceptance in HCWs. Read More

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September 2021

Heterogeneous development of children with Congenital Zika Syndrome-associated microcephaly.

PLoS One 2021 15;16(9):e0256444. Epub 2021 Sep 15.

Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brazil.

Objective: To describe the neurological and neurodevelopmental outcomes of children with Congenital Zika Syndrome (CZS) associated microcephaly beyond 2 years of age.

Method: We followed children with CZS-associated microcephaly in an outpatient clinic in Salvador, Brazil. Neurological and neurodevelopmental assessments were performed using the Hammersmith Infant Neurological Examination (HINE) and Bayley Scales of Infant and Toddler Neurodevelopment (Bayley-III) respectively. Read More

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September 2021

Exposure to authoritarian values leads to lower positive affect, higher negative affect, and higher meaning in life.

PLoS One 2021 15;16(9):e0256759. Epub 2021 Sep 15.

University of Missouri, Columbia, New York, United States of America.

Five studies tested the effect of exposure to authoritarian values on positive affect (PA), negative affect (NA), and meaning in life (MIL). Study 1 (N = 1,053) showed that simply completing a measure of right-wing authoritarianism (vs. not) prior to rating MIL led to higher MIL. Read More

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September 2021

Social reward and support effects on exercise experiences and performance: Evidence from parkrun.

PLoS One 2021 15;16(9):e0256546. Epub 2021 Sep 15.

Social Body Lab, Institute of Human Sciences, University of Oxford, Oxford, United Kingdom.

There is growing academic, civic and policy interest in the public health benefits of community-based exercise events. Shifting the emphasis from competitive sport to communal activity, these events have wide appeal. In addition to physical health benefits, regular participation can reduce social isolation and loneliness through opportunities for social connection. Read More

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September 2021

Association of physical activity intensity and bout length with mortality: An observational study of 79,503 UK Biobank participants.

PLoS Med 2021 Sep 15;18(9):e1003757. Epub 2021 Sep 15.

MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, United Kingdom.

Background: Spending more time active (and less sedentary) is associated with health benefits such as improved cardiovascular health and lower risk of all-cause mortality. It is unclear whether these associations differ depending on whether time spent sedentary or in moderate-vigorous physical activity (MVPA) is accumulated in long or short bouts. In this study, we used a novel method that accounts for substitution (i. Read More

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September 2021

Plasma glycated CD59 predicts postpartum glucose intolerance after gestational diabetes.

Eur J Endocrinol 2021 Sep 1. Epub 2021 Sep 1.

J Halperin, Divisions of Hematology, Bringham and Women's Hospital, Harvard Medical School, Boston, United States.

Aims: To assess whether in women with gestational diabetes mellitus (GDM), postpartum plasma glycated CD59 (pGCD59) levels predict conversion to glucose intolerance diagnosed with an oral glucose tolerance test (OGTT).

Methods: Blood levels of pGCD59 were measured in a case-control study of 105 women with GDM who underwent a 75g OGTT three months postpartum. The 35 postpartum glucose intolerant cases were individually matched for age, BMI, ethnic origin and parity with 70 women with GDM but normal postpartum OGTT (controls). Read More

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September 2021

Associations Between Social Media, Bedtime Technology Use Rules, and Daytime Sleepiness Among Adolescents: Cross-sectional Findings From a Nationally Representative Sample.

JMIR Ment Health 2021 Sep 15;8(9):e26273. Epub 2021 Sep 15.

Department of Psychology, Rutgers University, Piscataway, NJ, United States.

Background: Social media use is associated with poor sleep among adolescents, including daytime sleepiness, which affects adolescents' mental health. Few studies have examined the associations among specific aspects of social media, such as frequency of checking and posting, perceived importance of social media for social belonging, and daytime sleepiness. Identifying whether certain adolescents are more at risk or protected from the effects of social media on sleepiness may inform future interventions for social media, sleep, and mental health. Read More

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September 2021

The Association of Delayed Care With Depression Among US Middle-Aged and Older Adults During the COVID-19 Pandemic: Cross-sectional Analysis.

Authors:
Yan Luo

JMIR Aging 2021 Jul 31. Epub 2021 Jul 31.

The University of Alabama, 2106 Forest Lake Dr., Tuscaloosa, US.

Background: During the Coronavirus Disease 2019 (COVID-19) pandemic, the depression level among US adults has significantly increased. Age disparity in depression during the pandemic was also reported in recent studies. Delay or avoidance of medical care is one of the collateral damages caused by the COVID-19 pandemic and it can lead to increased morbidity and mortality. Read More

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Durability of Dolutegravir-Based Regimens: A 5-Year Prospective Observational Study.

AIDS Patient Care STDS 2021 Sep;35(9):342-353

Unit of Infectious and Tropical Diseases, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

This study evaluates the frequency and causes of dolutegravir (DTG) discontinuation along 5 years of follow-up, in both antiretroviral treatment (ART)-naive and experienced people living with HIV (PLWH). This is a prospective multi-center cohort study enrolling PLWH on DTG from July 2014 until November 2020. DTG-durability was investigated using the Kaplan-Meier survival curve. Read More

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September 2021

A cGAS-dependent response links DNA damage and senescence in alveolar epithelial cells: A potential drug target in IPF.

Am J Physiol Lung Cell Mol Physiol 2021 Sep 15. Epub 2021 Sep 15.

School of Biomedical Sciences and Pharmacy, grid.266842.cUniversity of Newcastle, Callaghan, NSW, Australia.

Alveolar epithelial cell (AEC) senescence is implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Mitochondrial dysfunction including release of mitochondrial DNA (mtDNA) is a feature of senescence, which led us to investigate the role of the DNA-sensing GMP-AMP synthase (cGAS) in IPF, with a focus on AEC senescence. cGAS expression in fibrotic tissue from lungs of IPF patients was detected within cells immunoreactive for epithelial cell adhesion molecule (EpCAM) and p21, epithelial and senescence markers respectively. Read More

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September 2021

Essential role of IL-23 in the development of acute exacerbation of pulmonary fibrosis.

Am J Physiol Lung Cell Mol Physiol 2021 Sep 15. Epub 2021 Sep 15.

Department of Medical Technology, grid.261356.5Okayama University Graduate School of Health Sciences, Okayama, Japan.

Acute exacerbation of idiopathic pulmonary fibrosis has a poor prognosis associated with neutrophilic inflammation. Interleukin-23 is a proinflammatory cytokine involved in neutrophilic inflammation. However, little is known about its role in acute exacerbation of pulmonary fibrosis. Read More

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September 2021

Chronic binge alcohol and ovariectomy-mediated impaired insulin responsiveness in SIV-infected female rhesus macaques.

Am J Physiol Regul Integr Comp Physiol 2021 Sep 15. Epub 2021 Sep 15.

Department of Physiology, grid.279863.1Louisiana State University Health Sciences Center New Orleans, New Orleans, Louisiana, United States.

Objective: Aging people living with HIV (PLWH), especially post-menopausal women may be at higher risk of comorbidities associated with HIV, ART, hypogonadism and at-risk alcohol use. Our studies in simian immunodeficiency virus (SIV)-infected male macaques demonstrated that chronic binge alcohol (CBA) reduced acute insulin response to glucose (AIRG), and at-risk alcohol use decreased HOMA-β in PLWH. The objective of this study was to examine the impact of ovariectomy (OVX), on glucose-insulin dynamics and integrity of pancreatic endocrine function in CBA/SIV-infected female macaques. Read More

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September 2021