307,398 results match your criteria associated greater


A systematic review of addiction substitution in recovery: Clinical lore or empirically-based?

Clin Psychol Rev 2021 Sep 10;89:102083. Epub 2021 Sep 10.

Department of Psychology, University of Calgary, Calgary, AB, Canada.

This systematic review synthesized the literature examining addiction substitution during recovery from substance use or behavioral addictions. A total of 96 studies were included with sample sizes ranging from 6 to 14,885. The most common recovery addictions were opioids (30. Read More

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September 2021

The impact of SARS-CoV-2 vaccination in Dravet syndrome: A UK survey.

Epilepsy Behav 2021 Aug 21;124:108258. Epub 2021 Aug 21.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK; Chalfont Centre for Epilepsy, Chalfont St. Peter, Buckinghamshire SL9 0RJ, UK. Electronic address:

Background: The COVID-19 pandemic led to the urgent need for accelerated vaccine development. Approved vaccines have proved to be safe and well tolerated across millions of people in the general population. Dravet syndrome (DS) is a severe, early onset, developmental and epileptic encephalopathy. Read More

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Association of perioperative hypotension with subsequent greater healthcare resource utilization.

J Clin Anesth 2021 Sep 15;75:110516. Epub 2021 Sep 15.

Mayo Clinic, Department of Anesthesiology & Critical Care Medicine, 200 1st Street SW, Rochester, MN 55905, USA.

Study Objective: Determine if perioperative hypotension, a modifiable risk factor, is associated with increased postoperative healthcare resource utilization (HRU).

Design: Retrospective cohort study.

Setting: Multicenter using the Optum® electronic health record database. Read More

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September 2021

The associations between asymmetries in quadriceps strength and gait in individuals with unilateral transtibial amputation.

Gait Posture 2021 Sep 8;90:267-273. Epub 2021 Sep 8.

Department of Life Sciences, Whitelands College, University of Roehampton, Holybourne Avenue, London, SW15 4JD, UK. Electronic address:

Background: Individuals with unilateral transtibial amputations (ITTAs) are asymmetrical in quadriceps strength. It is unknown if this is associated with gait performance characteristics such as walking speed and limb symmetry.

Research Question: Are quadriceps strength asymmetries related to walking speed and/ or gait asymmetries in ITTAs?

Methods: Knee-extensor isometric maximum voluntary torque (MVT) and rate of torque development (RTD) were measured in eight ITTAs. Read More

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September 2021

Farming systems influence the compositional, structural, and functional characteristics of the sugarcane-associated microbiome.

Microbiol Res 2021 Sep 9;252:126866. Epub 2021 Sep 9.

Laboratory of Bioinformatics, Department of Agricultural and Environmental Biotechnology, São Paulo State University (UNESP), School of Agricultural and Veterinary Sciences, Jaboticabal, 14884-900, SP, Brazil. Electronic address:

Sugarcane (Saccharum spp.) has been produced worldwide as a relevant source of food and sustainable energy. However, the constant need to increase crop yield has led to excessive use of synthetic agrochemical inputs such as inorganic fertilizers, herbicides, and pesticides in plant cultures. Read More

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September 2021

Self-Reported Physical Activity and Asthma Risk in Children.

J Allergy Clin Immunol Pract 2021 Sep 15. Epub 2021 Sep 15.

Background: Increased physical activity (PA) may protect against asthma but PA can trigger asthma symptoms.

Objective: To investigate relationships between moderate to vigorous PA (MVPA) assessed during routine care visits and incident asthma.

Methods: Retrospective cohort of 542,486 children, 2-17 years from 2010-2017 with MVPA assessed (exercise vital sign) during routine care visits. Read More

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September 2021

Tibiofemoral Articular Cartilage Composition Differs Based on Serum Biochemical Profiles Following Anterior Cruciate Ligament Reconstruction.

Osteoarthritis Cartilage 2021 Sep 15. Epub 2021 Sep 15.

Department of Exercise and Sports Science, University of North Carolina at Chapel Hill, NC.

Objective: Biochemical joint changes contribute to posttraumatic osteoarthritis (PTOA) development following anterior cruciate ligament reconstruction (ACLR). The purpose of this longitudinal cohort study was to compare tibiofemoral cartilage composition between ACLR patients with different serum biochemical profiles. We hypothesized that profiles of increased inflammation (monocyte chemoattractant protein-1 [MCP-1]), type-II collagen turnover (type-II collagen breakdown [C2C]:synthesis [CPII]), matrix degradation (matrix metalloproteinase-3 [MMP-3] and cartilage oligomeric matrix protein [COMP]) preoperatively to 6-months post-ACLR would be associated with greater tibiofemoral cartilage T1ρ relaxation times 12-months post-ACLR. Read More

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September 2021

Treadmill exercise sex-dependently alters susceptibility to depression-like behaviour, cytokines and BDNF in the hippocampus and prefrontal cortex of rats with sporadic Alzheimer-like disease.

Physiol Behav 2021 Sep 15:113595. Epub 2021 Sep 15.

Salari Institute of Cognitive and Behavioral Disorders (SICBD), Karaj, Alborz, Iran. Electronic address:

Alzheimer's disease (AD) is associated with increased depression-related behaviours. Previous studies have reported a greater risk of AD and depression in women. In recent years, we and others have provided evidence that exercise during life could be used as a therapeutic strategy for stress-related disorders such as depression. Read More

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September 2021

Neuroimaging and biomarker evidence of neurodegeneration in asthma.

J Allergy Clin Immunol 2021 Sep 15. Epub 2021 Sep 15.

Department of Medicine, University of Wisconsin-Madison, 600 Highland Ave, Madison, Wisconsin 53792, USA.

Background: Epidemiological studies have shown that Alzheimer's disease and related dementias (ADRD) are seen more frequently with asthma, especially with greater asthma severity or exacerbation frequency.

Objective: To examine the changes in brain structure that may underlie this phenomenon, we examined diffusion-weighted magnetic resonance imaging (dMRI) and blood-based biomarkers of AD (p-Tau181), neurodegeneration (NfL) and glial activation (GFAP).

Methods: dMRI data were obtained in 111 individuals with asthma, ranging in disease severity from mild to severe, and 135 healthy controls. Read More

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September 2021

Cancer in Cystic Fibrosis: A Narrative Review of Prevalence, Risk Factors, Screening and Treatment Challenges.

Chest 2021 Sep 15. Epub 2021 Sep 15.

Department of Surgery and Department of Family Medicine, New York Medical College, Valhalla, NY, USA.

Cystic fibrosis is a progressive monogenetic disorder that causes persistent pulmonary disease, but also affects other organ systems including the digestive tract. Recent advances in treatment and care of CF patients including the use of new and highly effective CFTR modulators, have led to a dramatic increase in survival; young patients with CF can now expect to live to or beyond middle age, where cancer is more frequent. CF patients are now known to face an increased risk of digestive tract cancer-particularly cancer of the colon. Read More

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September 2021

Changes in Activity Levels, Physical Functioning, and Fall Risk During the COVID-19 Pandemic.

J Am Geriatr Soc 2021 Sep 18. Epub 2021 Sep 18.

Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI.

Background: Physical function worsens with older age, particularly for sedentary and socially isolated individuals, and this often leads to injuries. Through reductions in physical activity, the COVID-19 pandemic may have worsened physical function and led to higher fall-related risks.

Methods: A nationally representative online survey of 2,006 US adults ages 50-80 was conducted in January 2021 to assess changes in health behaviors (worsened physical activity and less daily time spent on feet), social isolation (lack of companionship and perceived isolation), physical function (mobility and physical conditioning), and falls (falls and fear of falling) since March 2020. Read More

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September 2021

Local canopy disturbance as an explanation for long-term increases in liana abundance.

Ecol Lett 2021 Sep 18. Epub 2021 Sep 18.

Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin, USA.

Canopy disturbance explains liana abundance and distribution within tropical forests and thus may also explain the widespread pattern of increasing liana abundance; however, this hypothesis remains untested. We used a 10-year study (2007-2017) of 117,100 rooted lianas in an old-growth Panamanian forest to test whether local canopy disturbance explains increasing liana abundance. We found that liana density increased 29. Read More

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September 2021

Temporal trend of small nerve fibre degeneration in people with and without type 2 diabetes mellitus.

Diabet Med 2021 Sep 18:e14691. Epub 2021 Sep 18.

Department of Translational Medicine, Hand Surgery, Lund University, Malmö, Sweden.

Aims: We investigated the long-term temporal trend of intraepidermal nerve fibre density (IENFD) and the association between changes in IENFD and metabolic factors in individuals with and without type 2 diabetes.

Methods: A total of 66 participants were enrolled in this longitudinal population-based study, at baseline consisting of 35 individuals (median 61 years) without diabetes and 31 individuals with type 2 diabetes mellitus. Participants underwent clinical and electrophysiological examinations, as well as a skin biopsy both at baseline and at the follow-up visit (mean 8. Read More

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September 2021

Pulses of anthropogenic food availability appear to benefit parents, but compromise nestling growth in urban red-winged starlings.

Oecologia 2021 Sep 18. Epub 2021 Sep 18.

FitzPatrick Institute of African Ornithology, DSI-NRF Centre of Excellence, University of Cape Town, Private Bag X3, Rondebosch, 7701, South Africa.

The provision of anthropogenic food undoubtedly influences urban bird fitness. However, the nature of the impact is unclear, with both benefits and costs of urban diets documented. Moreover, the influence of short-term fluctuations in food availability, linked to urban weekday/weekend cycles of human presence, is largely unknown. Read More

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September 2021

Gingival recession treatment with enamel matrix derivative associated with coronally advanced flap and subepithelial connective tissue graft: a split-mouth randomized controlled clinical trial with molecular evaluation.

Clin Oral Investig 2021 Sep 18. Epub 2021 Sep 18.

Periodontics and Biomaterials, Faculty of Dental Medicine at the Universidade Católica Portuguesa, Viseu, Portugal.

Objectives: The goal of this study was to evaluate the impact of enamel matrix derivative (EMD) on periodontal healing after root coverage (RC) surgery, involving CAF in combination with SCTG, and to assess the molecular profile, verifying the inflammation level in early stage (1 and 2 weeks).

Materials And Methods: Thirty-two recessions (RT1) were submitted to periodontal surgery with (test) or without (control) EMD. The clinical parameters analyzed on the day of surgery and 6 months after the surgical procedure were as follows: recession height and width, keratinized tissue height, percentual root coverage, and the gingival thickness of keratinized tissue. Read More

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September 2021

Importance of Shared Treatment Goal Discussions in Rheumatoid Arthritis-A Cross-Sectional Survey: Patients Report Providers Seldom Discuss Treatment Goals and Outcomes Improve When Goals Are Discussed.

ACR Open Rheumatol 2021 Sep 18. Epub 2021 Sep 18.

Mayo Clinic, Rochester, Minnesota.

Objective: Treat-to-target (T2T) and shared decision-making are valued features of current guidelines for rheumatoid arthritis (RA) management. Although T2T has demonstrated value for improving RA outcomes, implementation remains inconsistent and lacks standardization and procedures for including patient input. We sought to better understand the impact of shared decisions on T2T and how treatment goal discussions between patients and providers impact RA treatment improvement and satisfaction. Read More

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September 2021

Historic land use and sedimentation in two urban reservoirs, Occoquan Reservoir and Lake Manassas, Virginia, USA.

Environ Sci Pollut Res Int 2021 Sep 18. Epub 2021 Sep 18.

Earth and Environmental Sciences, University of Mary Washington, Fredericksburg, VA, USA.

Human population growth and subsequent land use intensification are closely linked to contemporary increases in sediment and associated contaminants fluxes to fluvial systems, lakes, reservoirs, and coastal zones worldwide. In most urban areas, reservoirs that are the main source of fresh water supply, if not effectively managed, suffer from water quality decline and loss of capacity associated with accelerated siltation. This study analyzes watershed soil losses and sediment accumulation rates in two reservoirs in the Occoquan river basin, a sub-watershed of the Chesapeake Bay in the suburbs of the greater Washington, DC area. Read More

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September 2021

Association of hypertension with infection and inflammation in a setting of disadvantage in rural India.

J Hum Hypertens 2021 Sep 17. Epub 2021 Sep 17.

Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC, Australia.

We assessed the association of hypertension with markers of inflammation and infection in a rural and disadvantaged Indian population. In a case-control study, we age- and gender-matched 300 cases with hypertension to 300 controls without hypertension. Blood pressure was measured according to a strict protocol. Read More

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September 2021

Dietary tomato inhibits angiogenesis in TRAMP prostate cancer but is not protective with a Western-style diet in this pilot study.

Sci Rep 2021 Sep 17;11(1):18548. Epub 2021 Sep 17.

Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

Prostate cancer (PCa) remains the second most diagnosed cancer worldwide. Higher body weight is associated with chronic inflammation, increased angiogenesis, and treatment-resistant tumor phenotypes. Dietary tomato reduces PCa risk, which may be due to tomato inhibition of angiogenesis and disruption of androgen signaling. Read More

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September 2021

A phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes.

Nat Commun 2021 Sep 17;12(1):5503. Epub 2021 Sep 17.

Hightide Therapeutics, Rockville, MD, USA.

Non-alcoholic steatohepatitis is frequently associated with diabetes and may cause progressive liver disease. Current treatment options are limited. Here we report on a prospective, randomised, double-blind, placebo-controlled trial of two doses of HTD1801 (berberine ursodeoxycholate, an ionic salt of berberine and ursodeoxycholic acid), versus placebo that was conducted in 100 subjects with fatty liver disease and diabetes (NCT03656744). Read More

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September 2021

Talker Adaptation and Lexical Difficulty Impact Word Recognition in Adults with Cochlear Implants.

Audiol Neurootol 2021 Sep 14:1-10. Epub 2021 Sep 14.

Department of Otolaryngology, Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Introduction: Talker-specific adaptation facilitates speech recognition in normal-hearing listeners. This study examined talker adaptation in adult cochlear implant (CI) users. Three hypotheses were tested: (1) high-performing adult CI users show improved word recognition following exposure to a talker ("talker adaptation"), particularly for lexically hard words, (2) individual performance is determined by auditory sensitivity and neurocognitive skills, and (3) individual performance relates to real-world functioning. Read More

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September 2021

The PD-1 Regulatory Axis Inhibits T Cell-Independent B Cell Memory Generation and Reactivation.

J Immunol 2021 Sep 17. Epub 2021 Sep 17.

Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC

The inability of T cell-independent type 2 (TI-2) Ags to induce recall responses is a poorly understood facet of humoral immunity, yet critically important for improving vaccines. Using normal and VB1-8 transgenic mice, we demonstrate that B cell-intrinsic PD-1 expression negatively regulates TI-2 memory B cell (B) generation and reactivation in part through interacting with PDL1 and PDL2 on non-Ag-specific cells. We also identified a significant role for PDL2 expression on B in inhibiting reactivation and Ab production, thereby revealing a novel self-regulatory mechanism exists for TI-2 B This regulation impacts responses to clinically relevant vaccines, because PD-1 deficiency was associated with significantly increased Ab boosting to the pneumococcal vaccine after both vaccination and infection. Read More

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September 2021

C-Reactive Protein versus Erythrocyte Sedimentation Rate: Implications Among Patients with No Known Inflammatory Conditions.

J Am Board Fam Med 2021 Sep-Oct;34(5):974-983

From the Department of Internal Medicine, Complejo Hospitalario Universitario, University of Santiago de Compostela, Spain (VA-C, BS, AG-Q); Primary Care Center, A Estrada, Spain (CF-M, JS-C); Department of Clinical Epidemiology, Complejo Hospitalario Universitario, Santiago de Compostela, Spain (MA-S, FG).

Background: Measurements of C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) are frequently ordered jointly in clinical practice.

Aim: To investigate the factors associated with discordances between CRP concentration and ESR in adults.

Methods: We conducted a cross-sectional study of 1472 adults with no known inflammatory disorders (44. Read More

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February 2021

Patient, Provider, and Clinic Characteristics Associated with Opioid and Non-Opioid Pain Prescriptions for Patients Receiving Low Back Imaging in Primary Care.

J Am Board Fam Med 2021 Sep-Oct;34(5):950-963

From the Department of Radiology, School of Medicine, University of Washington, Seattle, WA (LSG, KTJ, SKJ, JGJ); Clinical Learning, Evidence, and Research Center, University of Washington, Seattle, WA (LSG, ENM, JAT, KTJ, JLF, PS, SKJ, PJH, JGJ); Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, WA (ZAM); Department of Biostatistics, University of Washington, Seattle, WA (ENM, PJH); Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA (JAT); Department of Rehabilitation Medicine, University of Washington, Seattle, WA (JAT, JLF); Department of Radiology Mayo Clinic, Rochester, MN (DFK, PHL); Department of Radiology, Henry Ford Hospital, Detroit, MI, (BG); Kaiser Permanente Washington, Seattle, WA (KJS); Rehabilitation Care Services, VA Puget Sound Health Care System, Seattle, WA (PS); Departments of Family Medicine and Internal Medicine, Oregon Health & Science University, Portland, OR (RAD); Division of Research, Kaiser Permanente Northern California, Oakland, CA (ALA).

Background: To describe characteristics of patients, providers, and clinics associated with opioid or non-opioid pain medication prescribing patterns for patients who received lower spine imaging in primary care clinics.

Methods: In these secondary analyses of the Lumbar Imaging with Reporting of Epidemiology (LIRE) study, a randomized controlled trial conducted in 4 health systems in the United States, we evaluated characteristics associated with receipt of pain medication prescriptions. The outcomes were receipt of prescriptions for opioid or, separately, non-opioid pain medications within 90 days after imaging. Read More

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January 2021

Willingness of tobacco farmers to accept compensation for tobacco crop substitution in Lichuan City, China.

Tob Control 2021 Sep 17. Epub 2021 Sep 17.

Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, People's Republic of China

Objective: This study, conducted in China, explores tobacco farmers' willingness to accept (WTA) compensation for tobacco crop substitution.

Methods: The contingent valuation method was used to elicit farmers' WTA compensation. A face-to-face survey was conducted with 280 tobacco farmers in Lichuan City, China. Read More

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September 2021

Effect of ethnicity and other sociodemographic factors on attendance at diabetic eye screening: a 12-month retrospective cohort study.

BMJ Open 2021 Sep 17;11(9):e046264. Epub 2021 Sep 17.

Homerton University Hospital NHS Foundation Trust, London, UK

Objectives: To examine the association of sociodemographic characteristics with attendance at diabetic eye screening in a large ethnically diverse urban population.

Design: Retrospective cohort study.

Setting: Screening visits in the North East London Diabetic Eye Screening Programme (NELDESP). Read More

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September 2021

Clinical-radiological Correlation in Temporal Bone Fractures.

Acta Otorrinolaringol Esp (Engl Ed) 2021 Sep-Oct;72(5):295-304

Servicio de Otorrinolaringología, Hospital Universitario La Paz, Madrid, Spain; Instituto de Investigación Hospital Universitario La Paz, Madrid, Spain; Centro de Investigación Biomédica en Red para Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.

Introduction: The diagnosis of temporal bone fractures (TBF) is based on radiological imaging. The most widely used classification divides fractures into longitudinal, transverse, and mixed. In recent years, other classifications have emerged to better predict clinical manifestations. Read More

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Acute ischemic stroke with cervical internal carotid artery steno-occlusive lesion: multicenter analysis of endovascular approaches.

BMC Neurol 2021 Sep 17;21(1):362. Epub 2021 Sep 17.

UOC Neurologia e Rete Stroke metropolitana Ospedale Maggiore CA Pizzardi - IRCCS delle scienze Neurologiche di Bologna, Bologna, Italy.

Background: Occlusion of the internal carotid artery (ICA), whether isolated or in the setting of a tandem lesion (TL) have a poor response to treatment with intravenous thrombolysis. Previous studies ​​have demonstrated the superiority of mechanical thrombectomy in the treatment of acute ischemic stroke (AIS) following large vessel occlusion, compared to standard intravenous fibrinolysis. The aim of our study was to describe endovascular treatment (EVT) in AIS due to isolated ICA occlusion or TL. Read More

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September 2021

Association of venous thromboembolism following pediatric traumatic spinal injuries with injury severity and longer hospital stays.

J Neurosurg Spine 2021 Sep 17:1-7. Epub 2021 Sep 17.

1Computational Neurosciences Outcomes Center, Department of Neurosurgery, Harvard Medical School, Brigham and Women's Hospital; and.

Objective: Venous thromboembolism (VTE) can cause significant morbidity and mortality in hospitalized patients, and may disproportionately occur in patients with limited mobility following spinal trauma. The authors aimed to characterize the epidemiology and clinical predictors of VTE in pediatric patients following traumatic spinal injuries (TSIs).

Methods: The authors conducted a retrospective cohort analysis of children who experienced TSI, including spinal fractures and spinal cord injuries, encoded within the National Trauma Data Bank from 2011 to 2014. Read More

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September 2021

Intraparenchymal hemorrhage after serial ventricular reservoir taps in neonates with hydrocephalus and association with neurodevelopmental outcome at 2 years of age.

J Neurosurg Pediatr 2021 Sep 17:1-8. Epub 2021 Sep 17.

7Division of Neuroscience, Department of Neurosurgery, University Medical Center Utrecht, and Utrecht University, Utrecht, The Netherlands.

Objective: Decompressing the ventricles with a temporary device is often the initial neurosurgical intervention for preterm infants with hydrocephalus. The authors observed a subgroup of infants who developed intraparenchymal hemorrhage (IPH) after serial ventricular reservoir taps and sought to describe the characteristics of IPH and its association with neurodevelopmental outcome.

Methods: In this multicenter, case-control study, for each neonate with periventricular and/or subcortical IPH, a gestational age-matched control with reservoir who did not develop IPH was selected. Read More

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September 2021